메뉴 건너뛰기




Volumn 10, Issue 4, 2010, Pages 254-266

Translational control in cancer

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 2ALPHA; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MESSENGER RNA; PP 242; RAPAMYCIN; UNCLASSIFIED DRUG; WYE 132;

EID: 77950002202     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2824     Document Type: Review
Times cited : (682)

References (148)
  • 1
    • 0003288676 scopus 로고
    • Beitrag zur histologie und Aetiologie der carcinoma histologische und experimentelle
    • Pianese, G. Beitrag zur histologie und Aetiologie der carcinoma histologische und experimentelle. Beitr. Pathol. Anat. Allgem. Pathol. 142, 1-193 (1896).
    • (1896) Beitr. Pathol. Anat. Allgem. Pathol. , vol.142 , pp. 1-193
    • Pianese, G.1
  • 2
    • 0017235694 scopus 로고
    • The nucleoli of cultured human lymphocytes. I. Nucleolar morphology in relation to transformation and the DNA cycle
    • Gani, R. The nucleoli of cultured human lymphocytes. I. Nucleolar morphology in relation to transformation and the DNA cycle. Exp. Cell Res. 97, 249-258 (1976).
    • (1976) Exp. Cell Res. , Issue.97 , pp. 249-258
    • Gani, R.1
  • 3
    • 0017152766 scopus 로고
    • Changes in RNA in relation to growth of the fibroblast. IV. Alterations in theproduction and processing of mRNA and rRNA in resting and growing cells
    • Johnson, L. F., Levis, R., Abelson, H. T., Green, H. & Penman, S. Changes in RNA in relation to growth of the fibroblast. IV. Alterations in theproduction and processing of mRNA and rRNA in resting and growing cells. J. Cell Biol. 71, 933-938 (1976).
    • (1976) J. Cell Biol. , vol.71 , pp. 933-938
    • Johnson, L.F.1    Levis, R.2    Abelson, H.T.3    Green, H.4    Penman, S.5
  • 5
    • 57749187631 scopus 로고    scopus 로고
    • Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency
    • Barna, M. et al. Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature 456, 971-975 (2008).
    • (2008) Nature , vol.456 , pp. 971-975
    • Barna, M.1
  • 6
    • 0017291166 scopus 로고
    • Effect of cell proliferation on levels and diversity of poly(A)-containing mRNA
    • Getz, M. J., Elder, P. K., Benz, E. W. Jr, Stephens, R. E. & Moses, H. L. Effect of cell proliferation on levels and diversity of poly(A)-containing mRNA. Cell 7, 255-265 (1976).
    • (1976) Cell , vol.7 , pp. 255-265
    • Getz, M.J.1    Elder, P.K.2    Benz Jr., E.W.3    Stephens, R.E.4    Moses, H.L.5
  • 7
    • 33646550165 scopus 로고    scopus 로고
    • Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells
    • Connolly, E., Braunstein, S., Formenti, S. & Schneider, R. J. Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol. Cell. Biol. 26, 3955-3965 (2006).
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 3955-3965
    • Connolly, E.1    Braunstein, S.2    Formenti, S.3    Schneider, R.J.4
  • 8
    • 32544446451 scopus 로고    scopus 로고
    • Coping with stress: EIF2 kinases and translational control
    • Wek, R. C., Jiang, H. Y. & Anthony, T. G. Coping with stress: eIF2 kinases and translational control. Biochem. Soc. Trans. 34, 7-11 (2006).
    • (2006) Biochem. Soc. Trans. , vol.34 , pp. 7-11
    • Wek, R.C.1    Jiang, H.Y.2    Anthony, T.G.3
  • 9
    • 0029118217 scopus 로고
    • Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells
    • Donze, O., Jagus, R., Koromilas, A. E., Hershey, J. W. & Sonenberg, N. Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J. 14, 3828-3834 (1995).
    • (1995) EMBO J. , vol.14 , pp. 3828-3834
    • Donze, O.1    Jagus, R.2    Koromilas, A.E.3    Hershey, J.W.4    Sonenberg, N.5
  • 10
    • 0026701570 scopus 로고
    • Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase
    • Koromilas, A. E., Roy, S., Barber, G. N., Katze, M. G. & Sonenberg, N. Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science 257, 1685-1689 (1992).
    • (1992) Science , vol.257 , pp. 1685-1689
    • Koromilas, A.E.1    Roy, S.2    Barber, G.N.3    Katze, M.G.4    Sonenberg, N.5
  • 11
    • 66149125713 scopus 로고    scopus 로고
    • Eukaryotic initiation factors (eIF) 2α and 4E expression, localization, and phosphorylation in brain tumors
    • Tejada, S. et al. Eukaryotic initiation factors (eIF) 2α and 4E expression, localization, and phosphorylation in brain tumors. J. Histochem. Cytochem. 57, 503-512 (2009).
    • (2009) J. Histochem. Cytochem. , vol.57 , pp. 503-512
    • Tejada, S.1
  • 12
    • 0033605371 scopus 로고    scopus 로고
    • Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase
    • Abraham, N. et al. Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J. Biol. Chem. 274, 5953-5962 (1999).
    • (1999) PKR. J. Biol. Chem. , vol.274 , pp. 5953-5962
    • Abraham, N.1
  • 13
    • 0029590069 scopus 로고
    • Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase
    • Yang, Y. L. et al. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J. 14, 6095-6106 (1995).
    • (1995) EMBO J. , vol.14 , pp. 6095-6106
    • Yang, Y.L.1
  • 14
    • 27144458505 scopus 로고    scopus 로고
    • ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
    • Bi, M. et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J. 24, 3470-3481 (2005).
    • (2005) EMBO J. , vol.24 , pp. 3470-3481
    • Bi, M.1
  • 15
    • 33644852277 scopus 로고    scopus 로고
    • Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
    • Koritzinsky, M. et al. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J. 25, 1114-1125 (2006).
    • (2006) EMBO J. , vol.25 , pp. 1114-1125
    • Koritzinsky, M.1
  • 16
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • Wouters, B. G. & Koritzinsky, M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nature Rev. Cancer 8, 851-864 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 17
    • 60549106248 scopus 로고    scopus 로고
    • Inhibition of eIF2α dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy
    • Schewe, D. M. & Aguirre-Ghiso, J. A. Inhibition of eIF2α dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. Cancer Res. 69, 1545-1552 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 1545-1552
    • Schewe, D.M.1    Aguirre-Ghiso, J.A.2
  • 18
    • 33748042296 scopus 로고    scopus 로고
    • Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer
    • Dong, Z. & Zhang, J. T. Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer. Crit. Rev. Oncol. Hematol. 59, 169-180 (2006).
    • (2006) Crit. Rev. Oncol. Hematol. , vol.59 , pp. 169-180
    • Dong, Z.1    Zhang, J.T.2
  • 19
    • 34247165835 scopus 로고    scopus 로고
    • Individual overexpression of five subunits of human translation initiation factor eIF3 promotes malignant transformation of immortal fibroblast cells
    • Zhang, L., Pan, X. & Hershey, J. W. Individual overexpression of five subunits of human translation initiation factor eIF3 promotes malignant transformation of immortal fibroblast cells. J. Biol. Chem. 282, 5790-5800 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 5790-5800
    • Zhang, L.1    Pan, X.2    Hershey, J.W.3
  • 20
    • 2342656309 scopus 로고    scopus 로고
    • Role of eIF3 p170 in controlling synthesis of ribonucleotide reductase M2 and cell growth
    • Dong, Z., Liu, L. H., Han, B., Pincheira, R. & Zhang, J. T. Role of eIF3 p170 in controlling synthesis of ribonucleotide reductase M2 and cell growth. Oncogene 23, 3790-3801 (2004).
    • (2004) Oncogene , vol.23 , pp. 3790-3801
    • Dong, Z.1    Liu, L.H.2    Han, B.3    Pincheira, R.4    Zhang, J.T.5
  • 21
    • 0141521573 scopus 로고    scopus 로고
    • EIF3 p170, a mediator of mimosine effect on protein synthesis and cell cycle progression
    • Dong, Z. & Zhang, J. T. EIF3 p170, a mediator of mimosine effect on protein synthesis and cell cycle progression. Mol. Biol. Cell 14, 3942-3951 (2003).
    • (2003) Mol. Biol. Cell , vol.14 , pp. 3942-3951
    • Dong, Z.1    Zhang, J.T.2
  • 22
    • 33645119208 scopus 로고    scopus 로고
    • Schwannomin inhibits tumorigenesis through direct interaction with the eukaryotic initiation factor subunit c (eIF3c)
    • Scoles, D. R., Yong, W. H., Qin, Y., Wawrowsky, K. & Pulst, S. M. Schwannomin inhibits tumorigenesis through direct interaction with the eukaryotic initiation factor subunit c (eIF3c). Hum. Mol. Genet. 15, 1059-1070 (2006).
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1059-1070
    • Scoles, D.R.1    Yong, W.H.2    Qin, Y.3    Wawrowsky, K.4    Pulst, S.M.5
  • 23
    • 0033052411 scopus 로고    scopus 로고
    • Amplification and overexpression of p40 subunit of eukaryotic translation initiation factor 3 in breast and prostate cancer
    • Nupponen, N. N. et al. Amplification and overexpression of p40 subunit of eukaryotic translation initiation factor 3 in breast and prostate cancer. Am. J. Pathol. 154, 1777-1783 (1999).
    • (1999) Am. J. Pathol. , vol.154 , pp. 1777-1783
    • Nupponen, N.N.1
  • 24
    • 0035184312 scopus 로고    scopus 로고
    • Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer
    • Saramaki, O. et al. Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer. Am. J. Pathol. 159, 2089-2094 (2001).
    • (2001) Am. J. Pathol. , vol.159 , pp. 2089-2094
    • Saramaki, O.1
  • 25
    • 67649392920 scopus 로고    scopus 로고
    • MYC and EIF3H coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib
    • Cappuzzo, F. et al. MYC and EIF3H coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib. J. Thorac Oncol. 4, 472-478 (2009).
    • (2009) J. Thorac Oncol. , vol.4 , pp. 472-478
    • Cappuzzo, F.1
  • 26
    • 33746899672 scopus 로고    scopus 로고
    • Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells
    • Shi, J. et al. Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells. Oncogene 25, 4923-4936 (2006).
    • (2006) Oncogene , vol.25 , pp. 4923-4936
    • Shi, J.1
  • 27
    • 0028836566 scopus 로고
    • Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia
    • Marchetti, A. et al. Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia. J. Virol. 69, 1932-1938 (1995).
    • (1995) J. Virol. , vol.69 , pp. 1932-1938
    • Marchetti, A.1
  • 28
    • 0035974883 scopus 로고    scopus 로고
    • Evidence for the transforming activity of a truncated Int6 gene, in vitro
    • Rasmussen, S. B., Kordon, E., Callahan, R. & Smith, G. H. Evidence for the transforming activity of a truncated Int6 gene, in vitro. Oncogene 20, 5291-5301 (2001).
    • (2001) Oncogene , vol.20 , pp. 5291-5301
    • Rasmussen, S.B.1    Kordon, E.2    Callahan, R.3    Smith, G.H.4
  • 29
    • 0037029145 scopus 로고    scopus 로고
    • Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e)
    • Mayeur, G. L. & Hershey, J. W. Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e). FEBS Lett. 514, 49-54 (2002).
    • (2002) FEBS Lett. , vol.514 , pp. 49-54
    • Mayeur, G.L.1    Hershey, J.W.2
  • 30
    • 36549028297 scopus 로고    scopus 로고
    • Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis
    • Mack, D. L., Boulanger, C. A., Callahan, R. & Smith, G. H. Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis. Breast Cancer Res. 9, R42 (2007).
    • (2007) Breast Cancer Res. , vol.9
    • MacK, D.L.1    Boulanger, C.A.2    Callahan, R.3    Smith, G.H.4
  • 32
    • 67650523623 scopus 로고    scopus 로고
    • Identification of a putative protein profile associating with tamoxifen therapy-resistance in breast cancer
    • Umar, A. et al. Identification of a putative protein profile associating with tamoxifen therapy-resistance in breast cancer. Mol. Cell. Proteomics 8, 1278-1294 (2009).
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 1278-1294
    • Umar, A.1
  • 33
    • 34547684737 scopus 로고    scopus 로고
    • Is there a role for eIF5A in translation?
    • Zanelli, C. F. & Valentini, S. R. Is there a role for eIF5A in translation? Amino Acids 33, 351-358 (2007).
    • (2007) Amino Acids , vol.33 , pp. 351-358
    • Zanelli, C.F.1    Valentini, S.R.2
  • 34
    • 0035143099 scopus 로고    scopus 로고
    • Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression
    • Jenkins, Z. A., Haag, P. G. & Johansson, H. E. Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression. Genomics 71, 101-109 (2001).
    • (2001) Genomics , vol.71 , pp. 101-109
    • Jenkins, Z.A.1    Haag, P.G.2    Johansson, H.E.3
  • 35
    • 0018096765 scopus 로고
    • Purification and characterization of protein synthesis initiation factors eIF-1, eIF-4C, eIF-4D, and eIF-5 from rabbit reticulocytes
    • Benne, R., Brown-Luedi, M. L. & Hershey, J. W. Purification and characterization of protein synthesis initiation factors eIF-1, eIF-4C, eIF-4D, and eIF-5 from rabbit reticulocytes. J. Biol. Chem. 253, 3070-3077 (1978).
    • (1978) J. Biol. Chem. , vol.253 , pp. 3070-3077
    • Benne, R.1    Brown-Luedi, M.L.2    Hershey, J.W.3
  • 36
    • 0017171975 scopus 로고
    • Purification and properties of rabbit reticulocyte protein synthesis initiation factors M2Bα and M2Bβ
    • Kemper, W. M., Berry, K. W. & Merrick, W. C. Purification and properties of rabbit reticulocyte protein synthesis initiation factors M2Bα and M2Bβ. J. Biol. Chem. 251, 5551-5557 (1976).
    • (1976) J. Biol. Chem. , vol.251 , pp. 5551-5557
    • Kemper, W.M.1    Berry, K.W.2    Merrick, W.C.3
  • 37
    • 65549167195 scopus 로고    scopus 로고
    • Hypusine-containing protein eIF5A promotes translation elongation
    • Saini, P., Eyler, D. E., Green, R. & Dever, T. E. Hypusine-containing protein eIF5A promotes translation elongation. Nature 459, 118-121 (2009).
    • (2009) Nature , vol.459 , pp. 118-121
    • Saini, P.1    Eyler, D.E.2    Green, R.3    Dever, T.E.4
  • 38
    • 3042616347 scopus 로고    scopus 로고
    • Oncogenic role of eIF-5A2 in the development of ovarian cancer
    • Guan, X. Y. et al. Oncogenic role of eIF-5A2 in the development of ovarian cancer. Cancer Res. 64, 4197-4200 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 4197-4200
    • Guan, X.Y.1
  • 39
    • 56349121125 scopus 로고    scopus 로고
    • An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer
    • Zender, L. et al. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell 135, 852-864 (2008).
    • (2008) Cell , vol.135 , pp. 852-864
    • Zender, L.1
  • 40
    • 0029019877 scopus 로고
    • Detection of a sub-set of polysomal mRNAs associated with modulation of hypusine formation at the G1-S boundary. Proposal of a role for eIF-5A in onset of DNA replication
    • Hanauske-Abel, H. M. et al. Detection of a sub-set of polysomal mRNAs associated with modulation of hypusine formation at the G1-S boundary. Proposal of a role for eIF-5A in onset of DNA replication. FEBS Lett. 366, 92-98 (1995).
    • (1995) FEBS Lett. , vol.366 , pp. 92-98
    • Hanauske-Abel, H.M.1
  • 41
    • 3242721547 scopus 로고    scopus 로고
    • Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva
    • Cracchiolo, B. M. et al. Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva. Gynecol. Oncol. 94, 217-222 (2004).
    • (2004) Gynecol. Oncol. , vol.94 , pp. 217-222
    • Cracchiolo, B.M.1
  • 42
    • 33846939244 scopus 로고    scopus 로고
    • Hypusination of eukaryotic initiation factor 5A (eIF5A): A novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach
    • Balabanov, S. et al. Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach. Blood 109, 1701-1711 (2007).
    • (2007) Blood , vol.109 , pp. 1701-1711
    • Balabanov, S.1
  • 43
    • 67349191553 scopus 로고    scopus 로고
    • Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation
    • Miluzio, A., Beugnet, A., Volta, V. & Biffo, S. Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation. EMBO Rep. 10, 459-465 (2009).
    • (2009) EMBO Rep. , vol.10 , pp. 459-465
    • Miluzio, A.1    Beugnet, A.2    Volta, V.3    Biffo, S.4
  • 44
    • 2342529191 scopus 로고    scopus 로고
    • Overexpression of p27BBP in head and neck carcinomas and their lymph node metastases
    • Rosso, P. et al. Overexpression of p27BBP in head and neck carcinomas and their lymph node metastases. Head Neck 26, 408-417 (2004).
    • (2004) Head Neck , vol.26 , pp. 408-417
    • Rosso, P.1
  • 45
    • 18544405840 scopus 로고    scopus 로고
    • Expression of a highly conserved protein, p27BBP, during the progression of human colorectal cancer
    • Sanvito, F. et al. Expression of a highly conserved protein, p27BBP, during the progression of human colorectal cancer. Cancer Res. 60, 510-516 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 510-516
    • Sanvito, F.1
  • 46
    • 44349092460 scopus 로고    scopus 로고
    • Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients
    • Flavin, R. J. et al. Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients. Mod. Pathol. 21, 676-684 (2008).
    • (2008) Mod. Pathol. , vol.21 , pp. 676-684
    • Flavin, R.J.1
  • 47
    • 53349147033 scopus 로고    scopus 로고
    • Eukaryotic initiation factor 6 is ratelimiting in translation, growth and transformation
    • Gandin, V. et al. Eukaryotic initiation factor 6 is ratelimiting in translation, growth and transformation. Nature 455, 684-688 (2008).
    • (2008) Nature , vol.455 , pp. 684-688
    • Gandin, V.1
  • 48
    • 60149091189 scopus 로고    scopus 로고
    • Regulation of translation initiation in eukaryotes: Mechanisms and biological targets
    • Sonenberg, N. & Hinnebusch, A. G. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136, 731-745 (2009).
    • (2009) Cell , vol.136 , pp. 731-745
    • Sonenberg, N.1    Hinnebusch, A.G.2
  • 49
    • 38849180436 scopus 로고    scopus 로고
    • Targeting the eukaryotic translation initiation factor 4E for cancer therapy
    • Graff, J. R., Konicek, B. W., Carter, J. H. & Marcusson, E. G. Targeting the eukaryotic translation initiation factor 4E for cancer therapy. Cancer Res. 68, 631-634 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 631-634
    • Graff, J.R.1    Konicek, B.W.2    Carter, J.H.3    Marcusson, E.G.4
  • 50
    • 0025314596 scopus 로고
    • Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap
    • Lazaris-Karatzas, A., Montine, K. S. & Sonenberg, N. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature 345, 544-547 (1990).
    • (1990) Nature , vol.345 , pp. 544-547
    • Lazaris-Karatzas, A.1    Montine, K.S.2    Sonenberg, N.3
  • 51
    • 0026583874 scopus 로고
    • The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts
    • Lazaris-Karatzas, A. & Sonenberg, N. The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts. Mol. Cell. Biol. 12, 1234-1238 (1992).
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 1234-1238
    • Lazaris-Karatzas, A.1    Sonenberg, N.2
  • 52
    • 0026784679 scopus 로고
    • Ras mediates translation initiation factor 4E-induced malignant transformation
    • Lazaris-Karatzas, A. et al. Ras mediates translation initiation factor 4E-induced malignant transformation. Genes Dev. 6, 1631-1642 (1992).
    • (1992) Genes Dev. , vol.6 , pp. 1631-1642
    • Lazaris-Karatzas, A.1
  • 53
    • 2442648845 scopus 로고    scopus 로고
    • The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
    • Ruggero, D. et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nature Med. 10, 484-486 (2004).
    • (2004) Nature Med. , vol.10 , pp. 484-486
    • Ruggero, D.1
  • 54
    • 1642586272 scopus 로고    scopus 로고
    • Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
    • Wendel, H. G. et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428, 332-337 (2004).
    • (2004) Nature , vol.428 , pp. 332-337
    • Wendel, H.G.1
  • 55
    • 0026723117 scopus 로고
    • MRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E
    • Koromilas, A. E., Lazaris-Karatzas, A. & Sonenberg, N. mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E. EMBO J. 11, 4153-4158 (1992).
    • (1992) EMBO J. , vol.11 , pp. 4153-4158
    • Koromilas, A.E.1    Lazaris-Karatzas, A.2    Sonenberg, N.3
  • 56
    • 0027289462 scopus 로고
    • Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2α in response to growth induction by c-myc
    • Rosenwald, I. B., Rhoads, D. B., Callanan, L. D., Isselbacher, K. J. & Schmidt, E. V. Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2α in response to growth induction by c-myc. Proc. Natl. Acad. Sci. USA 90, 6175-6178 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6175-6178
    • Rosenwald, I.B.1    Rhoads, D.B.2    Callanan, L.D.3    Isselbacher, K.J.4    Schmidt, E.V.5
  • 57
    • 34250755685 scopus 로고    scopus 로고
    • Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation
    • Mamane, Y. et al. Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS One 2, e242 (2007).
    • (2007) PLoS One , vol.2
    • Mamane, Y.1
  • 58
    • 34547114029 scopus 로고    scopus 로고
    • Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors
    • Larsson, O. et al. Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors. Cancer Res. 67, 6814-6824 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 6814-6824
    • Larsson, O.1
  • 59
    • 33750042335 scopus 로고    scopus 로고
    • (eds. Mathews M. B. Sonenberg N. & Hershey J. W. B.) (Cold Spring Harbor Laboratory Press Cold Spring Harbor
    • Schneider, R. J. & Sonenberg, N. in Translational Control in Biology and Medicine (eds. Mathews, M. B., Sonenberg, N. & Hershey, J. W. B.) (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 2007).
    • (2007) Translational Control in Biology and Medicine
    • Schneider, R.J.1    Sonenberg, N.2
  • 60
    • 0032981328 scopus 로고    scopus 로고
    • Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo
    • Waskiewicz, A. J. et al. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol. Cell. Biol. 19, 1871-1880 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1871-1880
    • Waskiewicz, A.J.1
  • 61
    • 65649106134 scopus 로고    scopus 로고
    • Proteomic and phosphoproteomic alterations in benign premalignant and tumor human breast epithelial cells and xenograft lesions: Biomarkers of progression
    • Kim, S. H., Miller, F. R., Tait, L., Zheng, J. & Novak, R. F. Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: biomarkers of progression. Int. J. Cancer 124, 2813-2828 (2009).
    • (2009) Int. J. Cancer , vol.124 , pp. 2813-2828
    • Kim, S.H.1    Miller, F.R.2    Tait, L.3    Zheng, J.4    Novak, R.F.5
  • 62
    • 65949111747 scopus 로고    scopus 로고
    • EIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival
    • Graff, J. R. et al. eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival. Cancer Res. 69, 3866-3873 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 3866-3873
    • Graff, J.R.1
  • 63
    • 37249042829 scopus 로고    scopus 로고
    • Dissecting eIF4E action in tumorigenesis
    • Wendel, H. G. et al. Dissecting eIF4E action in tumorigenesis. Genes Dev. 21, 3232-3237 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 3232-3237
    • Wendel, H.G.1
  • 64
    • 27444436166 scopus 로고    scopus 로고
    • Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation
    • Rahmani, M., Davis, E. M., Bauer, C., Dent, P. & Grant, S. Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. J. Biol. Chem. 280, 35217-35227 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 35217-35227
    • Rahmani, M.1    Davis, E.M.2    Bauer, C.3    Dent, P.4    Grant, S.5
  • 65
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • Liu, L. et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 66, 11851-11858 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 11851-11858
    • Liu, L.1
  • 66
    • 59249101893 scopus 로고    scopus 로고
    • Activation of mTOR in a subgroup of ovarian carcinomas: Correlation with p-eIF-4E and prognosis
    • Noske, A. et al. Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis. Oncol. Rep. 20, 1409-1417 (2008).
    • (2008) Oncol. Rep. , vol.20 , pp. 1409-1417
    • Noske, A.1
  • 67
    • 85046915181 scopus 로고    scopus 로고
    • Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues
    • Fan, S. et al. Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues. Cancer Biol. Ther. 8, 1463-1469 (2009).
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 1463-1469
    • Fan, S.1
  • 68
    • 65549108194 scopus 로고    scopus 로고
    • Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity
    • Coleman, L. J. et al. Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity. Br. J. Cancer 100, 1393-1399 (2009).
    • (2009) Br. J. Cancer , vol.100 , pp. 1393-1399
    • Coleman, L.J.1
  • 69
    • 33646089881 scopus 로고    scopus 로고
    • Expression of the eukaryotic translation initiation factor 4E (eIF4E) and 4E-BP1 in esophageal cancer
    • Salehi, Z. & Mashayekhi, F. Expression of the eukaryotic translation initiation factor 4E (eIF4E) and 4E-BP1 in esophageal cancer. Clin. Biochem. 39, 404-409 (2006).
    • (2006) Clin. Biochem. , vol.39 , pp. 404-409
    • Salehi, Z.1    Mashayekhi, F.2
  • 70
    • 35649001888 scopus 로고    scopus 로고
    • A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer
    • Braunstein, S. et al. A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol. Cell 28, 501-512 (2007).
    • (2007) Mol. Cell , vol.28 , pp. 501-512
    • Braunstein, S.1
  • 71
    • 0030722085 scopus 로고    scopus 로고
    • Malignant transformation by overproduction of translation initiation factor eIF4G
    • Fukuchi-Shimogori, T. et al. Malignant transformation by overproduction of translation initiation factor eIF4G. Cancer Res. 57, 5041-5044 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 5041-5044
    • Fukuchi-Shimogori, T.1
  • 72
    • 34247467477 scopus 로고    scopus 로고
    • Frequent overexpression of the genes FXR1 CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung
    • Comtesse, N. et al. Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung. Int. J. Cancer 120, 2538-2544 (2007).
    • (2007) Int. J. Cancer , vol.120 , pp. 2538-2544
    • Comtesse, N.1
  • 73
    • 0035880647 scopus 로고    scopus 로고
    • Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma
    • Bauer, C. et al. Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma. Cancer 92, 822-829 (2001).
    • (2001) Cancer , vol.92 , pp. 822-829
    • Bauer, C.1
  • 74
    • 0035886531 scopus 로고    scopus 로고
    • Expression of eukaryotic translation initiation factors 4E and 2α is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung
    • Rosenwald, I. B., Hutzler, M. J., Wang, S., Savas, L. & Fraire, A. E. Expression of eukaryotic translation initiation factors 4E and 2α is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung. Cancer 92, 2164-2171 (2001).
    • (2001) Cancer , vol.92 , pp. 2164-2171
    • Rosenwald, I.B.1    Hutzler, M.J.2    Wang, S.3    Savas, L.4    Fraire, A.E.5
  • 75
    • 67650080623 scopus 로고    scopus 로고
    • Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer
    • Silvera, D. et al. Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer. Naure Cell Biol. 11, 903-908 (2009).
    • (2009) Naure Cell Biol. , vol.11 , pp. 903-908
    • Silvera, D.1
  • 76
    • 70349914220 scopus 로고    scopus 로고
    • Inflammatory breast cancer cells are constitutively adapted to hypoxia
    • Silvera, D. & Schneider, R. J. Inflammatory breast cancer cells are constitutively adapted to hypoxia. Cell Cycle 8, 3091-3096 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 3091-3096
    • Silvera, D.1    Schneider, R.J.2
  • 77
    • 0033855877 scopus 로고    scopus 로고
    • Enhanced expression of translation factor mRNAs in hepatocellular carcinoma
    • Shuda, M. et al. Enhanced expression of translation factor mRNAs in hepatocellular carcinoma. Anticancer Res. 20, 2489-2494 (2000).
    • (2000) Anticancer Res. , vol.20 , pp. 2489-2494
    • Shuda, M.1
  • 78
    • 0030919560 scopus 로고    scopus 로고
    • Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro
    • Eberle, J., Krasagakis, K. & Orfanos, C. E. Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro. Int. J. Cancer 71, 396-401 (1997).
    • (1997) Int. J. Cancer , vol.71 , pp. 396-401
    • Eberle, J.1    Krasagakis, K.2    Orfanos, C.E.3
  • 79
    • 46749097944 scopus 로고    scopus 로고
    • Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
    • Bordeleau, M. E. et al. Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J. Clin. Invest. 11 8, 2651-2660 (2008).
    • (2008) J. Clin. Invest. , vol.11 , Issue.8 , pp. 2651-2660
    • Bordeleau, M.E.1
  • 80
    • 65549098672 scopus 로고    scopus 로고
    • Antitumor activity and mechanism of action of the cyclopenta[b] benzofuran, silvestrol
    • Cencic, R. et al. Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PLoS One 4, e5223 (2009).
    • (2009) PLoS One , vol.4
    • Cencic, R.1
  • 81
    • 67449104909 scopus 로고    scopus 로고
    • The tumour suppressor Pdcd4: Recent advances in the elucidation of function and regulation
    • Lankat-Buttgereit, B. & Goke, R. The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation. Biol. Cell 101, 309-317 (2009).
    • (2009) Biol. Cell , vol.101 , pp. 309-317
    • Lankat-Buttgereit, B.1    Goke, R.2
  • 82
    • 0037216626 scopus 로고    scopus 로고
    • The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation
    • Yang, H. S. et al. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol. Cell. Biol. 23, 26-37 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 26-37
    • Yang, H.S.1
  • 84
    • 2342421272 scopus 로고    scopus 로고
    • Targeting translation for treatment of cancer\a novel role for IRES? Curr
    • Holcik, M. Targeting translation for treatment of cancer\a novel role for IRES? Curr. Cancer Drug Targets. 4, 299-311 (2004).
    • (2004) Cancer Drug Targets. , vol.4 , pp. 299-311
    • Holcik, M.1
  • 85
    • 0035837395 scopus 로고    scopus 로고
    • Myc translation is initiated via an internal ribosome entry segment that displays enhanced activity in neuronal cells
    • Jopling, C. L. & Willis, A. E. N.-myc translation is initiated via an internal ribosome entry segment that displays enhanced activity in neuronal cells. Oncogene 20, 2664-26670 (2001).
    • (2001) Oncogene , vol.20 , pp. 2664-26670
    • Jopling, C.L.1    Willis, A.E.N.2
  • 86
    • 62849124523 scopus 로고    scopus 로고
    • Canonical initiation factor requirements of the Myc family of internal ribosome entry segments
    • Spriggs, K. A. et al. Canonical initiation factor requirements of the Myc family of internal ribosome entry segments. Mol. Cell. Biol. 29, 1565-1574 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 1565-1574
    • Spriggs, K.A.1
  • 87
    • 0034618402 scopus 로고    scopus 로고
    • A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: A novel mechanism of oncogene de-regulation
    • Chappell, S. A. et al. A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation. Oncogene 19, 4437-4440 (2000).
    • (2000) Oncogene , vol.19 , pp. 4437-4440
    • Chappell, S.A.1
  • 88
    • 0345549480 scopus 로고    scopus 로고
    • Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo
    • Evans, J. R. et al. Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo. Oncogene 22, 8012-8020 (2003).
    • (2003) Oncogene , vol.22 , pp. 8012-8020
    • Evans, J.R.1
  • 89
    • 57749102689 scopus 로고    scopus 로고
    • IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1
    • Shi, Y. et al. IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1. Cancer Res. 68, 10215-10222 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 10215-10222
    • Shi, Y.1
  • 90
    • 0034710543 scopus 로고    scopus 로고
    • Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death
    • Holcik, M., Yeh, C., Korneluk, R. G. & Chow, T. Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death. Oncogene 19, 4174-4177 (2000).
    • (2000) Oncogene , vol.19 , pp. 4174-4177
    • Holcik, M.1    Yeh, C.2    Korneluk, R.G.3    Chow, T.4
  • 91
    • 58149252352 scopus 로고    scopus 로고
    • Impact of XIAP protein levels on the survival of myeloma cells
    • Desplanques, G. et al. Impact of XIAP protein levels on the survival of myeloma cells. Haematologica 94, 87-93 (2009).
    • (2009) Haematologica , vol.94 , pp. 87-93
    • Desplanques, G.1
  • 92
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman, J. A. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nature Rev. Cancer 9, 550-562 (2009).
    • (2009) Nature Rev. Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 93
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma, X. M. & Blenis, J. Molecular mechanisms of mTOR-mediated translational control. Nature Rev. Mol. Cell. Biol. 10, 307-318 (2009).
    • (2009) Nature Rev. Mol. Cell. Biol. , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 94
    • 0030977269 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
    • Waskiewicz, A. J., Flynn, A., Proud, C. G. & Cooper, J. A. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16, 1909-1920 (1997).
    • (1997) EMBO J. , vol.16 , pp. 1909-1920
    • Waskiewicz, A.J.1    Flynn, A.2    Proud, C.G.3    Cooper, J.A.4
  • 95
    • 0033521535 scopus 로고    scopus 로고
    • Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
    • Pyronnet, S. et al. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J. 18, 270-279 (1999).
    • (1999) EMBO J. , vol.18 , pp. 270-279
    • Pyronnet, S.1
  • 96
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin, D. A. & Sabatini, D. M. Defining the role of mTOR in cancer. Cancer Cell 12, 9-22 (2007).
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 97
    • 70350241382 scopus 로고    scopus 로고
    • C-Myc and eIF4F constitute a feedforward loop that regulates cell growth: Implications for anticancer therapy
    • Lin, C. J., Malina, A. & Pelletier, J. c-Myc and eIF4F constitute a feedforward loop that regulates cell growth: implications for anticancer therapy. Cancer Res. 69, 7491-7494 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 7491-7494
    • Lin, C.J.1    Malina, A.2    Pelletier, J.3
  • 98
    • 50049123842 scopus 로고    scopus 로고
    • Tumorigenic activity and therapeutic inhibition of Rheb GTPase
    • Mavrakis, K. J. et al. Tumorigenic activity and therapeutic inhibition of Rheb GTPase. Genes Dev. 22, 2178-2188 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 2178-2188
    • Mavrakis, K.J.1
  • 99
    • 0032431032 scopus 로고    scopus 로고
    • The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
    • Wu, X., Senechal, K., Neshat, M. S., Whang, Y. E. & Sawyers, C. L. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc. Natl. Acad. Sci. USA 95, 15587-15591 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15587-15591
    • Wu, X.1    Senechal, K.2    Neshat, M.S.3    Whang, Y.E.4    Sawyers, C.L.5
  • 100
    • 6044223545 scopus 로고    scopus 로고
    • Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
    • Zhou, X. et al. Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin. Cancer Res. 10, 6779-6788 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6779-6788
    • Zhou, X.1
  • 101
    • 0037363075 scopus 로고    scopus 로고
    • Does the ribosome translate cancer? Nature Rev
    • Ruggero, D. & Pandolfi, P. P. Does the ribosome translate cancer? Nature Rev. Cancer 3, 179-192 (2003).
    • (2003) Cancer , vol.3 , pp. 179-192
    • Ruggero, D.1    Pandolfi, P.P.2
  • 102
    • 53049084191 scopus 로고    scopus 로고
    • S6K1 plays a key role in glial transformation
    • Nakamura, J. L., Garcia, E. & Pieper, R. O. S6K1 plays a key role in glial transformation. Cancer Res. 68, 6516-6523 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 6516-6523
    • Nakamura, J.L.1    Garcia, E.2    Pieper, R.O.3
  • 103
    • 27744569843 scopus 로고    scopus 로고
    • MTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    • Holz, M. K., Ballif, B. A., Gygi, S. P. & Blenis, J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123, 569-580 (2005).
    • (2005) Cell , vol.123 , pp. 569-580
    • Holz, M.K.1    Ballif, B.A.2    Gygi, S.P.3    Blenis, J.4
  • 104
    • 33750325725 scopus 로고    scopus 로고
    • S6K1-and βtRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
    • Dorrello, N. V. et al. S6K1-and βTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314, 467-471 (2006).
    • (2006) Science , vol.314 , pp. 467-471
    • Dorrello, N.V.1
  • 105
    • 43749110929 scopus 로고    scopus 로고
    • Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway
    • Carayol, N. et al. Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway. J. Biol. Chem. 283, 8601-8610 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 8601-8610
    • Carayol, N.1
  • 106
    • 33745570504 scopus 로고    scopus 로고
    • The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
    • Shahbazian, D. et al. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 25, 2781-2791 (2006).
    • (2006) EMBO J. , vol.25 , pp. 2781-2791
    • Shahbazian, D.1
  • 108
    • 61449235398 scopus 로고    scopus 로고
    • Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance and cancer therapy
    • Choo, A. Y. & Blenis, J. Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell Cycle 8, 567-572 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 567-572
    • Choo, A.Y.1    Blenis, J.2
  • 109
    • 76549107351 scopus 로고    scopus 로고
    • Beyond rapalog therapy: Preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2
    • Yu, K. et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Cancer Res. 70, 621-631 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 621-631
    • Yu, K.1
  • 110
    • 61349141302 scopus 로고    scopus 로고
    • Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
    • Feldman, M. E. et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 7, e38 (2009).
    • (2009) PLoS Biol. , vol.7
    • Feldman, M.E.1
  • 111
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • Thoreen, C. C. et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J. Biol. Chem. 284, 8023-8032 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1
  • 112
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki, K., Li, Y., Zhu, T., Wu, J. & Guan, K. L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nature Cell Biol. 4, 648-657 (2002).
    • (2002) Nature Cell Biol. , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 113
    • 59749090661 scopus 로고    scopus 로고
    • Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor
    • Avruch, J. et al. Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor. Biochem. Soc. Trans. 37, 223-226 (2009).
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 223-226
    • Avruch, J.1
  • 115
    • 34248545489 scopus 로고    scopus 로고
    • PRAS40 deregulates apoptosis in malignant melanoma
    • Madhunapantula, S. V., Sharma, A. & Robertson, G. P. PRAS40 deregulates apoptosis in malignant melanoma. Cancer Res. 67, 3626-3636 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 3626-3636
    • Madhunapantula, S.V.1    Sharma, A.2    Robertson, G.P.3
  • 116
    • 61349084198 scopus 로고    scopus 로고
    • Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas
    • Johnson, M. D., O'Connell, M., Vito, F. & Bakos, R. S. Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas. J. Neurooncol. 92, 129-136 (2009).
    • (2009) J. Neurooncol. , vol.92 , pp. 129-136
    • Johnson, M.D.1    O'Connell, M.2    Vito, F.3    Bakos, R.S.4
  • 117
    • 0041758428 scopus 로고    scopus 로고
    • Tuberous sclerosis: From tubers to mTOR
    • Kwiatkowski, D. J. Tuberous sclerosis: from tubers to mTOR. Ann. Hum. Genet. 67, 87-96 (2003).
    • (2003) Ann. Hum. Genet. , vol.67 , pp. 87-96
    • Kwiatkowski, D.J.1
  • 118
    • 48449101433 scopus 로고    scopus 로고
    • P53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
    • Budanov, A. V. & Karin, M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134, 451-460 (2008).
    • (2008) Cell , vol.134 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 120
    • 0027383066 scopus 로고
    • Expression of the double-stranded RNA-dependent protein kinase (p68) in squamous cell carcinoma of the head and neck region
    • Haines, G. K. 3rd. et al. Expression of the double-stranded RNA-dependent protein kinase (p68) in squamous cell carcinoma of the head and neck region. Arch. Otolaryngol. Head Neck Surg. 11 9, 1142-1147 (1993).
    • (1993) Arch. Otolaryngol. Head Neck Surg. , Issue.119 , pp. 1142-1147
    • Haines Iii, G.K.1
  • 121
    • 0027324680 scopus 로고
    • Correlation of the expression of double-stranded RNA-dependent protein kinase (p68) with differentiation in head and neck squamous cell carcinoma. Virchows Arch
    • Haines, G. K. et al. Correlation of the expression of double-stranded RNA-dependent protein kinase (p68) with differentiation in head and neck squamous cell carcinoma. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 63, 289-295 (1993).
    • (1993) B Cell Pathol. Incl. Mol. Pathol. , Issue.63 , pp. 289-295
    • Haines, G.K.1
  • 122
    • 0031458299 scopus 로고    scopus 로고
    • Interferon-responsive protein kinase (p68) and proliferating cell nuclear antigen are inversely distributed in head and neck squamous cell carcinoma
    • Haines, G. K. 3rd. et al. Interferon-responsive protein kinase (p68) and proliferating cell nuclear antigen are inversely distributed in head and neck squamous cell carcinoma. Tumour Biol. 19, 52-59 (1998).
    • (1998) Tumour Biol. , vol.19 , pp. 52-59
    • Haines Iii, G.K.1
  • 123
    • 0033943112 scopus 로고    scopus 로고
    • Protein expression of double-stranded RNA-activated protein kinase in thyroid carcinomas: Correlations with histologic types, pathologic parameters, and Ki-67 labeling
    • Terada, T., Maeta, H., Endo, K. & Ohta, T. Protein expression of double-stranded RNA-activated protein kinase in thyroid carcinomas: correlations with histologic types, pathologic parameters, and Ki-67 labeling. Hum. Pathol. 31, 817-821 (2000).
    • (2000) Hum. Pathol. , vol.31 , pp. 817-821
    • Terada, T.1    Maeta, H.2    Endo, K.3    Ohta, T.4
  • 124
    • 0034702174 scopus 로고    scopus 로고
    • Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR
    • Kim, S. H., Forman, A. P., Mathews, M. B. & Gunnery, S. Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR. Oncogene 19, 3086-3094 (2000).
    • (2000) Oncogene , vol.19 , pp. 3086-3094
    • Kim, S.H.1    Forman, A.P.2    Mathews, M.B.3    Gunnery, S.4
  • 125
    • 0029655361 scopus 로고    scopus 로고
    • Expression of the double-stranded RNA-dependent protein kinase (p68) in human breast tissues
    • Haines, G. K. et al. Expression of the double-stranded RNA-dependent protein kinase (p68) in human breast tissues. Tumour Biol. 17, 5-12 (1996).
    • (1996) Tumour Biol. , vol.17 , pp. 5-12
    • Haines, G.K.1
  • 126
    • 0032189405 scopus 로고    scopus 로고
    • Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma
    • Shimada, A. et al. Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma. Cancer Res. 58, 4434-4438 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 4434-4438
    • Shimada, A.1
  • 127
    • 0041386193 scopus 로고    scopus 로고
    • Expression of translation initiation factor eIF-2α is increased in benign and malignant melanocytic and colonic epithelial neoplasms
    • Rosenwald, I. B., Wang, S., Savas, L., Woda, B. & Pullman, J. Expression of translation initiation factor eIF-2α is increased in benign and malignant melanocytic and colonic epithelial neoplasms. Cancer 98, 1080-1088 (2003).
    • (2003) Cancer , vol.98 , pp. 1080-1088
    • Rosenwald, I.B.1    Wang, S.2    Savas, L.3    Woda, B.4    Pullman, J.5
  • 128
    • 0035678388 scopus 로고    scopus 로고
    • Expression of eukaryotic translation initiation factors 4E and 2α correlates with the progression of thyroid carcinoma
    • Wang, S. et al. Expression of eukaryotic translation initiation factors 4E and 2α correlates with the progression of thyroid carcinoma. Thyroid 11, 1101-1107 (2001).
    • (2001) Thyroid , vol.11 , pp. 1101-1107
    • Wang, S.1
  • 129
    • 0033031044 scopus 로고    scopus 로고
    • Expression of the eukaryotic translation initiation factors 4E and 2α in non-Hodgkin's lymphomas
    • Wang, S. et al. Expression of the eukaryotic translation initiation factors 4E and 2α in non-Hodgkin's lymphomas. Am. J. Pathol. 155, 247-255 (1999).
    • (1999) Am. J. Pathol. , vol.155 , pp. 247-255
    • Wang, S.1
  • 130
    • 44649178786 scopus 로고    scopus 로고
    • Expression of the translation initiation factors eIF-4E and eIF-2* is frequently increased in neoplastic cells of Hodgkin lymphoma
    • Rosenwald, I. B. et al. Expression of the translation initiation factors eIF-4E and eIF-2* is frequently increased in neoplastic cells of Hodgkin lymphoma. Hum. Pathol. 39, 910-916 (2008).
    • (2008) Hum. Pathol. , vol.39 , pp. 910-916
    • Rosenwald, I.B.1
  • 131
    • 1842413082 scopus 로고    scopus 로고
    • Cloning of a novel protein overexpressed in human mammary carcinoma
    • Bachmann, F., Banziger, R. & Burger, M. M. Cloning of a novel protein overexpressed in human mammary carcinoma. Cancer Res. 57, 988-994 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 988-994
    • Bachmann, F.1    Banziger, R.2    Burger, M.M.3
  • 132
    • 0032189714 scopus 로고    scopus 로고
    • Expression of p150 in cervical neoplasia and its potential value in predicting survival
    • Dellas, A. et al. Expression of p150 in cervical neoplasia and its potential value in predicting survival. Cancer 83, 1376-1383 (1998).
    • (1998) Cancer , vol.83 , pp. 1376-1383
    • Dellas, A.1
  • 133
    • 0035364978 scopus 로고    scopus 로고
    • Identification of a 170-kDa protein over-expressed in lung cancers
    • Pincheira, R., Chen, Q. & Zhang, J. T. Identification of a 170-kDa protein over-expressed in lung cancers. Br. J. Cancer 84, 1520-1527 (2001).
    • (2001) Br. J. Cancer , vol.84 , pp. 1520-1527
    • Pincheira, R.1    Chen, Q.2    Zhang, J.T.3
  • 134
    • 0033046231 scopus 로고    scopus 로고
    • P150 expression and its prognostic value in squamous-cell carcinoma of the esophagus
    • Chen, G. & Burger, M. M. p150 expression and its prognostic value in squamous-cell carcinoma of the esophagus. Int. J. Cancer 84, 95-100 (1999).
    • (1999) Int. J. Cancer , vol.84 , pp. 95-100
    • Chen, G.1    Burger, M.M.2
  • 135
    • 6344237621 scopus 로고    scopus 로고
    • P150 overexpression in gastric carcinoma: The association with p53, apoptosis and cell proliferation
    • Chen, G. & Burger, M. M. p150 overexpression in gastric carcinoma: the association with p53, apoptosis and cell proliferation. Int. J. Cancer 11 2, 393-398 (2004).
    • (2004) Int. J. Cancer , vol.11 , Issue.2 , pp. 393-398
    • Chen, G.1    Burger, M.M.2
  • 136
    • 0033709896 scopus 로고    scopus 로고
    • Eukaryotic initiation factor 3 p110 mRNA is overexpressed in testicular seminomas
    • Rothe, M., Ko, Y., Albers, P. & Wernert, N. Eukaryotic initiation factor 3 p110 mRNA is overexpressed in testicular seminomas. Am. J. Pathol. 157, 1597-1604 (2000).
    • (2000) Am. J. Pathol. , vol.157 , pp. 1597-1604
    • Rothe, M.1    Ko, Y.2    Albers, P.3    Wernert, N.4
  • 137
    • 0035328882 scopus 로고    scopus 로고
    • Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer
    • Guan, X. Y. et al. Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer. Cancer Res. 61, 3806-3809 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 3806-3809
    • Guan, X.Y.1
  • 138
    • 36749031659 scopus 로고    scopus 로고
    • Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma
    • Xie, D. et al. Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma. Hum. Pathol. 39, 80-86 (2008).
    • (2008) Hum. Pathol. , vol.39 , pp. 80-86
    • Xie, D.1
  • 139
    • 65349085547 scopus 로고    scopus 로고
    • Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder
    • Luo, J. H. et al. Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder. Cancer Sci. 100, 896-902 (2009).
    • (2009) Cancer Sci. , vol.100 , pp. 896-902
    • Luo, J.H.1
  • 140
    • 60549089824 scopus 로고    scopus 로고
    • Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy
    • Chen, W. et al. Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy. Cancer Epidemiol. Biomarkers Prev. 18, 400-408 (2009).
    • (2009) Cancer Epidemiol. Biomarkers Prev. , vol.18 , pp. 400-408
    • Chen, W.1
  • 141
    • 2342489456 scopus 로고    scopus 로고
    • EIF-4E expression and its role in malignancies and metastases
    • De Benedetti, A. & Graff, J. R. eIF-4E expression and its role in malignancies and metastases. Oncogene 23, 3189-3199 (2004).
    • (2004) Oncogene , vol.23 , pp. 3189-3199
    • De Benedetti, A.1    Graff, J.R.2
  • 142
    • 35348954728 scopus 로고    scopus 로고
    • Translational control: A target for cancer therapy
    • Thumma, S. C. & Kratzke, R. A. Translational control: a target for cancer therapy. Cancer Lett. 258, 1-8 (2007).
    • (2007) Cancer Lett. , vol.258 , pp. 1-8
    • Thumma, S.C.1    Kratzke, R.A.2
  • 143
    • 0037051093 scopus 로고    scopus 로고
    • Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma
    • Bauer, C. et al. Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma. Int. J. Cancer 98, 181-185 (2002).
    • (2002) Int. J. Cancer , vol.98 , pp. 181-185
    • Bauer, C.1
  • 144
    • 0031030030 scopus 로고    scopus 로고
    • Translation initiation factor eIF-4γ is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma
    • Brass, N. et al. Translation initiation factor eIF-4γ is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma. Hum. Mol. Genet. 6, 33-39 (1997).
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 33-39
    • Brass, N.1
  • 145
    • 49749125291 scopus 로고    scopus 로고
    • Targeting the eIF4F translation initiation complex for cancer therapy
    • Konicek, B. W., Dumstorf, C. A. & Graff, J. R. Targeting the eIF4F translation initiation complex for cancer therapy. Cell Cycle 7, 2466-2471 (2008).
    • (2008) Cell Cycle , vol.7 , pp. 2466-2471
    • Konicek, B.W.1    Dumstorf, C.A.2    Graff, J.R.3
  • 146
    • 33846449110 scopus 로고    scopus 로고
    • Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G
    • Moerke, N. J. et al. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell 128, 257-267 (2007).
    • (2007) Cell , vol.128 , pp. 257-267
    • Moerke, N.J.1
  • 147
    • 70349576526 scopus 로고    scopus 로고
    • Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia
    • Tamburini, J. et al. Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia. Blood 11 4, 1618-1627 (2009).
    • (2009) Blood , vol.11 , Issue.4 , pp. 1618-1627
    • Tamburini, J.1
  • 148
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre, S., Kroemer, G. & Raymond, E. Current development of mTOR inhibitors as anticancer agents. Nature Rev. Drug Discov. 5, 671-688 (2006).
    • (2006) Nature Rev. Drug Discov. , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.