Overexpression of Alpha2A-Adrenergic receptors contributes to type 2 diabetes

Science

Volumn 327, Issue 5962, 2010, Pages 217-220

  Rosengren, Anders H ^a   Jokubka, Ramunas ^a   Tojjar, Damon ^a   Granhall, Charlotte ^a   Hansson, Ola ^a   Li, Dai Qing ^b   Nagaraj, Vini ^a   Reinbothe, Thomas M ^a   Tuncel, Jonatan ^c   Eliasson, Lena ^a   Groop, Leif ^a   Rorsman, Patrik ^d   Salehi, Albert ^a   Lyssenko, Valeriya ^a   Luthman, Holger ^a   Renström, Erik ^a  

^a LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^b BEIJING HOSPITAL   (China)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; GLUCOSE; INSULIN;

ALLELE; DIABETES; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; POLYMORPHISM; RODENT;

ARTICLE; EXOCYTOSIS; GENE FREQUENCY; GENE LOCUS; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN SENSITIVITY; MOLECULAR DOCKING; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADULT; AGED; ANIMALS; ANIMALS, CONGENIC; BLOOD GLUCOSE; CELL MEMBRANE; CYCLIC AMP; DIABETES MELLITUS, TYPE 2; EXOCYTOSIS; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RATS; RATS, INBRED STRAINS; RECEPTORS, ADRENERGIC, ALPHA-2; RISK FACTORS; RNA INTERFERENCE; SECRETORY VESICLES; UP-REGULATION; YOUNG ADULT;

RATTUS;

EID: 74249123937     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1176827     Document Type: Article

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26. We thank I. Lundquist and T. Andersson for help with the in vivo and fura-2 data, and B.-M. Nilsson and M. Neptin for technical assistance. Supported by project grants from the Swedish Research Council, the European Foundation for the Study of Diabetes, the Novo Nordisk and Albert Påhlsson foundations (E. R), Kungliga Fysiografiska Sällskapet (A.R.), The Nordic Centre of Excellence in Disease Genetics (NCoEDG) (R.J.), a Linnaeus grant to the Lund University Diabetes Centre, and the Knut and Alice Wallenberg Foundation. Access to human pancreatic islets was granted by J. Taneera in collaboration with the Nordic Network for Clinical Islet Transplantation (NNCIT), O. Korsgren, Uppsala University.