G-protein-coupled receptor regulation of de novo purine biosynthesis: A novel druggable mechanism

Biotechnology and Genetic Engineering Reviews

Volumn 29, Issue 1, 2013, Pages 31-48

  Fang, Ye ^a   French, Jarrod ^a   Zhao, Hong ^a   Benkovic, Stephen ^b  

^a Corning Incorporated ^*  (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Drug discovery; Dynamic mass redistribution assay; G protein coupled receptor; Metabolic flux; Mitogenic signaling; Purine de novo biosynthesis; Purine salvage pathway; Purinosome

Indexed keywords

BIOCHEMISTRY; ENZYMES; METABOLISM;

DRUG DISCOVERY; DYNAMIC MASS REDISTRIBUTION; DYNAMIC MASS REDISTRIBUTION ASSAY; G PROTEIN COUPLED RECEPTORS; METABOLIC FLUX; MITOGENIC; MITOGENIC SIGNALING; PURINE DE NOVO BIOSYNTHESIS; PURINE SALVAGE PATHWAY; PURINOSOME; SALVAGE PATHWAY;

BIOSYNTHESIS;

ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; ANTIVIRUS AGENT; G PROTEIN COUPLED RECEPTOR; PURINE; PURINE NUCLEOTIDE; PYRIMIDINE; PYRIMIDINE NUCLEOTIDE; MACROMOLECULE; PURINE DERIVATIVE;

ARTICLE; BINDING SITE; BIOSYNTHESIS; CATABOLISM; CELL CYCLE REGULATION; CELL MEMBRANE; CELL PROLIFERATION; CELL TRANSFORMATION; DNA REPLICATION; DNA SYNTHESIS; DRUG SCREENING; HUMAN; MACROMOLECULE; METHYLATION; MOLECULAR GENETICS; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE METABOLISM; OXIDATION; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PURINE SYNTHESIS; PYRIMIDINE SYNTHESIS; REGULATORY MECHANISM; RNA SYNTHESIS; SIGNAL TRANSDUCTION; DRUG DEVELOPMENT; GENETICS; METABOLISM;

DRUG DISCOVERY; MACROMOLECULAR SUBSTANCES; PURINES; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84881174953     PISSN: 02648725     EISSN: None     Source Type: Journal    
DOI: 10.1080/02648725.2013.801237     Document Type: Article

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