Mthfs is an essential gene in mice and a component of the purinosome

Frontiers in Genetics

Volumn 2, Issue JUNE, 2011, Pages

  Field, Martha S ^a   Anderson, Donald D ^a   Stover, Patrick J ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

5 formyltetrahydrofolate; Folate; Leucovorin; Mthfs; Purine biosynthesis; Purinosome; Shmt; Sumo

Indexed keywords

ANIMALIA; ARABIDOPSIS; MAMMALIA; MUS;

EID: 84857765486     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2011.00036     Document Type: Article

References (39)

1. An, S., Deng, Y. J., Tomsho, J. W., Kyoung, M., and Benkovic, S. J. (2010a). Microtubule-assisted mechanism for functional metabolic macromolecular complex formation. Proc. Natl. Acad. Sci. U.S.A. 107, 12872-12876.
2. An, S., Kyoung, M., Allen, J. J., Shokat, K. M., and Benkovic, S. J. (2010b). Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. J. Biol. Chem. 285, 11093-11099.
3. An, S. G., Kumar, R., Sheets, E. D., and Benkovic, S. J. (2008). Reversible compartmentalization of de novo purine biosynthetic complexes in living cells. Science 320, 103-106.
4. Anguera, M. C., and Stover, P. J. (2006) Methenyltetrahydrofo-late synthetase is a high-affinity catecholamine-binding protein. Arch. Biochem. Biophys. 455, 175-187.
5. Anguera, M. C., Suh, J. R., Ghandour, H., Nasrallah, I. M., Selhub, J., and Stover, P. J. (2003). Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. J. Biol. Chem. 278,29856-29862.
6. Beaudin, A. E., and Stover, P. J. (2009). Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res. A Clin. Mol. Teratol. 85, 274-284.
7. Bensadoun, A., and Weinstein, D. (1976). Assay of proteins in the presence of interfering materials. Anal. Biochem. 70,241-250.
8. Bertrand, R., and Jolivet, J. (1989).Methenyltetrahydro-folate synthetase prevents the inhibition of phosphoribosyl 5-aminoimidazole 4-carboxamide ribonucleotide formyltransferase by 5-formyltetrahydrofolate polyglutamates. J. Biol. Chem. 264, 8843-8846.
9. Blount, B. C., Mack, M. M., Wehr, C. M., Macgregor, J. T., Hiatt, R. A., Wang, G., Wickramasinghe, S. N., Everson, R. B., and Ames, B. N. (1997). Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl. Acad. Sci. U.S.A. 94, 3290-3295.
10. Ching, Y. H., Munroe, R. J., Moran, J. L., Barker, A. K., Mauceli, E., Fennell, T., Dipalma, F., Lindblad-Toh, K., Abcunas, L.M., Gilmour, J. F., Harris, T. P., Kloet, S. L., Luo, Y., Mcelwee, J. L., Mu, W., Park, H. K., Rogal, D. L., Schimenti, K. J., Shen, L., Shindo, M., Shou, J. Y., Stenson, E. K., Stover, P. J., and Schimenti, J. C. (2010). High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5. BMC Genet. 11,106.
11. Field, M. S., Anguera, M. C., Page, R., and Stover, P. J. (2009). 5,10-Methenyltetrahydrofolate synthetase activity is increased in tumors and modifies the efficacy of antipurine LY309887. Arch. Biochem. Biophys. 481, 145-150.
12. Field, M. S., Szebenyi, D. M., and Stover, P. J. (2006). Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma. J. Biol. Chem. 281, 4215-4221.
13. Friso, S., Choi, S. W., Girelli, D., Mason, J. B., Dolnikowski, G. G., Bagley, P. J., Olivieri, O.,Jacques, P. F., Rosenberg, I. H., Corrocher, R., and Selhub, J. (2002). A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc. Natl. Acad. Sci U.S.A. 99,5606-5611.
14. Geiss-Friedlander, R., and Melchior, F. (2007). Concepts in sumoylation: a decade on. Nat. Rev. Mol. Cell Biol. 8, 947-956.
15. Girgis, S., Suh, J. R., Jolivet, J., and Stover, P. J. (1997). 5-Formyltetrahydrofolate regulates homocysteine remethylation in human neuroblastoma. J. Biol. Chem. 272, 4729-4734.
16. Goyer, A., Collakova, E., De La Garza, R. D., Quinlivan, E. P., Williamson, J., Gregory, J. F., Shachar-Hill, Y., and Hanson, A. D. (2005). 5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves. J. Biol. Chem. 280,26137-26142.
17. Habeck, L. L., Leitner, T. A., Shackelford, K. A., Gossett, L. S., Schultz, R. M., Andis, S. L., Shih, C., Grindey, G. B., and Mendelsohn, L. G. (1994). A novel class of monoglutamated antifolates exhibits tightbinding inhibition of human glycinamide ribonucleotide formyltrans-ferase and potent activity against solid tumors. Cancer Res. 54, 1021-1026.
18. Jackson, R. C., and Harkrader, R. J. (1981). "The contributions of de novo and salvage pathways of nucleotide biosynthesis in normal and malignant cells," in Nucleosides and Cancer Treatment, eds M. N. H. Tattersall and R. M. Fox (Sydney: Academic Press), 18-31.
19. Jeanguenin, L., Lara-Nunez, A., Pribat, A., Mageroy, M. H., Gregory, J. F. III, Rice, K. C., De Crecy-Lagard, V., and Hanson, A. D. (2010). Moonlighting glutamate formimino-transferases can functionally replace 5-formyltetrahydrofolate cycloligase. J. Biol. Chem. 285, 41557-41566.
20. Kondo, M., Yamaoka, T., Honda, S., Miwa, Y., Katashima, R., Moritani, M., Yoshimoto, K., Hayashi, Y., and Itakura, M. (2000). The rate of cell growth is regulated by purine biosynthesis via ATP production and G(1) to S phase transition. J. Biochem. 128, 57-64.
21. Kruschwitz, H. L., Mcdonald, D., Cossins, E. A., and Schirch, V. (1994). 5-Formyltetrahydroptero-ylpolyglutamates are the major folate derivatives in Neurospora crassa conidiospores. J. Biol. Chem. 269,28757-28763.
22. Lindenbaum, J.,and Allen, R.H. (1995). "Clinical spectrum and diagnosis of folate deficiency," in Folate in Health and Disease, ed. L. B. Bailey (New York: Marcel Dekker, Inc.), 43-73.
23. Macfarlane, A. J., Perry, C. A., Mcentee, M. F., Lin, D. M., and Stover, P. J. (2011). Shmt1 heterozygosity impairs folate-dependent thymidy-late synthesis capacity and modifies risk of Ap cminmediated intestinal cancer risk. Cancer Res. 71, 2098-2107.
24. Mathews, C. K. (2006). DNA precursor metabolism and genomic stability. FASEBJ. 20,1300-1314.
25. McGuire, J. J. (2003). Anticancer antifolates: current status and future directions. Curr. Pharm. Des. 9, 2593-2613.
26. Melnyk, S., Pogribna, M., Miller, B. J., Basnakian, A. G., Pogribny, I. P., and James, S. J. (1999). Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells. Cancer Lett. 146, 35-44.
27. Oppenheim, E. W., Adelman, C., Liu, X., and Stover, P. J. (2001). Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis. J. Biol. Chem. 276, 19855-19861.
28. Selhub, J. (1999). Homocysteine metabolism. Annu. Rev. Nutr. 19, 217-246.
29. Shane, B. (1995). "Folate chemistry and metabolism," in Folate in Health and Disease, ed. L. B. Bailey (New York: Marcel Dekker, Inc.), 1-22.
30. Stover, P., and Schirch, V. (1991). 5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase. J. Biol. Chem. 266, 1543-1550.
31. Stover, P., and Schirch, V. (1992). Evidence for the accumulation of a stable intermediate in the nonenzymatic hydrolysis of 5,10-methenyltetrahydropteroylglu-tamate to 5-formyltetrahydrop-teroylglutamate. Biochemistry 31, 2148-2155.
32. Stover, P., and Schirch, V. (1993). The metabolic role of leucovorin. Trends Biochem. Sci. 18, 102-106.
33. Suh, J. R., Herbig, A. K., and Stover, P. J. (2001). New perspectives on folate catabolism. Annu. Rev. Nutr. 21,255-282.
34. Suh, J. R., Oppenheim, E. W., Girgis, S., and Stover, P. J. (2000). Purification and properties of a folate-catabolizing enzyme. J. Biol. Chem. 275,35646-35655.
35. Taketo, M. M., and Edelmann, W. (2009). Mouse models of colon cancer. Gastroenterology 136, 780-798.
36. Ueland, P. M., Refsum, H., Beresford, S. A., and Vollset, S. E. (2000). The controversy over homocysteine and cardiovascular risk. Am. J. Clin. Nutr. 72,324-332.
37. Woeller, C. F., Anderson, D. D., Szebenyi, D. M., and Stover, P. J. (2007). Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway. J. Biol. Chem. 282, 17623-17631.
38. Yamaoka, T., Kondo, M., Honda, S., Iwahana, H., Moritani, M., Ii, S., Yoshimoto, K., and Itakura, M. (1997). Amidophosphoribosyl-transferase limits the rate of cell growth-linked de novo purine biosynthesis in the presence of constant capacity of salvage purine biosynthesis. J. Biol. Chem. 272, 17719-17725.
39. Yi, P., Melnyk, S., Pogribna, M., Pogribny, I. P., Hine, R. J., and James, S. J. (2000). Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J. Biol. Chem. 275,29318-29323.