Microtubule-assisted mechanism for functional metabolic macromolecular complex formation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 29, 2010, Pages 12872-12876

  An, Songon ^a   Deng, Yijun ^a   Tomsho, John W ^a   Kyoung, Minjoung ^b   Benkovic, Stephen J ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Metabolism; Protein complex; Purine biosynthesis

Indexed keywords

MULTIENZYME COMPLEX; NOCODAZOLE; PURINE; PURINOSOME ENZYME; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CYTOPLASM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME METABOLISM; HELA CELL; HUMAN; HUMAN CELL; IMAGING SYSTEM; MACROMOLECULE; MICROTUBULE; PRIORITY JOURNAL; PURINE SYNTHESIS;

BIOLOGICAL TRANSPORT; CARBON-NITROGEN LIGASES WITH GLUTAMINE AS AMIDE-N-DONOR; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MACROMOLECULAR SUBSTANCES; MICROFILAMENTS; MICROTUBULES; MULTIENZYME COMPLEXES; NOCODAZOLE; PURINES; RECOMBINANT FUSION PROTEINS; SUBCELLULAR FRACTIONS;

EID: 77955593994     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1008451107     Document Type: Article

References (11)

1. Rowe PB, Wyngaarden JB (1968) Glutamine phosphoribosylpyrophosphate amidotransferase. Purification, substructure, amino acid composition, and absorption spectra. J Biol Chem 243:6373-6383.
2. Smith GK, Mueller WT, Wasserman GF, Taylor WD, Benkovic SJ (1980) Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis. Biochemistry 19:4313-4321.
3. Srere PA (1987) Complexes of sequential metabolic enzymes. Annu Rev Biochem 56:89-124.
4. An S, Kumar R, Sheets ED, Benkovic SJ (2008) Reversible compartmentalization of de novo purine biosynthetic complexes in living cells. Science 320:103-106.
5. An S, Kyoung M, Allen JJ, Shokat KM, Benkovic SJ (2010) Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. J Biol Chem 285:11093-11099.
6. Minaschek G, Gröschel-Stewart U, Blum S, Bereiter-Hahn J (1992) Microcompartmentation of glycolytic enzymes in cultured cells. Eur J Cell Biol 58:418-428.
7. Pagliaro L, Taylor DL (1988) Aldolase exists in both the fluid and solid phases of cytoplasm. J Cell Biol 107:981-991.
8. Götz R, Schlüter E, Shoham G, Zimmermann FK (1999) A potential role of the cytoskeleton of Saccharomyces cerevisiae in a functional organization of glycolytic enzymes. Yeast 15:1619-1629.
9. Bereiter-Hahn J, Stübig C, Heymann V (1995) Cell cycle-related changes in F-actin distribution are correlated with glycolytic activity. Exp Cell Res 218:551-560.
10. Boss GR, Erbe RW (1982) Decreased purine synthesis during amino acid starvation of human lymphoblasts. J Biol Chem 257:4242-4247.
11. Yamaoka T, et al. (2001) Feedback inhibition of amidophosphoribosyltransferase regulates the rate of cell growth via purine nucleotide, DNA, and protein syntheses. J Biol Chem 276:21285-21291.