Tyrphostin analogs are GPR35 agonists

FEBS Letters

Volumn 585, Issue 12, 2011, Pages 1957-1962

  Deng, Huayun ^a   Hu, Haibei ^a   Fang, Ye ^a  

^a Corning Inc ^*  (United States)

Author keywords

Dynamic mass redistribution; G protein coupled receptor; GPR35; Optical biosensor; Tyrphostin

Indexed keywords

3 BROMO 5 TERT BUTYL 4 HYDROXYBENZYLIDENEMALONONITRILE; 5 (2 BENZOTHIAZOLYL)THIOMETHYL 4 HYDROXY 3 METHOXYBENZYLIDENECYANOACETAMIDE; BETA ARRESTIN; EMBONIC ACID; ENTACAPONE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 35; KYNURENIC ACID; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; TYRPHOSTIN; TYRPHOSTIN 1; TYRPHOSTIN 25; TYRPHOSTIN 27; TYRPHOSTIN 46; TYRPHOSTIN 47; TYRPHOSTIN 51; TYRPHOSTIN 9; TYRPHOSTIN AG 112; TYRPHOSTIN AG 126; TYRPHOSTIN AG 1288; TYRPHOSTIN AG 370; TYRPHOSTIN AG 494; UNCLASSIFIED DRUG; ZAPRINAST;

ANALYTIC METHOD; ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DYNAMIC MASS REDISTRIBUTION ASSAY; ENZYME ASSAY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ARRESTINS; DRUG DISCOVERY; ENDOCYTOSIS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RECEPTORS, G-PROTEIN-COUPLED; TYRPHOSTINS;

EID: 79958142575     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.05.026     Document Type: Article

References (19)

1. B.F. O'Dowd, T. Nguyen, A. Marchese, R. Cheng, K.R. Lynch, H.H. Heng, L.F. Kolakowski Jr., and S.R. George Discovery of three novel G-protein-coupled receptor genes Genomics 47 1998 310 313 (Pubitemid 28086858)
2. S. Okumura, H. Baba, T. Kumada, K. Nanmoku, H. Nakajima, Y. Nakane, K. Hioki, and K. Ikenaka Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells Cancer Sci. 95 2004 131 135 (Pubitemid 38404313)
3. M. Imielinski Common variants at five new loci associated with early-onset inflammatory bowel disease Nat. Genet. 41 2009 1335 1340
4. Y. Yang, J.Y.L. Lu, X. Wu, S. Summer, J. Whoriskey, C. Saris, and J.D. Reagan G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium Pharmacology 86 2010 1 5
5. L. Sparfel, M.-L. Pinel-Marie, M. Boize, S. Koscielny, S. Desmots, A. Pery, and O. Fardel Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(α)pyrene Toxicol. Sci. 114 2010 247 259
6. K.D. Min, M. Asakura, Y. Liao, K. Nakamaru, H. Okazaki, T. Takahashi, K. Fujimoto, S. Ito, A. Takahashi, H. Asanuma, S. Yamazaki, T. Minamino, S. Sanada, O. Seguchi, A. Nakano, Y. Ando, T. Otsuka, H. Furukawa, T. Isomura, S. Takashima, N. Mochizuki, and M. Kitakaze Identification of genes related to heart failure using global gene expression profiling of human failing myocardium Biochem. Biophys. Res. Commun. 393 2010 55 60
7. J. Wang, N. Simonavicius, X. Wu, G. Swaminath, J. Reagan, H. Tian, and L. Ling Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35 J. Biol. Chem. 281 2006 22021 22028 (Pubitemid 44181906)
8. S. Oka, R. Ota, M. Shima, A. Yamashita, and T. Sugiura GPR35 is a novel lysophosphatidic acid receptor Biochem. Biophys. Res. Commun. 395 2010 232 237
9. G. Milligan Orthologue selectivity and ligand bias: translating the pharmacology of GPR35 Trends Pharmacol. Sci. 32 2011 317 325
10. Y. Fang Label-free receptor assays Drug Discov. Today Technol. 7 2010 e5 e11
11. Y. Fang, A.M. Ferrie, N.H. Fontaine, J. Mauro, and J. Balakrishnan Resonant waveguide grating biosensor for living cell sensing Biophys. J. 2006 91 2006 1925 1940 (Pubitemid 44352454)
12. T. Kenakin Cellular assays as portals to seven-transmembrane receptor-based drug discovery Nat. Rev. Drug Discov. 8 2009 617 626
13. R. Schröder, N. Janssen, J. Schmidt, A. Kebig, N. Merten, S. Hennen, A. Müller, S. Blättermann, M. Mohr-Andrä, S. Zahn, J. Wenzel, N.J. Smith, J. Gomeza, C. Drewke, G. Milligan, K. Mohr, and E. Kostenis Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements Nat. Biotechnol. 28 2010 943 949
14. Y. Fang Probing cancer signaling with resonant waveguide grating biosensors Exp. Opin. Drug Discov. 5 2010 1237 1248
15. Y. Taniguchia, H. Tonai-Kachia, and K. Shinjo Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35 FEBS Lett. 580 2006 5003 5008 (Pubitemid 44332369)
16. P. Zhao, H. Sharir, A. Kapur, A. Cowan, E.B. Geller, M.W. Adler, H.H. Seltzman, P.H. Reggio, S. Heynen-Genel, M. Sauer, T.D.Y. Chung, Y. Bai, W. Chen, M.G. Caron, L.S. Barak, and M.E. Abood Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of ERK and β-arrestin2, with antinociceptive activity Mol. Pharmacol. 78 2010 560 568
17. α13 Biochem. J. 432 2010 451 459
18. D.S. Wishart, C. Knox, A.C. Guo, D. Cheng, S. Shrivastava, D. Tzur, B. Gautam, and M. Hassanali DrugBank: a knowledgebase for drugs, drug actions and drug targets Nucleic Acids Res. 36 2007 D901 D906
19. A. Levitzki, and E. Mishani Tyrphostins and other tyrosine kinase inhibitors Annu. Rev. Biochem. 75 2006 93 109 (Pubitemid 44118027)