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Volumn 64, Issue , 2013, Pages 380-388

Association of a deficit of arousal with fatigue in multiple sclerosis: Effect of modafinil

Author keywords

Alertness; Fatigue; Modafinil; Multiple sclerosis; Sympathetic activity

Indexed keywords

GLATIRAMER; LACTOSE; MODAFINIL; PLACEBO; RECOMBINANT BETA INTERFERON;

EID: 84866383725     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.06.036     Document Type: Article
Times cited : (33)

References (90)
  • 1
    • 0030950968 scopus 로고    scopus 로고
    • Effects of clonidine and diazepam on the acoustic startle response and on its inhibition by 'prepulses' in man
    • K.A.J. Abduljawad, R.W. Langley, C.M. Bradshaw, and E. Szabadi Effects of clonidine and diazepam on the acoustic startle response and on its inhibition by 'prepulses' in man J. Psychopharmacol. 11 1997 29 34
    • (1997) J. Psychopharmacol. , vol.11 , pp. 29-34
    • Abduljawad, K.A.J.1    Langley, R.W.2    Bradshaw, C.M.3    Szabadi, E.4
  • 2
    • 67649359872 scopus 로고    scopus 로고
    • Fatigued patients with multiple sclerosis have impaired central muscle activation
    • A.K. Andreasen, J. Jakobsen, T. Petersen, and H. Andersen Fatigued patients with multiple sclerosis have impaired central muscle activation Mult. Scler. 15 2009 818 827
    • (2009) Mult. Scler. , vol.15 , pp. 818-827
    • Andreasen, A.K.1    Jakobsen, J.2    Petersen, T.3    Andersen, H.4
  • 4
    • 0038518191 scopus 로고    scopus 로고
    • Fatigue associated with multiple sclerosis: Diagnosis, impact and management
    • R. Bakshi Fatigue associated with multiple sclerosis: diagnosis, impact and management Mult. Scler. 9 2003 219 227
    • (2003) Mult. Scler. , vol.9 , pp. 219-227
    • Bakshi, R.1
  • 6
    • 33646768643 scopus 로고    scopus 로고
    • A systematic review of modafinil: Potential clinical uses and mechanisms of action
    • J.S. Ballon, and D. Feifel A systematic review of modafinil: potential clinical uses and mechanisms of action J. Clin. Psychiatry 67 2006 554 566
    • (2006) J. Clin. Psychiatry , vol.67 , pp. 554-566
    • Ballon, J.S.1    Feifel, D.2
  • 7
    • 0029803149 scopus 로고    scopus 로고
    • Comparison of Beck depression Inventories-IA and -II in psychiatric outpatients
    • A.T. Beck, R.A. Steer, R. Ball, and W.F. Ranieri Comparison of Beck depression Inventories-IA and -II in psychiatric outpatients J. Personality Assess. 67 1996 588 597
    • (1996) J. Personality Assess. , vol.67 , pp. 588-597
    • Beck, A.T.1    Steer, R.A.2    Ball, R.3    Ranieri, W.F.4
  • 8
    • 0037782268 scopus 로고    scopus 로고
    • Cognitive dysfunction in multiple sclerosis: A review of recent developments
    • J.A. Bobholz, and S.M. Rao Cognitive dysfunction in multiple sclerosis: a review of recent developments Curr. Opin. Neurol. 16 2003 283 288
    • (2003) Curr. Opin. Neurol. , vol.16 , pp. 283-288
    • Bobholz, J.A.1    Rao, S.M.2
  • 9
    • 84987469571 scopus 로고
    • The use of analogue scales in rating subjective feelings
    • A. Bond, and M. Lader The use of analogue scales in rating subjective feelings Brit. J. Med. Psychol. 47 1974 211 218
    • (1974) Brit. J. Med. Psychol. , vol.47 , pp. 211-218
    • Bond, A.1    Lader, M.2
  • 10
    • 77955618678 scopus 로고    scopus 로고
    • Fatigue in multiple sclerosis: Mechanisms, evaluation, and treatment
    • T.J. Braley, and R.D. Chervin Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment Sleep 33 2010 1061 1067
    • (2010) Sleep , vol.33 , pp. 1061-1067
    • Braley, T.J.1    Chervin, R.D.2
  • 14
    • 0035077361 scopus 로고    scopus 로고
    • Physiopathology and treatment of fatigue in multiple sclerosis
    • G. Comi, L. Leocani, P. Rossi, and B. Colombo Physiopathology and treatment of fatigue in multiple sclerosis J. Neurol. 248 2001 174 179
    • (2001) J. Neurol. , vol.248 , pp. 174-179
    • Comi, G.1    Leocani, L.2    Rossi, P.3    Colombo, B.4
  • 15
    • 79959838445 scopus 로고    scopus 로고
    • Orexin A (hypocretin-1) levels are not reduced while cocaine/amphetamine regulated transcript levels are increased in the cerebrospinal fluid of patients with multiple sclerosis: No correlation with fatigue and sleepiness
    • C.S. Constantinescu, G. Niepel, M. Patterson, A. Judd, M. Braitch, A.J. Fahey, S. Harikrishnan, L.J. Edwards, C.R. Tench, G.W. Bennett, and M. Ghatei Orexin A (hypocretin-1) levels are not reduced while cocaine/amphetamine regulated transcript levels are increased in the cerebrospinal fluid of patients with multiple sclerosis: no correlation with fatigue and sleepiness J. Neurol. Sci. 307 2011 127 131
    • (2011) J. Neurol. Sci. , vol.307 , pp. 127-131
    • Constantinescu, C.S.1    Niepel, G.2    Patterson, M.3    Judd, A.4    Braitch, M.5    Fahey, A.J.6    Harikrishnan, S.7    Edwards, L.J.8    Tench, C.R.9    Bennett, G.W.10    Ghatei, M.11
  • 16
    • 0142182000 scopus 로고    scopus 로고
    • Tiredness versus sleepiness: Semantics or a target for public education?
    • W.C. Dement, J. Hall, and J.K. Walsh Tiredness versus sleepiness: semantics or a target for public education? Sleep 26 2003 485 486
    • (2003) Sleep , vol.26 , pp. 485-486
    • Dement, W.C.1    Hall, J.2    Walsh, J.K.3
  • 17
    • 0022626585 scopus 로고
    • Activation of the locus coeruleus induced by selective stimulation of the ventral tegmental area
    • A.Y. Deutch, M. Goldstein, and R.H. Roth Activation of the locus coeruleus induced by selective stimulation of the ventral tegmental area Brain Res. 363 1986 307 314
    • (1986) Brain Res. , vol.363 , pp. 307-314
    • Deutch, A.Y.1    Goldstein, M.2    Roth, R.H.3
  • 18
    • 0028870448 scopus 로고
    • Sympathetic skin response (SSR) is abnormal in multiple sclerosis
    • B. Elie, and J.P. Louboutin Sympathetic skin response (SSR) is abnormal in multiple sclerosis Muscle Nerve 18 1995 185 189
    • (1995) Muscle Nerve , vol.18 , pp. 185-189
    • Elie, B.1    Louboutin, J.P.2
  • 19
    • 0001771444 scopus 로고
    • Analysis of heart rate variability and other non-invasive tests with special reference to diabetes mellitus
    • R. Bannister, C.J. Mathias, third ed. Oxford University Press Oxford
    • D.J. Ewing Analysis of heart rate variability and other non-invasive tests with special reference to diabetes mellitus R. Bannister, C.J. Mathias, Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System third ed. 1992 Oxford University Press Oxford 667 689
    • (1992) Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System , pp. 667-689
    • Ewing, D.J.1
  • 20
    • 0031574307 scopus 로고    scopus 로고
    • Modafinil: An antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers
    • L. Ferraro, T. Antonelli, W.T. O'Connor, S. Tanganelli, F.A. Rambert, and K. Fuxe Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers Biol. Psychiatry 42 1997 1181 1183
    • (1997) Biol. Psychiatry , vol.42 , pp. 1181-1183
    • Ferraro, L.1    Antonelli, T.2    O'Connor, W.T.3    Tanganelli, S.4    Rambert, F.A.5    Fuxe, K.6
  • 21
    • 0027955307 scopus 로고
    • Measuring the functional impact of fatigue: Initial validation of the fatigue impact scale
    • J. Fisk, P. Ritvo, L. Ross, D. Haase, T. Marrie, and W. Schlech Measuring the functional impact of fatigue: initial validation of the fatigue impact scale Clin. Infect. Dis. 8 1994 S79 S83
    • (1994) Clin. Infect. Dis. , vol.8
    • Fisk, J.1    Ritvo, P.2    Ross, L.3    Haase, D.4    Marrie, T.5    Schlech, W.6
  • 22
    • 0036102082 scopus 로고    scopus 로고
    • Construction and validation of a fatigue impact scale for daily administration (D-FIS)
    • J.D. Fisk, and S.E. Doble Construction and validation of a fatigue impact scale for daily administration (D-FIS) Qual. of Life Res. 11 2002 263 272
    • (2002) Qual. of Life Res. , vol.11 , pp. 263-272
    • Fisk, J.D.1    Doble, S.E.2
  • 26
    • 34547653184 scopus 로고    scopus 로고
    • Mechanisms of modafinil: A review of current research
    • P. Gerrard, and R. Malcolm Mechanisms of modafinil: a review of current research Neuropsychiatr. Dis. Treat. 3 2007 349 364
    • (2007) Neuropsychiatr. Dis. Treat. , vol.3 , pp. 349-364
    • Gerrard, P.1    Malcolm, R.2
  • 27
    • 0342628997 scopus 로고    scopus 로고
    • Mood disorder
    • E.C. Johnstone, C.P.L. Freeman, A.K. Zealley, sixth ed. Churchill Livingstone Edinburgh
    • G. Goodwin Mood disorder E.C. Johnstone, C.P.L. Freeman, A.K. Zealley, Companion to Psychiatric Studies sixth ed. 1998 Churchill Livingstone Edinburgh 399 430
    • (1998) Companion to Psychiatric Studies , pp. 399-430
    • Goodwin, G.1
  • 28
    • 32544442650 scopus 로고    scopus 로고
    • Autonomic dysfunction in multiple sclerosis
    • C.A. Haensch, and J. Jörg Autonomic dysfunction in multiple sclerosis J. Neurol. 253 Suppl. 1 2006 I3 I9
    • (2006) J. Neurol. , vol.253 , Issue.SUPPL. 1
    • Haensch, C.A.1    Jörg, J.2
  • 29
    • 0018848762 scopus 로고
    • Psychomotor function and psychoactive drugs
    • I. Hindmarch Psychomotor function and psychoactive drugs Brit. J. Clin. Pharmacol. 10 1980 189 209
    • (1980) Brit. J. Clin. Pharmacol. , vol.10 , pp. 189-209
    • Hindmarch, I.1
  • 31
    • 26944450025 scopus 로고    scopus 로고
    • Does modafinil activate the locus coeruleus in man? Comparison of modafinil and clonidine on arousal and autonomic functions in human volunteers
    • R. Hou, C. Freeman, R. Langley, E. Szabadi, and C. Bradshaw Does modafinil activate the locus coeruleus in man? Comparison of modafinil and clonidine on arousal and autonomic functions in human volunteers Psychopharmacology 181 2005 537 549
    • (2005) Psychopharmacology , vol.181 , pp. 537-549
    • Hou, R.1    Freeman, C.2    Langley, R.3    Szabadi, E.4    Bradshaw, C.5
  • 32
    • 34748868985 scopus 로고    scopus 로고
    • Comparison of diphenhydramine and modafinil on arousal and autonomic functions in healthy volunteers
    • R.H. Hou, R.W. Langley, E. Szabadi, and C.M. Bradshaw Comparison of diphenhydramine and modafinil on arousal and autonomic functions in healthy volunteers J. Psychopharmacol. 21 2007 567 578
    • (2007) J. Psychopharmacol. , vol.21 , pp. 567-578
    • Hou, R.H.1    Langley, R.W.2    Szabadi, E.3    Bradshaw, C.M.4
  • 33
    • 77956296410 scopus 로고    scopus 로고
    • Modafinil activates the histaminergic system through the orexinergic neurons
    • T. Ishikuza, T. Murotani, and A. Yamatodani Modafinil activates the histaminergic system through the orexinergic neurons Neurosci. Lett. 483 2010 193 196
    • (2010) Neurosci. Lett. , vol.483 , pp. 193-196
    • Ishikuza, T.1    Murotani, T.2    Yamatodani, A.3
  • 34
    • 84861466610 scopus 로고    scopus 로고
    • Action of modafinil through histaminergic and orexinergic neurons
    • T. Ishikuza, T. Murotani, and A. Yamatodani Action of modafinil through histaminergic and orexinergic neurons Vitam. Horm. 89 2012 259 278
    • (2012) Vitam. Horm. , vol.89 , pp. 259-278
    • Ishikuza, T.1    Murotani, T.2    Yamatodani, A.3
  • 35
    • 0037457359 scopus 로고    scopus 로고
    • Modafinil increases histamine release in the anterior hypothalamus of rats
    • T. Ishikuza, Y. Sakamoto, T. Sakurai, and A. Yamatodani Modafinil increases histamine release in the anterior hypothalamus of rats Neurosci. Lett. 339 2003 143 146
    • (2003) Neurosci. Lett. , vol.339 , pp. 143-146
    • Ishikuza, T.1    Sakamoto, Y.2    Sakurai, T.3    Yamatodani, A.4
  • 36
    • 0037116191 scopus 로고    scopus 로고
    • Quality of life in patients with multiple sclerosis: The impact of fatigue and depression
    • V. Janardhan, and R. Bakshi Quality of life in patients with multiple sclerosis: the impact of fatigue and depression J. Neurol. Sci. 205 2002 51 58
    • (2002) J. Neurol. Sci. , vol.205 , pp. 51-58
    • Janardhan, V.1    Bakshi, R.2
  • 37
    • 0026333617 scopus 로고
    • A new method for measuring daytime sleepiness: The Epworth sleepiness scale
    • M.W. Johns A new method for measuring daytime sleepiness: the Epworth sleepiness scale Sleep 14 1991 540 545
    • (1991) Sleep , vol.14 , pp. 540-545
    • Johns, M.W.1
  • 38
    • 79951514673 scopus 로고    scopus 로고
    • Sleep disorders and fatigue in multiple sclerosis: Evidence for association and interaction
    • M. Kaminska, R.J. Kimoff, K. Schwartzman, and D.A. Trojan Sleep disorders and fatigue in multiple sclerosis: evidence for association and interaction J. Neurol. Sci. 302 2011 7 13
    • (2011) J. Neurol. Sci. , vol.302 , pp. 7-13
    • Kaminska, M.1    Kimoff, R.J.2    Schwartzman, K.3    Trojan, D.A.4
  • 41
    • 0024420189 scopus 로고
    • The fatigue severity scale: Application to patients with multiple sclerosis and systemic lupus erythematosus
    • L.B. Krupp, N.G. LaRocca, J. Muir-Nash, and A.D. Steinberg The fatigue severity scale: application to patients with multiple sclerosis and systemic lupus erythematosus Arch. Neurol. 46 1989 1121 1123
    • (1989) Arch. Neurol. , vol.46 , pp. 1121-1123
    • Krupp, L.B.1    Larocca, N.G.2    Muir-Nash, J.3    Steinberg, A.D.4
  • 42
    • 67349149115 scopus 로고    scopus 로고
    • Modafinil effects in multiple sclerosis patients with fatigue
    • R. Lange, M. Volkmer, C. Heesen, and J. Liepert Modafinil effects in multiple sclerosis patients with fatigue J. Neurol. 256 2009 645 650
    • (2009) J. Neurol. , vol.256 , pp. 645-650
    • Lange, R.1    Volkmer, M.2    Heesen, C.3    Liepert, J.4
  • 43
    • 53649111186 scopus 로고    scopus 로고
    • Physiopathology of fatigue in multiple sclerosis
    • L. Leocani, B. Colombo, and G. Comi Physiopathology of fatigue in multiple sclerosis Neurol. Sci. 29 2008 241 243
    • (2008) Neurol. Sci. , vol.29 , pp. 241-243
    • Leocani, L.1    Colombo, B.2    Comi, G.3
  • 47
    • 30644460902 scopus 로고    scopus 로고
    • Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter
    • J. Lu, T.C. Jhou, and C.B. Saper Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter J. Neurosci. 26 2006 193 202
    • (2006) J. Neurosci. , vol.26 , pp. 193-202
    • Lu, J.1    Jhou, T.C.2    Saper, C.B.3
  • 48
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: Results of an international survey. National multiple sclerosis society (USA) advisory committee on clinical trials of new agents in multiple sclerosis
    • F.D. Lublin, and S.C. Reingold Defining the clinical course of multiple sclerosis: results of an international survey. National multiple sclerosis society (USA) advisory committee on clinical trials of new agents in multiple sclerosis Neurology 46 1996 907 911
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 49
    • 18344409275 scopus 로고    scopus 로고
    • Mathematical procedures in data recording and processing of pupillary fatigue waves
    • H. Lüdtke, B. Wilhelm, M. Adler, F. Schaeffel, and H. Wilhelm Mathematical procedures in data recording and processing of pupillary fatigue waves Vis. Res. 38 1998 2889 2896
    • (1998) Vis. Res. , vol.38 , pp. 2889-2896
    • Lüdtke, H.1    Wilhelm, B.2    Adler, M.3    Schaeffel, F.4    Wilhelm, H.5
  • 51
    • 33751186720 scopus 로고    scopus 로고
    • Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro
    • B.K. Madras, Z. Xie, Z. Lin, A. Jassen, H. Panas, and L. Lynch Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro J. Pharmacol. Exp. Ther. 319 2006 561 569
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 561-569
    • Madras, B.K.1    Xie, Z.2    Lin, Z.3    Jassen, A.4    Panas, H.5    Lynch, L.6
  • 53
    • 0142089809 scopus 로고    scopus 로고
    • Autonomic nervous system function in multiple sclerosis
    • A.J. McDougall, and J.G. McLeod Autonomic nervous system function in multiple sclerosis J. Neurol. Sci. 215 2003 79 85
    • (2003) J. Neurol. Sci. , vol.215 , pp. 79-85
    • McDougall, A.J.1    McLeod, J.G.2
  • 55
    • 77949446396 scopus 로고    scopus 로고
    • Development of a patient reported outcome scale for fatigue in multiple sclerosis: The neurological fatigue index (NFI-MS)
    • R. Mills, C. Young, J. Pallant, and A. Tennant Development of a patient reported outcome scale for fatigue in multiple sclerosis: the neurological fatigue index (NFI-MS) Health Quality Life Outcomes 8 2010 22
    • (2010) Health Quality Life Outcomes , vol.8 , pp. 22
    • Mills, R.1    Young, C.2    Pallant, J.3    Tennant, A.4
  • 56
    • 43649090464 scopus 로고    scopus 로고
    • Modafinil: A review of neurochemical actions and effects on cognition
    • M.J. Minzenberg, and C.S. Carter Modafinil: a review of neurochemical actions and effects on cognition Neuropsychopharmacology 33 2008 1477 1502
    • (2008) Neuropsychopharmacology , vol.33 , pp. 1477-1502
    • Minzenberg, M.J.1    Carter, C.S.2
  • 57
    • 58149312741 scopus 로고    scopus 로고
    • Modafinil shifts human locus coeruleus to low-tonic, high-phasic activity during functional MRI
    • M.J. Minzenberg, A.J. Watrous, J.H. Yoon, S. Ursu, and C.S. Carter Modafinil shifts human locus coeruleus to low-tonic, high-phasic activity during functional MRI Science 322 2008 1700 1702
    • (2008) Science , vol.322 , pp. 1700-1702
    • Minzenberg, M.J.1    Watrous, A.J.2    Yoon, J.H.3    Ursu, S.4    Carter, C.S.5
  • 58
    • 80052010239 scopus 로고    scopus 로고
    • HAGIL (Hamburg Vigil Study): A randomized placebo-controlled double-blind study with modafinil for treatment of fatigue in patients with multiple sclerosis
    • F. Möller, J. Poettgen, F. Broemel, A. Neuhaus, M. Daumer, and C. Heesen HAGIL (Hamburg Vigil Study): a randomized placebo-controlled double-blind study with modafinil for treatment of fatigue in patients with multiple sclerosis Mult. Scler. 17 2011 1002 1009
    • (2011) Mult. Scler. , vol.17 , pp. 1002-1009
    • Möller, F.1    Poettgen, J.2    Broemel, F.3    Neuhaus, A.4    Daumer, M.5    Heesen, C.6
  • 60
    • 34547815646 scopus 로고    scopus 로고
    • Symptoms of autonomic dysfunction in chronic fatigue syndrome
    • J.L. Newton, O. Okonkwo, K. Sutcliffe, A. Seth, J. Shin, and D.E. Jones Symptoms of autonomic dysfunction in chronic fatigue syndrome QJM 100 2007 519 526
    • (2007) QJM , vol.100 , pp. 519-526
    • Newton, J.L.1    Okonkwo, O.2    Sutcliffe, K.3    Seth, A.4    Shin, J.5    Jones, D.E.6
  • 61
    • 33748876619 scopus 로고    scopus 로고
    • Utility of the National Eye Institute VFQ-25 questionnaire in a heterogeneous group of multiple sclerosis patients
    • J. Noble, F. Forooghian, M. Sproule, C. Westall, and P. O'Connor Utility of the National Eye Institute VFQ-25 questionnaire in a heterogeneous group of multiple sclerosis patients Am. J. Ophthalmol. 142 2006 464 468
    • (2006) Am. J. Ophthalmol. , vol.142 , pp. 464-468
    • Noble, J.1    Forooghian, F.2    Sproule, M.3    Westall, C.4    O'Connor, P.5
  • 62
    • 0015032067 scopus 로고
    • The action of sedatives on brain stem oculomotor systems in man
    • H. Norris The action of sedatives on brain stem oculomotor systems in man Neuropharmacology 10 1971 181 191
    • (1971) Neuropharmacology , vol.10 , pp. 181-191
    • Norris, H.1
  • 63
    • 79952147737 scopus 로고    scopus 로고
    • Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis
    • P.E. Polak, S. Kalinin, and D.L. Feinstein Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis Brain 134 2011 665 677
    • (2011) Brain , vol.134 , pp. 665-677
    • Polak, P.E.1    Kalinin, S.2    Feinstein, D.L.3
  • 64
    • 1042279528 scopus 로고    scopus 로고
    • Fatigue in multiple sclerosis: Is the picture getting simpler or more complex?
    • M.K. Racke, K. Hawker, and E.M. Frohman Fatigue in multiple sclerosis: is the picture getting simpler or more complex? Arch. Neurol. 61 2004 176 177
    • (2004) Arch. Neurol. , vol.61 , pp. 176-177
    • Racke, M.K.1    Hawker, K.2    Frohman, E.M.3
  • 66
    • 23944459442 scopus 로고    scopus 로고
    • Cognitive function in patients with multiple sclerosis: Impairment and treatment
    • S.M. Rao Cognitive function in patients with multiple sclerosis: impairment and treatment Int. J. MS Care 1 2004 9 22
    • (2004) Int. J. MS Care , vol.1 , pp. 9-22
    • Rao, S.M.1
  • 68
    • 35348857531 scopus 로고    scopus 로고
    • Modulation of the acoustic startle response by the level of arousal: Comparison of clonidine and modafinil in healthy volunteers
    • E.R. Samuels, R.H. Hou, R.W. Langley, E. Szabadi, and C.M. Bradshaw Modulation of the acoustic startle response by the level of arousal: comparison of clonidine and modafinil in healthy volunteers Neuropsychopharmacology 32 2007 2405 2421
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2405-2421
    • Samuels, E.R.1    Hou, R.H.2    Langley, R.W.3    Szabadi, E.4    Bradshaw, C.M.5
  • 69
    • 53249095795 scopus 로고    scopus 로고
    • Functional neuroanatomy of the noradrenergic locus coeruleus: Its roles in the regulation of arousal and autonomic function. Part II: Physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans
    • E.R. Samuels, and E. Szabadi Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function. Part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans Curr. Neuropharmacol 6 2008 254 285
    • (2008) Curr. Neuropharmacol , vol.6 , pp. 254-285
    • Samuels, E.R.1    Szabadi, E.2
  • 70
    • 21344446806 scopus 로고    scopus 로고
    • Abnormal heart rate and blood pressure responses to baroreflex stimulation in multiple sclerosis
    • E.O. Sanya, M. Tutaj, C.M. Brown, N. Goel, B. Neundorfer, and M.J. Hilz Abnormal heart rate and blood pressure responses to baroreflex stimulation in multiple sclerosis Clin. Auton. Res. 15 2005 213 218
    • (2005) Clin. Auton. Res. , vol.15 , pp. 213-218
    • Sanya, E.O.1    Tutaj, M.2    Brown, C.M.3    Goel, N.4    Neundorfer, B.5    Hilz, M.J.6
  • 71
    • 2442678139 scopus 로고    scopus 로고
    • Modafinil: A drug in search of a mechanism
    • C.B. Saper, and T.E. Scammell Modafinil: a drug in search of a mechanism Sleep 27 2004 11 12
    • (2004) Sleep , vol.27 , pp. 11-12
    • Saper, C.B.1    Scammell, T.E.2
  • 73
    • 0017134135 scopus 로고
    • Critical flicker frequency (CFF) and psychotropic drugs in normal human subjects. A review
    • J.M. Smith, and H. Misiak Critical flicker frequency (CFF) and psychotropic drugs in normal human subjects. A review Psychopharmacology 47 1976 175 182
    • (1976) Psychopharmacology , vol.47 , pp. 175-182
    • Smith, J.M.1    Misiak, H.2
  • 75
    • 33646924810 scopus 로고    scopus 로고
    • Drugs for sleep disorders: Mechanisms and therapeutic prospects
    • E. Szabadi Drugs for sleep disorders: mechanisms and therapeutic prospects Brit. J. Clin. Pharmacol. 61 2006 761 766
    • (2006) Brit. J. Clin. Pharmacol. , vol.61 , pp. 761-766
    • Szabadi, E.1
  • 76
    • 84866422371 scopus 로고    scopus 로고
    • Effects of modafinil on measures of alertness and psychomotor functions in multiple sclerosis
    • Abstract Supplement to
    • E. Szabadi, G. Niepel, J. Vilisaar, R.W. Langley, C. Constantinescu, and C.M. Bradshaw Effects of modafinil on measures of alertness and psychomotor functions in multiple sclerosis J. Psychopharmacol. 22 5 2008 A33 Abstract Supplement to
    • (2008) J. Psychopharmacol. , vol.22 , Issue.5 , pp. 33
    • Szabadi, E.1    Niepel, G.2    Vilisaar, J.3    Langley, R.W.4    Constantinescu, C.5    Bradshaw, C.M.6
  • 78
    • 84866403865 scopus 로고    scopus 로고
    • Stimulants: Mechanisms and therapeutic prospects
    • S.R. Pandi-Perumal, J.C. Verster, J.M. Monti, M. Lader, S.Z. Langer, Informa Healthcare UK London
    • E. Szabadi, and E.R. Samuels Stimulants: mechanisms and therapeutic prospects S.R. Pandi-Perumal, J.C. Verster, J.M. Monti, M. Lader, S.Z. Langer, Sleep Disorders: Diagnostics and Therapeutics 2008 Informa Healthcare UK London 281 294
    • (2008) Sleep Disorders: Diagnostics and Therapeutics , pp. 281-294
    • Szabadi, E.1    Samuels, E.R.2
  • 83
    • 0002699705 scopus 로고
    • Intraneural recordings of normal and abnormal sympathetic activity in man
    • R. Bannister, C.J. Mathias, third ed. Oxford University Press Oxford
    • B.G. Wallin Intraneural recordings of normal and abnormal sympathetic activity in man R. Bannister, C.J. Mathias, Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System third ed. 1992 Oxford University Press Oxford 359 377
    • (1992) Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System , pp. 359-377
    • Wallin, B.G.1
  • 87
    • 0014800605 scopus 로고
    • Pupil size and spontaneous pupillary waves associated with alertness, drowsiness, and sleep
    • R.E. Yoss, N.J. Moyer, and R.W. Hollenhorst Pupil size and spontaneous pupillary waves associated with alertness, drowsiness, and sleep Neurology 20 1970 545 554
    • (1970) Neurology , vol.20 , pp. 545-554
    • Yoss, R.E.1    Moyer, N.J.2    Hollenhorst, R.W.3
  • 88
    • 3142734448 scopus 로고    scopus 로고
    • Management of fatigue in patients with multiple sclerosis
    • U.A. Zifko Management of fatigue in patients with multiple sclerosis Drugs 64 2004 1295 1304
    • (2004) Drugs , vol.64 , pp. 1295-1304
    • Zifko, U.A.1
  • 89
    • 0036038978 scopus 로고    scopus 로고
    • Modafinil in treatment of fatigue in multiple sclerosis - Results of an open-label study
    • U.A. Zifko, M. Rupp, S. Schwarz, H.T. Zipko, and E.M. Maida Modafinil in treatment of fatigue in multiple sclerosis - results of an open-label study J. Neurol. 249 2002 983 987
    • (2002) J. Neurol. , vol.249 , pp. 983-987
    • Zifko, U.A.1    Rupp, M.2    Schwarz, S.3    Zipko, H.T.4    Maida, E.M.5


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