The suprachiasmatic nucleus and the circadian time-keeping system revisited

Brain Research Reviews

Volumn 33, Issue 1, 2000, Pages 34-77

  Van Esseveldt, Lisette K E ^a   Lehman, Michael N ^b   Boer, Gerard J ^a  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Adenoviral vector; Biological clock; Circadian rhythm; Clock genes; Neurotransplantation; Suprachiasmatic nucleus; Vasopressin

Indexed keywords

4 AMINOBUTYRIC ACID; ANGIOTENSIN; CALBINDIN; CALCITONIN GENE RELATED PEPTIDE; CHOLECYSTOKININ; CORTICOTROPIN RELEASING FACTOR; DYNORPHIN; ENKEPHALIN; GALANIN; GASTRIN RELEASING PEPTIDE; PEPTIDE HISTIDINE ISOLEUCINE; PROTIRELIN; SOMATOSTATIN; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOPRESSIN;

AGE; CELL COMMUNICATION; CIRCADIAN RHYTHM; GENE TRANSFER; LIGHT DARK CYCLE; NEUROTRANSMISSION; NONHUMAN; PHOTOSTIMULATION; PRIORITY JOURNAL; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SUPRACHIASMATIC NUCLEUS;

ANIMALS; CIRCADIAN RHYTHM; HUMANS; SUPRACHIASMATIC NUCLEUS;

EID: 0033856406     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(00)00025-4     Document Type: Review

References (412)

1. H. Abe, S. Honma, M. Namihira, Y. Tanahashi, M. Ikeda, W. Yu, K. Honma, Phase-dependent induction by light of rat Clock gene expression in the suprachiasmatic nucleus, Mol. Brain Res. 66 (1999) 104-110.
2. H. Abe, S. Honma, K. Shinohara, K. Honma, Substance P receptor regulates the photic induction of fos-like protein in the suprach-iasmatic nucleus of Syrian hamsters, Brain Res. 708 (1996) 135-142.
3. H. Abe, B. Rusak, H.A. Robertson, Photic induction of fos protein in the suprachiasmatic nucleus is inhibited by the NMDA receptor antagonist MK-801, Neurosci. Lett. 127 (1991) 9-12.
4. R. Aguilar-Roblero, R. Drucker-Colin, R.Y. Moore, Behavioral and morphological studies of fetal neural transplants into SCN-lesioned rats, Chronobiol. Int. 9 (1992) 278-296.
5. R. Aguilar-Roblero, L.P. Morin, R.Y. Moore, Morphological correlates of circadian rhythm restoration induced by transplantation of the suprachiasmatic nucleus in hamsters, Exp. Neurol. 130 (1994) 250-260.
6. R. Aguilar-Roblero, S. Shibata, J.C. Speh, R. Drucker-Colin, R.Y. Moore, Morphological and functional development of the suprach-iasmatic nucleus in transplanted fetal hypothalamus, Brain Res. 580 (1992) 288-296.
7. R. Aguilar-Roblero, L. Verduzco-Carbajal, C. Rodriguez, J. Mendez-Franco, J. Moran, M. Perez de la Mora, Circadian rhythmicity in the GABAergic system in the suprachiasmatic nuclei of the rat, Neurosci. Lett. 157 (1993) 199-202.
8. M. Akiyama, Y. Kouzo, S. Takahashi, H. Wakamatsu, T. Moriya, M. Maetani, S. Watanabe, H. Tei, Y. Sakaki, S. Shibata, Inhibition of light- and glutamate-induced mPer1 expression represses the phase shifts into the mouse circadian locomotor and suprachiasmatic firing rhythms, J. Neurosci. 19 (1999) 1115-1121.
9. S. Akli, C. Caillaud, E. Vigne, L.D. Stratford-Perricaudet, M. Perricaudet, M.R. Peschanski, Transfer of a foreign gene into the brain using adenovirus vectors, Nat. Genet. 3 (1993) 224-228.
10. H.E. Albers, S.-Y. Liou, E.G. Stopa, R.T. Zoeller, Interaction of colocalized neuropeptides: functional significance in the circadian timing system, J. Neurosci. 11 (1991) 846-851.
11. H.E. Albers, E.G. Stopa, R.T. Zoeller, J.S. Kauer, J.C. King, J.S. Fink, H. Mobtaker, H. Wolfe, Day-night variation in prepro vasoactive intestinal peptide/peptide histidine isoleucine mRNA within the rat suprachiasmatic nucleus, Mol. Brain Res. 7 (1990) 85-89.
12. U. Albrecht, Z.S. Sun, G. Eichele, C.C. Lee, A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light, Cell 91 (1997) 1055-1064.
13. R. Allada, N.E. White, W.V. So, J.C. Hall, M. Rosbash, A mutant Drosophila homolog of mammalian Clock disrupts rhythms and transcription of period and timeless, Cell 93 (1998) 791-804.
14. H.-L. Ang, D.A. Carter, D. Murphy, Neuron-specific expression and physiological regulation of bovine vasopressin transgenes in mice, EMBO J. 12 (1993) 2397-2409.
15. M.P. Antoch, E.J. Song, A.M. Chang, M.H. Vitaterna, Y. Zhao, L.D. Wilsbacher, A.M. Sangoram, D.P. King, L.H. Pinto, J.S. Takahashi, Functional identification of the mouse circadian Clock gene by transgenic BAC rescue, Cell 89 (1997) 655-717.
16. R. Arai, D.M. Jacobowitz, S. Deura, Colocalization of calbindin-D28k with vasopressin in hypothalamic cells of the rat: a double-labeling immunofluorescence study, Brain Res. 632 (1993) 342-345.
17. N. Aronin, S.M. Sagar, F.R. Sharp, W.J. Schwartz, Light regulates expression of a fos-related protein in rat suprachiasmatic nucleus, Proc. Natl. Acad. Sci. USA 87 (1990) 5959-5962.
18. B.D. Aronson, K.A. Johnson, J.J. Loros, J.C. Dunlap, Negative feedback defining a circadian clock: autoregulation of the lock gene frequency, Science 263 (1994) 1578-1584.
19. G. Bajocchi, S.H. Feldman, R.G. Crystal, A. Mastrangeli, Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors, Nat. Genet. 3 (1993) 229-234.
20. A. Balsalobre, F. Damiola, U. Schibler, A serum shock induces circadian gene expression in mammalian tissue culture cells, Cell 93 (1998) 929-937.
21. Y. Ban, Y. Shigeyoshi, H. Okamura, Development of vasoactive intestinal peptide mRNA rhythm in the rat suprachiasmatic nucleus, J. Neurosci. 17 (1997) 3920-3931.
22. B. Barbour, M. Szatkowski, N. Ingledew, D. Atwell, Arachidonic acid induced a prolonged inhibition of gutamate uptake into glial cells, Nature 342 (1989) 918-920.
23. T.A. Bargiello, M.W. Young, Molecular genetics of a biological clock in Drosophila, Proc Natl Acad Sci USA 81 (1984) 2142-2146.
24. M.K. Baylies, T.A. Bargiello, F.R. Jackson, M.W. Young, Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock, Nature 326 (1987) 390-392.
25. S.M. Biello, Enhanced photic phase shifting after treatment with antiserum to neuropeptide Y, Brain Res. 673 (1995) 25-29.
26. S.M. Biello, D. Janik, N. Mrosovsky, Neuropeptide Y and be-haviorally induced phase shifts, Neuroscience 62 (1994) 273-279.
27. C.H. Block, R.A. Santos, K.B. Brosnihan, C.M. Ferrario, Immuno-cytochemical localization of angiotensin-(1 -7) in the rat forebrain, Peptides 9 (1988) 1395-1401.
28. U. Blomer, L. Naldini, T. Kafri, D. Trono, I.M. Verma, F.H. Gage, Highly efficient and sustained gene transfer in adult neurons with lentivirus vector, J. Virol. 71 (1997) 6641-6649.
29. K.J. Bobrzynska, N. Vrang, N. Mrosovsky, Persistence of nonphotic phase shifts in hamsters after serotonin depletion in the suprach-iasmatic nucleus, Brain Res. 741 (1996) 205-214.
30. G.J. Boer, D.M. Gash, L. Dick, N. Schluter, Vasopressin neuron survival in neonatal Brattleboro rats; critical factors in graft development and innervation of the host brain, Neuroscience 15 (1985) 1087-1109.
31. G.J. Boer, H.A. Griffioen, Developmental and functional aspects of grafting of the suprachiasmatic nucleus in the Brattleboro and the arhythmic rat, Eur. J. Morphol. 28 (1990) 330-375.
32. G.J. Boer, H.A. Griffioen, H. Duindam, T.P. Van der Woude, W.J. Rietveld, Light/dark-induced effects on behavioral rhythms in suprachiasmatic nucleus-lesioned rats irrespective of the presence of functional suprachiasmatic nucleus brain implants, J. Interdiscipl. Cycle Res. 24 (1993) 118-136.
33. G.J. Boer, H.A. Griffioen, P. Saeed, Grafted fetal suprachiasmatic nucleus cells survive much better in tissue pieces than in suspension, Rest. Neurol. Neurosci. 4 (1992) 261-269.
34. G.J. Boer, K.E. van Esseveldt, W.T.J.M.C. Hermens, R. Liu, J. Verhaagen, Long-term transgene expression in fetal rat suprach-iasmatic nucleus neurografts following ex vivo adenoviral vector-mediated gene transfer, Exp. Neurol. 145 (1997) 536-545.
35. G.J. Boer, K.E. van Esseveldt, W.J. Rietveld, Cellular requirements of suprachiasmatic transplants for restoration of circadian rhythm, Chronobiol. Int. 15 (1998) 551-566.
36. G.J. Boer, K.E. van Esseveldt, B.A.M. Van der Geest, H. Duindam, W.J. Rietveld, Vasopressin-deficient suprachiamatic nucleus grafts re-instate circadian rhythmicity in SCN-lesioned arhythmic rats, Neuroscience 89 (1999) 375-385.
37. N.P.A. Bos, M. Mirmiran, Circadian rhythms in spontaneous neuronal discharge of the cultured suprachiasmatic nucleus, Brain Res. 511 (1990) 158-162.
38. O. Bosler, A. Beaudet, VIP neurons as prime synaptic targets for serotonin afferents in rat suprachiasmatic nucleus: a combined radioautographic and immunocytochemical study, J. Neurocytol. 14 (1985) 749-763.
39. Y. Bouskila, F.E. Dudek, Neuronal synchronization without calcium-dependent synaptic transmission in the hypothalamus, Proc. Natl. Acad. Sci. USA 90 (1993) 3207-3210.
40. C.L. Bowman, H.K. Kimelberg, Excitatory amino acids directly depolarize rat brain astrocytes in primary culture, Nature 311 (1984) 656-659.
41. M.J. Bradbury, W.C. Dement, D.M. Edgar, Serotonin-containing fibers in the suprachiasmatic hypothalamus attenuate light-induced phase delays in mice, Brain Res. 768 (1997) 125-134.
42. G. Brawerman, Determinants of messenger RNA stability, Cell 48 (1987) 4-6.
43. C.D. Breder, Y. Yamada, K. Yasuda, S. Seino, C.B. Saper, G.I. Bell, Differential expression of somatostatin receptor subtypes in brain, J. Neurosci. 12 (1992) 3920-3934.
44. M.A. Brock, Chronobiology and aging, J. Am. Geriat. Soc. 39 (1991) 74-91.
45. M.H. Brown, A.A. Nunez, Vasopressin-deficient rats show a reduced amplitude of the circadian sleep rhythm, Physiol. Behav. 46 (1989) 759-762.
46. R.M. Buijs, M.H. Hermes, A. Kalsbeek, The suprachiasmatic nucleus-paraventricular nucleus interactions: a bridge to the neuro-endocrine and autonomic nervous system, Prog. Brain Res. 119 (1998) 365-382.
47. R.M. Buijs, J. Wortel, J.J. van Heerikhuize, M.G.P. Feenstra, G.J. Ter Horst, H.J. Romijn, A. Kalsbeek, Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway, Eur. J. Neurosci. 11 (1999) 1535-1544.
48. A. Bult, L. Hiestand, E.A. Van der Zee, C.B. Lynch, Circadian rhythms differ between selected mouse lines: a model to study the role of vasopressin neurons in the suprachiasmatic nuclei, Brain Res. Bull. 32 (1993) 623-627.
49. A. Bult, E.A. Van der Zee, J.C. Compaan, C.B. Lynch, Differences in the number of arginine-vasopressin-immunoreactive neurons exist in the suprachiasmatic nuclei of house mice selected for differences in nest-building behavior, Brain Res. 578 (1992) 335-338.
50. A.P. Byrnes, R.E. MacLaren, H.M. Charlton, Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination, J. Neurosci. 16 (1996) 3045-3055.
51. A.P. Byrnes, J.E. Rusby, M.J.A. Wood, H.M. Charlton, Adenovirus gene transfer causes inflammation in the brain, Neuroscience 66 (1995) 1015-1024.
52. A.P. Byrnes, M.J.A. Wood, H.M. Charlton, Role of T cells in inflammation caused by adenovirus vectors in the brain, Gene Ther 3 (1996) 644-651.
53. F.R.A. Cagampang, S.-I.T. Inouye, Diurnal and circadian changes of serotonin in the suprachiasmatic nuclei: regulation by light and an endogenous pacemaker, Brain Res. 639 (1994) 175-179.
54. F.R.A. Cagampang, W.J. Sheward, A.J. Harmar, H.D. Piggins, C.W. Coen, Circadian changes in the expression of vasoactive intestinal peptide 2 receptor mRNA in the rat suprachiasmatic nuclei, Mol. Brain Res. 54 (1998) 108-112.
55. F.R.A. Cagampang, J. Yang, Y. Nakayama, C. Fukuhara, S.-I.T. Inouye, Circadian variation of arginine-vasopressin messenger RNA in the rat suprachiasmatic nucleus, Mol. Brain Res. 24 (1994) 179-184.
56. G.M. Cahill, J.C. Besharse, Circadian clock functions localized in Xenopus retinal photoreceptors, Neuron 10 (1993) 573-577.
57. G.M. Cahill, M. Menaker, Effects ofexcitatory amino acid receptor antagonists and agonists on suprachiasmatic nucleus responses to retinohypothalamic tract volleys, Brain Res. 479 (1989) 76-82.
58. A. Cai, M.N. Lehman, J.M. Lloyd, P.M. Wise, Transplantation of fetal suprachiasmatic nuclei into middle-aged rats restores diurnal Fos expression in host, Am. J. Physiol. 272 (1997) R422-428.
59. A. Cai, K. Scarbrough, D.A. Hinkle, P.M. Wise, Fetal grafts containing suprachiasmatic nuclei restore the diurnal rhythm of CRH and POMC mRNA in aging rats, Am. J. Physiol. 273 (1997) R1764-1770.
60. A. Cai, P.M. Wise, Age-related changes in the diurnal rhythm of CRH gene expression in the paraventricular nuclei, Am. J. Physiol. 270 (1996) E238-243.
61. A. Cai, P.M. Wise, Age-related changes in light-induced jun-B and jun-D expression: effects of transplantation of fetal tissue containing the suprachiasmatic nucleus, J. Biol. Rhythms 11 (1996) 284-290.
62. C. Caillaud, S. Akli, E. Vigne, A. Koulakoff, M. Perricaudet, L. Poenaru, A. Kahn, Y. Berwald-Netter, Adenoviral vector as a gene delivery system into cultured rat neuronal and glial cells, Eur. J. Neurosci. 5 (1993) 1287-1291.
63. L. Calza, L. Giardino, M. Zanni, A. Velardo, P. Parchi, P. Marrama, Daily changes of neuropeptide Y-like immunoreactivity in the suprachiasmatic nucleus of the rat, Regul. Pept. 27 (1990) 127-137.
64. R.S. Canbeyli, M.T. Romero, R. Silver, Neither Triazolam nor activity phase advance circadian locomotor activity in SCN-lesioned hamsters bearing fetal SCN transplants, Brain Res. 566 (1991) 40-45.
65. J.P. Card, N. Brecha, H.J. Karten, R.Y. Moore, Immunocytochemical localization of vasoactive intestinal polypeptide-containing cells and processes in the suprachiasmatic nucleus of the rat: light and electron microscopic analysis, J. Neurosci. 1 (1981 ) 1289-1303.
66. J.P. Card, S. Fitzpatrick-McElligott, I. Gozes, J.r. Baldino F, Localization of vasopressin-, vasoactive intestinal polypeptide-, peptide histidine isoleucine- and somatostatin-mRNA in rat suprachiasmatic nucleus, Cell Tissue Res. 252 (1988) 307-315.
67. D.A. Carter, D. Murphy, Diurnal rhythm of vasopressin mRNA species in the rat suprachiasmatic nucleus: independence ofneuroen-docrine modulation and maintenance in explant culture, Mol. Brain Res. 6 (1989) 233-239.
68. D.A. Carter, D. Murphy, Nuclear mechanisms mediate rhythmic changes in vasopressin mRNA expression in the rat suprachiasmatic nucleus, Mol. Brain Res. 12 (1991) 315-321.
69. M.S. Carter, J.E. Krause, Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma, J. Neurosci. 10 (1990) 2203-2214.
70. V.M. Cassone, Effects of melatonin on vertebrate circadian systems, Trends Neurosci. 13 (1990) 457-464.
71. M. Castel, M. Belenky, S. Cohen, S. Wagner, W.J. Schwartz, Light-induced c-fos expression in the mouse suprachiasmatic nucleus: immunoelectron microscopy reveals co-localization in multiple cell types, Eur. J. Neurosci. 9 (1997) 1950-1960.
72. M.F. Ceriani, T.K. Darlington, D. Staknis, P. Mas, A.A. Petti, C.J. Weitz, S.A. Kay, Light-dependent sequestration of TIMELESS by CRYPTOCHROME, Science 285 (1999) 553-556.
73. Y. Cheng, P.E. Hardin, Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling, J. Neurosci. 18 (1998) 741-750.
74. B.M. Chronwall, D.A. DiMaggio, V.J. Massari, V.M. Pickel, D.A. Ruggiero, T.L. O'Donohue, The anatomy of neuropeptide-Y-con-taining neurons in rat brain, Neuroscience 15 (1985) 1159-1181.
75. H.V Colot, J.C. Hall, M. Rosbash, Interspecific comparison of the period gene of Drosophila reveals large blocks of non-conserved coding DNA, EMBO J. 7 (1988) 3929-3937.
76. C.S. Colwell, R.G. Foster, Photic regulation of fos-like immuno-reactivity in the suprachiasmatic nucleus of the mouse, J. Comp. Neurol. 324 (1992) 135-142.
77. C.S. Colwell, C.M. Kaufman, M. Menaker, Photic induction ofFos in the hamster suprachiasmatic nucleus is inhibited by baclofen but not by diazepam or bicuculline, Neurosci. Lett. 163 (1993) 177181.
78. S.T. Crews, Control of cell lineage-specific development and transcription by bHLH-PAS proteins, Genes Dev. 12 (1998) 607620.
79. K.D. Curtin, Z.J. Huang, M. Rosbash, Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock, Neuron 14 (1995) 365-372.
80. R.A. Cutrera, A. Kalsbeek, P. Pevet, Specific destruction of the serotonergic afferents to the suprachiasmatic nuclei prevents triazolaminduced phase advances of hamster activity rhythms, Behav. Brain Res. 62 (1994) 21-28.
81. R.A. Cutrera, A. Ouarour, P. Pevet, Effects of the 5-HT1a receptor agonist 8-OH-DPAT and other non-photic stimuli on the circadian rhythm of wheel-running activity in hamsters under different constant conditions, Neurosci. Lett. 172 (1994) 27-30.
82. J. Dai, D.F. Swaab, R.M. Buijs, Distribution of vasopressin and vasoactive intestinal polypeptide (VIP) fibers in the human hypothalamus with special emphasis on suprachiasmatic nucleus efferent projections, J. Comp. Neurol. 383 (1997) 397-414.
83. J. Dai, D.F. Swaab, J. van derVliet, R.M. Buijs, Postmortem tracing reveals the organization of hypothalamic projections of the suprach-iasmatic nucleus in the human brain, J. Comp. Neurol. 400 (1998) 87-102.
84. J. Dai, J. van der Vliet, D.F. Swaab, R.M. Buijs, The human retinohypothalamic tract as revealed by in vitro postmortem tracing, J. Comp. Neurol. 397 (1998) 357-370.
85. Y. Dai, E.M. Schwarz, D. Gu, W. Zhang, N. Sarvetnick, I.M. Verma, Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression, Proc. Natl. Acad. Sci. USA 92 (1995) 1401-1405.
86. S. Daikoku, S. Hisano, Y. Kagotani, Neuronal associations in the rat suprachiasmatic nucleus demonstrated by immunoelectron microscopy, J. Comp. Neurol. 325 (1992) 559-571.
87. S. Daikoku, Y. Okamura, H. Kawano, Y. Tsuruo, M. Maegawa, T. Shibasaki, CRF-containing neurons of the rat hypothalamus, Cell Tissue Res. 240 (1985) 575-584.
88. J. Danguir, Sleep deficits in rats with hereditary diabetes insipidus, Nature 304 (1983) 163-164.
89. T.K. Darlington, K. Wager-Smith, M.F. Ceriani, D. Staknis, N. Gekakis, T.D. Steeves, C.J. Weitz, J.S. Takahashi, S.A. Kay, Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim, Science 280 (1998) 1599-1603.
90. B.L. Davidson, E.D. Allen, K.F. Kozarsky, J.M. Wilson, B.J. Roessler, A model system for in vivo gene transfer into the central nervous system using an adenoviral vector, Nat. Genet. 3 (1993) 219-233.
91. M. de Jeu, M. Hermes, C. Pennartz, Circadian modulation of membrane properties in slices of rat suprachiasmatic nucleus, Neuroreport 9 (1998) 3725-3729.
92. P.J. DeCoursey, J. Buggy, Circadian rhythmicity after neural transplant to hamster third ventricle: specificity of suprachiasmatic nuclei, Brain Res. 500 (1989) 263-275.
93. V. Della Maggiore, M.R. Ralph, Retinal GABA(A) receptors participate in the regulation of circadian responses to light, J. Biol. Rhythms 14 (1999) 47-53.
94. J.M. Ding, G.F. Buchanan, S.A. Tischkau, D. Chen, L. Kuriashkina, L.E. Faiman, J.M. Alster, P.S. McPherson, K.P. Campbell, M.U. Gillette, A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock, Nature 394 (1998) 381-384.
95. J.M. Ding, D. Chen, E.T. Weber, L.E. Faiman, M.A. Rea, M.U. Gilette, Resetting the biological clock: mediation of nocturnal circadian shifts by glutamate and NO, Science 266 (1994) 1713-1717.
96. L.J. Dorflinger, A. Schonbrunn, Somatostatin inhibits vasoactive intestinal peptide-stimulated cyclic adenosine monophosphate accumulation in GH pituitary cells, Endocrinology 113 (1983) 1541-1550.
97. J.C. Dunlap, Closely watched clocks: molecular analysis of circa-dian rhythms in Neuraspora and Drosophila, Trends Genet. 6 (1990) 159-165.
98. D.J. Earnest, S.M. Digiorgio, C.D. Sladek, Effects of tetrodotoxin on the circadian pacemaker mechanism in suprachiasmatic explants in vitro, Brain Res. Bull. 26 (1991) 677-682.
99. D.J. Earnest, M. Iadarola, H.H. Yeh, J.A. Olschowska, Photic regulation of c-fos expression in neural components governing the entrainment of circadian rhythms, Exp. Neurol. 109 (1990) 353-361.
100. D.J. Earnest, F.Q. Liang, M. Ratcliff, V.M. Cassone, Immortal time: circadian clock properties of rat suprachiasmatic cell lines, Science 283 (1999) 693-695.
101. D.J. Earnest, C.D. Sladek, Circadian rhythms of vasopressin release from individual rat suprachiasmatic explants in vitro, Brain Res. 382 (1986) 129-133.
102. F.J. Ebling, The role of glutamate in the photic regulation of the suprachiasmatic nucleus, Prog. Neurobiol. 50 (1996) 109-132.
103. I. Edery, J.E. Rutila, M. Rosbash, Phase shifting of the circadian clock by induction of the Drosophila period protein, Science 263 (1994) 237-240.
104. I. Edery, L.J. Zwiebel, M.E. Dembinska, M. Rosbash, Temporal phosphorylation of the Drosophila period protein, Proc. Natl. Acad. Sci. USA 91 (1994) 2260-2264.
105. P. Emery, W.V. So, M. Kaneko, J.C. Hall, M. Rosbash, CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity, Cell 95 (1998) 669-679.
106. W. Engelmann, H.W. Honegger, Circadian eclosion rhythm of an eyeless Drosophila melanogaster mutant, Naturwissenschaften 53 (1966) 588.
107. J. Ewer, B. Frisch, M.J. Hamblen-Coyle, M. Rosbash, J.C. Hall, Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms, J. Neurosci. 12 (1992) 3321-3349.
108. M.D. Field, E.S. Maywood, J.A. O'Brien, D.R. Weaver, S.M. Reppert, M.H. Hastings, Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms, Neuron 25 (2000) 437-447.
109. G. Fleissner, Isolation of an insect circadian clock, J. Comp. Physiol. 149 (1982) 311-316.
110. R.G. Foster, I. Provencio, D. Hudson, S. Fiske, W. DeGrip, M. Menaker, Circadian photoreception in the retinally degenerate mouse (rd/rd), J. Comp. Physiol. A 169 (1991) 39-50.
111. A.M. François-Bellan, O. Bosler, CoonvrggntterotooinaiKlGGAB innervation of VIP neurons in the suprachiasmatic nucleus demonstrated by triple labeling in the rat, Brain Res. 595 (1992) 149-153.
112. B. Frisch, P.E. Hardin, M.J. Hamblen-Coyle, M. Rosbash, J.C. Hall, A promotorless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system, Neuron 12 (1994) 555-570.
113. C. Fukuhara, T. Nishiwaki, F.R.A. Cagampang, S.-I.T. Inouye, Emergence of VIP rhythmicity following somatostatin depletion in the rat suprachiasmatic nucleus, Brain Res. 645 (1994) 343-346.
114. C. Fukuhara, K. Shinohara, K. Tominaga, Y. Otori, S.-I.T. Inouye, Endogenous circadian rhythmicity of somatostatin like-immuno-reactivity in the rat suprachiasmatic nucleus, Brain Res. 606 (1993) 28-35.
115. R.L. Gannon, M.A. Rea, Twelve-hour phase shifts of hamster circadian rhythms elicited by voluntary wheel running, J. Biol. Rhythms 10 (1995) 196-210.
116. F. Garcia-Hernandez, R. Aguilar-Roblero, R. Drucker-Colin, Transplantation of the fetal occipital cortex to the third ventricle of SCN-lesioned rats induces a diurnal rhythm in drinking behavior, Brain Res. 418 (1987) 193-197.
117. N. Gekakis, L. Saez, A.M. Delahaye-Brown, M.P. Myers, A. Sehgal, M.W. Young, C.J. Weitz, Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant perL, Science 270 (1995) 811-815.
118. N. Gekakis, D. Staknis, H.B. Nguyen, F.C. Davis, L.D. Wilsbacher, D.P. King, J.S. Takahashi, C.J. Weitz, Role of the CLOCK protein in the mammalian circadian mechanism, Science 280 (1998) 1564-1569.
119. M.P. Gerkema, E.A. Van der Zee, L.E. Feitsma, Expression of circadian rhythmicity correlates with the number of arginine-vasopressin-immunoreactive cells in the suprachiasmatic nucleus of common voles, Microtus arvalis, Brain Res. 639 (1994) 93-101.
120. C.F. Gillespie, E.M. Mintz, C.L. Marvel, K.L. Huhman, H.E. Albers, GABA(A) and GABA(B) agonists and antagonists alter the phase-shifting effects of light when microinjected into the suprach-iasmatic region, Brain Res. 759 (1997) 181-189.
121. D.D. Ginty, J.M. Kornhauser, M.A. Thompson, H. Bading, K.E. Mayo, J.S. Takahashi, M.E. Greenberg, Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock, Science 260 (1993) 238-241.
122. J.D. Glass, M. Selim, M.A. Rea, Modulation oflight-induced c-fos expression in the suprachiasmatic nuclei by 5-HT1A receptor agonists, Brain Res 638 (1994) 235-242.
123. J.D. Glass, M. Selim, G. Srkalovic, M.A. Rea, Tryptophan loading modulates light-induced responses in the mammalian circadian system, J. Biol. Rhythms 10 (1995) 80-90.
124. A. Goldbeter, A model for circadian oscillations in the Drosophila period protein (PER), Proc. R Soc. Lond. B Biol. Sci. 261 (1995) 319-324.
125. A.I. Goldman, P.S. Tierstein, P.J. O'Brien, The role of ambient lighting in circadian disk shedding in the rod outer segment of the rat retina, Invest. Ophthalmol. Vis. Sci. 19 (1980) 1257-1267.
126. B.D. Goldman, J.M. Darrow, The pineal gland and mammalian photoperiodism, Neuroendocrinology 37 (1983) 386-396.
127. M.S. Grace, L.A. Wang, G.E. Pickard, J.C. Besharse, M. Menaker, The tau mutation shortens the period of rhythmic photoreceptor outer segment disk shedding in the hamster, Brain Res. 735 (1996) 93-100.
128. V.K. Gribkoff, R.L. Pieschl, T.A. Wisialowski, W.K. Park, G.J. Strecker, M.T. de Jeu, C.M. Pennartz, F.E. Dudek, A reexamina-tion of the role of GABA in the mammalian suprachiasmatic nucleus, J. Biol. Rhythms 14 (1999) 126-130.
129. H.A. Griffioen, H. Duindam, T.P. Van der Woude, W.J. Rietveld, G.J. Boer, Functional development of fetal suprachiasmatic nucleus grafts in suprachiasmatic nucleus-lesioned rats, Brain Res. Bull. 31 (1993) 145-160.
130. T.A. Groblewski, A.A. Nunez, R.M. Gold, Circadian rhythms in vasopressin deficient rats, Brain Res. Bull. 6 (1981) 125-130.
131. J. Grosse, A.S.I. Loudon, M.H. Hastings, Behavioural and cellular responses to light of the circadian system of Tau mutant and wild-type syrian hamsters, Neuroscience 65 (1995) 587-597.
132. F.H. Guldner, J.R. Wolff, Complex synaptic arrangements in the rat suprachiasmatic nucleus: a possible basis for the 'Zeitgeber' and non-synaptic synchronization of neuronal activity, Cell Tissue Res. 284 (1996) 203-214.
133. H. Hao, D.L. Allen, P.E. Hardin, A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster, Mol. Cell. Biol. 17 (1997) 3687-3693.
134. P.E. Hardin, J.C. Hall, M. Rosbash, Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels, Nature 343 (1990) 536-540.
135. G.C. Hassink, K.E. van Esseveldt, P.A. Dijkhuizen, J. Verhaagen, G.J. Boer, Ontogeny of neurotrophin receptor TrkC Expression in the rat forebrain and anterior hypothalamus with emphasis on the suprachiasmatic nucleus, Neuroscience 92 (1999) 705-712.
136. M.H. Hastings, M.D. Field, E.S. Maywood, D.R. Weaver, S.M. Reppert, Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: new insights into a core clock mechanism, J. Neurosci. RC11 (1999) 1-7.
137. C. Helfrich, Role of the optic lobes in the regulation of the locomotor activity rhythm of Drosophila melanogaster: behavioral analysis of neural mutants, J. Neurogenet. 3 (1986) 321-343.
138. W.T.J.M.C. Hermens, R.J. Giger, A.J.G.D. Holtmaat, P.A. Dijkhuizen, D.A. Houweling, J. Verhaagen, Transient gene transfer to neurons and glia: analysis of adenoviral vector performance in the CNS and PNS, J. Neurosci. Methods 71 (1997) 85-98.
139. W.T.J.M.C. Hermens, J. Verhaagen, Adenoviral vector-mediated gene expression in the nervous system ofimmunocompetent Wistar and T cell-deficient nude rats: Preferential survival of transduced astroglial cells in nude rats, Hum. Gene Ther. 8 (1997) 1049-1063.
140. W.T.J.M.C. Hermens, J. Verhaagen, Viral vectors, tools for gene transfer in the nervous system, Prog. Neurobiol. 55 (1998) 399-432.
141. J.B. Hogenesch, W.K. Chan,VH. Jackiw, B.C. Brown, Y.-Z. Gu, M. Pray-Grant, G.H. Perdew, C.A. Bradfield, Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway, J. Biol. Chem. 272 (1997) 8581-8593.
142. J.B. Hogenesch, Y.-Z. Gu, S. Jain, C.A. Bradfield, The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors, Proc. Natl. Acad. Sci. USA 95 (1998) 5474-5479.
143. K. Honma, K. Watanabe, T. Hiroshige, Effects of para-chloro-phenylalanine and 5,6-dihydroxytryptamine on the free-running rhythms of locomotor activity and plasma corticosterone in the rat exposed to continuous light, Brain Res. 169 (1979) 531-544.
144. S. Honma, Y. Katsuno, Y. Tanahashi, H. Abe, K. Honma, Circadian rhythms of arginine vasopressin and vasoactive intestinal poly-peptide do not depend on cytoarchitecture of dispersed cell culture of rat suprachiasmatic nucleus, Neuroscience 86 (1998) 967-976.
145. G.I. Honrado, R.S. Johnson, D.A. Golombek, B.M. Spiegelman, V.E. Papaioannou, M.R. Ralph, The circadian system of c-fos deficient mice, J. Comp. Physiol. 178 (1996) 563-570.
146. E.M. Hoorneman, R.M. Buijs, Vasopressin fiber pathways in the rat brain following suprachiasmatic nucleus lesioning, Brain Res. 243 (1982) 235-241.
147. T.L. Horvath, V. Cela, E.M. VanderBeek, Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin- releasing hormone-producing neurons in the rat, Brain Res. 795 (1998) 277-281.
148. D.S. Hsu, X. Zhao, S. Zhao, A. Kazantsev, R.P. Wang, T. Todo, Y.F. Wei, A. Sancar, Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins, Biochemistry 35 (1996) 13871-13877.
149. Z.J. Huang, K.D. Curtin, M. Rosbash, PER protein interactions and temperature compensation of a circadian clock in Drosophila, Science 267 (1995) 1169-1172.
150. Z.J. Huang, I. Edery, M. Rosbash, PAS is a dimerization domain common to Drosophila period and several transcription factors, Nature 364 (1993) 259-262.
151. K.L. Huhman, A.C. Hennessey, H.E. Albers, Rhythms ofglutamic acid decarboxylase mRNA in the suprachiasmatic nucleus, J. Biol. Rhythms 11 (1996) 311-316.
152. M. Hunter-Ensor, A. Ousleuy, A. Sehgal, Regulation of the Drosophila protein Timeless suggests a mechanism for resetting the circadian clock by light, Cell 84 (1996) 677-685.
153. M.W. Hurd, K.A. Zimmer, M.N. Lehman, M.R. Ralph, Circadian locomotor rhythms in aged hamsters following suprachiasmatic transplant, Am. J. Physiol. 269 (1995) R958-968.
154. M. Ikeda, M. Nomura, cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage, Biochem. Biophys. Res. Commun. 233 (1997) 258-264.
155. C.D. Ingram, R.K. Snowball, R. Mihai, Circadian rhythm of neuronal activity in suprachiasmatic nucleus slices from the vasopressin-deficient Brattleboro rat, Neuroscience 75 (1996) 635-641.
156. M. Inoue, M. Yoshii, Modulation of ion channels by somatostatin and acetylcholine, Prog. Neurobiol. 38 (1992) 203-230.
157. S.-I.T. Inouye, H. Kawamura, Characteristic of a circadian pacemaker in the suprachiasmatic nucleus, J. Comp. Physiol. 146 (1982) 153-160.
158. N. Ishida, M. Matsui, S. Nishimatsu, K. Murakami, Y. Mitsui, Molecular cloning of a gene under control of the circadian clock and light in the rodent SCN, Mol. Brain Res. 26 (1994) 197-206.
159. N. Ishida, S. Nishimatsu, M. Matsui, Y. Mitsui, T. Nohno, N. Shibata, S. Noji, Diurnal regulation of per repeat family in the suprachiasmatic nucleus of rat brain, Neurosci. Biobehav. Rev. 18 (1994) 571-577.
160. N. Ishida, S. Noji, K. Ono, E. Koyama, T. Nohno, S. Taniguchi, A. Tokunaga, T. Fujii, Y. Mitsui, Diurnal regulation of per repeat mRNA in the suprachiasmatic nucleus in rat brain, Neurosci. Lett. 122 (1991) 113-116.
161. D. Janik, N. Mrosovsky, Nonphotically induced phase shifts of circadian rhythms in the golden hamster: activity-response curves at different ambient temperatures, Physiol. Behav. 53 (1993) 431-436.
162. D. Janik, N. Mrosovsky, Intergeniculate leaflet lesions and be-haviorally-induced shifts of circadian rhythms, Brain Res. 651 (1994) 174-182.
163. S. Jard, C. Barberis, S. Audigier, E. Tribollet, Neurohypophyseal hormone receptor systems in brain and periphery, Prog. Brain Res. 72 (1987) 173-187.
164. Z.G. Jiang, Y. Yang, Z.P. Liu, C.N. Allen, Membrane properties and synaptic inputs of suprachiasmatic nucleus neurons in rat brain slices, J. Physiol. 499 (Pt 1) (1997) 141-159.
165. X.W. Jin, L.P. Shearman, D.R. Weaver, M.J. Zylka, G.J. De Vries, S.M. Reppert, A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock, Cell 96 (1999) 57-68.
166. J. Jolkkonen, L. Tuomisto, T.B. Van Wimersma Greidanus, P.J. Riekkinen, Vasopressin levels in the cerebrospinal fluid of rats with lesions of the paraventricular and suprachiasmatic nuclei, Neurosci. Lett. 86 (1988) 184-188.
167. A. Kalsbeek, R.M. Buijs, M. Engelmann, C.T. Wotjak, R. Land-graf, In vivo measurement of a diurnal variation in vasopressin release in the rat suprachiasmatic nucleus, Brain Res. 682 (1995) 75-82.
168. A. Kalsbeek, R.A. Cutrera, J.J. van Heerikhuize, J. van der Vliet, R.M. Buijs, GABA release from suprachiasmatic nucleus terminals is necessary for the light-induced inhibition of nocturnal melatonin release in the rat, Neuroscience 91 (1999) 453-461.
169. A. Kalsbeek, J. van der Vliet, R.M. Buijs, Decrease of endogenous vasopressin release necessary for expression of the circadian rise in plasma corticosterone: a reverse microdialysis study, J. Neuroendocrinol. 8 (1996) 299-307.
170. A. Kalsbeek, J.J. van Heerikhuize, J. Wortel, R.M. Buijs, A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1 antagonist, J. Neurosci. 16 (1996) 5555-5565.
171. M. Kaneko, C. Helfrich-Forster, J.C. Hall, Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: newly identified pacemaker candidates and novel features of clock gene product cycling, J. Neurosci. 17 (1997) 6745-6760.
172. C.M. Kaufman, M. Menaker, Effect of transplanting suprach-iasmatic nuclei from donors of different ages into completely SCN lesioned hamsters, J. Neural Transplant Plast. 4 (1993) 257-265.
173. F. Kawakami, H. Okamura, Y. Tamada, T. Nakajima, Y. Ibata, Changes in vasoactive intestinal peptide mRNA levels in the rat suprachiasmatic nucleus following p-chlorophenylalanine (PCPA) treatment under light/dark conditions,
174. M.M. Kilcoyne, D.L. Hoffman, E.A. Zimmerman, Immuno-cytochemical localization of angiotensin II and vasopressin in rat hypothalamus: evidence for production in the same neuron, Clin. Sci. 59 (Suppl 6) (1980) 57-60.
175. Y.I. Kim, F.E. Dudek, Intracellular electrophysiological study of suprachiasmatic nucleus neurons in rodents: inhibitory synaptic mechanisms, J. Physiol. 458 (1992) 247-260.
176. D.P. King, Y. Zhao, A.M. Sangoram, L.D. Wilsbacher, M. Tanaka, M.P. Antoch, T.D. Steeves, M.H. Vitaterna, J.M. Kornhauser, P.L. Lowrey, F.W. Turek, J.S. Takahashi, Positional cloning of the mouse circadian clock gene, Cell 89 (1997) 641-653.
177. R.L. Klein, E.M. Meyer, A.L. Peel, S. Zolotukhin, C. Meyers, N. Muzyczka, M.A. King, Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors, Exp Neurol. 150 (1998) 183-190.
178. B. Kloss, J.L. Price, L. Saez, J. Blau, A. Rothenfluh, C.S. Wesley, M.W. Young, The Drosophila clock gene double-time encodes a protein closely related to human casein kinase IG, Cell 94 (1998) 97-107.
179. K. Kobayashi, S. Kanno, B. Smit, G.T. van der Horst, M. Takao, A. Yasui, Characterization of photolyase /blue-light receptor homologs in mouse and human cells, Nucleic Acids Res. 26 (1998) 5086-5092.
180. R.J. Konopka, S. Benzer, Clock mutants of Drosophila melano-gaster, Proc. Natl. Acad. Sci. USA 68 (1971) 2112-2116.
181. J.M. Kornhauser, D.E. Nelson, K.E. Mayo, J.S. Takahashi, Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus, Neuron 5 (1990) 127-134.
182. J.M. Kornhauser, D.E. Nelson, K.E. Mayo, J.S. Takahashi, Regulation of junB messenger RNA and AP-1 activity by light and a circadian clock, Science 255 (1992) 1581-1584.
183. J. Kruisbrink, M. Mirmiran, T.P. Van der Woude, G.J. Boer, Effects of enhanced cerebrospinal fluid levels of vasopressin, vasopressin antagonist or vasoactive intestinal polypeptide on circadian sleep-wake rhythm in the rat, Brain Res. 419 (1987) 76-86.
184. K. Kume, M.J. Zylka, S. Sriram, L.P. Shearman, D.R. Weaver, X.W. Jin, E.S. Maywood, M.H. Hastings, S.M. Reppert, mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop, Cell 98 (1999) 193-205.
185. S.E. La Fleur, A. Kalsbeek, J. Wortel, R.M. Buijs, Polysynaptic neural pathways between the hypothalamus, including the suprach-iasmatic nucleus and the liver, Brain Res., in press.
186. M.M. LaVail, Rod outer segment disk shedding in the retina: relationship to cyclic lighting, Science 194 (1976) 1071-1074.
187. G. Le Gal La Salle, J.J. Robert, S. Berrard, V. Ridoux, L.D. Stratford-Perricaudet, M. Perricaudet, J. Mallet, An adenovirus vector for gene transfer into neurons and glia in the brain, Science 259 (1993) 988-990.
188. R.K. Leak, J.P. Card, R.Y. Moore, Suprachiasmatic pacemaker organization analyzed by viral transynaptic transport, Brain Res. 819 (1999) 23-32.
189. R.M. Lechan, I.M. Jackson, Immunohistochemical localization of thyrotropin-releasing hormone in the rat hypothalamus and pituitary, Endocrinology 111 (1982) 55-65.
190. C. Lee, V. Parikh, T. Itsukaichi, K. Bae, I. Edery, Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex, Science 271 (1996) 1740-1744.
191. M.N. Lehman, C. Cutter, Nelms, L. Coolen, R. Silver, Restricted distribution and rhythmicity of CLOCK-immunoreactivity in the SCN: Implications for circadian outputs controlling behavioral rhythms, Abstract at the 7th Meeting of the Society for Research on Biological Rhythms, Amelia Island, FL (2000) in press.
192. M.N. Lehman, J. LeSauter, R. Silver, Fiber outgrowth from anterior hypothalamic and cortical xenografts in the third ventricle, J. Comp. Neurol. 391 (1998) 133-145.
193. M.N. Lehman, M.R. Ralph, Modulation and restitution ofcircadian rhythms, in: S.B. Dunnett, A. Bjorklund (Eds.), Functional Neural Transplantation, Raven Press, New York, 1994, pp. 467-487.
194. M.N. Lehman, R. Silver (Eds.), Restoration of Circadian Rhythms By Neural Transplants. Neurotransplantation, Cns Injury and Regeneration, CRC Press, New York, 1993, pp. 141-160.
195. M.N. Lehman, R. Silver, W.R. Gladstone, R.M. Kahn, M. Gibson, E.L. Bittman, Circadian rhythmicity restored by neural transplant. Immunocytochemical characterization of the graft and its integration with the host brain, J. Neurosci. 7 (1987) 1626-1638.
196. J. LeSauter, M.N. Lehman, R. Silver, Restoration of circadian rhythmicity by transplants of SCN 'micropunches', J. Biol. Rhythms 11 (1996) 163-171.
197. J. LeSauter, P. Romero, M. Cascio, R. Silver, Attachment site of grafted SCN influences precision of restored circadian rhythm, J. Biol. Rhythms 12 (1997) 327-338.
198. J. LeSauter, R. Silver, Heavy water lengthens the period of freerunning rhythms in lesioned hamsters bearing SCN grafts, Physiol. Behav. 54 (1993) 599-604.
199. J. LeSauter, R. Silver, Localization of a suprachiasmatic nucleus subregion regulating locomotor rhythmicity, J. Neurosci. 19 (1999) 5574-5585.
200. J.D. Levine, I. Sauman, M. Imbalzano, S.M. Reppert, F.R. Jackson, Period protein from the giant silkmoth Antheraea pernyi functions as a circadian clock element in Drosophila melanogaster, Neuron 15 (1995) 147-197.
201. R.D. Lewis, G.R. Warman, D.S. Saunders, Simulations of free-running rhythms, light entrainment and the light-pulse phase response curves for the locomotor activity rhythm in period mutant of Drosophila melanogaster, J. Theor. Biol. 185 (1997) 503-510.
202. A.J. Lewy, S. Ahmed, J.M. Jackson, Melatonin shifts human circadian rhythms according to a phase-response curve, Chronobiol. Int. 9 (1992) 380-392.
203. H. Li, E. Satinoff, Fetal tissue containing the suprachiasmatic nucleus restores multiple circadian rhythms in old rats, Am. J. Physiol. 275 (1998) R1735-1744.
204. F.Q. Liang, F. Sohrabji, R. Miranda, B. Earnest, D. Earnest, Expression of brain-derived neurotrophic factor and its cognate receptor, TrkB, in the rat suprachiasmatic nucleus, Exp. Neurol. 151 (1998) 184-193.
205. F.Q. Liang, R. Walline, D.J. Earnest, Circadian rhythm of brain-derived neurotrophic factor in the rat suprachiasmatic nucleus, Neurosci. Lett. 242 (1998) 89-92.
206. M.E. Lickey, G.D. Block, D.J. Hudson, J.T. Smith, Circadian oscillators and photoreceptors in the gastropod, Aplysia, Photochem. Photobiol. 23 (1976) 253-273.
207. R.W. Lind, L.W. Swanson, D. Ganten, Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. An immunohistochemical study, Neuroendocrinology 40 (1985) 2-24.
208. S.Y. Liou, H.E. Albers, Single unit response of suprachiasmatic neurons to arginine vasopressin (AVP) is mediated by a V1-like receptor in the hamster, Brain Res. 477 (1989) 336-343.
209. S.Y. Liou, H.E. Albers, Single unit response of neurons within the hamster suprachiasmatic nucleus to GABA and low chloride perfusate during the day and night, Brain Res. Bull. 25 (1990) 93-98.
210. S.Y. Liou, S. Shibata, H.E. Albers, S. Ueki, Effects of GABA and anxiolytics on the single unit discharge of suprachiasmatic neurons in rat hypothalamic slices, Brain Res. Bull. 25 (1990) 103-107.
211. S.Y. Liou, S. Shibata, K. Iwasaki, S. Ueki, Optic nerve stimulation-induced increase of release of 3H-glutamate and 3H-aspartate but not 3H-GABA from the suprachiasmatic nucleus in slices of rat hypothalamus, Brain Res. Bull. 16 (1986) 527-531.
212. S.Y. Liou, S. Shibata, S. Ueki, Effect of monoamines on field potentials in the suprachiasmatic nucleus of slices of hypothalamus of the rat evoked by stimulation of the optic nerve, Neuro-pharmacology 25 (1986) 1009-1014.
213. C. Liu, J.M. Ding, L.E. Faiman, M.U. Gillette, Coupling of muscarinic cholinergic receptors and cGMP in nocturnal regulation of the suprachiasmatic circadian clock, J. Neurosci. 17 (1997) 659-666.
214. X. Liu, L. Lorenz, Q. Yu, J.C. Hall, M. Rosbash, Spatial and temporal expression of the period gene in Drosophila melanogaster., Genes Dev. 2 (1988) 228-238.
215. C. Liu, S.M. Reppert, GABA synchronizes clock cells within the suprachiasmatic circadian clock, Neuron 25 (2000) 123-128.
216. S.W. Lockley, D.J. Skene, K. Thapan, J. English, D. Ribeiro, I. Haimov, S. Hampton, B. Middleton, M. von Schantz, J. Arendt, Extraocular light exposure does not suppress plasma melatonin in humans, J. Clin. Endocrinol. Metab. 83 (1998) 3369-3372.
217. M. Maegawa, S. Hisano, Y. Tsuruo, S. Katoh, J. Nakanishi, M. Chikamori-Aoyama, S. Daikoku, Differential immunolabeling for electron microscopy of diverse peptidergic neurons, J. Histochem. Cytochem. 35 (1987) 251-255.
218. R. Mason, S.M. Biello, M.E. Harrington, The effects of GABA and benzodiapines on neurones in the suprachiasmatic nucleus (SCN) of Syrian hamsters, Brain Res. 552 (1991) 53-57.
219. R. Mason, A. Brooks, The electrophysiological effects of melatonin and a putative antagonist (W-acetyltryptamine) on rat suprachiasmatic neurones in vitro, Neurosci. Lett. 95 (1988) 296301.
220. A. Mathur, D.A. Golombek, M.R. Ralph, cGMP-dependent kinase inhibitors block light-induced phase advances of circadian rhythms in vivo, Am. J. Physiol. 270 (1996) R1031-1036.
221. M. Matsui, Y. Mitsui, N. Ishida, Circadian regulation of per repeat mRNA in the suprachiasmatic nucleus of rat brain, Neurosci. Lett. 163 (1993) 189-192.
222. S. Matsumoto, J. Basil, A.E. Jetton, M.N. Lehman, E.L. Bittman, Regulation of the phase and period of circadian rhythms restored by suprachiasmatic transplants, J. Biol. Rhythms 11 (1996) 145-162.
223. E.S. Maywood, N. Mrosovsky, M.D. Field, M.H. Hastings, Rapid down-regulation of mammalian Period genes during behavioral resetting of the circadian clock, Proc. Natl. Acad. Sci. 96 (1999) 15211-15216.
224. E.S. Maywood, E. Smith, S.J. Hall, M.H. Hastings, A thalamic contribution to arousal-induced, non-photic entrainment of the circadian clock of the Syrian hamster, Eur. J. Neurosci. 9 (1997) 1739-1747.
225. P.S. McPherson, Y.K. Kim, H. Valdivia, C.M. Knudson, H. Takekura, C. Franzini-Armstrong, R. Coronado, K.P. Campbell, The brain ryanodine receptor: a caffeine-sensitive calcium release channel, Neuron 7 (1991) 17-25.
226. S. Mead, F.J.P. Ebling, E.S. Maywood, T. Humby, J. Herbert, M.H. Hastings, A nonphotic stimulus causes instantaneous phase advances of the light-entrainable circadian oscillator of the Syrian hamster but does not induce the expression of c-fos in the suprachiasmatic nuclei, J. Neurosci. 12 (1992) 2516-2522.
227. I. Merchenthaler, V. Csernus, C. Csontos, P. Petrusz, B. Mess, New data on the immunocytochemical localization of thyrotropin-releas-ing hormone in the rat central nervous system, Am. J. Anat. 181 (1988) 359-376.
228. M.O. Miceli, D. van der Kooy, C.A. Post, M.A. Della-Fera, C.A. Baile, Differential distributions of cholecystokinin in hamster and rat forebrain, Brain Res. 402 (1987) 318-330.
229. R. Mihai, M. Coculescu, J.B. Wakerley, C.D. Ingram, The effects of [Arg8]vasopressin and [Arg8]vasotocin on the firing rate of suprachiasmatic neurons in vitro, Neuroscience 62 (1994) 783-792.
230. R. Mihai, T.S. Juss, C.D. Ingram, Suppression of suprachiasmatic nucleus neurone activity with a vasopressin receptor antagonist: possible role for endogenous vasopressin in circadian activity cycles in vitro, Neurosci. Lett. 179 (1994) 95-99.
231. J.D. Mikkelsen, P.J. Larsen, Substance P in the suprachiasmatic nucleus of the rat: an immunohistochemical and in situ hybridization study, Histochemistry 100 (1993) 3-16.
232. J.D. Mikkelsen, P.J. Larsen, M.M. O'Hare, S.J. Wiegand, Gastrin releasing peptide in the rat suprachiasmatic nucleus: an immuno-histochemical, chromatographic and radioimmunological study, Neuroscience 40 (1991) 55-66.
233. J.D. Miller, C.A. Fuller, The response of suprachiasmatic neurons of the rat hypothalamus to photic and serotonergic stimulation, Brain Res. 515 (1990) 155-162.
234. Y. Miyamoto, A. Sancar, Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals, Proc. Natl. Acad. Sci. USA 95 (1998) 6097-6102.
235. M.M. Moga, R.Y. Moore, Afferents to the suprachiasmatic nucleus shown by anterograde and retrograde tracing studies, J. Comp. Neurol. 389 (1997) 508-534.
236. R.Y. Moore, V.B. Eichler, Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat, Brain Res. 42 (1972) 201-206.
237. R.Y. Moore, N.J. Lenn, A retinohypothalamic projection in the rat, J. Comp. Neurol. 146 (1972) 1-14.
238. R.Y. Moore, J.C. Speh, GABA is the principal neurotransmitter of the circadian system, Neurosci. Lett. 150 (1993) 112-116.
239. A.J. Morin, L. Denoroy, M. Jouvet, Daily variations in concentration of vasoactive intestinal polypeptide immunoreactivity in discrete brain areas of the rat, Brain Res. 538 (1991) 136-140.
240. L.P. Morin, The circadian visual system, Brain Res. Rev. 67 (1994) 102-127.
241. L.P. Morin, J. Blanchard, Depletion of brain serotonin by 5,7-DHT modifies hamster circadian rhythm response to light, Brain Res. 566 (1991) 173-185.
242. D.M. Murakami, B.A. Horwitz, C.A. Fuller, Circadian rhythms of temperature and activity in obese and lean Zucker rats, Am. J. Physiol. 269 (1995) R1038-1043.
243. H.M. Murphy, C.H. Wideman, G.R. Nadzam, Vasopressin deficiency and circadian rhythms during food-restriction stress, Peptides 14 (1993) 1215-1220.
244. H.M. Murphy, C.H. Wideman, G.R. Nadzam, The interaction of vasopressin and the photic oscillator in circadian rhythms, Peptides 17 (1996) 467-475.
245. C. Murre, P.S. McCaw, D. Baltimore, A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughter-less, MyoD, and myc proteins, Cell 56 (1989) 777-783.
246. M.P. Myers, K. Wager-Smith, A. Rothenfluh-Hilfiker, M.W. Young, Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock, Science 271 (1996) 1736-1740.
247. M.P. Myers, K. Wager-Smith, C.S. Wesley, M.W. Young, A. Sehgal, Positional cloning and sequence analysis of the Drosophila clock gene, timeless, Science 270 (1995) 805-808.
248. T. Nagase, K. Ishikawa, D. Nakajima, M. Ohira, N. Seki, N. Miyajima, A. Tanaka, H. Kotani, N. Nomura, O. Ohara, Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro, DNA Res. 4 (1997) 141-150.
249. H. Nishino, K. Koizumi, Responses of neurons in the suprach-iasmatic nuclei of the hypothalamus to putative transmitters, Brain Res. 120 (1977) 167-172.
250. H. Okamura, Y. Ibata, GRP immunoreactivity shows a day-night difference in the suprachiasmatic nuclear soma and efferent fibers: comparison to VIP immunoreactivity, Neurosci. Lett. 181 (1994) 165-168.
251. H. Okamura, S. Miyake, Y. Sumi, S. Yamagushi, A. Yasai, M. Muijtjens, J.H.J. Hoeijmakers, G.T.J. Van der Horst, Photic induction of mPer1 and mPer2 in Cry-deficient mice lacking a biological clock, Science 286 (1999) 2531-2534.
252. H. Okamura, S. Murakami, K. Uda, T. Sugano, Y. Takahashi, C. Yanaihara, N. Yanaihara, Y. Ibata, Coexistence of vasoactive intestinal peptide (VIP)-, peptide histidine isoleucine amide (PHI)-, and gastrin releasing peptide (GRP)-like immunoreactivity in neurons of the rat suprachiasmatic nucleus, Biomed. Res. 7 (1986) 295-299.
253. H. Okamura, M. Tanaka, K. Kanemasa, Y. Ban, S.-I.T. Inouye, Y. Ibata, In situ hybridization histochemistry of vgf mRNA in the rat suprachiasmatic nucleus: co-localization with vasopressin/neuro-physin and VIP/PHI, Neurosci. Lett. 189 (1995) 181-184.
254. T.L. Page, Transplantation of the cockroach circadian pacemaker, Science 216 (1982) 73-75.
255. C.M. Palatnik, C. Wilkins, A. Jacobson, Translational control during early Dictyostelium development: possible involvement of poly(A) sequences, Cell 36 (1984) 1017-1025.
256. H.T. Park, S.Y. Baek, B.S. Kim, J.B. Kim, J.J. Kim, Calcitonin gene-related peptide-like immunoreactive (CGRPI) elements in the circadian system of the mouse: an immunohistochemistry combined with retrograde transport study, Brain Res. 629 (1993) 335-341.
257. A.L. Peel, S. Zolotukhin, G.W. Schrimsher, N. Muzyczka, P.J. Reier, Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promotors, Gene Ther. 4 (1997) 16-25.
258. P.D. Penev, F.W. Turek, P.C. Zee, A serotonin neurotoxin attenuates the phase-shifting effects of triazolam on the circadian clock in hamsters, Brain Res. 669 (1995) 207-216.
259. P.D. Penev, P.C. Zee, F.W. Turek, Monoamine depletion blocks triazolam-induced phase advances of the circadian clock in hamsters, Brain Res. 637 (1994) 255-261.
260. G.M. Peterson, W.B. Watkins, R.Y. Moore, The suprachiasmatic hypothalamic nuclei of the rat. VI. Vasopressin neurons and circadian rhythmicity, Behav. Neural Biol. 29 (1980) 236-245.
261. G.E. Pickard, Bifurcating axons of retinal ganglion cells terminate in the hypothalamic suprachiasmatic nucleus and the intergenicu-late leaflet of the thalamus, Neurosci. Lett. 55 (1985) 211-217.
262. G.E. Pickard, M.A. Rea, TFMPP, a 5HT1B receptor agonist, inhibits light-induced phase shifts of the circadian activity rhythm and c-Fos expression in the mouse suprachiasmatic nucleus, Neurosci. Lett. 231 (1997) 95-98.
263. G.E. Pickard, M.A. Rea, Serotonergic innervation of the hypo-thalamic suprachiasmatic nucleus and photic regulation of circadian rhythms, Biol. Cell. 89 (1997) 513-523.
264. G.E. Pickard, M.A. Rea, TFMPP, a 5HT(1B) receptor agonist, inhibits light-induced phase shifts of the circadian activity rhythm and c-fos expression in the mouse suprachiasmatic nucleus, Neurosci. Lett. 231 (1997) 95-98.
265. G.E. Pickard, E.T. Weber, P.A. Scott, A.F. Riberdy, M.A. Rea, 5HT1B receptor agonists inhibit light-induced phase shifts of behavioral circadian rhythms and expression of the immediate-early gene c-fos in the suprachiasmatic nucleus, J. Neurosci. 16 (1996) 8208-8220.
266. H.D. Piggins, M.C. Antle, B. Rusak, Neuropeptides phase shift the mammalian circadian pacemaker, J. Neurosci. 15 (1995) 5612-5622.
267. J.D. Plautz, M. Kaneko, J.C. Hall, S.A. Kay, Independent photoreceptive circadian clocks throughout Drosophila, Science 278 (1997) 1632-1635.
268. J.L. Price, J. Blau, A. Rothenfluh, M. Abodeely, B. Kloss, M.W. Young, Double-time is a novel Drosophila Clock gene that regulates PERIOD protein accumulation, Cell 94 (1998) 83-95.
269. J.L. Price, M.E. Dembinska, M.W. Young, M. Rosbash, Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless, EMBO J. 14 (1995) 4044-4049.
270. R.A. Prosser, D.M. Edgar, H.C. Heller, J.D. Miller, A possible glial role in the mammalian clock, Brain Res. 643 (1994) 296-301.
271. R.A. Prosser, A.J. McArthur, M.U. Gillette, cGMP induces phase shifts of a mammalian circadian pacemaker at night, in antiphase to cAMP effects, Proc. Natl. Acad. Sci. USA 86 (1989) 6812-6815.
272. R.A. Prosser, J.D. Miller, H.C. Heller, A serotonin agonist phase-shifts the circadian clock in the suprachiasmatic nuclei in vitro, Brain Res. 534 (1990) 336-339.
273. M.R. Ralph, R.G. Foster, F.C. Davis, M. Menaker, Transplanted suprachiasmatic nucleus determines circadian period, Science 247 (1990) 975-978.
274. M.R. Ralph, M. Menaker, A mutation of the circadian system in golden hamsters, Science 241 (1988) 1225-1227.
275. M.R. Ralph, M. Menaker, GABA regulation of circadian responses to light. I Involvement of GABAA-benzodiazepine and GABAB receptors, J. Neurosci. 9 (1989) 2858-2865.
276. M.A. Rea, Light increases fos-related protein immunoreactivity in the rat suprachiasmatic nuclei, Brain Res. Bull. 23 (1989) 577-581.
277. M.A. Rea, Different populations of cells in the suprachiasmatic nucleus express c-fos in association with light-induced phase delays and advances of the free-running activity rhythm in hamsters, Brain Res. 579 (1992) 107-112.
278. M.A. Rea, B. Buckley, L.M. Lutton, Local administration ofEAA antagonists blocks light-induced phase shifts and c-fos expression in hamster SCN, Am. J. Physiol. 265 (1993) R1191-1198.
279. R.J. Reiter, The melatonin rhythm: both a clock and a calendar, Experientia 49 (1993) 654-664.
280. S.M. Reppert, H.G. Artman, S. Swaminathan, D.A. Fisher, Vasopressin exhibits a rhythmic daily pattern in cerebrospinal fluid but not in blood, Science 213 (1981) 1256-1257.
281. S.M. Reppert, I. Sauman, period and timeless tango: a dance of two clock genes, Neuron 15 (1995) 983-986.
282. S.M. Reppert, T. Tsai, A.L. Roca, I. Sauman, Cloning of a structural and functional homolog of the circadian clock gene period from the giant silkmoth Antheraea pernyi, Neuron 13 (1994) 1167-1176.
283. S.M. Reppert, G.R. Uhl, Vasopressin messenger ribonucleic acid in supraoptic and suprachiasmatic nuclei: appearance and circadian regulation during development, Endocrinology 120 (1987) 2483-2487.
284. V. Ridoux, J.J. Robert, X. Zhang, M. Perricaudet, J. Mallet, G. Le Gal La Salle, The use of adenovirus vectors for intracerebral grafting of transfected nervous cells, Neuroreport 5 (1994) 801-804.
285. M. Roberts, G. Block, Mutual coupling between the ocular circadian pacemaker of Bulla gouldiana, Science 221 (1983) 87-89.
286. B.G. Robinson, D.M. Frim, W.J. Schwartz, J.A. Majzoub, Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length, Science 241 (1988) 342-344.
287. M.T. Romero, R. Silver, Time course of peptidergic expression in fetal suprachiasmatic nucleus transplanted into adult hamster, Dev. Brain Res. 57 (1990) 1-6.
288. H.J. Romijn, A.A. Sluiter, C.W. Pool, J. Wortel, R.M. Buijs, Differences in colocalization between Fos and PHI, GRP, VIP and VP in neurons of the rat suprachiasmatic nucleus after a light stimulus during the phase delay versus the phase advance period of the night, J. Comp. Neurol. 372 (1996) 1-8.
289. L. Rondi-Reig, Y. Lemaigre Dubreuil, J.C. Martinou, N. Delhaye-Bouchaud, J. Caston, J. Mariani, Fear decrease in transgenic mice overexpressing bcl-2 in neurons, Neuroreport 8 (1997) 2429-2432.
290. B. Rusak, H.A. Robertson, W. Wisden, S.P. Hunt, Light pulses that shift rhythms induce gene expression in the suprachiasmatic nucleus, Science 248 (1990) 1237-1240.
291. J.E. Rutila, H. Zeng, M. Le, K.D. Curtin, J.C. Hall, M. Rosbash, The tim SL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants, Neuron 17 (1996) 921-929.
292. J.E. Rutila, V Suri, M. Le, WV. So, M. Rosbash, J.C. Hall, CYCLE is a second bHLH-PAS Clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless, Cell 93 (1998) 805-814.
293. L. Saez, M.W. Young, Regulation of nuclear entry of the Dro-sophila clock proteins Period and Timeless, Neuron 17 (1996) 911-920.
294. Y. Saitoh, Y. Matsui, I. Nihonmatsu, H. Kawamura, Cross-species transplantation of the suprachiasmatic nuclei from rats to Siberian chipmunks (Eutamias sibiricus) with suprachiasmatic lesions, Neurosci. Lett. 123 (1991) 77-81.
295. Y. Saitoh, I. Nihonmatsu, H. Kawamura, Location of the suprach-iasmatic nucleus grafts in rats which restored circadian rhythmicity after transplantation, Neurosci. Lett. 118 (1990) 45-48.
296. M. Sakanaka, S. Magari, N. Inoue, K. Lederis, Co-localization of arginine vasopressin- and enkephalin-like immunoreactivities in nerve cells of the rat hypothalamus, Cell Tissue Res. 260 (1990) 549-554.
297. A.M. Sangoram, L. Saez, M.P. Antoch, N. Gekakis, D. Staknis, A. Whiteley, E.M. Fruechte, M.H. Vitaterna, K. Shimomura, D.P. King, M.W. Young, C.J. Weitz, J.S. Takahashi, Mammalian circadian autoregulatory loop: a Timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription, Neuron 21 (1998) 1101-1113.
298. I. Sauman, S.M. Reppert, Circadian clock neurons in the silkmoth Antheraea pernyi: novel mechanisms of Period protein regulation, Neuron 17 (1996) 889-900.
299. K. Scarbrough, F.W. Turek, Quantitative differences in the circa-dian rhythm of locomotor activity and vasopressin and vasoactive intestinal peptide gene expression in the suprachiasmatic nucleus of tau mutant compared to wildtype hamsters, Brain. Res. 736 (1996) 251-259.
300. T. Scheper, D. Klinkenberg, C. Pennartz, J. Van Pelt, A mathematical model for the intracellular circadian rhythm generator, J. Neurosci. 19 (1999) 40-47.
301. W.J. Schwartz, Further evaluation of the tetrodotoxin-resistant pacemaker in the suprachiasmatic nuclei, J. Biol. Rhythms 6 (1991) 149-158.
302. W.J. Schwartz, R.J. Coleman, S.M. Reppert, A daily vasopressin rhythm in rat cerebrospinal fluid, Brain Res. 263 (1983) 105-112.
303. W.J. Schwartz, L.C. Davidsen, C.B. Smith, In vivo metabolic activity of a putative circadian oscillator, the rat suprachiasmatic nucleus, J. Comp. Neurol. 189 (1980) 157-167.
304. W.J. Schwartz, R.A. Gross, M.T. Morton, The suprachiasmatic nuclei contain a tetrodotoxin-resistant circadian pacemaker, Proc. Natl. Acad. Sci. USA 84 (1987) 1694-1698.
305. W.J. Schwartz, S.M. Reppert, Neural regulation of the circadian vasopressin rhythm in cerebrospinal fluid: a pre-eminent role for the suprachiasmatic nuclei, J. Neurosci. 5 (1985) 2771-2778.
306. J.R. Seckl, S.L. Lightman, Diurnal rhythm of vasopressin but not of oxytocin in the cerebrospinal fluid of the goat: lack of association with plasma cortisol rhythm, J. Endocrinol. 114 (1987) 477-482.
307. A. Sehgal, J.L. Price, B. Man, M.W. Young, Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless, Science 263 (1994) 1603-1606.
308. A. Sehgal, A. Rothenfluh-Hilfiker, M. Hunter-Ensor, Y. Chen, M.P. Myers, M.W. Young, Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation, Science 270 (1995) 808-810.
309. J. Serviere, G. Gendrot, J. LeSauter, R. Silver, Host resets phase of grafted suprachiasmatic nucleus: a 2-DG study of time course of entrainment, Brain Res. 655 (1994) 168-176.
310. J. Serviere, G. Gendrot, J. LeSauter, R. Silver, Host resets phase of grafted SCN: influence of implant site, tissue specificity and pineal secretion, Neurosci. Lett. 176 (1994) 80-84.
311. L.P. Shearman, M.J. Zylka, D.R. Weaver, L.F. Kolakowski, S.M. Reppert, Two period homologs: Circadian expression and photic regulation in the suprachiasmatic nuclei, Neuron 19 (1997) 1261-1269.
312. M. Sheng, M.E. Greenberg, The regulation and function of c-fos and other immediate early genes in the nervous system, Neuron 4 (1990) 477-485.
313. S. Shibata, VM. Cassone, R.Y. Moore, Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro, Neurosci. Lett. 97 (1989) 140-144.
314. S. Shibata, R.Y. Moore, Neuropeptide Y and vasopressin effects on rat suprachiasmatic nucleus neurons in vitro, Brain Res. 3 (1988) 265-276.
315. S. Shibata, R.Y. Moore, Tetrodotoxin does not affect circadian rhythms in neuronal activity and metabolism in rodent suprach-iasmatic nucleus in vitro, Brain Res. 606 (1993) 259-266.
316. S. Shibata, A. Tsuneyoshi, T. Hamada, K. Tominaga, S. Watanabe, Effect of substance P on circadian rhythms of firing activity and the 2-deoxyglucose uptake in the rat suprachiasmatic nucleus in vitro, Brain Res. 597 (1992) 257-263.
317. Y. Shigeyoshi, K. Taguchi, S. Yamamoto, S. Takekida, L. Yan, H. Tei, T. Moriya, S. Shibata, J.J. Loros, J.C. Dunlap, H. Okamura, Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript, Cell 91 (1997) 1043-1053.
318. K. Shimizu, K. Nagai, H. Nakagawa, An immunotoxin, anti-VIP antibody-ricin A chain conjugate eliminates neurons in the hypo-thalamic suprachiasmatic nucleus selectively and abolishes the circadian rhythm of water intake, Brain Res. Bull. 41 (1996) 369-438.
319. K. Shimomura, M. Menaker, Light-induced phase shifts in tau mutant hamsters, J. Biol. Rhythms 9 (1994) 97-110.
320. K. Shinohara, Y. Isobe, J. Takeuchi, S.T. Inouye, Circadian rhythms of somatostatin-immunoreactivity in the suprachiasmatic nucleus of the rat, Neurosci. Lett. 129 (1991) 59-62.
321. K. Shinohara, K. Tominaga, C. Fukuhara, Y. Otori, S.-I.T. Inouye, Processing of photic information within the intergeniculate leaflet of the lateral geniculate body: assessed by neuropeptide Y im-munoreactivity in the suprachiasmatic nucleus of rats, Neuro-science 56 (1993) 813-822.
322. K. Shinohara, K. Tominaga, Y. Isobe, S.-I.T. Inouye, Photic regulation of peptides located in the ventrolateral subdivision of the suprachiasmatic nucleus of the rat: daily variations of vasoactive intestinal polypeptide, gastrin releasing peptide and neuropeptide Y, J. Neurosci. 13 (1993) 793-800.
323. R. Silver, M.N. Lehman, M. Gibson, W.R. Gladstone, E.L. Bittman, Dispersed cell suspensions of fetal SCN restore circadian rhythmicity in SCN-lesioned adult hamsters, Brain Res. 525 (1990) 45-58.
324. R. Silver, M.T. Romero, H.R. Besmer, R. Leak, J.M. Nunez, J. LeSauter, Calbindin-D28K cells in the hamster SCN express light-induced Fos, Neuroreport 7 (1996) 1224-1228.
325. R. Silver, A.I. Sookhoo, J. LeSauter, P. Stevens, H.T. Jansen, M.N. Lehman, Multiple regulatory elements result in regional specificity in circadian rhythms of neuropeptide expression in mouse SCN, Neuroreport, (1999), in press.
326. K.B. Sims, D.L. Hoffman, S.I. Said, E.A. Zimmerman, Vasoactive intestinal polypeptide (VIP) in mouse and rat brain: an immuno-cytochemical study, Brain Res. 186 (1980) 165-183.
327. K.K. Siwicki, C. Eastman, G. Petersen, M. Rosbash, J.C. Hall, Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system, Neuron 1 (1988) 141-150.
328. G. Skofitsch, D.M. Jacobowitz, Immunohistochemical mapping of galanin-like neurons in the rat central nervous system, Peptides 6 (1985) 509-546.
329. W.V. So, M. Rosbash, Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling, EMBO J. 16 (1997) 7146-7155.
330. P.J. Sollars, D.P. Kimble, G.E. Pickard, Restoration of circadian behavior by anterior hypothalamic heterografts, J. Neurosci. 15 (1995) 2109-2122.
331. P.J. Sollars, G.E. Pickard, Time course of fiber outgrowth from fetal anterior hypothalamic heterografts, Brain Res. 614 (1993) 212-219.
332. P.J. Sollars, G.E. Pickard, Vasoactive intestinal peptide efferent projections of the suprachiasmatic nucleus in anterior hypothalamic transplants: correlation with functional restoration of circadian behavior, Exp. Neurol. 136 (1995) 1-11.
333. P.J. Sollars, A. Ryan, M.D. Ogilvie, G.E. Pickard, Altered circadian rhythmicity in the Wocko mouse, a hyperactive transgenic mutant, Neuroreport 7 (1996) 1245-1248.
334. R. Stanewsky, M. Kaneko, P. Emery, B. Beretta, K. Wager-Smith, S.A. Kay, M. Rosbash, J.C. Hall, The cry mutation identifies cryptochrome as a circadian photoreceptor in Drosophila, Cell 95 (1998) 681-692.
335. T.D. Steeves, D.P. King, Y. Zhao, A.M. Sangoram, F. Du, A.M. Bowcock, R.Y. Moore, J.S. Takahashi, Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei, Genomics 57 (1999) 189-200.
336. F.K. Stephan, I. Zucker, Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions, Proc. Natl. Acad. Sci. USA. 69 (1972) 1583-1586.
337. E.G. Stopa, J.K. Johnson, D.I. Friedman, H.I. Ryer, J. Reidy, V.K. LeBlanc, H.E. Albers, Neuropeptide Y receptor distribution and regulation in the suprachiasmatic nucleus of the Syrian hamster (Mesocricetus auratus), Peptide Res. 8 (1995) 95-100.
338. A. Sumova, F.J.P. Ebling, E.S. Maywood, J. Herbert, M.H. Hastings, Non-photic circadian entrainment in the syrian hamster is not associated with phosphorylation of the transcriptional regulator CREB within the suprachiasmatic nucleus, but is associated with adrenocortical activation, Neuroendocrinology 59 (1994) 579-589.
339. A. Sumova, E.S. Maywood, D. Selvage, F.J.P. Ebling, M.H. Hastings, Serotonergic antagonists impair arousal-induced phase shifts of the circadian system of the Syrian hamster, Brain Res. 709 (1996) 88-96.
340. Z.S. Sun, U. Albrecht, O. Zhuchenko, J. Bailey, G. Eichele, C.C. Lee, RIGUI, a putative mammalian ortholog of the Drosophila period gene, Cell 90 (1997) 1003-1011.
341. D.F. Swaab, C.W. Pool, F. Nijveldt, Immunofluorescence of vasopressin and oxytocin in the rat hypothalamo-neurohypo-phypopseal system, J. Neural Transm. 36 (1975) 195-215.
342. H.I. Swanson, W.K. Chan, C.A. Bradfield, DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins, J. Biol. Chem. 270 (1995) 26292-26302.
343. L.W. Swanson, W.M. Cowan, E.G. Jones, An autoradiographic study of the efferent connections of the ventral lateral geniculate nucleus in the albino rat and cat, J. Comp. Neurol. 156 (1974) 143-163.
344. J.S. Takahashi, P.J. DeCoursey, L. Bauman, M. Menaker, Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms, Nature 308 (1984) 186-188.
345. Y. Takahashi, H. Okamura, N. Yanaihara, S. Hamada, S. Fujita, Y. Ibata, Vasoactive intestinal peptide immunoreactive neurons in the rat suprachiasmatic nucleus demonstrate diurnal variation, Brain Res. 497 (1989) 374-377.
346. J. Takeuchi, W. Shannon, N. Aronin, W.J. Schwartz, Compositional changes of AP-1 DNA-binding proteins are regulated by light in a mammalian clock, Neuron 11 (1993) 825-836.
347. T. Takumi, C. Matsubara, Y. Shigeyoshi, K. Taguchi, K. Yagita, Y. Maebayashi, Y. Sakakida, K. Okumura, N. Takashima, H. Oka-mura, A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus, Genes Cells 3 (1998) 167-176.
348. M. Tanaka, H. Okamura, T. Matsuda, Y. Shigeyoshi, Y. Hisa, K. Chihara, Y. Ibata, Somatostatin neurons form a distinct peptidergic neuronal group in the rat suprachiasmatic nucleus: a double labeling in situ hybridization study, Neurosci Lett. 215 (1996) 119-132.
349. H. Tei, H. Okamura, Y. Shigeyoshi, C. Fukuhara, R. Ozawa, M. Hirose, Y. Sakaki, Circadian oscillation of a mammalian homo-logue of the Drosophila period gene, Nature 389 (1997) 512-516.
350. I. Tobler, S.E. Gaus, T. DeBoer, P. Achermann, M. Fischer, T. Rulicke, M. Moser, B. Oesch, P.A. McBride, J.C. Manson, Altered circadian activity rhythms and sleep in mice devoid of prion protein, Nature 380 (1996) 639-642.
351. K. Tominaga, K. Shinohara, Y. Otori, C. Fukuhara, S.-I.T. Inouye, Circadian rhythms of vasopressin content in the suprachiasmatic nucleus of the rat, Neuroreport 3 (1992) 809-812.
352. G. Tosini, M. Menaker, Circadian rhythms in cultured mammalian retina, Science 272 (1996) 419-421.
353. J.A. Treep, H. Abe, B. Rusak, D.M. Goguen, Two distinct retinal projections to the hamster suprachiasmatic nucleus, J. Biol. Rhythms 10 (1995) 299-307.
354. T. Ueyama, K.E. Krout, X. Van Nguyen, V. Karpitskiy, A. Kollert, T.C. Mettenleiter, D. Loewy, Suprachiasmatic nucleus: a central autonomic clock, Nature Neurosci. 2 (1999) 1051-1053.
355. G.R. Uhl, S.M. Reppert, Suprachiasmatic nucleus vasopressin messenger RNA: circadian variation in normal and Brattleboro rats, Science 232 (1986) 390-393.
356. M.M. Usowicz, V. Gallo, S.G. Cull-Candy, Multiple conductance channels in type-2 cerebellar astrocytes activated by excitatory amino acids, Nature 339 (1989) 380-383.
357. A.N. van den Pol, The hypothalamic suprachiasmatic nucleus of rat: intrinsic anatomy, J. Comp. Neurol. 191 (1980) 661-702.
358. A.N. van den Pol, S.M. Finkbeiner, A.H. Cornell-Bell, Calcium excitability and oscillations in suprachiasmatic nucleus neurons and glia in vitro, J. Neurosci. 12 (1992) 2648-2664.
359. A.N. van den Pol, K.L. Tsujimoto, Neurotransmitters of the hypothalamic suprachiasmatic nucleus: immunocytochemical analysis of25 neuronal antigens, Neuroscience 15 (1985) 1049-1086.
360. E.M. van der Beek, T.L. Horvath, V.M. Wiegant, R. van den Hurk, R.M. Buijs, Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin-releasing hormone system: combined tracing and light and electron microscopic immunocytochemical studies, J. Comp. Neurol. 384 (1997) 569579.
361. G.T. van der Horst, M. Muijtjens, K. Kobayashi, R. Takano, S. Kanno, M. Takao, J. de Wit, A. Verkerk, A.P. Eker, D. van Leenen, R. Buijs, D. Bootsma, J.H. Hoeijmakers, A. Yasui, Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms, Nature 398 (1999) 627-630.
362. K.E. van Esseveldt, Transplantation of the rat suprachiasmatic nucleus. Functional studies and ex vivo adenoviral vector-mediated gene transfer (thesis), 1999, 219 pp.
363. K.E. van Esseveldt, W.T.J.M.C. Hermens, J. Verhaagen, G.J. Boer, Transgene expression in rat fetal brain grafts is maintained for 7 months after ex vivo adenoviral vector-mediated gene transfer, Neurosci. Lett. 240 (1998) 116-120.
364. K.E. van Esseveldt, R. Liu, W.T.J.M.C. Hermens, J.Verhaagen, G.J. Boer, Adenoviral vector-mediated gene transfer and neurotrans-plantation: possibilities and limitations in grafting of the fetal rat suprachiasmatic nucleus, J. Neurosci. Methods 71 (1997) 113-123.
365. K.E. van Esseveldt, B.A.M. Van der Geest, H. Duindam, W.J. Rietveld, G.J. Boer, Circadian rhythmicity of vasopressin levels in the cerebrospinal fluid of suprachiasmatic nucleus-lesioned and -grafted rats, J. Biol. Rhythms 14 (1999) 28-36.
366. O. Van Reeth, F.W. Turek, Stimulated activity mediates phase shifts in the hamster circadian clock induced by dark pulses or benzo-diazepines, Nature 339 (1989) 49-51.
367. O. Van Reeth, Y. Zhang, P.C. Zee, F.W. Turek, Grafting fetal suprachiasmatic nuclei in the hypothalamus of old hamsters restores responsiveness of the circadian clock to a phase shifting stimulus, Brain Res. 643 (1994) 338-342.
368. F. Vandesande, K. Dierickx, J. DeMey, Identification of the vasopressin-neurophysin producing neurons of the rat suprachiasmatic nuclei, Cell Tissue Res. 156 (1975) 377-380.
369. N. Viswanathan, F.C. Davis, Suprachiasmatic nucleus grafts restore circadian function in aged hamsters, Brain Res. 686 (1995) 10-16.
370. M.H. Vitaterna, D.P. King, A.-M. Chang, J.M. Kornhauser, P.L. Lowrey, J.D. McDonald, W.F. Dove, L.H. Pinto, F.W. Turek, J.S. Takahashi, Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior, Science 264 (1994) 719-725.
371. M.A. Vogelbaum, M. Menaker, Temporal chimeras produced by hypothalamic transplants, J. Neurosci. 12 (1992) 3619-3627.
372. L.B. Vosshall, J.L. Price, A. Sehgal, L. Saez, M.W. Young, Block in nuclear localization of period protein by a second clock mutation, timeless, Science 263 (1994) 1606-1609.
373. L.B. Vosshall, M.W. Young, Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells, Neuron 15 (1995) 345-400.
374. S. Wagner, M. Castel, H. Gainer, Y. Yarom, GABA in the mammalian suprachiasmatic nucleus and its role in diurnal rhythmicity, Nature 387 (1997) 598-603.
375. S.J. Watson, H. Akil, W. Fischli, A. Goldstein, E. Zimmerman, G. Nilaver, T.B. Van Wimersma Greidanus, Dynorphin and vasopres-sin coomon localization in magnocellular neurons, Science 216 (1982) 85-87.
376. A.G. Watts, The efferent projections of the suprachiasmatic nucleus: anatomical insights into the control of circadian rhythms, in: D.C. Klein, R.Y. Moore, S.M. Reppert (Eds.), Suprachiasmatic Nucleus. the Mind's Clock, Oxford University Press, New York, 1991, pp. 77-106.
377. A.G. Watts, L.W. Swanson, Efferent projections of the suprach-iasmatic nucleus: II. Studies using retrograde transport of fluorescent dyes and simultaneous peptide immunohistochemistry in the rat, J. Comp. Neurol. 258 (1987) 230-252.
378. A.G. Watts, L.W. Swanson, G. Sanchez-Watts, Efferent projections of the suprachiasmatic nucleus: I. Studies using anterograde transport of Phaseolus vulgaris leucoagglutinin in the rat, J. Comp. Neurol. 258 (1987) 204-229.
379. E.T. Weber, R.L. Gannon, M.A. Rea, cGMP-dependent protein kinase inhibitor blocks light-induced phase advances of circadian rhythms in vivo, Neurosci. Lett. 197 (1995) 227-230.
380. E.T. Weber, R.L. Gannon, M.A. Rea, Local administration of serotonin agonists blocks light-induced phase advances of the circadian activity rhythm in the hamster, J. Biol. Rhythms 13 (1998) 209-218.
381. D. Weissmann, M.F. Belin, M. Aguera, C. Meunier, M. Maitre, C.D. Cash, M. Ehret, P. Mandel, J.F. Pujol, Immunohistochemistry of tryptophan hydroxylase in the rat brain, Neuroscience 23 (1987) 291-304.
382. D.K. Welsh, D.E. Logothetis, M. Meister, S.M. Reppert, Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms, Neuron 14 (1995) 697-706.
383. D.K. Welsh, S.M. Reppert, Gap junctions couple astrocytes but not neurons in dissociated cultures of rat suprachiasmatic nucleus, Brain Res. 706 (1996) 30-36.
384. D.A. Wheeler, M.J. Hamblen-Coyle, M.S. Dushay, J.C. Hall, Behavior in light-dark cycles of Drosophila mutants that are arrhythmic, blind or both, J. Biol. Rhythms 8 (1993) 67-94.
385. C. Wickland, F.W. Turek, Lesions of the thalamic intergeniculate leaflet block activity-induced phase shifts in the circadian activity rhythm of the golden hamster, Brain Res. 660 (1994) 293-300.
386. C.R. Wickland, F.W. Turek, Phase-shifting effects of acute increases in activity on circadian locomotor rhythms in hamsters, Am. J. Physiol. 261 (1991) R1109-1117.
387. S.J. Wiegand, D.M. Gash, Organization and efferent connections of transplanted suprachiasmatic nuclei, J. Comp. Neurol. 267 (1988) 562-579.
388. F. Wollnik, S. Bihler, Strain differences in the distribution of arginine-vasopressin-and neuropeptide Y-immunoreactive neurons in the suprachiasmatic nucleus of laboratory rats, Brain Res. 724 (1996) 191-199.
389. F. Wollnik, W. Brysch, E. Uhlmann, F. Gillardon, R. Bravo, M. Zimmermann, K.H. Schlingensiepen, T. Herdegen, Block ofc-Fos and JunB expression by antisense oligonucleotides inhibits light-induced phase shifts of the mammalian circadian clock, Eur. J. Neurosci. 7 (1995) 388-393.
390. Z. Xia, H. Dudek, C.K. Miranti, M.E. Greenberg, Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism, J. Neurosci. 16 (1996) 5425-5436.
391. K. Yamase, S. Takahashi, K. Nomura, K. Haruta, S. Kawashima, Circadian changes in arginine vasopressin level in the suprach-iasmatic nuclei in the rat, Neurosci. Lett. 130 (1991) 255-258.
392. N. Yamazaki, K. Watanabe, Z. Qu, S. Yamaoka, N. Ishida, Efficient gene expression in mammalian clock pacemaker cell in vitro by an adenovirus vector, Neurosci Lett. 221 (1997) 193-196.
393. Q. Yan, E.M. Johnson, An immunohistochemical study ofthe nerve growth factor receptor in developing rats, J. Neurosci. 8 (1988) 3481-3498.
394. L. Yan, S. Takekida, Y. Shigeyoshi, H. Okamura, Per1 and Per2 gene expression in the rat suprachiasmatic nucleus: circadian profile and the compartment-specific response to light, Neuroscience 94 (1999) 141-150.
395. Y. Yang, F.A. Nunes, K. Berencsi, E.E. Furth, E. Gonczol, J.M. Wilson, Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy, Proc. Natl. Acad. Sci. USA 91 (1994) 4407-4411.
396. Z. Yang, M. Emerson, H.S. Su, A. Sehgal, Response ofthe timeless protein to light correlates with behavioral entrainment and suggests a nonvisual pathway for circadian photoreception, Neuron 21 (1998) 215-223.
397. W.S. Young, K. KOVKCS, S.J. Lolait, The diurnal rhythm in vasopressin V1a receptor expression in the suprachiasmatic nucleus is not dependent on vasopressin, Endocrinology 133 (1993) 585-670.
398. W.S. Young, K. KOVKCS, S.J. Lolait, The diurnal rhythm in vasopressin V1a receptor expression in the suprachiasmatic nucleus is not dependent on vasopressin, Endocrinology 133 (1993) 585-590.
399. Q. Yu, H.V Colot, C.P. Kyriacou, J.C. Hall, M. Rosbash, Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila, Nature 326 (1987) 765-769.
400. N. Zamir, M. Palkovits, M.J. Brownstein, Distribution of immuno-reactive dynorphin in the central nervous system of the rat, Brain Res. 280 (1983) 81-93.
401. M. Zatz, J.R. Heath, Calcium and photoentrainment in chick pineal cells revisited: effects of caffeine, thapsigargin, EGTA, and light on the melatonin rhythm, J. Neurochem. 65 (1995) 1332-1341.
402. M. Zeevi, J.R. Nevins, J.E. Darnell, Newly formed mRNA lacking polyadenylic acid enters the cytoplasm and the polyribosomes but has a shorter half-life in the absence of polyadenylic acid, Mol. Cell. Biol. 2 (1982) 517-525.
403. H. Zeng, P.E. Hardin, M. Rosbash, Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling, EMBO J. 13 (1994) 3590-3598.
404. H. Zeng, Z. Qian, M.P. Myers, M. Rosbash, A light-entrainment mechanism for the Drosophila circadian clock, Nature 380 (1996) 129-135.
405. D.M. Zerr, J.C. Hall, M. Rosbash, K.K. Siwicki, Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila, J. Neurosci. 10 (1990) 2749-2762.
406. Y. Zhang, J.M. Kornhauser, P.C. Zee, K.E. Mayo, J.S. Takahashi, F.W. Turek, Effects of aging on light-induced phase-shifting of circadian behavioral rhythms, FOS expression and CREB phos-phorylation in the hamster suprachiasmatic nucleus,. Neuroscience 70 (1996) 951-961.
407. Y. Zhang, O. Van Reeth, P.C. Zee, J.S. Takahashi, F.W. Turek, Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam, Neurosci. Lett. 164 (1993) 203-208.
408. I.V. Zhdanova, H.J. Lynch, R.J. Wurtman, Melatonin: a sleeppromoting hormone, Sleep 20 (1997) 899-907.
409. I.V. Zhdanova, R.J. Wurtman, Efficacy of melatonin as a sleeppromoting agent, J. Biol. Rhythms 12 (1997) 644-650.
410. M.J. Zylka, L.P. Shearman, J.D. Levine, X.W. Jin, D.R. Weaver, S.M. Reppert, Molecular analysis of mammalian Timeless, Neuron 21 (1998) 1115-1122.
411. M.J. Zylka, L.P. Shearman, D.R. Weaver, S.M. Reppert, Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain, Neuron 20 (1998) 1103-1110.
412. R. Silver, J. Le Sauter, P.A. Tresco, M.N. Lehman, A diffusable coupling signal from the transplanted suprachiasmatic nucleus controlling circadian motor rhytms, Nature 382 (1996) 810-813.