메뉴 건너뛰기




Volumn 17, Issue 6, 2012, Pages 813-822

Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: A meta-analysis

Author keywords

Cancer; Diabetes; Meta analysis; Metformin; Oral antidiabetic therapy; Sulfonylurea

Indexed keywords

INSULIN; METFORMIN; SULFONYLUREA;

EID: 84862848716     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2011-0462     Document Type: Review
Times cited : (231)

References (56)
  • 1
    • 0031752685 scopus 로고    scopus 로고
    • Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections
    • King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998;21:1414-1431.
    • (1998) Diabetes Care , vol.21 , pp. 1414-1431
    • King, H.1    Aubert, R.E.2    Herman, W.H.3
  • 2
    • 84860390016 scopus 로고    scopus 로고
    • Significantly increased risk of cancer in patients with diabetes mellitus: A systematic review and meta-analysis
    • Noto H, Tsuijmoto T, Takehiko S et al. Significantly increased risk of cancer in patients with diabetes mellitus: a systematic review and meta-analysis. Endocr Pract 2011;17:616-628.
    • (2011) Endocr Pract , vol.17 , pp. 616-628
    • Noto, H.1    Tsuijmoto, T.2    Takehiko, S.3
  • 3
    • 77952098898 scopus 로고    scopus 로고
    • Diabetes and cancer risk: Causal effects and other possible explanations
    • Hernandez-Diaz S, Adami H-O. Diabetes and cancer risk: causal effects and other possible explanations. Diabetologia 2010;53:802-808.
    • (2010) Diabetologia , vol.53 , pp. 802-808
    • Hernandez-Diaz, S.1    Adami, H.-O.2
  • 4
    • 48449104660 scopus 로고    scopus 로고
    • Managing type 2 diabetes: Going beyond glycaemic control
    • Stolar MW, Hoogwerf BJ, Gorshow SM et al. Managing type 2 diabetes: going beyond glycaemic control. J Manag Care Pharm 2008;14(5 suppl B):S2-S19.
    • (2008) J Manag Care Pharm , vol.14 , Issue.5 SUPPL. B
    • Stolar, M.W.1    Hoogwerf, B.J.2    Gorshow, S.M.3
  • 5
    • 13644263258 scopus 로고    scopus 로고
    • Oral antidiabetic agents: Current role in type 2 diabetes mellitus
    • Krentz AJ, Bailey CJ. Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 2005;65:385-411.
    • (2005) Drugs , vol.65 , pp. 385-411
    • Krentz, A.J.1    Bailey, C.J.2
  • 6
    • 40549125281 scopus 로고    scopus 로고
    • Glycemic index, glycemic load, and chronic disease risk-a meta-analysis of observational studies
    • Barclay AW, Petocz P, McMillan-Price J et al. Glycemic index, glycemic load, and chronic disease risk-a meta-analysis of observational studies. Am J Clin Nutr 2008;87:627-637.
    • (2008) Am J Clin Nutr , vol.87 , pp. 627-637
    • Barclay, A.W.1    Petocz, P.2    McMillan-Price, J.3
  • 8
    • 0032884082 scopus 로고    scopus 로고
    • Growth hormone, IGF-I and cancer. Less intervention to avoid cancer? More intervention to prevent cancer?
    • Holly JMP, Gunnell DJ, Davey Smith G. Growth hormone, IGF-I and cancer. Less intervention to avoid cancer? More intervention to prevent cancer? J Endocrinol 1999;162:321-330.
    • (1999) J Endocrinol , vol.162 , pp. 321-330
    • Holly, J.M.P.1    Gunnell, D.J.2    Davey Smith, G.3
  • 9
    • 79953661884 scopus 로고    scopus 로고
    • Understanding the benefit of metformin use in cancer treatment
    • Dowling RJ, Goodwin PJ, Stambolic V. Understanding the benefit of metformin use in cancer treatment. BMC Med 2011;9:33.
    • (2011) BMC Med , vol.9 , pp. 33
    • Dowling, R.J.1    Goodwin, P.J.2    Stambolic, V.3
  • 10
    • 25444462729 scopus 로고    scopus 로고
    • Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice
    • Anisimov VN, Egormin PA, Berstein LM. Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice. Bull Exp Biol Med 2005;139:721-723.
    • (2005) Bull Exp Biol Med , vol.139 , pp. 721-723
    • Anisimov, V.N.1    Egormin, P.A.2    Berstein, L.M.3
  • 11
    • 19544379375 scopus 로고    scopus 로고
    • Clinical usage of hypolipidemic and antidiabetic drugs in the prevention and treatment of cancer
    • Berstein LM. Clinical usage of hypolipidemic and antidiabetic drugs in the prevention and treatment of cancer. Cancer Lett 2005;224:203-212.
    • (2005) Cancer Lett , vol.224 , pp. 203-212
    • Berstein, L.M.1
  • 12
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • Zakikhani M, Dowling R, Fantus IG et al. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 2006;66:10269-10273.
    • (2006) Cancer Res , vol.66 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3
  • 13
    • 28944443806 scopus 로고    scopus 로고
    • Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers
    • Stolzenberg-Solomon RZ, Graubard BI, Chari S et al. Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers. JAMA 2005;294:2872-2878.
    • (2005) JAMA , vol.294 , pp. 2872-2878
    • Stolzenberg-Solomon, R.Z.1    Graubard, B.I.2    Chari, S.3
  • 14
    • 34547114031 scopus 로고    scopus 로고
    • Systematic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumour cell growth
    • Buzzai M, Jones RG, Amaravadi RK et al. Systematic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumour cell growth. Cancer Res 2007;67:6745-6752.
    • (2007) Cancer Res , vol.67 , pp. 6745-6752
    • Buzzai, M.1    Jones, R.G.2    Amaravadi, R.K.3
  • 15
    • 66949121471 scopus 로고    scopus 로고
    • AMP-activated protein kinase pathway: Potential therapeutic target in cardiometabolic disease
    • Wong AK, Howie J, Petrie JR et al. AMP-activated protein kinase pathway: potential therapeutic target in cardiometabolic disease. Clin Sci (Lond) 2009;116:607-620.
    • (2009) Clin Sci (Lond) , vol.116 , pp. 607-620
    • Wong, A.K.1    Howie, J.2    Petrie, J.R.3
  • 16
    • 78649302320 scopus 로고    scopus 로고
    • Metformin and cancer risk in diabetic patients: A systematic review and meta-analysis
    • Decensi A, Puntoni M, Goodwin P et al. Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res (Phila) 2010;3: 1451-1461.
    • (2010) Cancer Prev Res (Phila) , vol.3 , pp. 1451-1461
    • Decensi, A.1    Puntoni, M.2    Goodwin, P.3
  • 17
    • 79953776342 scopus 로고    scopus 로고
    • Intensive glycaemic control and cancer risk in type 2 diabetes: A meta-analysis of major trials
    • Johnson JA, Bowker SL. Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials. Diabetologia 2011;54:25-31.
    • (2011) Diabetologia , vol.54 , pp. 25-31
    • Johnson, J.A.1    Bowker, S.L.2
  • 18
    • 77955923866 scopus 로고    scopus 로고
    • Metformin: Taking away the candy for cancer?
    • Jalving M, Gietema JA, Lefrandt JD et al. Metformin: taking away the candy for cancer? Eur J Cancer 2010;46:2369-2380.
    • (2010) Eur J Cancer , vol.46 , pp. 2369-2380
    • Jalving, M.1    Gietema, J.A.2    Lefrandt, J.D.3
  • 20
    • 41049093347 scopus 로고
    • The combination of estimates from different experiments
    • Cochran WG. The combination of estimates from different experiments. Biometrics 1954;10:101-129.
    • (1954) Biometrics , vol.10 , pp. 101-129
    • Cochran, W.G.1
  • 21
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • Higgins JPT, Thompson SG, Deeks JJ et al. Measuring inconsistency in meta-analyses. BMJ 2003;327: 557-560.
    • (2003) BMJ , vol.327 , pp. 557-560
    • Higgins, J.P.T.1    Thompson, S.G.2    Deeks, J.J.3
  • 22
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Smith DG, Schneider M et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-634.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Smith, D.G.2    Schneider, M.3
  • 23
    • 5144234027 scopus 로고    scopus 로고
    • Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients
    • Yang YX, Hennessy S, Lewis JD. Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients. Gastroenterology 2004;127:1044-1050.
    • (2004) Gastroenterology , vol.127 , pp. 1044-1050
    • Yang, Y.X.1    Hennessy, S.2    Lewis, J.D.3
  • 25
    • 53749089278 scopus 로고    scopus 로고
    • Antidiabetic medication and prostate cancer risk: A populationbased case-control study
    • Murtola TJ, Tammela TL, Lahtela J et al. Antidiabetic medication and prostate cancer risk: a populationbased case-control study. Am J Epidemiol 2008;168: 925-931.
    • (2008) Am J Epidemiol , vol.168 , pp. 925-931
    • Murtola, T.J.1    Tammela, T.L.2    Lahtela, J.3
  • 26
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • Currie CJ, Poole CD, Gale EA. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 2009;52:1766-1777.
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.3
  • 27
    • 67650945180 scopus 로고    scopus 로고
    • Antidiabetic therapies affect risk of pancreatic cancer
    • Li D, Yeung SC, Hassan MM et al. Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology 2009;137:482-488.
    • (2009) Gastroenterology , vol.137 , pp. 482-488
    • Li, D.1    Yeung, S.C.2    Hassan, M.M.3
  • 28
    • 69549097703 scopus 로고    scopus 로고
    • New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
    • Libby G, Donnelly LA, Donnan PT et al. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 2009;32:1620-1625.
    • (2009) Diabetes Care , vol.32 , pp. 1620-1625
    • Libby, G.1    Donnelly, L.A.2    Donnan, P.T.3
  • 29
    • 77953539812 scopus 로고    scopus 로고
    • Longterm metformin use is associated with decreased risk of breast cancer
    • Bodmer M, Meier C, Krähenbühl S et al. Longterm metformin use is associated with decreased risk of breast cancer. Diabetes Care 2010;33:1304-1308.
    • (2010) Diabetes Care , vol.33 , pp. 1304-1308
    • Bodmer, M.1    Meier, C.2    Krähenbühl, S.3
  • 30
    • 77953537179 scopus 로고    scopus 로고
    • Glucoselowering agents and cancer mortality rates in type 2 diabetes: Assessing effects of time-varying exposure
    • Bowker SL, Yasui Y, Veugelers P et al. Glucoselowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure. Diabetologia 2010;53:1631-1637.
    • (2010) Diabetologia , vol.53 , pp. 1631-1637
    • Bowker, S.L.1    Yasui, Y.2    Veugelers, P.3
  • 31
    • 77954365681 scopus 로고    scopus 로고
    • Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease
    • Donadon V, Balbi M, Mas MD et al. Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease. Liver Int 2010;30: 750-758.
    • (2010) Liver Int , vol.30 , pp. 750-758
    • Donadon, V.1    Balbi, M.2    Mas, M.D.3
  • 32
    • 77951006620 scopus 로고    scopus 로고
    • Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma
    • Hassan MM, Curley SA, Li D et al. Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma. Cancer 2010;116:1938-1946.
    • (2010) Cancer , vol.116 , pp. 1938-1946
    • Hassan, M.M.1    Curley, S.A.2    Li, D.3
  • 33
    • 75149179169 scopus 로고    scopus 로고
    • Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16
    • Landman GW, Kleefstra N, van Hateren KJ et al. Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16. Diabetes Care 2010;33: 322-326.
    • (2010) Diabetes Care , vol.33 , pp. 322-326
    • Landman, G.W.1    Kleefstra, N.2    van Hateren, K.J.3
  • 34
    • 79951592967 scopus 로고    scopus 로고
    • Metformin and the incidence of prostate cancer in patients with type 2 diabetes
    • Azoulay L, Dell'Aniello S, Gagnon B et al. Metformin and the incidence of prostate cancer in patients with type 2 diabetes. Cancer Epidemiol Biomarkers Prev 2011;20:337-344.
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , pp. 337-344
    • Azoulay, L.1    Dell'Aniello, S.2    Gagnon, B.3
  • 35
    • 78651415908 scopus 로고    scopus 로고
    • Metformin and incident breast cancer among diabetic women: A population-based case-control study in Denmark
    • Bosco JL, Antonsen S, Sørensen HT et al. Metformin and incident breast cancer among diabetic women: a population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev 2011; 20:101-111.
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , pp. 101-111
    • Bosco, J.L.1    Antonsen, S.2    Sørensen, H.T.3
  • 36
    • 78651451726 scopus 로고    scopus 로고
    • Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: A representative population prospective cohort study of 800,000 individuals
    • Lee MS, Hsu CC, Wahlqvist ML et al. Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals. BMC Cancer 2011;11:20.
    • (2011) BMC Cancer , vol.11 , pp. 20
    • Lee, M.S.1    Hsu, C.C.2    Wahlqvist, M.L.3
  • 37
    • 79951708837 scopus 로고    scopus 로고
    • Metformin and cancer occurrence in insulin-treated type 2 diabetic patients
    • Monami M, Colombi C, Balzi D et al. Metformin and cancer occurrence in insulin-treated type 2 diabetic patients. Diabetes Care 2011;34:129-131.
    • (2011) Diabetes Care , vol.34 , pp. 129-131
    • Monami, M.1    Colombi, C.2    Balzi, D.3
  • 38
    • 79956098758 scopus 로고    scopus 로고
    • Diabetes and risk of prostate cancer: A study using the National Health Insurance
    • Tseng CH. Diabetes and risk of prostate cancer: a study using the National Health Insurance. Diabetes Care 2011;34:616-621.
    • (2011) Diabetes Care , vol.34 , pp. 616-621
    • Tseng, C.H.1
  • 39
    • 79951700516 scopus 로고    scopus 로고
    • Low HDL cholesterol, metformin use, and cancer risk in type 2 diabetes: The Hong Kong Diabetes Registry
    • Yang X, So WY, Ma RC et al. Low HDL cholesterol, metformin use, and cancer risk in type 2 diabetes: the Hong Kong Diabetes Registry. Diabetes Care 2011; 34:375-380.
    • (2011) Diabetes Care , vol.34 , pp. 375-380
    • Yang, X.1    So, W.Y.2    Ma, R.C.3
  • 40
    • 40349105880 scopus 로고    scopus 로고
    • Metabolic syndrome, hyperinsulinemia, and colon cancer: A review
    • Giovannucci E. Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. Am J Clin Nutr 2007;86:836s-842s.
    • (2007) Am J Clin Nutr , vol.86
    • Giovannucci, E.1
  • 41
    • 40349112853 scopus 로고    scopus 로고
    • Metabolic syndrome, hyperinsulinemia, and cancer
    • Hsu IR, Kim SP, Kabir M et al. Metabolic syndrome, hyperinsulinemia, and cancer. Am J Clin Nutr 2007;86:s867-s871.
    • (2007) Am J Clin Nutr , vol.86
    • Hsu, I.R.1    Kim, S.P.2    Kabir, M.3
  • 42
    • 34247869042 scopus 로고    scopus 로고
    • The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas
    • Giovannucci E, Michaud D. The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology 2007;132: 2208-2225.
    • (2007) Gastroenterology , vol.132 , pp. 2208-2225
    • Giovannucci, E.1    Michaud, D.2
  • 43
    • 34249023717 scopus 로고    scopus 로고
    • Relation between insulin resistance and breast cancer among Chilean women
    • Garmendia ML, Pereira A, Alvarado ME et al. Relation between insulin resistance and breast cancer among Chilean women. Ann Epidemiol 2007;17:403-409.
    • (2007) Ann Epidemiol , vol.17 , pp. 403-409
    • Garmendia, M.L.1    Pereira, A.2    Alvarado, M.E.3
  • 44
    • 76749106139 scopus 로고    scopus 로고
    • Diabetes mellitus type 2-an independent risk factor for cancer?
    • Grote VA, Becker S, Kaaks R. Diabetes mellitus type 2-an independent risk factor for cancer? Exp Clin Endocrinol Diabetes 2010;118:4-8.
    • (2010) Exp Clin Endocrinol Diabetes , vol.118 , pp. 4-8
    • Grote, V.A.1    Becker, S.2    Kaaks, R.3
  • 45
    • 47349117519 scopus 로고    scopus 로고
    • Hyper-insulinaemia and cancer, metaanalyses of epidemiological studies
    • Pisani P. Hyper-insulinaemia and cancer, metaanalyses of epidemiological studies. Arch Physiol Biochem 2008;114:63-70.
    • (2008) Arch Physiol Biochem , vol.114 , pp. 63-70
    • Pisani, P.1
  • 47
    • 33847080728 scopus 로고    scopus 로고
    • AMP-activated protein kinase in metabolic control and insulin signaling
    • Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 2007;100:328-341.
    • (2007) Circ Res , vol.100 , pp. 328-341
    • Towler, M.C.1    Hardie, D.G.2
  • 48
    • 33751550904 scopus 로고    scopus 로고
    • AMP-activated protein kinase-the fat controller of the energy railroad
    • Steinberg GR, Macaulay SL, Febbraio MA et al. AMP-activated protein kinase-the fat controller of the energy railroad. Can J Physiol Pharmacol 2006;84:655-665.
    • (2006) Can J Physiol Pharmacol , vol.84 , pp. 655-665
    • Steinberg, G.R.1    Macaulay, S.L.2    Febbraio, M.A.3
  • 49
    • 77952940043 scopus 로고    scopus 로고
    • Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle
    • Palacios OM, Carmona JJ, Michan S et al. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Aging (Albany NY) 2009;1:771-783.
    • (2009) Aging (Albany NY) , vol.1 , pp. 771-783
    • Palacios, O.M.1    Carmona, J.J.2    Michan, S.3
  • 50
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003;115:577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 51
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker SL, Majumdar SR, Veugelers P et al. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 2006;29:254-258.
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3
  • 52
    • 33751184340 scopus 로고    scopus 로고
    • Three-year mortality in diabetic patients treated with different combinations of insulin secretagogues and metformin
    • Monami M, Luzzi C, Lamanna C et al. Three-year mortality in diabetic patients treated with different combinations of insulin secretagogues and metformin. Diabetes Metab Res Rev 2006;22:477-482.
    • (2006) Diabetes Metab Res Rev , vol.22 , pp. 477-482
    • Monami, M.1    Luzzi, C.2    Lamanna, C.3
  • 53
    • 34948847587 scopus 로고    scopus 로고
    • Are sulfonylureas all the same? A cohort study on cardiovascular and cancer-related mortality
    • Monami M, Balzi D, Lamanna C et al. Are sulfonylureas all the same? A cohort study on cardiovascular and cancer-related mortality. Diabetes Metab Res Rev 2007;23:479-484.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 479-484
    • Monami, M.1    Balzi, D.2    Lamanna, C.3
  • 54
    • 68349148204 scopus 로고    scopus 로고
    • Insulin glargine and malignancy: An unwarranted alarm
    • Pocock SJ, Smeeth L. Insulin glargine and malignancy: an unwarranted alarm. Lancet 2009;374:511-513.
    • (2009) Lancet , vol.374 , pp. 511-513
    • Pocock, S.J.1    Smeeth, L.2
  • 55
    • 80052965382 scopus 로고    scopus 로고
    • Diabetes mellitus, medications for type 2 diabetes mellitus, and cancer risk
    • La Vecchia C. Diabetes mellitus, medications for type 2 diabetes mellitus, and cancer risk. Metabolism 2011;60:1357-1358.
    • (2011) Metabolism , vol.60 , pp. 1357-1358
    • La Vecchia, C.1
  • 56
    • 79952260043 scopus 로고    scopus 로고
    • Metformin use and mortality in ambulatory patients with diabetes and heart failure
    • Aguilar D, Chan W, Bozkurt B et al. Metformin use and mortality in ambulatory patients with diabetes and heart failure. Circ Heart Fail 2011;4:53-58.
    • (2011) Circ Heart Fail , vol.4 , pp. 53-58
    • Aguilar, D.1    Chan, W.2    Bozkurt, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.