Hypothalamic adrenergic receptor changes in the metabolic syndrome of genetically obese (ob/ob) mice

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 279, Issue 2 48-2, 2000, Pages

  Boundy, Virginia A ^a   Cincotta, Anthony H ^a,b  

^a Ergo Science Corporation   (United States)

^b NONE   (United States)

Author keywords

Autoradiography; Insulin resistance; Norepinephrine; Obesity

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; IODO 4 HYDROXYPHENYL ETHYL AMINOMETHYLTETRALONE; NORADRENALIN; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; CONTROLLED STUDY; FEMALE; HYPOTHALAMUS; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR GENE;

EID: 0033857560     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.2000.279.2.r505     Document Type: Article

References (67)

1. 125I]Para-iodoclonidine versus [3H]para-aminoclonidine
2. Intra-ventromedial hypothalamic injection of glutamate stimulates brown adipose tissue thermogenesis in the rat
3. The dorsomedial hypothalamic nucleus revisited: 1998 update
4. Hypoglycemia-induced changes in GABA and norepinephrine in the hypothalamus of rats
5. Dopaminergic agonists normalize elevated hypothalamic neuropeptide Y and corticotropin-releasing hormone, body weight gain, and hyperglycemia in ob/ob mice
6. Stress-induced increases in blood-glucose in ob/ob mice are mediated by corticotropin releasing factor, independent of the hypothalamo-pituitary-adrenal axis
7. Species differences in the localization and number of CNS beta adrenergic receptors: Rat versus guinea pig
8. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats
9. Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release
10. 2-adrenergic receptors: Comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning
11. Relationships between medial hypothalamic alpha 2-receptor binding, norepinephrine, and circulating glucose
12. Hyperinsulinemia increases norepinephrine metabolism in the ventromedial hypothalamus of rats
13. Chronic infusion of norepinephrine into the VMH of normal rats induces the obese glucose-intolerant state
14. Norepinephrine and epinephrine
15. Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerosis
16. Hypothalamic influence on insulin and glucagon release in the rat
17. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
18. Elevated hypothalamic norepinephrine content in mice with the hereditary obese-hyperglycemic syndrome
19. Leptin and the regulation of body weight in mammals
20. Age- and diabetes-associated alterations in regional brain norepinephrine concentrations and adrenergic receptor populations in C57BL/KsJ mice
21. p-[125I]Iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor
22. Swimming stress that causes hyperglycemia increases in vivo release of noradrenaline, but not acetylcholine, from the hypothalamus of conscious rats
23. Chronic reserpine administration selectively up-regulates beta 1- and alpha 1b-adrenergic receptors in rat brain: An autoradiographic study
24. Effects of leptin on corticotropin-releasing factor (CRF) synthesis and CRF neuron activation in the paraventricular hypothalamic nucleus of obese (ob/ob) mice
25. Feeding and body-weight regulation by hypothalamic neuropeptides - Mediation of the actions of leptin
26. The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus
27. Higher alpha-noradrenergic receptors in paraventricular nucleus of obese Zucker rats: Decline after food deprivation
28. Maternal hormonal manipulations in rats cause obesity and increase medial hypothalamic norepinephrine release in male offspring
29. Anatomy of brain alpha 1-adrenergic receptors: In vitro autoradiography with [125I]-HEAT
30. Increased responsiveness of ventromedial hypothalamic neurons to norepinephrine in obese versus lean mice: Relation to the metabolic syndrome
31. Hypothalamic paraventricular nucleus: Interaction between alpha 2-noradrenergic system and circulating hormones and nutrients in relation to energy balance
32. Increased brain 3H-paraminoclonidine (alpha 2-adrenoceptor) binding associated with perpetuation of diet-induced obesity in rats
33. Obesity-prone and -resistant rats differ in their brain [3H]paraminoclonidine binding
34. Reduced paraventricular nucleus norepinephrine responsiveness in obesity-prone rats
35. Reduced glucose-induced neuronal activation in the hypothalamus of diet-induced obese rats
36. 2-adrenoceptors in the arcuate and dorsomedial nucleus
37. Defective glucoregulation of brain alpha 2-adrenoceptors in obesity-prone rats
38. Altered alpha 1-adrenoceptor binding in intact and adrenalectomized obese Zucker rats (fa/fa)
39. Glucose-induced norepinephrine levels and Obesity resistance
40. Long-term infusion of norepinephrine plus serotonin into the ventromedial hypothalamus impairs pancreatic islet function
41. Central catecholamine levels in genetically obese mice (ob/ob and db/db)
42. Chronic ventromedial hypothalamic infusion of norepinephrine and serotonin promotes insulin resistance and glucose intolerance
43. Increased daily turnover of noradrenaline and serotonin in ventral medial hypothalamus (VMH) of obese versus lean Zucker rats assessed by in vivo microdialysis
44. Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters
45. Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats
46. Effect of paroxetine, a selective 5-hydroxytryptamine uptake inhibitor, on beta-adrenoceptors in rat brain: Autoradiographic and functional studies
47. Norepinephrine and dopamine levels in hypothalamic nuclei of the genetically obese mouse (ob/ob)
48. Increases in alpha-adrenergic receptors in the hypothalamus of the genetically obese mouse (ob/ob)
49. Effects of food restriction and mutation on central catecholamine levels in genetically obese mice
50. Norepinephrine but not epinephrine stimulates the release of corticotropin-releasing factor from in vitro superfused rat hypothalamus
51. 2-Deoxy-D-glucose-induced hyperglycemia: Role for direct sympathetic nervous system activation of liver glucose output
52. Beta-adrenoceptor subtypes in the human brain: Autoradiographic localization
53. Facilitation of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation after activation of catecholaminergic pathways or central norepinephrine injection
54. Biochemical mechanisms responsible for the attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists
55. Hepatic glycolytic and gluconeogenic enzymes of the obese hyperglycemic mouse
56. Neuronal regulation of hepatic glucose metabolism in mammals
57. Central nervous system regulation of liver and adipose tissue metabolism
58. Modulation by the hypothalamus of glucagon and insulin secretion in rabbits: Studies with electrical and chemical stimulations
59. Chronic infusion of norepinephrine into the ventromedial hypothalamus induces obesity in rats
60. Co-release of endogenous ATP and [3H]noradrenaline from rat hypothalamic slices: Origin and modulation by alpha2-adrenoceptors
61. The modulatory effect of the hypothalamus on glucagon and insulin secretion in the rat
62. Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats
63. Hypothalamically-induced insulin release and its potentiation during oral and intravenous glucose loads
64. Differential localization of alpha 2-adrenergic receptor subtypes in brain
65. Effects of diet and obesity on brain alpha 1- and alpha 2-noradrenergic receptors in the rat
66. Sympathetic nerve activity after discrete hypothalamic injections of L-glutamate
67. Diminished sympathetic nervous system activity in genetically obese (ob/ob) mouse