Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer

Chemical Reviews

Volumn 109, Issue 7, 2009, Pages 2880-2893

  Parker, William B ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE METABOLITES; ANTI-CANCER AGENTS; ANTI-TUMOR ACTIVITIES; ANTI-TUMOR AGENTS; APHIDICOLIN; APOPTOSIS; BIOCHEMICAL CHARACTERISTICS; BIOLOGICAL ACTIVITIES; CATABOLIC ENZYMES; CONTINUED USE; CONTRIBUTING FACTOR; CYTOTOXIC; DNA DAMAGES; DNA FUNCTION; DNA MOLECULES; DNA POLYMERASE; DNA REPLICATIONS; DNA SYNTHESIS; DRUG DISCOVERY; GEMCITABINE; HOST TISSUES; INTRACELLULAR RETENTION; MERCAPTOPURINE; MINIMAL EFFECTS; MOLECULAR TARGETS; NATURAL PROCESS; NUCLEOSIDE ANALOGUES; NUCLEOTIDE ANALOGUES; POTENT INHIBITOR; PROTEIN SYNTHESIS; RIBONUCLEOTIDE; RIBONUCLEOTIDE REDUCTASE; RNA SYNTHESIS; SELECTIVE ACTIVATION; SELECTIVE INHIBITORS; SOLID TUMORS; STRUCTURAL MODIFICATIONS; SYNTHETASE; TRIPHOSPHATE; TUMOR CELLS; VIRAL DISEASE;

BIOACTIVITY; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOMOLECULES; CATALYSTS; CELL DEATH; CHEMICAL ACTIVATION; CHEMICAL MODIFICATION; CHEMICAL STABILITY; COMPLEXATION; DNA; ENZYME ACTIVITY; ENZYMES; GENES; METABOLISM; METABOLITES; METAL RECOVERY; NUCLEIC ACIDS; RNA; TARGETS; TOXICITY; TUMORS;

CELL MEMBRANES;

ANTINEOPLASTIC ANTIMETABOLITE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ARTICLE; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; GENE THERAPY; HUMAN; METABOLISM; NEOPLASM;

ANTIMETABOLITES, ANTINEOPLASTIC; DRUG DESIGN; GENE THERAPY; HUMANS; NEOPLASMS; PURINES; PYRIMIDINES;

EID: 67650685040     PISSN: 00092665     EISSN: 15206890     Source Type: Journal    
DOI: 10.1021/cr900028p     Document Type: Article

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