Noradrenergic changes, aggressive behavior, and cognition in patients with dementia

Biological Psychiatry

Volumn 51, Issue 5, 2002, Pages 407-416

  Matthews, Kim L ^a   Chen, Christopher P L H ^b   Esiri, Margaret M ^c   Keene, Janet ^c   Minger, Stephen L ^a   Francis, Paul T ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

2 adrenoceptors; Alzheimer's disease; Locus coeruleus; Noradrenaline

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; NORADRENALIN; RADIOLIGAND;

AGED; AGGRESSION; ALZHEIMER DISEASE; ARTICLE; BRAIN LEVEL; BRAIN REGION; CELL LOSS; COGNITION; COGNITIVE DEFECT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DEMENTIA; DEPRESSION; FEMALE; HUMAN; LIGAND BINDING; LOCUS CERULEUS; MAJOR CLINICAL STUDY; MALE; NEUROCHEMISTRY; NEUROFIBRILLARY TANGLE; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; PSYCHOSIS; RECEPTOR DENSITY; SYMPTOM;

AGED; AGGRESSION; ALZHEIMER DISEASE; BRAIN MAPPING; CELL COUNT; CEREBRAL CORTEX; FEMALE; HUMANS; LOCUS COERULEUS; MALE; NEUROPSYCHOLOGICAL TESTS; NOREPINEPHRINE; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 0036501401     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(01)01235-5     Document Type: Article

References (57)

1. Short and long-term changes in tyrosine-hydroxylase activity in rat-brain after subtotal destruction of central noradrenergic neurons
2. 2A-adrenergic receptor-like immunoreactivity
3. 2-noradrenergic mechanisms to prefrontal cortical cognitive function: Potential significance for attention-deficit hyperactivity disorder
4. Behavioral functions of locus coeruleus derived from cellular attributes
5. Neurochemical correlates of dementia severity in Alzheimer's disease - Relative importance of the cholinergic deficits
6. Selective loss of neurones of origin of adrenergic projection to cerebral cortex (nucleus locus coeruleus) in senile dementia
7. Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia
8. Selective increase of alpha(2A)-adrenoceptor agonist binding sites in brains of depressed suicide victims
9. Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer type and in Parkinson's disease with and without dementia and depression
10. Subtotal destruction of central noradrenergic projections increases the firing rate of locus coeruleus cells
11. Aminergic systems in Alzheimer's disease and Parkinson's disease
12. Brain alpha-adrenoceptors in depressed suicides
13. "Mini-mental state": A practical method for grading the cognitive state of patients for the clinician
14. Clinical and neuropathological correlates of depression in Alzheimer's disease
15. Neurochemical studies of early-onset Alzheimer's disease. Possible influence on treatment
16. 2-Adrenoceptor-mediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression. Effect of long-term cyclic antidepressant drug treatment
17. Disease-specific patterns of locus ceruleus cell loss
18. Locus coeruleus neurons in the rat containing neuropeptide-Y, tyrosine-hydroxylase or galanin and their efferent projections to the spinal-cord, cerebral-cortex and hypothalamus
19. Increased activity of surviving locus ceruleus neurons in Alzheimer's disease
20. Image analyzer-assisted morphometry of the locus-coeruleus in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis
21. Lack of association between depression and loss of neurons in the locus coeruleus in Alzheimer disease
22. The Present Behavioural Examination (PBE): The development of an interview to measure current behavioural abnormalities
23. Behaviour changes in dementia 2: Are there behavioural syndromes?
24. Behaviour changes in dementia 1: Point of entry data of a prospective study
25. 3H] p- aminoclonidine binding in prefrontal cortex
26. Adrenergic-receptors in aging and Alzheimer's disease - Increased beta-2-receptors in prefrontal cortex and hippocampus
27. The natural history of aggressive behaviour in dementia
28. Efferent projections of nucleus locus-coeruleus - Topographic organization of cells of origin demonstrated by 3-dimensional reconstruction
29. The locus coeruleus and its possible role in aging and degenerative disease of the human central nervous system
30. Regional topography within noradrenergic locus coeruleus as revealed by retrograde transport of horseradish peroxidase
31. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of department of Health and Human Services Task Force on Alzheimer's disease
32. Analysis of radioligand binding experiments: A collection of computer programs for the IBM PC
33. 2-adrenceptors in postmortem human brain using the full agonist
34. Decreased density of presynaptic alpha-2-adrenoceptors in postmortem brains of patients with Alzheimer's disease
35. Cholinergic deficits contribute to behavioural disturbance in patients with dementia
36. The consortium to establish a registry for Alzheimer's disease (CERAD) Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
37. Electrophysiologic evidence for desensitization of alpha(2)-adrenoceptors on serotonin terminals following long-term treatment with drugs increasing norepinephrine synaptic concentration
38. Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's disease
39. 2-adrenoceptors: An autoradiographic study in human brain
40. Loss of high-affinity alpha-2-adrenoceptors in Alzheimer's disease - An autoradiographic study in frontal cortex and hippocampus
41. Effects of Alzheimer's disease and normal aging on cerebrospinal fluid norepinephrine responses to yohimbine and clonidine
42. Evaluation and management of aggressive behavior in the elderly demented patient
43. CAMDEX - A standardized instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia
44. Adrenergic receptors in Alzheimer's disease brain: Selective increases in the cerebella of aggressive patients
45. Preserved cerebellar tyrosine hydroxylase-immunoreactive neuronal fibers in a behaviorally aggressive subgroup of Alzheimer's disease patients
46. Idazoxan, an alpha-2 antagonist, facilitates memory retrieval in the rat
47. Alpha(2)-adrenoceptor subtypes identified by [H-3] RX821002 binding in the human brain - The agonist guanoxabenz does not discriminate different forms of the predominant alpha(2A) subtype
48. Modulation of neurotransmitter release by presynaptic autoreceptors
49. Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer's disease
50. The alpha-2-adrenergic receptor: Multiple affinity states and regulation of a receptor inversely coupled to adenylate-cyclase
51. The distribution of neocortical projection neurones in the locus coeruleus
52. Origins and terminations of descending noradrenergic projections to the spinal-cord of monkey
53. Major depression in primary dementia: Clinical and neuropathologic correlates
54. Neurochemical correlates of major depression in primary dementia
55. The neuropathology of aminergic nuclei in Alzheimer's disease