Functional neuroanatomy of the central noradrenergic system

Journal of Psychopharmacology

Volumn 27, Issue 8, 2013, Pages 659-693

  Szabadi, Elemer ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

arousal; autonomic functions; brainstem; diencephalon; forebrain; Locus coeruleus; neuroanatomy; noradrenaline; photomodulation; spinal cord; telencephalon

Indexed keywords

ADRENERGIC RECEPTOR;

AMYGDALOID NUCLEUS; ARCUATE NUCLEUS; AROUSAL; AUTONOMIC NERVOUS SYSTEM; BRAIN FUNCTION; BRAIN NUCLEUS; BRAIN STEM; CEREBELLUM; CEREBROVASCULAR DISEASE; COCHLEAR NUCLEUS; DIENCEPHALON; DORSAL RAPHE NUCLEUS; FACIAL NERVE NUCLEUS; FOREBRAIN; HIPPOCAMPUS; HUMAN; HYPOGLOSSAL NUCLEUS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; LIMBIC SYSTEM; LOCUS CERULEUS; MEDULLA OBLONGATA; MOTONEURON NUCLEUS; NEOCORTEX; NERVE CELL NETWORK; NERVE DEGENERATION; NEUROANATOMY; NEUROPATHOLOGY; NEUROTRANSMISSION; NONHUMAN; NORADRENERGIC NERVE; NORADRENERGIC SYSTEM; OCULOMOTOR NUCLEUS; PATHOPHYSIOLOGY; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; PERIAQUEDUCTAL GRAY MATTER; PHOTORECEPTOR; PHOTOSENSITIVITY; PREGANGLIONIC NERVE; PREMOTOR CORTEX; PRINCIPAL SENSORY NUCLEUS; PRIORITY JOURNAL; REVIEW; SENSORY NERVE; SPINAL CORD DORSAL HORN; SPINAL CORD VENTRAL HORN; SUPERIOR SALIVATORY NUCLEUS; SYNAPTIC TRANSMISSION; TELENCEPHALON; TRIGEMINAL MOTOR NUCLEUS; VAGUS NERVE NUCLEUS; VENTRAL TEGMENTUM;

AROUSAL; AUTONOMIC FUNCTIONS; BRAINSTEM; DIENCEPHALON; FOREBRAIN; LOCUS COERULEUS; NEUROANATOMY; NORADRENALINE; PHOTOMODULATION; SPINAL CORD; TELENCEPHALON;

ADRENERGIC NEURONS; ANIMALS; HUMANS; LOCUS COERULEUS; NEUROANATOMY; NOREPINEPHRINE;

EID: 84880477026     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881113490326     Document Type: Review

References (547)

1. Acosta-Martinez M, Fiber JM, Brown RD, et al. Localization of α1B-adrenergic receptor in female rat brain regions involved in stress and neuroendocrine function. Neurochem Int. 1999 ; 35: 383-391
2. Adidharma W, Leach G, Yan L. Orexinergic signaling mediates light-induced neuronal activation in the dorsal raphe nucleus. Neuroscience. 2012 ; 220: 201-207
3. Aldes LD. Topographically organized projections from the nucleus subcoeruleus to the hypoglossal nucleus in the rat: A light and electron microscopic study with complementary axonal transport techniques. J Comp Neurol. 1990 ; 302: 643-656
4. Aldes LD, Shaw B, Chronister RB, et al. Catecholamine-containing axon terminals in the hypoglossal nucleus of the rat: An immuno-electronmicroscopic study. Exp Brain Res. 1990 ; 81: 167-178
5. Allen GV, Cechetto DF. Serotoninergic and nonserotoninergic neurons in the medullary raphe system have axon collateral projections to autonomic and somatic cell groups in the medulla and spinal cord. J Comp Neurol. 1994 ; 350: 357-366
6. Altimus CM, Güler AD, Villa KL, et al. Rods-cones and melanopsin detect light and dark to modulated sleep independent of image formation. Proc Nat Acad Sci USA. 2008 ; 105: 19998-20003
7. Amaral DG, Sinnamon HM. The locus coeruleus: Neurobiology of a central noradrenergic nucleus. Prog Neurobiol. 1977 ; 9: 147-196
8. Amir RE, Van den Veyver IB, Wan M, et al. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet. 1999 ; 23: 185-188
9. Andrews GD, Lavin A. Methylphenidate increases cortical excitability via activation of alpha-2 noradrenergic receptors. Neuropsychopharmacology. 2006 ; 31: 594-601
10. Appel NM, Elde RP. The intermediolateral cell column of the thoracic spinal cord is comprised of target-specific subnuclei: Evidence from retrograde transport studies and immunohistochemistry. J Neurosci. 1988 ; 8: 1767-1775
11. Arima K, Akashi T. Involvement of the locus coeruleus in Pick's disease with or without Pick body formation. Acta Neuropathol. 1990 ; 79: 629-633
12. Arima K, Murayama S, Oyanagi S, et al. Presenile dementia with progressive supranuclear palsy tangles and Pick bodies: An unusual degenerative disorder involving the cerebral cortex, cerebral nuclei, and brain stem nuclei. Acta Neuropathol. 1992 ; 84: 128-134
13. Arnsten AF, Goldman-Rakic PS. Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in rhesus monkey. Brain Res. 1984 ; 306: 9-18
14. Arnulf I, Konofal E, Merino-Andreu M, et al. Parkinson's disease and sleepiness. Neurology. 2002 ; 58: 1019-1024
15. Astier B, Van Bockstaele EJ, Aston-Jones G, et al. Anatomical evidence for multiple pathways leading from the rostral ventrolateral medulla (nucleus paragigantocellularis) to the locus coeruleus in the rat. Neurosci Lett. 1990 ; 118: 141-146
16. Aston-Jones G. Brain structures and receptors involved in alertness. Sleep Med. 2005 ; 6: S3 - S7
17. Aston-Jones G, Bloom FE. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci. 1981 ; 1: 876-886
18. Aston-Jones G, Cohen JD. An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance. Ann Rev Neurosci. 2005 ; 28: 403-450
19. Aston-Jones G, Astier B, Ennis M. Inhibition of noradrenergic locus coeruleus neurons by C1 adrenergic cells in the rostral ventral medulla. Neuroscience. 1992 ; 48: 371-381
20. Aston-Jones G, Chen S, Zhu Y, et al. A neural circuit for circadian regulation of arousal. Nature Neurosci. 2001 ; 4: 732-738
21. Aston-Jones G, Chiang C, Alexinsky T. Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance. Prog Brain Res. 1991a ; 88: 501-520
22. Aston-Jones G, Ennis M, Pieribone VA, et al. The brain nucleus locus coeruleus: Restricted afferent control of a broad efferent network. Science. 1986 ; 234: 734-737
23. Aston-Jones G, Shipley MT, Chouvet G, et al. Afferent regulation of locus coeruleus neurons: Anatomy, physiology and pharmacology. Prog Brain Res. 1991b ; 88: 47-75
24. Bajic D, Proudfit HK. Projections of neurons in the periaqueductal gray to pontine and medullary catecholamine cell groups involved in the modulation of nociception. J Comp Neurol. 1999 ; 405: 359-379
25. Bajic D, Proudfit HK, Van Bockstaele EJ. Periaqueductal gray neurons monosynaptically innervate extranuclear dendrites in the rat pericoerulear region. J Comp Neurol. 2000 ; 427: 649-662
26. Bajic D, Van Bockstaele, Proudfit HK. Ultrastructural analysis of ventrolateral periaqueductal gray projections to the A7 catecholamine cell group. Neuroscience. 2001 ; 104: 181-197
27. Bajic D, Van Bockstaele, Proudfit HK. Ultrastructural analysis of rat ventrolateral periaqueductal gray projections to the A5 cell group. Neuroscience. 2012 ; 224: 145-159
28. Bakes A, Bradshaw CM, Szabadi E. Attenuation of the pupillary light reflex in anxious patients. Br J Clin Pharmacol. 1990 ; 30: 377-381
29. Baldo BA, Daniel RA, Berridge CW, et al. Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress. J Comp Neurol. 2003 ; 464: 220-237
30. Barber A, Dashtipour K. Sleep disturbances in Parkinson's disease with emphasis on rapid eye movement sleep behaviour disorder. Int J Neurosci. 2012 ; 122: 407-412
31. Barman SM, Gebber GL. Axonal projection patterns of ventrolateral medullospinal sympathoexcitatory neurons. J Neurophysiol. 1985 ; 53: 1551-1566
32. Bateman RJ, Boychuk CR, Philbin KE, et al. β-adrenergic receptor modulation of neurotransmission to cardiac vagal neurons in the nucleus ambiguous. Neuroscience. 2012 ; 210: 58-66
33. Baumann N, Pham-Dinh D. Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev. 2001 ; 81: 871-927
34. Baver SB, Pickard GE, Sollars PJ, et al. Two types of melanopsin retinal ganglion cell differentially innervate the hypothalamic suprachiasmatic nucleus and the olivary pretectal nucleus. Eur J Neurosci. 2008 ; 27: 1763-1770
35. Bay KD, Mamiya K, Good CH, et al. Alpha-2 adrenergic regulation of pedunculopontine nucleus neurons during development. Neuroscience. 2006 ; 141: 769-779
36. Beaudet A, Descarries L. The monoamine innervation of the rat cerebral cortex: Synaptic and nonsynaptic axon terminals. Neuroscience. 1978 ; 3: 851-860
37. Beckstead RM, Domesick VB, Nauta WJ. Efferent connections of the substantia nigra and ventral tegmental area in the rat. Brain Res. 1979 ; 175: 191-217
38. Ben-Jonathan N, Hnasko R. Dopamine as a prolactin (PRL) inhibitor. Endocr Rev. 2001 ; 22: 724-763
39. Berridge CW, Abercrombie ED. Relationship between locus coeruleus discharge rates and rates of norepinephrine release within neocortex as assessed by in vivo microdialysis. Neuroscience. 1999 ; 93: 1263-1270
40. Berridge CW, Foote SL. Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus. J Neurosci. 1991 ; 11: 3135-3145
41. Berridge CW, Isaac SO, España RA. Additive wake-promoting actions of medial basal forebrain noradrenergic α1- and β-receptor stimulation. Behav Neurosci. 2003 ; 117: 350-359
42. Berridge CW, Page ME, Valentino RJ, et al. Effects of locus coeruleus inactivation on electroencephalographic activity in neocortex and hippocampus. Neuroscience. 1993 ; 55: 381-393
43. Bertrand E, Lechowicz W, Szpak GM, et al. Qualitative and quantitative analysis of locus coeruleus neurons in Parkinson's disease. Folia Neuropathol. 1997 ; 35: 80-86
44. Bie B, Fields HL, Williams JT, et al. Roles of α1- and α2-adrenoceptors in the nucleus raphe magnus in opioid analgesia and opioid abstinence-induced hyperalgesia. J Neurosci. 2003 ; 23: 7950-7957
45. Bienkowski MS, Rinaman L. Noradrenergic inputs to the paraventricular hypothalamus contribute to hypothalamic-pituitary-adrenal axis and central Fos activation in rats after acute systemic endotoxin exposure. Neuroscience. 2008 ; 156: 1093-1102
46. Bitsios P, Szabadi E, Bradshaw CM. The inhibition of the light reflex by the threat of an electric shock: A potential laboratory model of human anxiety. J Psychopharmacol. 1996 ; 10: 279-287
47. Blake TJ, Tillery CE, Reynolds GP. Antipsychotic drug affinities at alpha2-adrenoceptor subtypes in post-mortem human brain. J Psychopharmacol. 1998 ; 12: 151-154
48. Bogerts B. A brainstem atlas of catecholaminergic neurons in man, using melanin as a natural marker. J Comp Neurol. 1981 ; 197: 63-80
49. Bondareff W, Mountjoy CQ, Roth M, et al. Neuronal degeneration in locus coeruleus and cortical correlates of Alzheimer disease. Alzheimer Dis Assoc Disord. 1987 ; 1: 256-262
50. Booze RM, Crisostomo EA, Davis JN. Species differences in the localization and number of CNS beta adrenergic receptors: Rat versus guinea pig. J Pharmacol Exp Ther. 1989 ; 249: 911-920
51. Boundy VA, Cincotta AH. Hypothalamic adrenergic receptor changes in the metabolic syndrome of genetically obese (ob/ob) mice. Am J Physiol Regul Integr Comp Physiol. 2000 ; 279: R505 - R514
52. Bourgin P, Huitrón-Reséndiz S, Spier AD, et al. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J Neurosci. 2000 ; 20: 7760-7765
53. Braak H, Del Tredici K, Rüb U, et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging. 2003 ; 24: 197-211
54. Breen LA, Burde R, Loewy AD. Brainstem connections to the Edinger-Westphal nucleus of the cat: A retrograde tracer study. Brain Res. 1983 ; 261: 303-306
55. Brown RE, Sergeeva OA, Eriksson KS, et al. Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline). J Neurosci. 2002 ; 22: 8850-8859
56. Bubar MJ, Cunningham KA. Distribution of serotonin 5-HT2C receptors in the ventral tegmental area. Neuroscience. 2007 ; 146: 286-297
57. Buffalari DM, Grace AA. Noradrenergic modulation of basolateral amygdala neuronal activity: Opposing influences of α-2 and β receptor activation. J Neurosci. 2007 ; 27: 12358-12366
58. Buijs RM, la Fleur SE, Wortel J, et al. The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons. J Comp Neurol. 2003 ; 464: 36-48
59. Burnstock G. Cotransmission. Curr Opin Pharmacol. 2004 ; 4: 47-52
60. Burnstock G. Purinergic cotransmission. Exp Physiol. 2009 ; 94: 20-24
61. Busch C, Bohl J, Ohm TG. Spatial, temporal and numeric analysis of Alzheimer changes in the nucleus coeruleus. Neurobiol Aging. 1997 ; 18: 401-406
62. Byrum CE, Guyenet PG. Afferent and efferent connections of the A5 noradrenergic cell group in the rat. J Comp Neurol. 1987 ; 261: 529-542
63. Cahusac PMB, Morris R, Hill RG. A pharmacological study of the modulation of neuronal and behavioural nociceptive responses in the rat trigeminal region. Brain Res. 1995 ; 700: 70-82
64. Cajochen C, Münch M, Kobialka S, et al. High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light. J Clin Endocrin Metab. 2005 ; 90: 1311-1316
65. Cameron AA, Khan IA, Westlund KN, et al. The efferent projections of the periaqueductal gray in the rat: A Phaseolus vulgaris-leucoagglutinin study. II Descending projections. J Comp Neurol. 1995 ; 351: 585-601
66. Campbell G. Cotransmission. Ann Rev Pharmacol Toxicol. 1987 ; 27: 51-70
67. Canteras NS, Resstel LB, Bertoglio LJ, et al. Neuroanatomy of anxiety. Curr Top Behav Neurosci. 2010 ; 2: 77-96
68. Carpenter MB, Periera AB, Guha N. Immunocytochemistry of oculomotor afferents in the squirrel monkey (Saimiri sciureus). J Hirnforsch. 1992 ; 33: 151-167
69. Catus SL, Gibbs ME, Sato M, et al. Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice. Br J Pharmacol. 2011 ; 162: 1700-1715
70. Cechetto DF, Saper CB Central Regulation of Autonomic Functions. Loewy AD Spyer KM, ed. Oxford: Oxford University Press, pp ; 1990: 208-223.
71. Cedarbaum JM, Aghajanian GK. Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique. J Comp Neurol. 1978 ; 178: 1-16
72. Chahrour M, Zoghbi HY. The story of Rett syndrome: From clinic to neurobiology. Neuron. 2007 ; 56: 58-65
73. Chan-Palay V. Alterations in the locus coeruleus in dementias of Alzheimer's and Parkinson's disease. Prog Brain Res. 1991 ; 88: 625-630
74. Chan-Palay V, Asan E. Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer's type and in Parkinson's disease with and without dementia and depression. J Comp Neurol. 1989 ; 287: 373-392
75. Charney DS, Redmond DE. Neurobiological mechanisms in human anxiety. Neuropharmacology. 1983 ; 22: 1531-1536
76. Charney DS, Grillon C, Bremner JD. The neurobiological basis of anxiety and fear: Circuits, mechanisms, and neurochemical interactions (Part 1). Neuroscientist. 1998 ; 4: 35-44
77. Charney DS, Woods SW, Nagy LM, et al. Noradrenergic function in panic disorder. J Clin Psychiatry. 1990 ; 51: S5 - S11
78. Chen A, Kelley LD, Janušonis S. Effects of prenatal stress and monoaminergic perturbations on the expression of serotonin 5-HT4 and adrenergic β2 receptors in the embryonic mouse telencephalon. Brain Res. 2012 ; 1459: 27-34
79. Chen F-J, Sara SJ. Locus coeruleus activation by foot shock or electrical stimulation inhibits amygdala neurons. Neuroscience. 2007 ; 144: 472-481
80. Chen SK, Badea TC, Hattar S. Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs. Nature. 2011 ; 476: 92-95
81. Chen SY, Chai CY. Coexistence of neurons integrating urinary bladder activity and pelvic nerve activity in the same cardiovascular areas of the pontomedulla in cats. Chin J Physiol. 2002 ; 45: 41-50
82. Cheng Z, Zhang H, Yu J, et al. Attenuation of baroreflex sensitivity after domoic acid lesion of the nucleus ambiguus of rats. J Appl Physiol. 2004 ; 96: 1137-1145
83. Chibuzo GA, Cummings JF. Motor and sensory centers for the innervation of mandibular and sublingual salivary glands: A horseradish peroxidase study in the dog. Brain Res. 1980 ; 189: 301-313
84. Chiti Z, Teschemacher AG. Exocytosis of norepinephrine at axon varicosities and neuronal cell bodies in the rat brain. FASEB J. 2007 ; 21: 2540-2550
85. Chong W, Li LH, Lee K, et al. Subtypes of alpha1- and alpha2-adrenoceptors mediating noradrenergic modulation of spontaneous inhibitory postsynaptic currents in the hypothalamic paraventricular nucleus. J Neuroendcrinol. 2004 ; 16: 450-457
86. Chou TC, Bjorkum AA, Gaus SE, et al. Afferents to the ventrolateral preoptic nucleus. J Neurosci. 2002 ; 22: 977-990
87. Chronwall BM. Anatomy and physiology of the neuroendocrine arcuate nucleus. Peptides. 1985 ; 6: S1 - S11
88. Civantos Calzada B, Aleixandre de Artiñano A. Alpha-adrenoceptor subtypes. Pharmacol Res. 2001 ; 44: 195-208
89. Cohen Z, Molinatti G, Hamel E. Astroglial and vascular interactions of noradrenaline terminals in the rat cerebral cortex. J Cerebr Blood Flow Metab. 1997 ; 17: 894-904
90. Couto B, Moroni CR, dos Reis Ferreira CM, et al. Descriptive and functional neuroanatomy of locus coeruleus-noradrenaline-containing neurons involvement in bradykinin-induced antinociception on principal sensory trigeminal nucleus. J Chem Neuroanat. 2006 ; 32: 28-45
91. Craig AD. Spinal and trigeminal lamina I input to the locus coeruleus anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) in the cat and monkey. Brain Res. 1992 ; 584: 325-328
92. Crochet S, Sakai K. Dopaminergic modulation of behavioural states in mesopontine tegmentum: A reverse microdialysis study in freely moving cats. Sleep. 2003 ; 26: 801-806
93. Cullinan WE, Herman JP, Battaglia DF, et al. Pattern and time course of immediate early gene expression in rat brain following acute stress. Neuroscience. 1995 ; 64: 477-505
94. Cunningham ET, Sawchenko PE. Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J Comp Neurol. 1988 ; 274: 60-76
95. Daftary SS, Boudaba C, Tasker JG. Noradrenergic regulation of parvocellular neurons in the rat hypothalamic paraventricular nucleus. Neuroscience. 2000 ; 96: 743-751
96. Dahlström A, Fuxe K. Evidence for the existence of monoamine-containing neurones in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurones. Acta Physiol Scand. 1964 ; 62 232: S1 - S55
97. Damasio AR. Emotion in the perspective of an integrated nervous system. Brain Res Rev. 1998 ; 26: 83-86
98. Dampney RA, Furlong TM, Horiuchi J, et al. Role of dorsolateral preiaqueductal grey in the coordinated regulation of cardiovascular and respiratory function. Auton Neurosci. 2013 ; 175: 17-25
99. Dampney RAL. Functional organization of central pathways regulating the cardiovascular system. Physiol Rev. 1994 ; 74: 332-364
100. Danysz W, Dyr W, Plaznik A, et al. The effect of microinjections of clonidine into the locus coeruleus on cortical EEG in rats. Pol J Pharmacol Pharm. 1989 ; 41: 45-50
101. Date Y, Ueta Y, Yamashita H, et al. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci USA. 1999 ; 96: 748-753
102. Datta S, O'Malley MW, Patterson EH. Calcium/calmodulin kinase II in the pedunculopontine tegmental nucleus modulates the initiation and maintenance of wakefulness. J Neurosci. 2011 ; 31: 17007-17016
103. Davis M, Falls WA, Campeau S, et al. Fear-potentiated startle: A neural and pharmacological analysis. Behav Brain Res. 1993 ; 58: 175-198
104. Davis H, Guo X, Lambert S, et al. Small molecule induction of human umbilical stem cells into myelin basic protein positive ologodendrocytes in defined three-dimensional environment. ACS Chem Neurosci. 2012 ; 3: 31-39
105. Day HEW, Campeau S, Watson SJ Jr, et al. Distribution of α1a-, α1b- and α1d-adrenergic receptor mRNA in the rat brain and spinal cord. J Chem Neuroanat. 1997 ; 13: 115-139
106. Day HEW, Greenwood BN, Hammack SE, et al. Differential expression of 5HT-1A, α1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, γ-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. J Comp Neurol. 2004 ; 474: 364-378
107. De Andrés I, Garzón M, Reinoso-Suárez F. Functional anatomy of non-REM sleep. Front Neurol. 2011 ; 2: 1-14
108. De Lecea L, Kilduff TS, Peyron C, et al. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA. 1998 ; 95: 322-327
109. Del Cid-Pellitero E, Garzón M. Hypocretin1/OrexinA-containing axons innervate locus coeruleus neurons that project to the rat medial prefrontal cortex. Implication in the sleep-wakefulness cycle and cortical activation. Synapse. 2011 ; 65: 843-857
110. Del Tredici K, Rub U, De Vos RA, et al. Where does Parkinson disease pathology begin in the brain?. J Neuropathol Exp Neurol. 2002 ; 61: 413-426
111. Descarries L, Mechawar N. Ultrastructural evidence for diffuse transmission by monoamine and acetylcholine neurons in the central nervous system. Prog Brain Res. 2000 ; 125: 27-47
112. Descarries L, Watkins KC, Lapierre Y. Noradrenergic axon terminals in the cerebral cortex of rat. III. Topometric ultrastructural analysis. Brain Res. 1977 ; 133: 197-222
113. Deutch AY, Goldstein M, Roth RH. Activation of the locus coeruleus induced by selective stimulation of the ventral tegmental area. Brain Res. 1986 ; 363: 307-314
114. Domyancic AV, Morilak DA. Distribution of α1A adrenergic receptor mRNA in the rat brain visualized by in situ hybridization. J Comp Neurol. 1997 ; 386: 358-378
115. Drolet G, Gauthier P. Peripheral and central mechanisms of the pressor response elicited by stimulation of the locus coeruleus in the rat. Can J Physiol Pharmacol. 1985 ; 63: 599-605
116. Drolet G, Van Bockstaele EJ, Aston-Jones G. Robust enkephalin innervation of the locus coeruleus from the rostral medulla. J Neurosci. 1992 ; 12: 3162-3174
117. Dugger BN, Murray ME, Boeve BF, et al. Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder. Neuroathol Appl Neurobiol. 2012 ; 38: 142-152
118. Ebert U. Noradrenalin enhances the activity of cochlear nucleus neurons in the rat. Eur J Neurosci. 1996 ; 8: 1306-1314
119. Eccles J. From electrical to chemical transmission in the central nervous system. Notes Rec R Soc Lond. 1976 ; 30: 219-230
120. Egan TM, North RA. Acetylcholine acts on m2-muscarinic receptors to excite rat locus coeruleus neurones. Br J Pharmacol. 1985 ; 85: 733-735
121. Eisenach JC, De Kock M, Klimscha W. Alpha(2)-adrenergic agonists for regional anesthesia. A clinical review of clonidine. Anesthesiology. 1996 198401995 ; 85: 655-674
122. El Mansari M, Sakai K, Jouvet M. Unitary characteristics of presumptive cholinergic tegmental neurons during the sleep-waking cycle in freely moving cats. Exp Brain Res. 1989 ; 76: 519-529
123. Elam M, Svensson TH, Thorén P. Locus coeruleus neurons and sympathetic nerves: Activation by cutaneous sensory afferents. Brain Res. 1986 ; 366: 254-261
124. Engberg G, Svensson TH. Pharmacological analysis of a cholinergic receptor mediated regulation of brain norepinephrine neurons. J Neural Transm. 1980 ; 49: 137-150
125. Ennis M, Aston-Jones G. A potent excitatory input to the nucleus locus coeruleus from the ventrolateral medulla. Neurosci Lett. 1986 ; 71: 299-305
126. Ennis M, Aston-Jones G. Activation of locus coeruleus from nucleus paragigantocellularis: A new excitatory amino acid pathway in brain. J Neurosci. 1988 ; 8: 3644-3657
127. Ennis M, Aston-Jones G. GABA-mediated inhibition of locus coeruleus from the dorsomedial rostral medulla. J Neurosci. 1989a ; 9: 2973-2981
128. Ennis M, Aston-Jones G. Potent inhibitory input to locus coeruleus from the nucleus prepositus hypoglossi. Brain Res Bull. 1989b ; 22: 793-803
129. Ennis M, Behbehani M, Shipley MT, et al. Projections from the periaqueductal gray to the rostromedial periocular region and the nucleus locus coeruleus. J Comp Neurol. 1991 ; 306: 480-494
130. Ericson H, Blomqvist A, Köhler C. Brainstem afferents to the tuberomammillary nucleus in the rat brain with special reference to monoaminergic innervation. J Comp Neurol. 1989 ; 281: 169-192
131. España RA, Berridge CW. Organisation of noradrenergic efferents to arousal-related basal forebrain structures. J Comp Neurol. 2006 ; 496: 668-683
132. España RA, Reis KM, Valentino RJ, et al. Organization of hypocretin/orexin efferents to locus coeruleus and basal forebrain arousal-related structures. J Comp Neurol. 2005 ; 481: 160-178
133. Fallon JH, Koziell DA, Moore RY. Catecholamine innervation of the basal forebrain. II. Amygdala, suprarhinal cortex and entorhinal cortex. J Comp Neurol. 1978 ; 180: 509-532
134. Farb CR, Chang W, LeDoux JE. Ultrastructural characterization of noradrenergic axons and beta-adrenergic receptors in the lateral nucleus of the amygdala. Front Behav Neurosci. 2010 ; 4: 1-9
135. Felten DL, Sladek Jr. Monoamine distribution in primate brain. V. Monoaminergic nuclei: Anatomy, pathways and local organization. Brain Res Bull. 1983 ; 10: 171-284
136. Flügge G, van Kampen M, Meyer H, et al. Alpha2A and apha2C-adrenoceptor regulation in the brain: Alpha2A changes persist after chronic stress. Eur J Neurosci. 2003 ; 17: 917-928
137. Foote SL, Berridge CW, Adams LM, et al. Electrophysiological evidence for the involvement of the locus coeruleus in alerting, orienting, and attending. Prog Brain Res. 1991 ; 88: 521-532
138. Foote SL, Bloom FE, Aston-Jones G. Nucleus locus coeruleus: New evidence of anatomical and physiological specificity. Physiol Rev. 1983 ; 63: 844-914
139. Forstl H, Levy R, Burns A, et al. Disproportionate loss of noradrenergic and cholinergic neurons as cause of depression in Alzheimer's disease - a hypothesis. Pharmacopsychiatry. 1994 ; 27: 11-15
140. Fort P, Bassetti CL, Luppi PH. Alternating vigilance states: New insights regarding neuronal networks and mechanisms. Eur J Neurosci. 2009 ; 29: 1741-1753
141. Fort P, Khateb A, Pegna A, et al. Noradrenergic modulation of cholinergic nucleus basalis neurons demonstrated by in vitro pharmacological and immunohistochemical evidence in the guinea-pig brain. Eur J Neurosci. 1995 ; 7: 1502-1511
142. Fortaleza EAT, Scopinho AA, Corrêa FMA. Paraventricular and supraoptic nuclei of the hypothalamus mediate cardiovascular responses evoked by the microinjection of noradrenaline into the medial amygdaloid nucleus of the rat brain. Neuroscience. 2012 ; 219: 157-165
143. Fritschy JM, Grzanna R. Demonstration of two separate descending noradrenergic pathways to the rat spinal cord: Evidence for an intragriseal trajectory of locus coeruleus axons in the superficial layers of the dorsal horn. J Comp Neurol. 1990 ; 291: 553-582
144. Fu Y, Matta SG, McIntosh JM, et al. Inhibition of nicotine-induced hippocampal norepinephrine release in rats by alpha-conotoxins MII and AuIB microinjected into the locus coeruleus. Neurosci Lett. 1999 ; 266: 113-116
145. Fukami H, Bradley RM. Biophysical and morphological properties of parasympathetic neurons controlling the parotid and von Ebner salivary glands in rats. J Neurophysiol. 2005 ; 93: 678-686
146. Fukuda A, Minami T, Nabekura J, et al. The effects of noradrenaline on neurones in the rat dorsal motor nucleus of the vagus, in vitro. J Physiol. 1987 ; 393: 213-231
147. Fuller PM, Gooley JJ, Saper CB. Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback. J Biol Rhythms. 2006 ; 21: 482-493
148. Fuller PM, Saper CB, Lu J. The pontine REM switch: Past and present. J Physiol. 2007 ; 584: 735-741
149. Fuller P, Sherman D, Pedersen NP, et al. Reassessment of the structural basis of the ascending arousal system. J Comp Neurol. 2011 ; 519: 933-956
150. Fung SJ, Chan JY, Manzoni D, et al. Cotransmitter-mediated locus coeruleus action on motoneurons. Brain Res Bull. 1994a ; 35: 423-432
151. Fung SJ, Reddy VK, Zhuo H, et al. Anatomical evidence for the presence of glutamate or enkephalin in noradrenergic projection neurons of the locus coeruleus. Microsc Res Tech. 1994b ; 29: 219-225
152. Furst S. Transmitters involved in antinociception in the spinal cord. Brain Res Bull. 1999 ; 48: 129-141
153. Fuxe K, Dahlström JG, Marcellino D, et al. The discovery of central monoamine neurons gave volume transmission to the wired brain. Prog Neurobiol. 2010 ; 90: 82-100
154. Gallopin T, Fort P, Eggermann E, et al. Identification of sleep-promoting neurons in vitro. Nature. 2000 ; 404: 992-995
155. Gatter KC, Powell TPS. The projection of the locus coeruleus upon the neocortex in the macaque monkey. Neuroscience. 1977 ; 2: 441-445
156. Geffen LB, Livett BG. Synaptic vesicles in sympathetic neurons. Physiol Rev. 1971 ; 51: 98-157
157. German DC, Manaye KF, White CL, et al. Disease-specific patterns of locus coeruleus cell loss. Ann Neurol. 1992 ; 32: 667-676
158. Gervasoni D, Darracq L, Fort P, et al. Electrophysiological evidence that noradrenergic neurons of the rat locus coeruleus are tonically inhibited by GABA during sleep. Eur J Neurosci. 1998 ; 10: 964-970
159. Ghiasvand M, Rezayof A, Ahmadi S, et al. β1-noradrenergic system of the central amygdala is involved in state-dependent memory induced by a cannabinoid agonist, WIN55,212, in rat. Behav Brain Res. 2011 ; 225: 1-6
160. Gibb WR, Luthert PJ, Marsden CD. Corticobasal degeneration. Brain. 1989 ; 112: 1171-1192
161. Gilsbach R, Hein L. Are the pharmacology and physiology of α2-adrenoceptors determined by α2-heteroreceptors and autoreceptors respectively?. Br J Pharmacol. 2012 ; 165: 90-102
162. Giuliano F, Rampin O. Central noradrenergic control of penile erection. Int J Impot Res. 2000 ; 12: S13 - S19
163. Glass MJ, Colago EE, Pickel VM. Alpha-2A-adrenergic receptors are present on neurons in the central nucleus of the amygdala that project to the dorsal vagal complex in the rat. Synapse. 2002 ; 46: 258-268
164. Gobert A, Rivet J-M, Lejeune F, et al. Serotonin2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat. Synapse. 2000 ; 36: 205-221
165. Gonzalez MMC, Aston-Jones G. Circadian regulation of arousal: Role of noradrenergic locus coeruleus system and light exposure. Sleep. 2006 ; 29: 1327-1336
166. Goodchild AK, Moon EA. Maps of cardiovascular and respiratory regions of rat ventral medulla: Focus on the caudal medulla. J Chem Neuroanat. 2009 ; 38: 209-221
167. Gooley JJ, Lu J, Fischer D, et al. A broad role for melanopsin in nonvisual photoreception. J Neurosci. 2003 ; 23: 7093-7106
168. Gottesmann. C. The involvement of noradrenaline in rapid eye movement sleep mentation. Front Neurol. 2011 ; 2: 1-10
169. Goutagny R, Luppi PH, Salvert D, et al. Role of the dorsal paragigantocellular reticular nucleus in paradoxical (rapid eye movement) sleep generation: A combined electrophysiological and anatomical study in the rat. Neuroscience. 2008 ; 152: 849-857
170. Green GM, Lyons L, Dickenson AH. α2-adrenoceptor antagonists enhance responses of dorsal horn neurones to formalin induced inflammation. Eur J Pharmacol. 1998 ; 347: 201-204
171. Greenblatt SH. John Hughlings Jackson and the conceptual foundations of the neurosciences. Physis Riv Stor Sci. 1999 ; 36: 367-386
172. Grillon C, Ameli R, Woods SW, et al. Fear-potentiated startle in humans: Effects of anticipatory anxiety on the acoustic blink reflex. Psychophysiology. 1991 ; 28: 588-595
173. Gritti I, Maiville L, Jones BE. Codistribution of GABA- with acetylcholine-synthesizing neurons in the basal forebrain of the rat. J Comp Neurol. 1993 ; 329: 438-457
174. Grudzien A, Shaw P, Weintraub S, et al. Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease. Neurobiol Aging. 2007 ; 28: 327-335
175. Guistina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and humans. Endocr Rev. 1998 ; 19: 717-797
176. Güler AD, Ecker JL, Lall GS, et al. Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision. Nature. 2008 ; 453: 102-106
177. Guo N-N, Li B-M. Cellular and subcellular distributions of β1- and β2-adrenoceptors in the CA1 and CA3 regions of the rat hippocampus. Neuroscience. 2007 ; 146: 298-305
178. Gurtu S, Pant KK, Sinha JN, et al. An investigation into the mechanism of cardiovascular responses elicited by electrical stimulation of locus coeruleus and subcoeruleus in the cat. Brain Res. 1984 ; 301: 59-64
179. Guyenet PG. Central noradrenergic neurons: The autonomic connection. Prog Brain Res. 1991 ; 88: 365-380
180. Guyenet PG, Young BS. Projections of nucleus paragigantocellularis lateralis to locus coeruleus and other structures in rat. Brain Res. 1987 ; 406: 171-184
181. Guyenet PG, Stornetta RL, Riley T, et al. Alpha 2A-adrenergic receptors are present in lower brainstem catecholaminergic and serotonergic neurons innervating spinal cord. Brain Res. 1994 ; 638: 285-294
182. Haas HL, Lin J-S. Waking with the hypothalamus. Pflugers Arch - Eur J Physiol. 2012 ; 463: 31-42
183. Haas H, Panula P. The role of histamine and the tuberomammillary nucleus in the nervous system. Nature Rev Neurosci. 2003 ; 4: 121-130
184. Hagan JJ, Leslie RA, Patel S, et al. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci USA. 1999 ; 96: 10911-10916
185. Hagberg B, Aicardi J, Dias K, et al. A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome. Ann Neurol. 1983 ; 14: 471-479
186. Hamill RW Primer on the Autonomic Nervous System. Robertson D Low PA Polinsky RJ, ed. San Diego: Academic Press, pp ; 1996: 12-25.
187. Hancock MB, Fougerousse CL. Spinal projections from the nucleus locus coeruleus and nucleus subcoeruleus in the cat and monkey as demonstrated by the retrograde transport of horseradish peroxidase. Brain Res Bull. 1976 ; 1: 229-234
188. Hartman BK, Zide D, Undenfriend S. The use of dopamine β-hydroxylase as a marker for the central noradrenergic nervous system in the rat brain. Proc Nat Acad Sci USA. 1972 ; 69: 2722-2726
189. Head GA, Chan CKS, Burke SL. Relationship between imidazoline and α 2-adrenoceptors involved in the sympatho-inhibitory actions of centrally acting antihypertensive agents. J Auton Nerv Syst. 1998 ; 72: 163-169
190. Heinricher MM, Taveras I, Leith JL, et al. Descending control of nociception: Specificity, recruitment and plasticity. Brain Res Rev. 2009 ; 60: 214-225
191. Herbert H, Saper CB. Organization of medullary adrenergic and noradrenergic projections to the periaqueductal gray matter in the rat. J Comp Neurol. 1992 ; 315: 34-52
192. Herman JP, Figueiredo H, Mueller NK, et al. Central mechanisms of stress integration: Hierarchical circuitry controlling hypothalamo-pituitary- adrenocortical responsiveness. Front Neuroendocrin. 2003 ; 24: 151-180
193. Hermann DM, Luppi P-H, Peyron C, et al. Afferent projections to the rat nuclei raphe magnus, raphe pallidus and reticularis gigantocellularis pars α demonstrated by iontophoretic application of choleratoxin (subunit b). J Chem Neuroanat. 1997 ; 13: 1-21
194. Herring N, Paterson DJ. Neuromodulators of peripheral cardiac sympatho-vagal balance. Exp Physiol. 2009 ; 94: 46-53
195. Hertz L, Chen Y, Gibbs ME, et al. Astrocytic adrenoceptors: A major target in neurological and psychiatric disorders?. Curr Drug Targets CNS Neurol Disord. 2004 ; 3: 239-268
196. Hieble JP, Ruffolo RR. Subclassification of the β-adrenoceptors. Pharmacol Commmun. 1995 ; 6: 183-193
197. Higo S, Ito K, Fuchs D, et al. Anatomical interconnections of the pedunculopontine tegmental nucleus and the nucleus prepositus hypoglossi in the cat. Brain Res. 1990 ; 536: 79-85
198. Hillman KL, Doze VA, Porter JE. Functional characterization of the β-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus. J Pharmacol Exp Ther. 2005 ; 314: 561-567
199. Hirata H, Aston-Jones G. A novel long-latency response of locus coeruleus neurons to noxious stimuli: Mediation by peripheral C-fibers. J Neurophysiol. 1994 ; 71: 1752-1761
200. Hirota K, Kushikata T. Central noradrenergic neurones and the mechanism of general anaesthesia. Br J Anaesth. 2001 ; 87: 811-812
201. Holstege G. Some anatomical observations on the projections from the hypothalamus to brainstem and spinal cord: An HRP and autoradiographic tracing study in the cat. J Comp Neurol. 1987 ; 260: 98-126
202. Horvath TL, Peyron C, Diano S, et al. Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J Comp Neurol. 1999 ; 415: 145-159
203. Hosoya Y, Sugiura Y, Okado N, et al. Descending input from the hypothalamic paraventricular nucleus to sympathetic preganglionic neurons in the rat. Exp Brain Res. 1991 ; 85: 10-20
204. Hou RH, Freeman C, Langley RW, et al. Does modafinil activate the locus coeruleus in man? Comparison of modafinil and clonidine on arousal and autonomic functions in human volunteers. Psychopharmacology. 2005 ; 181: 537-549
205. Hou RH, Samuels ER, Langley RW, et al. Arousal and the pupil: Why diazepam-induced sedation is not accompanied by miosis. Psychopharmacology. 2007 ; 195: 41-59
206. Hou RH, Scaife J, Freeman C, et al. Relationship between sedation and pupillary function: Comparison of diazepam and diphenhydramine. Br J Clin Pharmacol. 2006 ; 61: 752-760
207. Hou YP, Manns ID, Jones BE. Immunostaining of cholinergic pontomesencephalic neurons for α1 versus α2 adrenergic receptors suggests different sleep-wake state activities and roles. Neuroscience. 2002 ; 114: 517-521
208. Hrabovszky E, Liposits Z. Adrenergic innervation of dopamine neurons in the hypothalamic arcuate nucleus of the rat. Neurosci Lett. 1994 ; 182: 143-146
209. Huang H-P, Zhu F-P, Chen X-W, et al. Physiology of quantal norepinephrine release from somatodendritic sites of neurones in locus coeruleus. Front Mol Neurosci. 2012 ; 5: 1-5
210. Illes P, Norenberg W. Blockade of alpha 2-adrenoceptors increases opioid mu-receptor-mediated inhibition of the firing rate of rat locus coeruleus neurones. Naunyn-Schmiedebergs Arch Pharmacol. 1990 ; 342: 490-496
211. Ishida Y, Hashiguchi H, Takeda R, et al. Conditioned-fear stress increases Fos expression in monoaminergic and GABAergic neurons in the locus coeruleus and dorsal raphe nuclei. Synapse. 2002 ; 45: 46-51
212. Ishikawa M, Tanaka C. Morphological organization of catecholamine terminals in the diencephalon of the rhesus monkey. Brain Res. 1977 ; 119: 43-55
213. Ishikawa M, Shimada S, Tanaka C. Histochemical mapping of catecholamine neurons and fibre pathways in the pontine tegmentum of the dog. Brain Res. 1975 ; 86: 1-6
214. Iversen LL The Uptake and Storage of Noradrenaline in Sympathetic Nerves. Cambridge: Cambridge University Press ; 1967:
215. Iwase M, Homma I, Shioda S, et al. Histamine immunoreactive neurons in the brain stem of the rabbit. Brain Res Bull. 1993 ; 32: 267-272
216. Jacobowitz DM, MacLean PD. A brainstem atlas of catecholaminergic neurons and serotonergic perikarya in a pygmy primate (Cebuella pygmaca). J Comp Neurol. 1978 ; 177: 397-416
217. Jacobsen LK, Southwick SM, Kosten TR. Substance use disorders in patients with posttraumatic stress disorder: A review of the literature. Am J Psychiatry. 2001 ; 158: 1184-1190
218. Jansen AS, Ter Horst GJ, Mettenleiter TC, et al. CNS cell groups projecting to the submandibular parasympathetic preganglionic neurons in the rat: A retrograde transneuronal viral cell body labeling study. Brain Res. 1992 ; 572: 253-260
219. Jiménez-Rivera CA, Figueroa J, Vázquez-Torres R, et al. Presynaptic inhibition by α2 receptors in the VTA. Eur J Neurosci. 2012 ; 35: 1406-1415
220. Jodo E, Aston-Jones G. Activation of locus coeruleus by prefrontal cortex is mediated by excitatory amino acid inputs. Brain Res. 1997 ; 768: 327-332
221. Jodo E, Chiang C, Aston-Jones G. Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons. Neuroscience. 1998 ; 83: 3-79
222. Johnson AD, Peoples J, Stornetta RL, et al. Opioid circuits originating from the nucleus paragigantocellularis and their potential role in opiate withdrawal. Brain Res. 2002 ; 955: 72-84
223. Jones BE. Immunohistochemical study of choline acetyltransferase- immunoreactive processes and cells innervating the pontomedullary reticular formation in the rat. J Comp Neurol. 1990 ; 295: 485-514
224. Jones BE. Paradoxical sleep and its chemical/structural substrates in the brain. Neuroscience. 1991 ; 40: 637-656
225. Jones BE. Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex. Prog Brain Res. 2004 ; 145: 157-169
226. Jones BE. From waking to sleeping: Neuronal and chemical substrates. Trends Pharmacol Sci. 2005 ; 26: 578-586
227. Jones BE, Moore RY. Ascending projections of the locus coeruleus in the rat. II Autoradiographic study. Brain Res. 1977 ; 127: 25-53
228. Jones BE, Yang T-Z. The efferent projections from the reticular formation and the locus coeruleus studied by anterograde and retrograde axonal transport in the rat. J Comp Neurol. 1985 ; 242: 56-92
229. Jones LS, Gauger LL, Davis JN. Anatomy of brain alpha1-adrenergic receptors: In vitro autoradiography with [125I]-HEAT. J Comp Neurol. 1985 ; 231: 190-208
230. Joyce JN, Lexow N, Soo JK, et al. Distribution of beta-adrenergic receptor subtypes in human post-mortem brain: Alterations in limbic regions of schizophrenics. Synapse. 1992 ; 10: 228-246
231. Kalsbeek A, Cutrera RA, Van Heerikhulze JJ, et al. GABA release from suprachiasmatic nucleus is necessary for the light-induced inhibition of nocturnal melatonin release in the rat. Neuroscience. 1999 ; 91: 453-461
232. Kalsbeek A, Garidou ML, Palm IF, et al. Melatonin sees the light: Blocking GABA-ergic transmission in the paraventricular nucleus induces daytime secretion of melatonin. Eur J Neurosci. 2000 ; 12: 3146-3154
233. Kalsbeek A, Palm IF, La Fleur SE, et al. SCN outputs and the hypothalamic balance of life. J Biol Rhythms. 2006 ; 21: 458-469
234. Kang Y-M, Ouyang W, Chen J-Y, et al. Norepinephrine modulates single hypothalamic arcuate neurons via α1 and β adrenergic receptors. Brain Res. 2000 ; 869: 146-157
235. Kapoor V, Minson J, Chalmers J. Ventral medulla stimulation increases blood pressure and spinal cord amino acid release. Neuroreport. 1992 ; 3: 55-58
236. Kasparov S, Teschemacher AG. Altered central catecholaminergic transmission and cardiovascular disease. Exp Physiol. 2008 ; 93: 725-740
237. Kaur S, Saxena RN, Mallick BN. GABAergic neurons in prepositus hypoglossi regulate REM sleep by its action on locus coeruleus in freely moving rats. Synapse. 2001 ; 42: 141-150
238. Kawasaki A, Kardon RH. Intrinsically photosensitive retinal ganglion cells. J Neuro-Ophthalmol. 2007 ; 27: 195-204
239. Kayama Y, Ohta M, Jodo E. Firing of 'possibly' cholinergic neurons in the rat laterodorsal tegmental nucleus during sleep and wakefulness. Brain Res. 1992 ; 569: 210-220
240. Kiernan JA Barr's The Human Nervous System: An Anatomical Viewpoint. 2005 ) Barr's The Human Nervous System: An Anatomical Viewpoint, 8th ed.Philadelphia: Lippincott Williams & Wilkins. Philadelphia: Lippincott Williams & Wilkins ; 2005:
241. Kim M, Chiego DJ, Bradley RM. Morphology of parasympathetic neurons innervating rat lingual salivary glands. Auton Neurosci. 2004a ; 111: 27-36
242. Kim M-A, Lee HS, Lee BY, et al. Reciprocal connections between subdivisions of the dorsal raphe and the nuclear core of the locus coeruleus in the rat. Brain Res. 2004b ; 1026: 56-67
243. Kimura F, Nakamura S. Locus coeruleus neurons in the neonatal rat: Electrical activity and responses to sensory stimulation. Brain Res. 1985 ;: 301-305
244. Klepper A, Herbert H. Distribution and origin of noradrenergic and serotonergic fibers in the cochlear nucleus and inferior colliculus of the rat. Brain Res. 1991 ; 557: 190-201
245. Kobayashi H, Frattola L, Ferrarese C, et al. Characterization of beta-adrenergic receptors on human cerebral microvessels. Neurology. 1982 ; 32: 1384-1387
246. Korotkova TM, Sergeeva OA, Ponomarenko AA, et al. Histamine excites noradrenergic neurons in locus coeruleus in rats. Neuropharmacology. 2005 ; 49: 129-134
247. Koss MC. Pupillary dilation as an index of central nervous system α2-adrenoceptor activation. J Pharmacol Met. 1986 ; 15: 1-19
248. Koss MC, Gherezghiher T, Nomura A. CNS adrenergic inhibition of parasympathetic oculomotor tone. J Auton Nerv Syst. 1984 ; 10: 55-68
249. Kromer LF, Moore RY. Norepinephrine innervation of the cochlear nuclei by locus coeruleus neurons in the rat. Anat Embryol (Berl). 1980 ; 158: 227-244
250. Kumagai H, Oshima N, Matsuura T, et al. Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure. Hypertens Res. 2012 ; 35: 132-141
251. Kupfermann I. Functional studies of cotransmission. Physiol Rev. 1991 ; 71: 683-732
252. Kushikata T, Hirota K, Yoshida H, et al. Alpha-2 adrenoceptor activity affects propofol-induced sleep time. Anesth Analg. 2002 ; 94: 1201-1206
253. Kushikata T, Yoshida H, Kudo M, et al. Role of coerulean noradrenergic neurones in general anaesthesia in rats. Br J Anaesth. 2011 ; 107: 924-929
254. Kwiat GC, Basbaum AI. The origin of brainstem noradrenergic and serotonergic projections to the spinal cord dorsal horn in the rat. Somatosens Mot Res. 1992 ; 9: 157-173
255. Larkman PM, Kelly JS. Ionic mechanisms mediating 5-hydroxytryptamine- and noradrenaline-evoked depolarization of adult rat facial motoneurones. J Physiol. 1992 ; 456: 473-490
256. LeDoux J. Fear and the brain: Where have we been, and where are we going?. Biol Psychiatry. 1998 ; 44: 1229-1238
257. Lee HS, Kim M-A, Waterhouse BD. Retrograde double-labeling study of common afferent projections to the dorsal raphe and the nuclear core of the locus coeruleus in the rat. J Comp Neurol. 2005a ; 481: 179-193
258. Lee HS, Lee BY, Waterhouse BD. Retrograde study of projections from the tuberomammillary nucleus to the dorsal raphe and the locus coeruleus in the rat. Brain Res. 2005b ; 1043: 65-75
259. Lee VM, Goedert M, Trojanowski JQ. Neurodegenerative taupathies. Annu Rev Neurosci. 2001 ; 24: 1121-1159
260. Le Maître E, Barde SS, Palkovits M, et al. Distinct features of neurotransmitter systems in the human brain with focus on the galanin system in locus coeruleus and dorsal raphe. Proc Natl Acad Sci USA. 2013 ; 110: E536-545
261. Leong SK, Shieh JY, Wong WC. Localizing spinal-cord-projecting neurons in adult albino rats. J Comp Neurol. 1984 ; 228: 1-17
262. LePard KJ, Ren J, Galligan JJ. Presynaptic modulation of cholinergic and non-cholinergic fast synaptic transmission in the myenteric plexus of guinea pig ileum. Neurogastroenterol Motil. 2004 ; 16: 355-364
263. Levitt P, Moore RY. Origin and organization of brainstem catecholamine innervation in the rat. J Comp Neurol. 1979 ; 186: 505-528
264. Levitt P, Rakic P, Goldman-Rakic P. Region-specific distribution of catecholamine afferents in primate cerebral cortex: A fluorescence histochemical analysis. J Comp Neurol. 1984 ; 227: 23-36
265. Lewis DI, Coote JH. Excitation and inhibition of rat sympathetic preganglionic neurones by catecholamines. Brain Res. 1990 ; 530: 229-234
266. Li D-P, Atnip LM, Chen S-R, et al. Regulation of synaptic inputs to paraventricular-spinal output neurons by α2 adrenergic receptors. J Neurophysiol. 2005 ; 93: 393-402
267. Li H-Y, Ericsson A, Sawchenko PE. Distinct mechanisms underlie activation of hypothalamic neurosecretory neurons and their medullary catecholaminergic afferents in categorically different stress paradigms. Proc Natl Acad Sci USA. 1996 ; 93: 2359-2364
268. Li X, Rainnie DG, McCarley RW, et al. Presynaptic nicotinic receptors facilitate monoaminergic transmission. J Neurosci. 1998 ; 18: 1904-1912
269. Li Y, Van den Pol AN. Direct and indirect inhibition by catecholamines of hypocretin/orexin neurons. J Neurosci. 2005 ; 25: 173-183
270. Lin J-S, Anaclet C, Sergeeva OA, et al. The waking brain: An update. Cell Mol Life Sci. 2011 ; 68: 2499-2512
271. Liu L, Tsuruoka M, Maeda M, et al. Coerulospinal inhibition of visceral nociceptive processing in the rat spinal cord. Neurosi Lett. 2007 ; 426: 139-144
272. Livett BG. Histochemical visualization of peripheral and central adrenergic neurones. Br Med Bull. 1973 ; 29: 93-99
273. Lockley SW, Evans EE, Scheer FA, et al. Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans. Sleep. 2006 ; 29: 161-168
274. Lockrow J, Boger G, Aston-Jones G, et al. A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model. J Alzheimer Dis. 2011 ; 23: 471-489
275. Lockrow JP, Fortress AM, Granholm A-CE. Age-related neurodegeneration and memory loss in Down syndrome. Curr Gerontol Geriatr Res. 2012 2012 ;:
276. Loewi O. Über humorale Uebertragbarkeit der Herzenwirkung. Pflügers Arch ges Physiol. 1921 ; 237: 504-514
277. Loewy AD. Raphe pallidus and raphe obscurus projections to the intermediolateral cell column in the rat. Brain Res. 1981 ; 222: 129-133
278. Loewy AD Central Regulation of Autonomic Functions. Loewy AD Spyer KM, ed. Oxford: Oxford University Press, pp ; 1990a: 3-16.
279. Loewy AD Central Regulation of Autonomic Functions. Loewy AD Spyer KM, ed. Oxford: Oxford University Press, pp ; 1990b: 88-103.
280. Loewy AD, Spyer KM Central Regulation of Autonomic Functions. Loewy AD Spyer KM, ed. Oxford: Oxford University Press, pp ; 1990: 68-87.
281. Loewy AD, McKellar S, Saper CB. Direct projections from A5 catecholamine cell group to the intermedio-lateral cell column. Brain Res. 1979 ; 174: 309-314
282. Loughlin SE, Foote SL, Bloom FE. Efferent projections of nucleus locus coeruleus: Topographic organization of cells of origin demonstrated by three-dimensional reconstruction. Neuroscience. 1986a ; 18: 291-306
283. Loughlin SE, Foote SL, Fallon JH. Locus coeruleus projections to the cortex: Topography, morphology and collaterization. Brain Res Bull. 1982 ; 9: 287-294
284. Loughlin SE, Foote SL, Grzanna R. Efferent projections of nucleus locus coeruleus: Morphologic subpopulations have different efferent targets. Neuroscience. 1986b ; 18: 307-319
285. Lu J, Jhou TC, Saper CB. Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter. J Neurosci. 2006 ; 26: 193-202
286. Lu J, Shiromani P, Saper CB. Retinal input to the sleep-active ventrolateral preoptic nucleus in the rat. Neurosci. 1999 ; 93: 209-214
287. Luiten PGM, Ter Horst GJ, Karst H, et al. The course of the paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord. Brain Res. 1985 ; 329: 374-378
288. Lung MA. Mechanisms of sympathetic enhancement and inhibition of parasympathetically induced salivary secretion in anaesthetized dogs. Br J Pharmacol. 1994 ; 112: 411-416
289. Luppi P-H, Aston-Jones G, Akaoka H, et al. Afferent projections to the rat locus coeruleus demonstrated by retrograde and anterograde tracing with cholera-toxin B subunit and Phaseolus vulgaris leucoagglutinin. Neuroscience. 1995 ; 65: 119-160
290. Luppi PH, Clement O, Sapin E, et al. Brainstem mechanisms of paradoxical (REM) sleep generation. Pflugers Arch. 2012 ; 463: 43-52
291. Lyness SA, Zarow C, Chui HC. Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: A meta-analysis. Neurobiol Aging. 2003 ; 24: 1-23
292. Lyons DJ, Hellysaz R, Broberger C. Prolactin regulates tuberoinfundibular dopamine neuron discharge pattern: Novel feedback control mechanisms in the lactotrophic axis. J Neurosci. 2012 ; 32: 8074-8083
293. Lyons WE, Grzanna R. Noradrenergic neurons with divergent projections to the motor trigeminal nucleus and the spinal cord: A double retrograde neuronal labeling study. Neuroscience. 1988 ; 26: 681-693
294. McBride RL, Sutin J. Projections of the locus coeruleus and adjacent pontine tegmentum in the cat. J Comp Neurol. 1976 ; 165: 265-284
295. McCormick DA, Pape HC, Williamson A. Actions of norepinephrine in the cerebral cortex and thalamus: Implications for function of the central noradrenergic system. Prog Brain Res. 1991 ; 88: 293-305
296. McDougle CJ, Krystal JH, Price LH, et al. Noradrenergic response to acute ethanol administration in healthy subjects: Comparison with intravenous yohimbine. Psychopharmacology. 1995 ; 118: 127-135
297. McGinty DJ, Harper RM. Dorsal raphe neurons: Depression of firing during sleep in cats. Brain Res. 1976 ; 101: 569-575
298. Machado BH, Brody MJ. Mechanisms of pressor response produced by stimulation of nucleus ambiguus. Am J Physiol. 1990 ; 259: R955 - R962
299. McKitrick DJ, Calaresu FR. Nucleus ambiguus inhibits activity of cardiovascular units in RVLM. Brain Res. 1996 ; 742: 203-210
300. McSharry C. Multiple sclerosis: Noradrenaline deficits suggest novel MS treatments. Nat Rev Neurol. 2011 ; 7: 184
301. Mann DM, Yates PO, Hawkes J. The pathology of the human locus coeruleus. Clin Neuropathol. 1983 ; 2: 1-7
302. Manns ID, Alonso A, Jones BE. Discharge properties of juxtacellularly labelled and immunohistochemically identified cholinergic basal forebrain neurons recorded in association with the electroencephalogram in anesthetized rats. J Neurosci. 2000a ; 20: 1505-1518
303. Manns ID, Alonso A, Jones BE. Discharge profiles of juxtacellularly labelled and immunohistochemically identified GABAergic basal forebrain neurons recorded in association with the electroencephalogram in anesthetized rats. J Neurosci. 2000b ; 20: 9252-9263
304. Manns ID, Lee MG, Modirrousta M, et al. Alpha 2 adrenergic receptors on GABAergic, putative sleep-promoting basal forebrain neurons. Eur J Neurosci. 2003 ; 18: 723-727
305. Margalit D, Segal M. A pharmacologic study of analgesia produced by stimulation of the nucleus locus coeruleus. Psychopharmacology. 1979 ; 62: 169-173
306. Marotte LR, Raisman G. An experimental investigation of the relationship between granular vesicles and noradrenergic axons in the preoptic area of the rat. Brain Res. 1974 ; 70: 335-339
307. Martinez-Peña y, Valenzuela I, Rogers RC, Hermann E, et al. Norepinephrine effects on identified neurons of the rat dorsal motor nucleus of the vagus. Am J Physiol Gastrointest Liver Physiol. 2004 ; 286: G333 - G339
308. Mathis J, Hess CW, Bassetti C. Isolated mediotegmental lesion causing narcolepsy and rapid eye movement sleep behaviour disorder: A case evidencing a common pathway in narcolepsy and rapid eye movement sleep behaviour disorder. J Neurol Neurosurg Psychiatry. 2007 ; 78: 427-429
309. Matsutani K, Tsuruoka M, Shinya A, et al. Stimulation of the locus coeruleus suppresses trigeminal sensorimotor function in the rat. Brain Res Bull. 2000 ; 53: 827-832
310. Matthews KL, Chen CPL-H, Esiri MM, et al. Noradrenergic changes, aggressive behavior, and cognition in patients with dementia. Biol Psychiatry. 2002 ; 51: 407-416
311. Mehler MF, Purpura DP. Autism, fever, epigenetics and the locus coeruleus. Brain Res Rev. 2009 ; 59: 388-392
312. Michimori A, Araki K, Hagiwara H. Effects of illuminance levels on sympathetic activities. Sleep Res. 1997 ; 26: 677
313. Millan MJ. Descending control of pain. Prog Neurobiol. 2002 ; 66: 355-474
314. Millan MJ. The neurobiology and control of anxious states. Prog Neurobiol. 2003 ; 70: 83-244
315. Millan MJ, Lejeune F, Gobert A. Reciprocal autoreceptor and heteroreceptor control of serotonergic, dopaminergic and noradrenergic transmission in the frontal cortex: Relevance to the actions of antidepressant agents. J Psychopharmacol. 2000 ; 14: 114-138
316. Mistlberger RE. Circadian regulation of sleep in mammals: Role of the suprachiasmatic nucleus. Brain Res Rev. 2005 ; 49: 429-454
317. Modirrousta M, Mainville L, Jones BE. GABAergic neurons with α2-adrenergic receptors in basal forebrain and preoptic area express c-Fos during sleep. Neuroscience. 2004 ; 129: 803-810
318. Monti JM. Serotonin control of sleep-wake behaviour. Sleep Med Rev. 2011 ; 15: 269-281
319. Monti JM, Jantos H. The roles of dopamine and serotonin, and their receptors, in regulating sleep and waking. Prog Brain Res. 2008 ; 172: 625-646
320. Monti JM, Monti D. The involvement of dopamine in the modulation of sleep and waking. Sleep Med Rev. 2007 ; 11: 113-133
321. Moore RY, Bloom FE. Central catecholamine neuron systems: Anatomy and physiology of the norepinephrine and epinephrine systems. Ann Rev Neurosci. 1979 ; 2: 113-168
322. Morrison JH, Foote SL, O'Connor D, et al. Laminar, tangential and regional organization of the noradrenergic innervation of monkey cortex: Dopamine-β-hydroxylase immunohistochemistry. Brain Res Bull. 1982 ; 9: 309-319
323. Morrison JH, Molliver ME, Grzanna R, et al. Noradrenergic innervation patterns in three regions of medial cortex: An immunofluorescence characterization. Brain Res Bull. 1979 ; 4: 849-857
324. Morrison SF, Nakamura K. Central neural pathways for thermoregulation. Front Biosci. 2011 ; 16: 74-104
325. Mosqueda-Garcia R Primer on the Autonomic Nervous System. Robertson D Low PA Polinsky RJ, ed. San Diego: Academic Press, pp ; 1996: 3-12.
326. Nagai T, Satoh K, Imamoto K, et al. Divergent projections of catecholamine neurons of the locus coeruleus as revealed by fluorescent retrograde double labelling technique. Neurosci Lett. 1981 ; 23: 117-123
327. Nakamura K, Matsumura K, Hübschle T, et al. Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J Neurosci. 2004 ; 24: 5370-5380
328. Nakamura K, Matsumura K, Kobayashi S, et al. Sympathetic premotor neurons mediating thermoregulatory function. Neurosci Res. 2005 ; 51: 1-8
329. Nelson LE, Guo TZ, Lu J, et al. The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway. Nature Neuroscience. 2002 ; 5: 979-984
330. Nelson LE, Lu J, Guo TZ, et al. The α2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. 2003 ; 98: 428-436
331. Nemoto T, Konno A, Chiba T. Synaptic contact of neuropeptide-and amine-containing axons on parasympathetic preganglionic neurons in the superior salivatory nucleus of the rat. Brain Res. 1995 ; 685: 33-45
332. Nicholson JE, Severin CM. The superior and inferior salivatory nuclei in the rat. Neurosci Lett. 1981 ; 21: 149-154
333. Nicola SM, Taha SA, Kim SW, et al. Nucleus accumbens dopamine release is necessary and sufficient to promote the behavioural response to reward- predictive cues. Neuroscience. 2005 ; 135: 1025-1033
334. Niepel G, Bibani RH, Vilisaar J, et al. Association of a deficit of arousal with fatigue in multiple sclerosis: Effect of modafinil. Neuropharmacology. 2013 ; 664: 380-388
335. Nieuwenhuys R Chemoarchitecture of the Brain. Berlin: Springer-Verlag ; 1985:
336. Nishino H, Koizumi K, Brooks CM. The role of suprachiasmatic nuclei of the hypothalamus in the production of circadian rhythm. Brain Res. 1976 ; 112: 45-59
337. Nitz D, Siegel JM. GABA release in the locus coeruleus as a function of sleep/wake state. Neuroscience. 1997 ; 78: 795-801
338. Nosaka S, Yasunaga K, Tamai S. Vagal cardiac preganglionic neurons: Distribution, cell types, and reflex discharges. Am J Physiol. 1982 ; 243: R92 - R98
339. Nygren L-G, Olson L. A new major projection from locus coeruleus: The main source of noradrenergic nerve terminals in the ventral and dorsal columns of the spinal cord. Brain Res. 1977 ; 132: 85-93
340. Olave MJ, Maxwell DJ. An investigation of neurones that possess the α2C-adrenergic receptor in the rat dorsal horn. Neuroscience. 2002 ; 115: 31-40
341. Olson L, Fuxe K. On the projections from the locus coeruleus noradrenaline neurons: The cerebellar innervation. Brain Res. 1971 ; 28: 165-171
342. O'Malley SS, Chen TB, Francis BE, et al. Characterization of specific binding of [125I]L-762,459, a selective alpha1A-adrenoceptor radioligand to rat and human tissues. Eur J Pharmacol. 1998 ; 348: 287-295
343. Ornstein K, Milon H, McRae-Degueurce A, et al. Biochemical and radioautographic evidence for dopaminergic afferents of the locus coeruleus originating in the ventral tegmental area. J Neural Transm. 1987 ; 70: 183-191
344. Osaka T, Matsumura H. Noradrenergic inputs to sleep-related neurons in the preoptic area from the locus coeruleus and the ventrolateral medulla in the rat. Neurosci Res. 1994 ; 19: 39-50
345. Ossipov MH, Dussor GO, Porreca F. Central modulation of pain. J Clin Invest. 2010 ; 120: 3779-3787
346. Owesson CA, Seif I, McLaughlin DP, et al. Different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-A knockout mice. Eur J Neurosci. 2003 ; 18: 34-42
347. Pacák K, Palkovits M. Stressor specificity of central neuroendocrine responses: Implications for stress-related disorders. Endocr Rev. 2001 ; 22: 502-548
348. Pal D, Mallick BN. Neural mechanism of rapid eye movement sleep generation with reference to REM-OFF neurons in locus coeruleus. Indian J Med Res. 2007 ; 125: 721-739
349. Palacios JM, Hoyer D, Cortés R. α1-Adrenoceptors in the mammalian brain: Similar pharmacology but different distribution in rodents and primates. Brain Res. 1987 ; 419: 65-75
350. Palkovits M, Baffi JS, Dvori S. Neuronal organization of stress response. Pain-induced c-fos expression in brain stem catecholaminergic cell groups. Ann NY Acad Sci. 1995 ; 29: 313-326
351. Palkovits M, Záborsky L, Feminger A, et al. Noradrenergic innervation of the rat hypothalamus: Experimental biochemical and electron microscopic studies. Brain Res. 1980 ; 191: 161-171
352. Pan ZZ, Grudt TJ, Williams JT. Alpha 1-adrenoceptors in rat dorsal raphe neurons: Regulation of two potassium conductances. J Physiol (Lond). 1994 ; 478: 437-447
353. Papadopoulos GC, Parnavelas JG. Monoamine systems in the cerebral cortex: Evidence for anatomical specificity. Prog Neurobiol. 1991 ; 36: 195-200
354. Papay R, Gaivin R, Jha A, et al. Localization of the mouse α1A-adrenergic receptor (AR) in the brain: α1AAR is expressed in neurons, GABAergic interneurons, and NG2 oligodendrocyte progenitors. J Comp Neurol. 2006 ; 497: 209-222
355. Pare D, Duvarci S. Amygdala microcircuits mediating fear expression and extinction. Curr Opin Neurobiol. 2012 ; 22: 717-723
356. Parkis MA, Bayliss DA, Berger AJ. Actions of norepinephrine on rat hypoglossal motoneurons. J Neuropsysiol. 1995 ; 74: 1911-1919
357. Parvizi J, Damasio AR. Neurochemical correlates of brainstem coma. Brain. 2003 ; 126: 1524-1536
358. Paschalis A, Churchill L, Marina N, et al. β1-Adrenoceptor distribution in the rat brain: An immunohistochemical study. Neurosci Lett. 2009 ; 458: 84-88
359. Pascoe JP, Kapp BS. Electrophysiological characteristics of amygdaloid central nucleus neurons during Pavlovian fear conditioning in the rabbit. Behav Brain Res. 1985 ; 16: 117-133
360. Pascual J, del Arco C, Gonzalez AM, et al. Quantitative light microscope autoradiographic localization of alpha 2-adrenoceptors in the human brain. Brain Res. 1992 ; 585: 116-127
361. Paspalas CD, Papadopoulos GC. Ultrastructural relationships between noradrenergic nerve fibers and non-neuronal elements in the rat cerebral cortex. Glia. 1996 ; 17: 133-146
362. Pasquier DA, Kemper TL, Forbes WB, et al. Dorsal raphe, substantia nigra and locus coeruleus: Interconnections with each other and the neostriatum. Brain Res Bull. 1977 ; 2: 323-339
363. Passatore M. Physiological characterization of efferent cervical sympathetic fibers influenced by changes of illumination. Exp Neurol. 1976 ; 53: 71-81
364. Passatore M, Pettorossi VE. Efferent fibers in the cervical sympathetic nerve influenced by light. Exp Neurol. 1976 ; 52: 66-82
365. Peever J. Control of motoneuron function and muscle tone during REM sleep, REM sleep behaviour disorder and cataplexy/narcolepsy. Arch Ital Biol. 2011 ; 149: 454-466
366. Pepper CM, Henderson G. Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro. Science. 1980 ; 209: 394-395
367. Perreau-Lenz S, Kalsbeek A, Garidou ML, et al. Suprachiasmatic control of melatonin synthesis in rats: Inhibitory and stimulatory mechanisms. Eur J Neurosci. 2003 ; 17: 221-228
368. Pertovaara A, Almeida A Handbook of Clinical Neurology: Pain. Cervero F Jensen TS, ed. Amsterdam: Elsevier ; 2006: 179-192.
369. Peyron C, Luppi P-H, Rampon C, et al. Localization of the GABA-ergic neurons projecting to the rat dorsal raphe and locus coeruleus. Soc Neurosc Abs. 1995 ; 21: 373
370. Phillips MA, Szabadi E, Bradshaw CM. Comparison of the effects of clonidine and yohimbine on pupillary diameter at different illumination levels. Br J Clin Pharmacol. 2000a ; 50: 65-68
371. Phillips MA, Szabadi E, Bradshaw CM. Comparison of the effects of clonidine and yohimbine on spontaneous pupillary fluctuations in healthy human volunteers. Psychopharmacology. 2000b ; 150: 85-89
372. Pickel VM, Segal M, Bloom FE. A radioautographic study of the efferent pathways of the nucleus locus coeruleus. J Comp Neurol. 1974 ; 155: 15-42
373. Pieribone VA, Nicholas AP, Dagerlind Å, et al. Distribution of α1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype-specific probes. J Neurosci. 1994 ; 14: 4252-4268
374. Poitras D, Parent A. Atlas of the distribution of monoamine-containing nerve cell bodies in the brain stem of the cat. J Comp Neurol. 1978 ; 179: 699-718
375. Polak PE, Kalinin S, Feinstein DL. Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain. 2011 ; 134: 665-677
376. Proudfit HK, Clark FM. The projections of locus coeruleus neurons to the spinal cord. Prog Brain Res. 1991 ; 88: 123-141
377. Pudovkina OL, Cremers TIFH, Westerink BHC. Regulation of the release of serotonin in the dorsal raphe nucleus by α1 and α2 adrenoceptors. Synapse. 2003 ; 50: 77-82
378. Puschmann A, Bhidayasiri R, Weiner WJ. Synucleinopathies from bench to bedside. Parkinsonism Relat Disord. 2012 ; 18: S24 - S27
379. Pyner S. Neurochemistry of the paraventricular nucleus of the hypothalamus: Implications for cardiovascular regulation. J Chem Neuroanat. 2009 ; 38: 197-208
380. Qu LL, Guo NN, Li BM. Beta1- and beta2-adrenoceptors in basolateral nucleus of amygdala and their roles in consolidation of fear memory in rats. Hippocampus. 2008 ; 18: 1131-1139
381. Raichle ME, Hartman BK, Eichling JO, et al. Central noradrenergic regulation of cerebral blood flow and vascular permeability. Proc Nat Acad Sci USA. 1975 ; 72: 3726-3730
382. Rajkowski J, Kubiak P, Aston-Jones G. Correlations between locus coeruleus (LC) neural activity, pupil diameter and behaviour in monkey support a role of LC in attention. Abstr Soc Neurosci. 1993 ; 19: 974
383. Rajkowski J, Kubiak P, Aston-Jones G. Locus coeruleus activity in monkey: Phasic and tonic changes are associated with altered vigilance. Brain Res Bull. 1994 ; 35: 607-616
384. Ranson RN, Motawei K, Pyner S, et al. The paraventricular nucleus of the hypothalamus sends efferents to the spinal cord of the rat that closely appose sympathetic preganglionic neurones projecting to the stellate ganglion. Exp Brain Res. 1998 ; 120: 164-172
385. Ranson RN, Santer RM, Watson AH. The relationship between serotonin, dopamine beta hydroxylase and GABA immunoreactive inputs and spinal preganglionic neurones projecting to the major pelvic ganglion of Wistar rats. Neuroscience. 2006 ; 141: 1935-1949
386. Rasmussen K, Aghajanian GK. Serotonin excitation of facial motoneurons: Receptor subtype characterization. Synapse. 1990 ; 5: 324-332
387. Rasmussen K, Jacobs BL. Single unit activity of locus coeruleus neurons in the freely moving cat. II. Conditioning and pharmacologic studies. Brain Res.
388. Rasmussen K, Morilak D, Jacobs BL. Single unit activity of locus coeruleus neurons in the freely moving cat. I. During naturalistic behaviors and in response to simple and complex stimuli. Brain Res. 1986 ; 371: 324-334
389. Rathner JA, Owens NC, McAllen RM. Cold-activated raphe-spinal neurons in rats. J Physiol. 2001 ; 535: 841-854
390. Redmond DE Psychopharmacology: The Third Generation of Progress. Meltzer HY, ed. New York: Raven Press ; 1987: 467-974.
391. Redmond DE, Huang YH. New evidence for a locus coeruleus-norepinephrine connection with anxiety. Life Sci. 1979 ; 25: 2149-2162
392. Remy P, Doder M, Lees A, et al. Depression in Parkinson's disease: Loss of dopamine and noradrenaline innervation in the limbic system. Brain. 2005 ; 128: 1314-1322
393. Revell VL, Arendt J, Fogg LF, et al. Alerting effects of light are sensitive to very short wavelengths. Neurosci Lett. 2006 ; 399: 96-100
394. Reyes BAS, Valentino RJ, Xu G, et al. Hypothalamic projections to locus coeruleus neurons in rat brain. Eur J Neurosci. 2005 ; 22: 93-106
395. Rivot JP, Chiang CY, Besson JM. Increase of serotonin metabolism within the dorsal horn of the spinal cord during nucleus raphe magnus stimulation, as revealed by in vivo electrochemical detection. Brain Res. 1982 ; 238: 117-126
396. Robertson HA, Leslie RA. Noradrenergic alpha 2 binding sites in vagal dorsal motor nucleus and nucleus tractus solitarius: Autoradiographic localization. Can Physiol Pharmacol. 1985 ; 63: 1190-1194
397. Rodriguez M, Carillon C, Coquerel A, et al. Evidence for the presence of beta 3-adrenergic receptor mRNA in the human brain. Brain Res Mol Brain Res. 1995 ; 29: 369-375
398. Roux JC, Panyotis N, Dura E, et al. Progressive noradrenergic deficits in the locus coeruleus of Mecp2 deficient mice. J Neurosci Res. 2010 ; 88: 1500-1509
399. Saigal RP, Karamanlidis A, Voogd J, et al. Cerebellar afferents from motor nuclei of cranial nerves, the nucleus of the solitary tract, and nuclei coeruleus and parabrachialis in sheep, demonstrated with retrograde transport of horseradish peroxidase. Brain Res. 1980 ; 197: 200-206
400. Saint-Mleux B, Eggermann E, Bisetti A, et al. Nicotinic enhancement of the noradrenergic inhibition of sleep-promoting neurons in the ventrolateral preoptic area. J Neurosci. 2004 ; 24: 63-67
401. Sakai K. Executive mechanisms of paradoxical sleep. Arch Ital Biol. 1988 ; 126: 239-257
402. Sakai K, Salvert D, Touret M, et al. Afferent connections of the nucleus raphe dorsalis in the cat as visualized by the horseradish peroxidase technique. Brain Res. 1977 ; 137: 11-35
403. Samaco RC, Mandel-Brehm C, Chao HT, et al. Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioural abnormalities. Proc Natl Acad Sci USA. 2009 ; 106: 21966-21971
404. Samuels ER, Szabadi E. Functional neuroanatomy of the noradrenergic locus coeruleus: Its roles in the regulation of arousal and autonomic function. Part I: Principles of functional organisation. Curr Neuropharmacol. 2008a ; 6: 235-253
405. Samuels ER, Szabadi E. Functional neuroanatomy of the noradrenergic locus coeruleus: Its roles in the regulation of arousal and autonomic function. Part II: Physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans. Curr Neuropharmacol. 2008b ; 6: 254-285
406. Samuels ER, Hou RH, Langley RW, et al. Comparison of pramipexole and modafinil on arousal, autonomic, and endocrine functions in healthy volunteers. J Psychopharmacol. 2006 ; 20: 756-770
407. Sands SA, Morilak DA. Expression of α1D adrenergic receptor messenger RNA in oxytocin- and corticotropin-releasing hormone-synthesizing neurons in the rat paraventricular nucleus. Neuroscience. 1999 ; 91: 639-649
408. Saper CB, Loewy AD, Swanson LW, et al. Direct hypothalamo-autonomic connections. Brain Res. 1976 ; 117: 305-312
409. Sara SJ, Devauges V. Priming stimulation of locus coeruleus facilitates memory retrieval in the rat. Brain Res. 1988 ; 438: 299-303
410. Sasa M, Munekiyo H, Ikeda S, et al. Noradrenaline-mediated inhibition by locus coeruleus of spinal trigeminal neurons. Brain Res. 1974 ; 80: 443-460
411. Sasa M, Yoshimura N. Locus coeruleus noradrenergic neurons as a micturition center. Microsc Res Tech. 1994 ; 29: 226-230
412. Sasaki M, Shibata E, Tohyama K, et al. Neuromelanin magnetic resonance imaging of locus coeruleus and substantia nigra in Parkinson's disease. Neuroreport. 2006 ; 17: 1215-1218
413. Sawchenko PE, Swanson LW. Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat. J Comp Neurol. 1982 ; 205: 260-272
414. Sawynok J, Reid A. Role of ascending and descending noradrenergic pathways in the antinociceptive effect of clonidine and baclofen. Brain Res. 1986 ; 386: 341-350
415. Schambra UB, Mackensen GB, Stafford-Smith M, et al. Neuron specific α-adrenergic receptor expression in human cerebellum: Implications for emerging cerebellar roles in neurologic disease. Neuroscience. 2005 ; 135: 507-523
416. Scheer FA, Ter Hors GJ, Van Der Vliet J, et al. Physiological and anatomic evidence for regulation of the heart by suprachiasmatic nucleus in rats. Am J Physiol Heart Circ Physiol. 2001 ; 280: H1391 - H1399
417. Scheer FA, Van Doormen LJ, Buijs RM. Light and diurnal cycle affect human heart rate: Possible role for the circadian pacemaker. J Biol Rhythms. 1999 ; 14: 202-212
418. Scheibner J, Trendelenburg AU, Hein L, et al. Alpha 2-adrenoceptors modulating neuronal serotonin release: A study in alpha 2A-adrenoceptor- deficient mice. Br J Pharmacol. 2001 ; 132: 925-933
419. Scheibner J, Trendelenburg AU, Hein L, et al. Alpha 2-adrenoceptors in the enteric nervous system: A study in alpha 2A-adrenoceptor-deficient mice. Br J Pharmacol. 2002 ; 135: 697-704
420. Scheinin M, Lomasney JW, Hayden-Hixson DM, et al. Distribution of α2-adrenergic receptor subtype gene expression in rat brain. Mol Brain Res. 1994 ; 21: 133-149
421. Schofield SPM, Everitt BJ. The organisation of catecholamine-containing neurons in the brain of the rhesus monkey (Macaca mulatta). J Anat. 1981 ; 132: 391-418
422. Schuerger RJ, Balaban CD. Immunohistochemical demonstration of regionally selective projections from locus coeruleus to the vestibular nuclei in rats. Exp Brain Res. 1993 ; 92: 351-359
423. Schwartz JRL, Roth T. Neurophysiology of sleep and wakefulness: Basic science and clinical implications. Curr Neuropharmacol. 2008 ; 6: 367-378
424. Séguéla P, Watkins KC, Geffard M, et al. Noradrenaline axon terminals in adult rat neocortex: An immunocytochemical analysis in serial thin sections. Neuroscience. 1990 ; 35: 249-264
425. Semo M, Muñoz Llamosas M, Foster RG, et al. Melanopsin ( positive cells in the cat retina are randomly distributed across the ganglion cell layer. Opn4 Vis Neurosci. 2005 ; 22: 111-116
426. Senba E, Tohyama M, Shiosaka H, et al. Experimental and morphological studies of the noradrenaline innervations in the nucleus tractus spinal nervi trigemini of the rat with special reference to their fine structures. Brain Res. 1981 ; 206: 39-50
427. Sesack SR, Deutch AY, Roth RH, et al. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract-tracing study with phaseolus vulgaris leucoagglutinin. J Comp Neurol. 1989 ; 290: 213-242
428. Shao YP, Sutin J. Noradrenergic facilitation of motor neurons: Localization of adrenergic receptors in neurons and nonneuronal cells in the trigeminal motor nucleus. Exp Neurol. 1991 ; 114: 216-227
429. Shefchyk SJ. Sacral spinal interneurones and the control of urinary bladder and urethral striated sphincter muscle function. J Physiol. 2001 ; 533: 57-63
430. Shen H, Peri KG, Deng XF, et al. Distribution of alpha1-adrenoceptor subtype proteins in different tissues of neonatal and adult rats. Can J Physiol Pharmacol. 2000 ; 78: 237-243
431. Shi TJ, Winzer-Serhan U, Leslie F, et al. Distribution of alpha2-adrenoceptor mRNAs in the rat lumbar spinal cord in normal and axotomized rats. Neuroreport. 1999 ; 10: 2835-2839
432. Shibata E, Sasaki M, Tohyama K, et al. Age-related changes in locus coeruleus on neuromelanin magnetic resonance imaging at 3 tesla. Magn Reson Med Sci. 2006 ; 5: 197-200
433. Shields AD, Wand Q, Winder DG. Alpha2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis. Neuroscience. 2009 ; 163: 339-351
434. Silberman Y, Ariwodola OJ, Weiner JL. β1-adrenoceptor activation is required for ethanol enhancement of lateral paracapsular GABAergic synapses in the basolateral amygdala. J Pharmacol Exp Ther. 2012 ; 343: 451-459
435. Simon H, Le Moal M, Stinus L, et al. Efferents and afferents of the ventral tegmental-A10 region studied after local injection of [3H]leucine and horseradish peroxidase. Brain Res. 1979a ; 178: 17-40
436. Simon H, Le Moal M, Stinus L, et al. Anatomical relationships between the ventral mesencephalic tegmentum-A10 region and the locus coeruleus as demonstrated by anterograde and retrograde tracing techniques. J Neural Transm. 1979b ; 44: 77-86
437. Singewald N, Philippu A. Release of neurotransmitters in the locus coeruleus. Prog Neurobiol. 1998 ; 56: 237-267
438. Singewald N, Kaehler ST, Philippu A. Noradrenaline release in the locus coeruleus of conscious rats triggered by drugs, stress and blood pressure changes. Neuroreport. 1999 ; 10: 1583-1587
439. Sirieix C, Gervasoni D, Luppi PH, et al PLoS One. sleep: An electrophysiological and anatomical study in the rat ; 2012: e28724.
440. Sluka KA, Westlund KN. Spinal projections of the locus coeruleus and the nucleus subcoeruleus in the Harlan and the Sasco Sprague-Dawley rat. Brain Res. 1992 ; 579: 67-73
441. Smith MS, Schambra UB, Wilson KH, et al. Alpha 2-adrenergic receptors in human spinal cord: Specific localized expression of mRNA encoding alpha 2-adrenergic receptor subtypes at four distinct levels. Brain Res Mol Brain Res. 1995 ; 34: 109-117
442. Smith MS, Schambra UB, Wilson KH, et al. α1-adrenergic receptors in human spinal cord: Specific localized expression of mRNA encoding α1-adrenergic receptor subtypes at four distinct levels. Mol Brain Res. 1999 ; 63: 254-261
443. Southwick SM, Krystal JH, Morgan CA, et al. Abnormal noradrenergic function in posttraumatic stress disorder. Arch Gen Psychiatry. 1993 ; 50: 266-274
444. Spencer SE, Sawyer WB, Wada H, et al. CNS projections to the pterygopalatine parasympathetic preganglionic neurons in the rat: A retrograde transneuronal viral cell body labeling study. Brain Res. 1990 ; 534: 149-169
445. Starke K. Presynaptic autoreceptors in the third decade: Focus on α2-adrenoceptors. J Neurochem. 2001 ; 78: 685-693
446. Steininger TL, Gong H, McGinty D, et al. Subregional organization of preoptic area/anterior hypothalamic projections to arousal-related monoaminergic cell groups. J Comp Neurol. 2001 ; 429: 638-653
447. Sterpenich V, D'Argembeau A, Desseilles M, et al. The locus coeruleus is involved in the successful retrieval of emotional memories in humans. J Neurosci. 2006 ; 26: 7416-7423
448. Stock G, Rupprecht U, Stumpf H, et al. Cardiovascular changes during arousal elicited by stimulation of amygdala, hypothalamus and locus coeruleus. J Auton Nerv Syst. 1981 ; 3: 503-510
449. Stone A, Quartermain D, Lin Y, et al. Central α1-adrenergic system in behavioural activity and depression. Biochem Pharmacol. 2006 ; 73: 1063-1075
450. Stone EA, Ariano MA. Are glial cells targets of the central noradrenergic system? A review of the evidence. Brain Res Rev. 1989 ; 14: 297-309
451. Sugiyama D, Hur SW, Pickering AE, et al. In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem. J Physiol. 2012 ; 590: 2225-2231
452. Sullivan RM, Wilson DA, Lemon C, et al. Bilateral 6-OHDA lesions of the locus coeruleus impair associative olfactory learning in newborn rats. Brain Res. 1994 ; 643: 306-309
453. Summers RJ, Papaionnaou M, Harris S, et al. Expression of beta 3-adrenoceptor mRNA in rat brain. Br J Pharmacol. 1995 ; 116: 2547-2548
454. Sun M-K. Central neural organization and control of sympathetic nervous system in mammals. Prog Neurobiol. 1995 ; 47: 157-233
455. Swanson LW, Sawchenko PE. Paraventricular nucleus: A site for the integration of neuroendocrine and autonomic mechanisms. Neuroendocrinology. 1980 ; 31: 410-417
456. Swanson LW, Sawchenko PE. Hypothalamic integration: Organization of the paraventricular and supraoptic nuclei. Ann Rev Neurosci. 1983 ; 6: 269-324
457. Szabadi E Companion to Psychiatric Studies, Fifth Edition. Kendell RE Zeally AK, ed. Edinburgh: Churchill Livingstone ; 1993: 77-104.
458. Szabadi E. Drugs for sleep disorders: Mechanisms and therapeutic prospects. Br J Clin Pharmacol. 2006 ; 61: 761-766
459. Szabadi E. Modulation of physiological reflexes by pain: Role of the locus coeruleus. Front Integr Neurosci. 2012 ; 6: 1-15
460. Szabadi E, Bradshaw CM Recent Advances in Clinical Psychiatry. Granville-Grosman K, ed. Edinburgh: Churchill Livingstone ; 1988: 69-99.
461. Szabadi E, Bradshaw CM Adrenoceptors: Structure, Mechanisms, Function. Basel: Birkhäuser ; 1991:
462. Szabadi E, Tavernor S. Hypo- and hypersalivation induced by psychoactive drugs. Incidence, mechanisms and therapeutic implications. CNS Drugs. 1999 ; 11: 449-466
463. Szabadi E, Biswas A, Langley R, et al. Effects of clonidine on responses of the human pupil to monochromatic light stimuli. Br J Clin Pharmacol. 2010 ; 70: 300-301
464. Szabadi E, Bradshaw CM, Nahorski SR Pharmacology of Adrenoceptors. Basingstoke: Macmillan ; 1985:
465. Szot P, White SS, Greenup JL, et al. Alpha1-adrenoceptor in human hippocampus: Binding and receptor subtype mRNA expression. Brain Res Mol Brain Res. 2005 ; 139: 367-371
466. Szymusiak R, McGinty D. Hypothalamic regulation of sleep and arousal. Ann N Y Acad Sci. 2008 ; 1129: 275-286
467. Takakura ACT, Moreira TS, De Luca LA Jr, et al. Central α2 adrenergic receptors and cholinergic-induced salivation in rats. Brain Res Bull. 2003 ; 59: 383-386
468. Takano T, Kubota Y, Wanaka A, et al. β-Adrenergic receptors in the vasopression-containing neurons in the paraventricular and supraoptic nucleus of the rat. Brain Res. 1989 ; 499: 174-178
469. Takauchi S, Yamauchi S, Morimura Y, et al. Coexistence of Pick bodies and atypical Lewy bodies in the locus coeruleus neurons of Pick's disease. Acta Neuropathol. 1995 ; 90: 93-100
470. Talley EM, Rosin DL, Lee A, et al. Distribution of alpha 2A-adrenergic receptor-like immunoreactivity in the rat central nervous system. J Comp Neurol. 1996 ; 372: 111-134
471. Taneja P, Ogier M, Brooks-Haris G, et al. Pathophysiology of locus ceruleus neurons in a mouse model of Rett syndrome. J Neurosci. 2009 ; 29: 12187-12195
472. Tavares A, Handy DE, Bogdanova NN, et al. Localization of α2A- and α2B-adrenergic receptor subtypes in brain. Hypertension. 1996 ; 27: 449-455
473. Ter Horst GJ, Toes GJ, Van Willigen JD. Locus coeruleus projections to the dorsal motor vagus nucleus in the rat. Neuroscience. 1991 ; 45: 153-160
474. Thapan K, Arendt J, Skene DJ. An action spectrum for melatonin suppression: Evidence for a novel non-rod, non-cone photoreceptor system in humans. J Physiol. 2001 ; 535: 261-267
475. Thompson HS Primer on the Autonomic Nervous System. Robertson D Low PA Polinsky RJ, ed. San Diego: Academic Press ; 1996: 74-79.
476. Tillet Y, Kitahama K. Distribution of central catecholaminergic neurons: A comparison between ungulates, humans and other species. Histol Histopathol. 1998 ; 13: 1163-1177
477. Tillet Y, Thibault J. Catecholamine-containing neurons in the sheep brainstem and diencephalon: Immunohistochemical study with tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) antibodies. J Comp Neurol. 1989 ; 290: 69-104
478. Tomlinson BE, Irving D, Blessed G. Cell loss in the locus coeruleus in senile dementia of Alzheimer's type. J Neurol Sci. 1981 ; 49: 419-428
479. Tóth IE, Boldogkoi Z, Medveczky I, et al. Lacrimal preganglionic neurons form a subdivision of the superior salivatory nucleus of rat: Transneuronal labelling by pseudorabies virus. J Auton Nerv Syst. 1999 ; 77: 45-54
480. Trulson ME, Jacobs BL. Raphe unit activity in freely moving cats: Correlation with level of behavioural arousal. Brain Res. 1979 ; 163: 135-150
481. Tsai JW, Hannibal J, Hagiware G, et al. Melanopsin as a sleep modulator: Circadian gating of the direct effects of light on sleep and altered homeostasis in Opn4-/- mice. PLoS Biol. 2009 ; 7: e1000125
482. Tsuruoka M, Matsutani K, Maeda M, et al. Coeruleotrigeminal inhibition of nociceptive processing in the rat trigeminal subnucleus caudalis. Brain Res. 2003 ; 993: 146-153
483. Unnerstall JR, Kopajtic TA, Kuhar MJ. Distribution of alpha 2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents. Brain Res. 1984 ; 319: 69-101
484. Ursino MG, Vasina V, Raschi E, et al. The β3-adrenoceptor as a therapeutic target: Current perspectives. Pharmacol Res. 2009 ; 59: 221-234
485. Uschakov A, Grivel J, Cvetkovic-Lopes V, et al. Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons. PLoS ONE. 2011 ; 6: e16672
486. Valentino RJ, Van Bockstaele E. Convergent regulation of locus coeruleus connectivity as an adaptive response to stress. Eur J Pharmacol. 2008 ; 83: 194-203
487. Van Bockstaele EJ. Morphological substrates underlying opioid, epinephrine and γ-aminobutyric acid inhibitory actions in the rat locus coeruleus. Brain Res Bull. 1998 ; 47: 1-15
488. Van Bockstaele EJ, Aston-Jones G. Collateralized projections from neurons in the rostral medulla to the nucleus locus coeruleus, the nucleus of the solitary tract and the periaqueductal gray. Neuroscience. 1992 ; 49: 653-668
489. Van Bockstaele EJ, Aston-Jones G. Integration in the ventral medulla and coordination of sympathetic, pain and arousal functions. Clin Exp Hypertens. 1995 ; 17: 153-165
490. Van Bockstaele EJ, Bajic D, Proudfit H, et al. Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleus. Physiol Behav. 2001 ; 73: 273-283
491. Van Bockstaele EJ, Colago EE, Aicher S. Light and electron microscopic evidence for topographic and monosynaptic projections from neurons in the ventral medulla to noradrenergic dendrites in the rat locus coeruleus. Brain Res. 1998a ; 784: 123-138
492. Van Bockstaele EJ, Colago EEO, Valentino RJ. Amygdaloid corticotrophin-releasing factor targets locus coeruleus dendrites: Substrate for the co-ordination of emotional and cognitive limbs of the stress response. J Neurosci. 1998b ; 10: 743-757
493. Van Bockstaele EJ, Pieribone VA, Aston-Jones G. Diverse afferents converge on the nucleus paragigantocellularis in the rat ventrolateral medulla: Retrograde and anterograde tracing studies. J Comp Neurol. 1989 ; 290: 561-584
494. Van Dongen PA. The central noradrenergic transmission and the locus coeruleus: A review of the data, and their implications for neurotransmission and neuromodulation. Prog Neurobiol. 1981 ; 16: 117-143
495. Van Esseveldt KE, Lehman MN, Boer GJ. The suprachiasmatic nucleus and the circadian time-keeping system revisited. Brain Res Rev. 2000 ; 33: 34-77
496. Van Waarde, Visser TJ, Elsinga PH, et al. Imaging beta-adrenoceptors in the human brain with (S )-1'-[18F]Fluorocarazol. J Nucl Med. 1997 ; 38: 934-939
497. VanderMaelen CP, Aghajanian GK. Intracellular studies showing modulation of facial motoneurone excitability by serotonin. Nature. 1980 ; 287: 346-347
498. Vandewalle G, Schmidt C, Albouy G, et al. Brain responses to violet, blue and green monochromatic light exposures in humans: Prominent role of blue light and the brainstem. PLoS ONE. 2007 ; 11: e1247
499. Vazey EM, Aston-Jones G. The emerging role of norepinephrine in cognitive dysfunctions in Parkinson's disease. Front Behav Neurosci. 2012 ; 6: 1-6
500. Verleye M, Bernet F. Behavioural effects of lesions of the central noradrenergic bundle in the rat. Pharmacol Biochem Behav. 1983 ; 19: 407-414
501. Vertes RP, Kocsis B. Projections of the dorsal raphe nucleus to the brainstem: PHA-L analysis in the rat. J Comp Neurol. 1994 ; 340: 11-26
502. Vetrivelan R, Chang C, Lu J. Muscle tone regulation during REM sleep: Neural circuitry and clinical significance. Arch Ital Biol. 2011 ; 149: 348-366
503. Viemari JC, Roux JC, Tryba AK, et al. Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice. J Neurosci. 2005 ; 25: 11521-11530
504. Vogt M. The concentration of sympathin in different parts of the central nervous system under normal conditions and after administration of drugs. J Physiol. 1954 ; 123: 451-481
505. Voisin DL, Guy N, Chalus M, et al. Nociceptive stimulation activates locus coeruleus neurones projecting to the somatosensory thalamus in the rat. J Physiol. 2005 ; 566: 929-937
506. Voituron N, Zanella S, Menuet C, et al. Early abnormalities of post-sigh breathing in a mouse model of Rett syndrome. Respir Physiol Neurobiol. 2010 ; 170: 173-182
507. Von Euler US. The nature of adrenergic nerve mediators. Pharmacol Rev. 1951 ; 3: 247-277
508. Wallace DM, Magnuson DJ, Gray TS. The amygdalo-brainstem pathway: Selective innervation of dopaminergic, noradrenergic and adrenergic cells in the rat. Neurosci Lett. 1989 ; 97: 252-258
509. Wanaka A, Kiyama H, Murakami T, et al. Immunocytochemical localization of β-adrenergic receptors in the rat brain. Brain Res. 1989 ; 485: 125-140
510. Wang LN, Zhu MW, Feng YQ, et al. Pick's disease with Pick bodies combined with progressive supranuclear palsy without tuft-shaped astrocytes: A clinical, neuroradiologic and pathological study of an autopsied case. Neuropathology. 2006 ; 26: 222-230
511. Warner JJ Atlas of Neuroanatomy. Boston: Butterworth-Heinemann ; 2001:
512. Watson M, McElligott JG. Cerebellar noradrenaline depletion and impaired acquisition of specific locomotor tasks in rats. Brain Res. 1984 ; 296: 129-138
513. West WL, Yeomans DC, Proudfit HK. The function of noradrenergic neurons in mediating antinociception induced by electrical stimulation of the locus coeruleus in two different sources of Sprague-Dawley rats. Brain Res. 1993 ; 626: 127-135
514. Westlund KN, Coulter JD. Descending projections of the locus coeruleus and subcoeruleus/medial parabrachial nuclei in monkey: Axonal transport studies and dopamine-beta-hydroxylase immunocytochemistry. Brain Res. 1980 ; 2: 235-264
515. Westlund KN, Bowker RM, Ziegler MG, et al. Noradrenergic projections to the spinal cord of the rat. Brain Res. 1983 ; 263: 15-31
516. Westlund KN, Bowker RM, Ziegler MG, et al. Origins and terminations of descending noradrenergic projections to the spinal cord of the monkey. Brain Res. 1984 ; 292: 1-16
517. Westlund KN, Zhang D, Carlton SM, et al. Noradrenergic innervation of somatosensory thalamus and spinal cord. Prog Brain Res. 1991 ; 88: 77-88
518. White SR, Fung SJ, Barnes CD. Norepinephrine effects on spinal motoneurons. Prog Brain Res. 1991 ; 88: 343-350
519. Wier WG, Zang WJ, Lamont C, et al. Sympathetic neurogenic Ca2+ signalling in rat arteries: ATP, noradrenaline and neuropeptide Y. Exp Physiol. 2009 ; 94: 31-37
520. Wilhelm B, Giedke H, Lüdtke H, et al. Daytime variations in central nervous system activation measured by a pupillographic sleepiness test. J Sleep Res. 2001 ; 10: 1-7
521. Williams AM, Morilak DA. Alpha1B adrenoceptors in rat paraventricular nucleus overlap with, but do not mediate, the induction of c-Fos expression by osmotic or restraint stress. Neuroscience. 1997 ; 76: 901-913
522. Williams AM, Nguyen ML, Morilak DA. Co-localization of alpha1D adrenergic receptor mRNA with mineralocorticoid and glucocorticoid receptor mRNA in rat hippocampus. J Neuroendocrinol. 1997 ; 9: 113-119
523. Willis WD, Westlund KN. Neuroanatomy of the pain system and the pathways that modulate pain. J Clin Neurophysiol. 1997 ; 14: 2-31
524. Wise RA. Dopamine, learning and motivation. Nat Rev Neurosci. 2004 ; 5: 483-494
525. Wu MF, Gulyani SA, Yau E, et al. Locus coeruleus neurons: Cessation of activity during cataplexy. Neuroscience. 1999 ; 91: 1389-1399
526. Xi M, Fung SJ, Zhang J, et al. The amygdala and the pedunculopontine tegmental nucleus: Interactions controlling active (rapid eye movement) sleep. Exp Neurol. 2012 ; 238: 44-51
527. Xu ZQ, Shi TJ, Hökfelt T. Galanin/GMAP- and NPY-like immunoreactivities in locus coeruleus and noradrenergic nerve terminals in the hippocampal formation and cortex with notes on the galanin-R1 and -R2 receptors. J Comp Neurol. 1998 ; 392: 227-251
528. Yaïci E-D, Rampin O, Calas A, et al. α2a and α2c adrenoceptors on spinal neurons controlling penile erection. Neuroscience. 2002 ; 114: 945-960
529. Yamanaka A, Muraki Y, Tsujino N, et al. Regulation of orexin neurons by the monoaminergic and cholinergic systems. Biochem Biophys Res Commun. 2003 ; 303: 120-129
530. Yamazato M, Sakima A, Nakazato J, et al. Hypotensive and sedative effects of clonidine injected into the rostral ventrolateral medulla of conscious rats. Am J Physiol Regulatory Integrative Comp Physiol. 2001 ; 281: 1868-1876
531. Yang Y, Beyreuther K, Schmitt HP. Spatial analysis of the neuronal density of aminergic brainstem nuclei in primary neurodegenerative and vascular dementia: A comparative immunocytochemical and quantitative study using a graph method. Anal Cell Pathol. 1999 ; 19: 125-138
532. Yokoo H, Kobayashi H, Minami S, et al. alpha(1)-Adrenergic receptor subtypes in rat cerebral microvessels. Brain Res. 2000 ; 878: 183-187
533. Yoshimura M, Higashi H, Nishi S. Noradrenaline mediates slow excitatory synaptic potentials in rat dorsal raphe neurons in vitro. Neurosci Lett. 1985 ; 61: 305-310
534. Yoshimura M, Polosa C, Nishi S. Slow EPSP and the depolarizing action of noradrenaline on sympathetic preganglionic neurons. Brain Res. 1987 ; 414: 138-142
535. Yoshimura N, Sasa M, Yoshida O, et al. Alpha 1-adrenergic receptor- mediated excitation from the locus coeruleus of the sacral parasympathetic preganglionic neuron. Life Sci. 1990a ; 47: 789-797
536. Yoshimura N, Sasa M, Yoshida O, et al. Mediation of micturition reflex by central norepinephrine from the locus coeruleus in the cat. J Urol. 1990b ; 143: 840-843
537. Yoss RE, Moyer NJ, Hollenhurst RW. Pupil size and spontaneous pupillary waves associated with alertness, drowsiness, and sleep. Neurology. 1970 ; 20: 545-554
538. Young WS, Kuhar MJ. Noradrenergic α1 and α2 receptors: Light microscopic autoradiographic localization. Proc Natl Acad Sci USA. 1980 ;: 1696-1700
539. Zagon A, Smith AD. Monosynaptic projections from the rostral ventrolateral medulla oblongata to identified sympathetic preganglionic neurons. Neuroscience. 1993 ; 54: 729-743
540. Zarow C, Lyness SA, Mortimer JA, et al. Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch Neurol. 2003 ; 60: 337-341
541. Zecharia AY, Yu X, Götz T, et al. GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J Neurosci. 2012 ; 32: 13062-13075
542. Zeitzer JM, Dijk DJ, Kronauer R, et al. Sensitivity of the human circadian pacemaker to nocturnal light: Melatonin phase resetting and suppression. J Physiol. 2000 ; 526: 695-702
543. Zhang C, Guo Y-Q, Qiao J-T, et al. Locus coeruleus modulates thalamic nociceptive responses via adrenoceptors. Brain Res. 1998a ; 784: 116-122
544. Zhang K-M, Wang X-M, Peterson AM, et al. α2-adrenoceptors modulate NMDA-evoked responses of neurons in superficial and deeper dorsal horn of the medulla. J Neurophysiol. 1998b ; 80: 2210-2214
545. Zhang X, Su J, Rojas A, et al. Pontine norepinephrine defects in Mecp2-null mice involve deficient expression of dopamine beta-hydroxylase but not a loss of catecholaminergic neurons. Biochem Biophys Res Commun. 2010 ; 394: 285-290
546. Zoghbi HY, Milstien S, Butler IJ, et al. Cerebrospinal fluid biogenic amines and biopterin in Rett syndrome. Ann Neurol. 1989 ; 25: 56-60
547. Zweig RM, Cardillo JE, Cohen M, et al. The locus coeruleus and dementia in Parkinson's disease. Neurology. 1993 ; 43: 986-991