-
1
-
-
27844519281
-
New concepts in drug discovery: Collateral efficacy and permissive antagonism
-
T.P. Kenakin New concepts in drug discovery: collateral efficacy and permissive antagonism Nat. Rev. Drug Discov. 4 2005 919 927
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 919-927
-
-
Kenakin, T.P.1
-
2
-
-
34447642715
-
The evasive nature of drug efficacy: Implications for drug discovery
-
S. Galandrin The evasive nature of drug efficacy: implications for drug discovery Trends Pharmacol. Sci. 8 2007 423 430
-
(2007)
Trends Pharmacol. Sci.
, vol.8
, pp. 423-430
-
-
Galandrin, S.1
-
3
-
-
45149110002
-
Label-free cell assays for GPCR screening
-
Y. Fang Label-free cell assays for GPCR screening Comb. Chem. High Throughput Screen. 11 2008 357 369
-
(2008)
Comb. Chem. High Throughput Screen.
, vol.11
, pp. 357-369
-
-
Fang, Y.1
-
4
-
-
33746889808
-
A comprehensive pathway map of epidermal growth factor receptor signaling
-
K. Oda A comprehensive pathway map of epidermal growth factor receptor signaling Mol. Syst. Biol. 1 2005 0010
-
(2005)
Mol. Syst. Biol.
, vol.1
, pp. 0010
-
-
Oda, K.1
-
5
-
-
0034644509
-
Signaling networks: The origins of cellular multitasking
-
J.D. Jordan Signaling networks: the origins of cellular multitasking Cell 103 2000 193 200
-
(2000)
Cell
, vol.103
, pp. 193-200
-
-
Jordan, J.D.1
-
6
-
-
0038608273
-
Four-dimensional organization of protein kinase signaling cascades: The roles of diffusion, endocytosis and molecular motors
-
B.N. Kholodenko Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors J. Exp. Biol. 206 2003 2073 2082
-
(2003)
J. Exp. Biol.
, vol.206
, pp. 2073-2082
-
-
Kholodenko, B.N.1
-
7
-
-
68249113457
-
Cellular assays as portals to seven-transmembrane receptor-based drug discovery
-
T. Kenakin Cellular assays as portals to seven-transmembrane receptor-based drug discovery Nat. Rev. Drug Discov. 8 2009 617 626
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 617-626
-
-
Kenakin, T.1
-
8
-
-
33748469378
-
Resonant waveguide grating biosensor for living cell sensing
-
Y. Fang Resonant waveguide grating biosensor for living cell sensing Biophys. J. 91 2006 1925 1940
-
(2006)
Biophys. J.
, vol.91
, pp. 1925-1940
-
-
Fang, Y.1
-
9
-
-
33845877164
-
Label-free cell-based assays with optical biosensors in drug discovery
-
Y. Fang Label-free cell-based assays with optical biosensors in drug discovery Assays Drug Dev. Technol. 4 2006 583 595
-
(2006)
Assays Drug Dev. Technol.
, vol.4
, pp. 583-595
-
-
Fang, Y.1
-
10
-
-
0032834377
-
Analysis of molecular recognition using optical biosensors
-
R.J. Leatherbarrow, and P.R. Edwards Analysis of molecular recognition using optical biosensors Curr. Opin. Chem. Biol. 3 1999 544 547
-
(1999)
Curr. Opin. Chem. Biol.
, vol.3
, pp. 544-547
-
-
Leatherbarrow, R.J.1
Edwards, P.R.2
-
11
-
-
0345550287
-
Techniques: Plasmon-waveguide resonance (PWR) spectroscopy as a tool to study ligand-GPCR interactions
-
G. Tollin Techniques: plasmon-waveguide resonance (PWR) spectroscopy as a tool to study ligand-GPCR interactions Trends Pharmacol. Sci. 24 2003 655 659
-
(2003)
Trends Pharmacol. Sci.
, vol.24
, pp. 655-659
-
-
Tollin, G.1
-
12
-
-
0026738687
-
Electrical method for detection of endothelial cell shape change in real time: Assessment of endothelial barrier function
-
C. Tiruppathi Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function Proc. Natl. Acad. Sci. U. S. A. 89 1992 7919 7923
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 7919-7923
-
-
Tiruppathi, C.1
-
13
-
-
0028410230
-
Kinetics of adhesion and spreading of animal cells
-
J.J. Ramsden Kinetics of adhesion and spreading of animal cells Biotechnol. Bioeng. 43 1994 939 945
-
(1994)
Biotechnol. Bioeng.
, vol.43
, pp. 939-945
-
-
Ramsden, J.J.1
-
14
-
-
0037112536
-
Assessment of cytotoxicity using electric cell-substrate impedance sensing: Concentration and time response function approach
-
C. Xiao Assessment of cytotoxicity using electric cell-substrate impedance sensing: concentration and time response function approach Anal. Chem. 74 2002 5748 5753
-
(2002)
Anal. Chem.
, vol.74
, pp. 5748-5753
-
-
Xiao, C.1
-
15
-
-
35248895259
-
Impedance-based cellular assay technologies: Recent advances, future promise
-
R. McGuinness Impedance-based cellular assay technologies: recent advances, future promise Curr. Opin. Pharmacol. 7 2007 535 540
-
(2007)
Curr. Opin. Pharmacol.
, vol.7
, pp. 535-540
-
-
McGuinness, R.1
-
16
-
-
30044448180
-
Real-time monitoring of morphological changes in living cells by electronic cell sensor arrays: An approach to study G protein-coupled receptors
-
N. Yu Real-time monitoring of morphological changes in living cells by electronic cell sensor arrays: an approach to study G protein-coupled receptors Anal. Chem. 78 2006 35 43
-
(2006)
Anal. Chem.
, vol.78
, pp. 35-43
-
-
Yu, N.1
-
17
-
-
8844247382
-
Label-free assays on the BIND system
-
P. Li Label-free assays on the BIND system J. Biomol. Screen. 9 2004 481 490
-
(2004)
J. Biomol. Screen.
, vol.9
, pp. 481-490
-
-
Li, P.1
-
18
-
-
36048969417
-
Non-invasive optical biosensor for probing cell signaling
-
Y. Fang Non-invasive optical biosensor for probing cell signaling Sensors 7 2007 2316 2329
-
(2007)
Sensors
, vol.7
, pp. 2316-2329
-
-
Fang, Y.1
-
19
-
-
67650373898
-
Resonant waveguide grating biosensor for whole cell GPCR assays
-
Y. Fang Resonant waveguide grating biosensor for whole cell GPCR assays W.R. Leifert, G Protein-coupled Receptors in Drug Discovery 2009 Humana Press 239 252
-
(2009)
G Protein-coupled Receptors in Drug Discovery
, pp. 239-252
-
-
Fang, Y.1
-
20
-
-
24644496122
-
Characteristics of dynamic mass redistribution of epidermal growth factor receptor signaling in living cells measured with label-free optical biosensors
-
DOI 10.1021/ac050887n
-
Y. Fang Characteristics of dynamic mass redistribution of EGF receptor signaling in living cells measured with label free optical biosensors Anal. Chem. 77 2005 5720 5725 (Pubitemid 41266070)
-
(2005)
Analytical Chemistry
, vol.77
, Issue.17
, pp. 5720-5725
-
-
Fang, Y.1
Ferrie, A.M.2
Fontaine, N.H.3
Yuen, P.K.4
-
21
-
-
33748159230
-
Label-free and real-time cell-based kinase assay for screening selective and potent receptor tyrosine kinase inhibitors using microelectronic sensor array
-
J.M. Atienza Label-free and real-time cell-based kinase assay for screening selective and potent receptor tyrosine kinase inhibitors using microelectronic sensor array J. Biomol. Screen. 11 2006 634 643
-
(2006)
J. Biomol. Screen.
, vol.11
, pp. 634-643
-
-
Atienza, J.M.1
-
22
-
-
70349416545
-
7TM pharmacology measured by label-free: A holistic approach to cell signaling
-
M. Rocheville, and J.C. Jerman 7TM pharmacology measured by label-free: a holistic approach to cell signaling Curr. Opin. Pharmacol. 9 2009 643 649
-
(2009)
Curr. Opin. Pharmacol.
, vol.9
, pp. 643-649
-
-
Rocheville, M.1
Jerman, J.C.2
-
23
-
-
73949120732
-
GPCRs: Insane in the membrane
-
M. Eisenstein GPCRs: insane in the membrane Nat. Methods 6 2009 929 933
-
(2009)
Nat. Methods
, vol.6
, pp. 929-933
-
-
Eisenstein, M.1
-
24
-
-
60149093870
-
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons
-
A. Thathiah The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons Science 323 2009 946 951
-
(2009)
Science
, vol.323
, pp. 946-951
-
-
Thathiah, A.1
-
25
-
-
65549096659
-
GPR40: Good cop, bad cop?
-
T. Alquier, and V. Poitout GPR40: good cop, bad cop? Diabetes 58 2009 1035 1036
-
(2009)
Diabetes
, vol.58
, pp. 1035-1036
-
-
Alquier, T.1
Poitout, V.2
-
26
-
-
0038540318
-
Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors
-
E. Hermans Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors Pharmacol. Ther. 99 2003 25 44
-
(2003)
Pharmacol. Ther.
, vol.99
, pp. 25-44
-
-
Hermans, E.1
-
27
-
-
34447626644
-
Ligand-selective signaling and high content for GPCR drugs
-
R.B. Mailman Ligand-selective signaling and high content for GPCR drugs Trends Pharmacol. Sci. 8 2007 390 396
-
(2007)
Trends Pharmacol. Sci.
, vol.8
, pp. 390-396
-
-
Mailman, R.B.1
-
28
-
-
27744501166
-
2 receptor signaling in A431 cells
-
2 receptor signaling in A431 cells FEBS Lett. 579 2005 6365 6374
-
(2005)
FEBS Lett.
, vol.579
, pp. 6365-6374
-
-
Fang, Y.1
-
29
-
-
59449089513
-
The C-terminal tail of CRTH2 is a key molecular determinant that constrains Gαi- and downstream-signaling cascade activation
-
R. Schroeder The C-terminal tail of CRTH2 is a key molecular determinant that constrains Gαi- and downstream-signaling cascade activation J. Biol. Chem. 284 2009 1324 1336
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 1324-1336
-
-
Schroeder, R.1
-
30
-
-
34447510936
-
2+ regulation of adenylyl cyclases in cAMP microdomains
-
2+ regulation of adenylyl cyclases in cAMP microdomains Physiol. Rev. 87 2007 965 1010
-
(2007)
Physiol. Rev.
, vol.87
, pp. 965-1010
-
-
Willoughby, D.1
Cooper, D.M.2
-
31
-
-
33947217218
-
Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells
-
Y. Fang Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells J. Pharmacol. Toxicol. Methods 55 2007 314 322
-
(2007)
J. Pharmacol. Toxicol. Methods
, vol.55
, pp. 314-322
-
-
Fang, Y.1
-
32
-
-
58149391231
-
Duplexed label-free G protein-coupled receptor assays for high throughput screening
-
E. Tran, and Y. Fang Duplexed label-free G protein-coupled receptor assays for high throughput screening J. Biomol. Screen. 13 2008 975 985
-
(2008)
J. Biomol. Screen.
, vol.13
, pp. 975-985
-
-
Tran, E.1
Fang, Y.2
-
33
-
-
0035318509
-
Oligomerization of G-protein-coupled transmitter receptors
-
M. Bouvier Oligomerization of G-protein-coupled transmitter receptors Nat. Rev. Neurosci. 2 2001 274 286
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 274-286
-
-
Bouvier, M.1
-
34
-
-
0033807228
-
Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling
-
M.D. Houslay, and W. Kolch Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling Mol. Pharmacol. 58 2000 659 668
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 659-668
-
-
Houslay, M.D.1
Kolch, W.2
-
35
-
-
0030296744
-
G protein-coupled receptors: Heterologous regulation of homologous desensitization and its implications
-
T.T. Chuang G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications Trends Pharmacol. Sci. 17 1996 416 421
-
(1996)
Trends Pharmacol. Sci.
, vol.17
, pp. 416-421
-
-
Chuang, T.T.1
-
36
-
-
40349088827
-
G-protein-coupled receptor phosphorylation: Where, when and by whom
-
A.B. Tobin G-protein-coupled receptor phosphorylation: where, when and by whom Br. J. Pharmacol. 153 S1 2008 S167 S176
-
(2008)
Br. J. Pharmacol.
, vol.153
, Issue.S1
-
-
Tobin, A.B.1
-
37
-
-
70349773826
-
Label-free optical biosensor for probing integrative role of adenylyl cyclase in G protein-coupled receptor signaling
-
E. Tran, and Y. Fang Label-free optical biosensor for probing integrative role of adenylyl cyclase in G protein-coupled receptor signaling J. Recept. Signal Transduct. 29 2009 154 162
-
(2009)
J. Recept. Signal Transduct.
, vol.29
, pp. 154-162
-
-
Tran, E.1
Fang, Y.2
-
38
-
-
39649108870
-
2 adrenoceptor in living cells
-
2 adrenoceptor in living cells FEBS Lett. 582 2008 558 564
-
(2008)
FEBS Lett.
, vol.582
, pp. 558-564
-
-
Fang, Y.1
Ferrie, A.M.2
-
39
-
-
0141593597
-
β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
-
M. Azzi β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors Proc. Natl. Acad. Sci. U. S. A. 100 2003 11406 11411
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 11406-11411
-
-
Azzi, M.1
-
40
-
-
0024600440
-
The theoretical effects of single and multiple transducer receptor coupling proteins on estimates of the relative potency of agonists
-
T.P. Kenakin, and P.H. Morgan The theoretical effects of single and multiple transducer receptor coupling proteins on estimates of the relative potency of agonists Mol. Pharmacol. 35 1989 214 222
-
(1989)
Mol. Pharmacol.
, vol.35
, pp. 214-222
-
-
Kenakin, T.P.1
Morgan, P.H.2
-
41
-
-
0345791508
-
2 adrenoceptor: Kinetic evidence for intermediate conformational states
-
2 adrenoceptor: kinetic evidence for intermediate conformational states J. Biol. Chem. 279 2004 686 691
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 686-691
-
-
Swaminath, G.1
-
42
-
-
20444499405
-
2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists
-
2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists J. Biol. Chem. 280 2005 22165 22171
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 22165-22171
-
-
Swaminath, G.1
-
43
-
-
0029841642
-
2-adrenergic receptor
-
2-adrenergic receptor J. Biol. Chem. 271 1996 24029 24035
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24029-24035
-
-
Green, S.A.1
-
44
-
-
27144475519
-
2-adrenergic receptors and β-arrestin 2 using β-galactosidase complementation in C2C12 cells
-
2-adrenergic receptors and β-arrestin 2 using β-galactosidase complementation in C2C12 cells J. Pharmacol. Exp. Ther. 315 2005 839 848
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.315
, pp. 839-848
-
-
Carter, A.A.1
Hill, S.J.2
-
45
-
-
33846895899
-
2-adrenergic receptor phosphorylation and internalization
-
2- adrenergic receptor phosphorylation and internalization Am. J. Respir. Cell Mol. Biol. 36 2007 254 261
-
(2007)
Am. J. Respir. Cell Mol. Biol.
, vol.36
, pp. 254-261
-
-
Moore, R.H.1
-
46
-
-
34347395367
-
A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties
-
E.L. Maillet A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties FASEB J. 21 2007 2124 2134
-
(2007)
FASEB J.
, vol.21
, pp. 2124-2134
-
-
Maillet, E.L.1
-
47
-
-
77149174796
-
Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7
-
C.M. Niswender Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7 Mol. Pharmacol. 77 2010 459 468
-
(2010)
Mol. Pharmacol.
, vol.77
, pp. 459-468
-
-
Niswender, C.M.1
-
48
-
-
59649112659
-
Dulasteric GPCR targeting: A novel route to binding and signaling pathway selectivity
-
J. Antony Dulasteric GPCR targeting: a novel route to binding and signaling pathway selectivity FASEB J. 23 2009 442 450
-
(2009)
FASEB J.
, vol.23
, pp. 442-450
-
-
Antony, J.1
-
49
-
-
0026035523
-
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
-
T.K. Vu Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation Cell 64 1991 1057 1068
-
(1991)
Cell
, vol.64
, pp. 1057-1068
-
-
Vu, T.K.1
-
50
-
-
0035019636
-
Proteinase-activated receptors
-
S.R. Macfarlane Proteinase-activated receptors Pharmacol. Rev. 53 2001 245 282
-
(2001)
Pharmacol. Rev.
, vol.53
, pp. 245-282
-
-
MacFarlane, S.R.1
-
51
-
-
21644449969
-
Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1
-
J.N. McLaughlin Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1 J. Biol. Chem. 280 2005 25048 25059
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 25048-25059
-
-
McLaughlin, J.N.1
-
52
-
-
0033663775
-
The use of stimulus-biased assay systems to detect agonist-specific receptor active states: Implications for the trafficking of receptor stimulus by agonists
-
C. Watson The use of stimulus-biased assay systems to detect agonist-specific receptor active states: implications for the trafficking of receptor stimulus by agonists Mol. Pharmacol. 58 2000 1230 1238
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 1230-1238
-
-
Watson, C.1
-
53
-
-
33846503153
-
Both ligand- and cell-specific parameters control ligand agonism in a kinetic model of G protein-coupled receptor signaling
-
T.L. Kinzer-Ursem, and J.J. Linderman Both ligand- and cell-specific parameters control ligand agonism in a kinetic model of G protein-coupled receptor signaling PLoS Comput. Biol. 3 2007 e6
-
(2007)
PLoS Comput. Biol.
, vol.3
, pp. 6
-
-
Kinzer-Ursem, T.L.1
Linderman, J.J.2
-
54
-
-
63849235865
-
Evaluating cellular impedance assays for detection of GPCR pleiotropic signaling and functional selectivity
-
M.F. Peters, and C.W. Scott Evaluating cellular impedance assays for detection of GPCR pleiotropic signaling and functional selectivity J. Biomol. Screen. 14 2009 246 255
-
(2009)
J. Biomol. Screen.
, vol.14
, pp. 246-255
-
-
Peters, M.F.1
Scott, C.W.2
-
55
-
-
67549117747
-
Mutlidepth screening of living cells using optical waveguide
-
R. Horvath Mutlidepth screening of living cells using optical waveguide Biosens. Bioelectron. 24 2008 799 804
-
(2008)
Biosens. Bioelectron.
, vol.24
, pp. 799-804
-
-
Horvath, R.1
-
56
-
-
33646173602
-
Infrared surface plasmon resonance: A novel tool for real time sensing of variations in living cells
-
R. Ziblat Infrared surface plasmon resonance: a novel tool for real time sensing of variations in living cells Biophys. J. 90 2006 2592 2599
-
(2006)
Biophys. J.
, vol.90
, pp. 2592-2599
-
-
Ziblat, R.1
-
57
-
-
0032441150
-
Cluster analysis and display of genome-wide expression patterns
-
M.B. Eisen Cluster analysis and display of genome-wide expression patterns Proc. Natl. Acad. Sci. U. S. A. 95 1998 14863 14868
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 14863-14868
-
-
Eisen, M.B.1
|