Two types of melanopsin retinal ganglion cell differentially innervate the hypothalamic suprachiasmatic nucleus and the olivary pretectal nucleus

European Journal of Neuroscience

Volumn 27, Issue 7, 2008, Pages 1763-1770

  Baver, Scott B ^a   Pickard, Galen E ^b   Sollars, Patricia J ^a   Pickard, Gary E ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Circadian rhythm; Intrinsically photosensitive retinal ganglion cell; Melanopsin; Pupillary light reflex; Retinohypothalamic tract

Indexed keywords

BETA GALACTOSIDASE; TAU PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CONTROLLED STUDY; HYPOTHALAMUS; INNERVATION; MOUSE; NONHUMAN; OLIVARY NUCLEUS; PREGANGLIONIC NERVE CELL; PRETECTUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDORABIES HERPETOVIRUS; RETINA GANGLION CELL; SUPRACHIASMATIC NUCLEUS;

ANIMALS; CIRCADIAN RHYTHM; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; OLIVARY NUCLEUS; OPSIN; RETINAL GANGLION CELLS; SUPRACHIASMATIC NUCLEUS; VISUAL PATHWAYS;

EID: 41549089600     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2008.06149.x     Document Type: Article

References (27)

1. Belenky, M.A., Smeraski, C.A., Provencio, I., Sollars, P.J. Pickard, G.E. (2003) Melanopsin retinal ganglion cells receive bipolar and amacrine cell synapses. J. Comp. Neurol., 460, 380 393.
2. Berson, D.M., Dunn, F.A. Takao, M. (2002) Phototransduction by retinal ganglion cells that set the circadian clock. Science, 295, 1070 1073.
3. Clarke, R.J. Ikeda, H. (1985) Luminance and darkness detectors in the olivary and posterior pretectal nuclei and their relationship to the pupillary light reflex in the rat. I. Studies with steady luminance levels. Exp. Brain. Res., 57, 224 232.
4. Dacey, D.M., Liao, H.W., Peterson, B.B., Robinson, F.R., Smith, V.C., Pokorny, J., Yau, K.W. Gamlin, P.D. (2005) Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN. Nature, 433, 749 754.
5. Gooley, J.J., Lu, J., Fischer, D. Saper, C.B. (2003) A broad role for melanopsin in nonvisual photoreception. J. Neurosci., 23, 7093 7106.
6. Guler, A.D., Ecker, J.L., Lall, G., Altimus, C.M., Haq, S., Badea, T., Hankins, M.W., Lucas, R.J., Yau, K.W. Hattar, S. (2007) Melanopsin expressing retinal ganglion cells relay rod and cone generated light signals for non-image forming visual functions. Soc. Neurosci. Abstr, 21.1.
7. Hartwick, A.T., Bramley, J.R., Yu, J., Stevens, K.T., Allen, C.N., Baldridge, W.H., Sollars, P.J. Pickard, G.E. (2007) Light-evoked calcium responses of isolated melanopsin-expressing retinal ganglion cells. J. Neurosci., 27, 13468 13480.
8. Hattar, S., Kumar, M., Park, A., Tong, P., Tung, J., Yau, K.W. Berson, D.M. (2006) Central projections of melanopsin-expressing retinal ganglion cells in the mouse. J. Comp. Neurol., 497, 326 349.
9. Hattar, S., Liao, H.W., Takao, M., Berson, D.M. Yau, K.W. (2002) Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science, 295, 1065 1070.
10. Lucas, R.J., Hattar, S., Takao, M., Berson, D.M., Foster, R.G. Yau, K.W. (2003) Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice. Science, 299, 245 247.
11. Moore, R.Y. Lenn, N.J. (1972) A retinohypothalamic projection in the rat. J. Comp. Neurol., 146, 1 14.
12. Morin, L.P., Blanchard, J.H. Provencio, I. (2003) Retinal ganglion cell projections to the hamster suprachiasmatic nucleus, intergeniculate leaflet, and visual midbrain: bifurcation and melanopsin immunoreactivity. J. Comp. Neurol., 465, 401 416.
13. Pak, M.W., Giolli, R.A., Pinto, L.H., Mangini, N.J., Gregory, K.M. Vanable, J.W. (1987) Retinopretectal and accessory optic projections of normal mice and the OKN-defective mutant mice beige, beige-J, and pearl. J. Comp. Neurol., 258, 435 446.
14. Pickard, G.E. (1982) The afferent connections of the suprachiasmatic nucleus of the golden hamster with emphasis on the retinohypothalamic projection. J. Comp. Neurol., 211, 65 83.
15. Pickard, G.E., Ralph, M.R. Menaker, M. (1987) The intergeniculate leaflet partially mediates effects of light on circadian rhythms. J. Biol. Rhythms, 2, 35 56.
16. Pickard, G.E., Smeraski, C.A., Tomlinson, C.C., Banfield, B.W., Kaufman, J., Wilcox, C.L., Enquist, L.W. Sollars, P.J. (2002) Intravitreal injection of the attenuated pseudorabies virus PRV Bartha results in infection of the hamster suprachiasmatic nucleus only by retrograde transsynaptic transport via autonomic circuits. J. Neurosci., 22, 2701 2710.
17. Provencio, I., Rollag, M.D. Castrucci, A.M. (2002) Photoreceptive net in the mammalian retina. This mesh of cells may explain how some blind mice can still tell day from night. Nature, 415, 493.
18. Scalia, F. (1972) The termination of retinal axons in the pretectal region of mammals. J. Comp. Neurol., 145, 223 257.
19. Scalia, F. Arango, V. (1979) Topographic organization of the projections of the retina to the pretectal region in the rat. J. Comp. Neurol., 186, 272 291.
20. Sekaran, S., Foster, R.G., Lucas, R.J. Hankins, M.W. (2003) Calcium imaging reveals a network of intrinsically light-sensitive inner-retinal neurons. Curr. Biol., 13, 1290 1298.
21. Semo, M., Lupi, D., Peirson, S.N., Butler, J.N. Foster, R.G. (2003) Light-induced c-fos in melanopsin retinal ganglion cells of young and aged rodless/coneless (rd/rd cl) mice. Eur. J. Neurosci., 18, 3007 3017.
22. Smeraski, C.A., Sollars, P.J., Ogilvie, M.D., Enquist, L.W. Pickard, G.E. (2004) Suprachiasmatic nucleus input to autonomic circuits identified by retrograde transsynaptic transport of pseudorabies virus from the eye. J. Comp. Neurol., 471, 298 313.
23. Smith, B.N., Banfield, B.W., Smeraski, C.A., Wilcox, C.L., Dudek, F.E., Enquist, L.W. Pickard, G.E. (2000) Pseudorabies virus expressing enhanced green fluorescent protein: a tool for in vitro electrophysiological analysis of transsynaptically labeled neurons in identified central nervous system circuits. Proc. Natl Acad. Sci. USA, 97, 9264 9269.
24. Sollars, P.J., Smeraski, C.A., Kaufman, J.D., Ogilvie, M.D., Provencio, I. Pickard, G.E. (2003) Melanopsin and non-melanopsin expressing retinal ganglion cells innervate the hypothalamic suprachiasmatic nucleus. Vis. Neurosci., 20, 601 610.
25. Trejo, L.J. Cicerone, C.M. (1984) Cells in the pretectal olivary nucleus are in the pathway for the direct light reflex of the pupil in the rat. Brain Res., 300, 49 62.
26. Tu, D.C., Zhang, D., Demas, J., Slutsky, E.B., Provencio, I., Holy, T.E. van Gelder, R.N. (2005) Physiologic diversity and development of intrinsically photosensitive retinal ganglion cells. Neuron, 48, 987 999.
27. Warren, E.J., Allen, C.N., Brown, R.L. Robinson, D.W. (2003) Intrinsic light responses of retinal ganglion cells projecting to the circadian system. Eur. J. Neurosci., 17, 1727 1735.