Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients

Diabetes

Volumn 62, Issue 3, 2013, Pages 855-863

  Qatanani, Mohammed ^a   Tan, Yejun ^a   Dobrin, Radu ^a   Greenawalt, Danielle M ^a   Hu, Guanghui ^a   Zhao, Wenqing ^a   Olefsky, Jerrold M ^a   Sears, Dorothy D ^b,c   Kaplan, Lee M ^b   Kemp, Daniel M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; TRANSCRIPTOME;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CITRIC ACID CYCLE; DOWN REGULATION; FATTY ACID OXIDATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HOMEOSTASIS; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INFLAMMATION; INFORMATION SCIENCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MITOCHONDRION; MORBID OBESITY; PRIORITY JOURNAL; REGULATORY MECHANISM; UPREGULATION;

ADULT; BIOPSY; BODY MASS INDEX; CITRIC ACID CYCLE; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OBESITY, MORBID; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE PHOSPHORYLATION; RNA, MESSENGER; SUBCUTANEOUS FAT, ABDOMINAL; THIAZOLIDINEDIONES;

EID: 84874410516     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0399     Document Type: Article

References (47)

1. Li Z, Bowerman S, Heber D. Health ramifications of the obesity epidemic. Surg Clin North Am 2005;85:681-701
2. Olshansky SJ. Projecting the future of U.S. health and longevity. Health Aff (Millwood) 2005;24(Suppl 2):W5R86-89
3. American Diabetes Association. Diabetes statistics. 2011. Available from http://www.diabetes.org/diabetes-statistics/prevalence.jsp. Accessed 21 August 2011
4. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001;414:782-787
5. Flier JS. Obesity wars: Molecular progress confronts an expanding epidemic. Cell 2004;116:337-350
6. Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest 2000;106: 473-481
7. Qatanani M, Lazar MA. Mechanisms of obesity-associated insulin resistance: Many choices on the menu. Genes Dev 2007;21:1443-1455
8. Goldfine AB, Fonseca V, Shoelson SE. Therapeutic approaches to target inflammation in type 2 diabetes. Clin Chem 2011;57:162-167
9. Sims EA, Danforth E Jr, Horton ES, Bray GA, Glennon JA, Salans LB. Endocrine and metabolic effects of experimental obesity in man. Recent Prog Horm Res 1973;29:457-496
10. Freidenberg GR, Reichart D, Olefsky JM, Henry RR. Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss. J Clin Invest 1988;82:1398-1406
11. Bak JF, Møller N, Schmitz O, Saaek A, Pedersen O. In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: Effects of diet treatment. Diabetologia 1992;35:777-784
12. McLaughlin T, Abbasi F, Lamendola C, Reaven G. Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals: Effect of differences in insulin sensitivity. Arch Intern Med 2007;167:642-648
13. Reaven G. All obese individuals are not created equal: Insulin resistance is the major determinant of cardiovascular disease in overweight/obese individuals. Diab Vasc Dis Res 2005;2:105-112
14. Sims EA. Are there persons who are obese, but metabolically healthy? Metabolism 2001;50:1499-1504
15. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444: 860-867
16. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006;444:847-853
17. Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007;132:2169-2180
18. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-1808
19. Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112:1821-1830
20. Dahlman I, Kaaman M, Olsson T, et al. A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects. J Clin Endocrinol Metab 2005;90:5834-5840
21. Dolinková M, Dostálová I, Lacinová Z, et al. The endocrine profile of subcutaneous and visceral adipose tissue of obese patients. Mol Cell Endocrinol 2008;291:63-70
22. McLaughlin T, Sherman A, Tsao P, et al. Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis. Diabetologia 2007;50:1707-1715
23. McLaughlin T, Deng A, Gonzales O, et al. Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women. Diabetologia 2008;51:2303-2308
24. Liu A, McLaughlin T, Liu T, et al. Differential intra-abdominal adipose tissue profiling in obese, insulin-resistant women. Obes Surg 2009;19:1564-1573
25. Hardy OT, Perugini RA, Nicoloro SM, et al. Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surg Obes Relat Dis 2011;7:60-67
26. Elbein SC, Kern PA, Rasouli N, Yao-Borengasser A, Sharma NK, Das SK. Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI. Diabetes 2011;60:1019-1029
27. Rasouli N, Kern PA, Elbein SC, Sharma NK, Das SK. Improved insulin sensitivity after treatment with PPARg and PPARa ligands is mediated by genetically modulated transcripts. Pharmacogenet Genomics 2012;22: 484-497
28. Greenawalt DM, Dobrin R, Chudin E, et al. A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Res 2011;21:1008-1016
29. Hughes TR, Mao M, Jones AR, et al. Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. Nat Biotechnol 2001; 19:342-347
30. Sears DD, Hsiao G, Hsiao A, et al. Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. Proc Natl Acad Sci USA 2009;106:18745-18750
31. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419
32. Alssema M, Dekker JM, Nijpels G, Stehouwer CD, Bouter LM, Heine RJ; Hoorn Study. Proinsulin concentration is an independent predictor of allcause and cardiovascular mortality: An 11-year follow-up of the Hoorn Study. Diabetes Care 2005;28:860-865
33. Bhatia V, Viswanathan P. Insulin resistance and PPAR insulin sensitizers. Curr Opin Investig Drugs 2006;7:891-897
34. Vozarova B, Weyer C, Lindsay RS, Pratley RE, Bogardus C, Tataranni PA. High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 2002; 51:455-461
35. Anderson EK, Gutierrez DA, Hasty AH. Adipose tissue recruitment of leukocytes. Curr Opin Lipidol 2010;21:172-177
36. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011;29:415-445
37. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117:175-184
38. Liu J, Divoux A, Sun J, et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 2009;15:940-945
39. Feuerer M, Herrero L, Cipolletta D, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 2009;15:930-939
40. Colca JR, McDonald WG, Waldon DJ, et al. Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe. Am J Physiol Endocrinol Metab 2004;286:E252-E260
41. Mori MA, Liu M, Bezy O, et al. A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease. Diabetes 2010;59:2960-2971
42. Solomon DH, Massarotti E, Garg R, Liu J, Canning C, Schneeweiss S. Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis. JAMA 2011;305: 2525-2531
43. Fleischman A, Shoelson SE, Bernier R, Goldfine AB. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care 2008;31:289-294
44. Alvehus M, Burén J, Sjöström M, Goedecke J, Olsson T. The human visceral fat depot has a unique inflammatory profile. Obesity (Silver Spring) 2010;18:879-883
45. Arner P, Bernard S, Salehpour M, et al. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 2011;478:110-113
46. Hoffstedt J, Arner E, Wahrenberg H, et al. Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity. Diabetologia 2010;53:2496-2503
47. Arner P, Arner E, Hammarstedt A, Smith U. Genetic predisposition for type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis. PLoS One 2011;6:e18284