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Volumn 53, Issue 4, 2012, Pages 792-801

Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue

Author keywords

Adenosine monophosphate activated protein kinase; Inflammation; Insulin sensitivity

Indexed keywords

ANGIOTENSINOGEN; ANTIDEPRESSANT AGENT; CARBONYL DERIVATIVE; CD4 ANTIGEN; GAMMA INTERFERON; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; METFORMIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A;

EID: 84859412650     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.P022905     Document Type: Article
Times cited : (186)

References (63)
  • 2
    • 0035655253 scopus 로고    scopus 로고
    • Are there persons who are obese, but metabolically healthy?
    • DOI 10.1053/meta.2001.27213
    • Sims, E. A. 2001. Are there persons who are obese, but metabolically healthy? Metabolism. 50: 1499-1504. (Pubitemid 34007425)
    • (2001) Metabolism: Clinical and Experimental , vol.50 , Issue.12 , pp. 1499-1504
    • Sims, E.A.H.1
  • 3
    • 28144442030 scopus 로고    scopus 로고
    • All obese individuals are not created equal: Insulin resistance is the major determinant of cardiovascular disease in overweight/obese individuals
    • Reaven, G. 2005. All obese individuals are not created equal: insulin resistance is the major determinant of cardiovascular disease in overweight/obese individuals. Diab. Vasc. Dis. Res. 2: 105-112. (Pubitemid 41695168)
    • (2005) Diabetes and Vascular Disease Research , vol.2 , Issue.3 , pp. 105-112
    • Reaven, G.1
  • 5
    • 77956666561 scopus 로고    scopus 로고
    • Adipose tissue inflammation and insulin resistance: All obese humans are not created equal
    • Gauthier, M. S., and N. B. Ruderman. 2010. Adipose tissue inflammation and insulin resistance: all obese humans are not created equal. Biochem. J. 430: e1-e4.
    • (2010) Biochem. J. , vol.430
    • Gauthier, M.S.1    Ruderman, N.B.2
  • 6
    • 0030884698 scopus 로고    scopus 로고
    • Insulin resistance and hypersecretion in obesity
    • European Group for the Study of Insulin Resistance (EGIR)
    • Ferrannini, E., A. Natali, P. Bell, P. Cavallo-Perin, N. Lalic and G. Ningrone. 1997. Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J. Clin. Invest. 100: 1166-1173.
    • (1997) J. Clin. Invest. , vol.100 , pp. 1166-1173
    • Ferrannini, E.1    Natali, A.2    Bell, P.3    Cavallo-Perin, P.4    Lalic, N.5    Ningrone, G.6
  • 8
    • 78650964142 scopus 로고    scopus 로고
    • Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
    • Gauthier, M-S., E. L. O'Brien, S. Bigornia, M. Mott, J. M. Cacicedo, X. J. Xu, N. Gokce, C. Apovian, and N. Ruderman. 2011. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem. Biophys. Res. Commun. 404: 382-387.
    • (2011) Biochem. Biophys. Res. Commun. , vol.404 , pp. 382-387
    • Gauthier, M.-S.1    O'Brien, E.L.2    Bigornia, S.3    Mott, M.4    Cacicedo, J.M.5    Xu, X.J.6    Gokce, N.7    Apovian, C.8    Ruderman, N.9
  • 9
    • 0035029874 scopus 로고    scopus 로고
    • Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese zucker rats
    • Bergeron, R., S. F. Previs, G. W. Cline, P. Perret, R. R. Russell 3rd, L. H. Young, and G. I. Shulman. 2001. Effect of 5-aminoimidazole-4-carboxamide- 1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. Diabetes. 50: 1076-1082. (Pubitemid 32374538)
    • (2001) Diabetes , vol.50 , Issue.5 , pp. 1076-1082
    • Bergeron, R.1    Previs, S.F.2    Cline, G.W.3    Perret, P.4    Russell III, R.R.5    Young, L.H.6    Shulman, G.I.7
  • 11
    • 0036788292 scopus 로고    scopus 로고
    • AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats
    • Iglesias, M. A., J. M. Ye, G. Frangioudakis, A. K. Saha, E. Tomas, N. B. Ruderman, G. J. Cooney, and E. W. Kraegen. 2002. AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes. 51: 2886-2894.
    • (2002) Diabetes , vol.51 , pp. 2886-2894
    • Iglesias, M.A.1    Ye, J.M.2    Frangioudakis, G.3    Saha, A.K.4    Tomas, E.5    Ruderman, N.B.6    Cooney, G.J.7    Kraegen, E.W.8
  • 12
    • 3843061592 scopus 로고    scopus 로고
    • AMP kinase and malonyl-CoA: Targets for therapy of the metabolic syndrome
    • Ruderman, N., and M. Prentki. 2004. AMP kinase and malonyl- CoA: targets for therapy of the metabolic syndrome. Nat. Rev. Drug Discov. 3: 340-351. (Pubitemid 38499761)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.4 , pp. 340-351
    • Ruderman, N.1    Prentki, M.2
  • 13
    • 33749370466 scopus 로고    scopus 로고
    • Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects
    • DOI 10.2337/db06-0062
    • Bandyopadhyay, G. K., J. G. Yu, J. Ofrecio, and J. M. Olefsky. 2006. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis. Diabetes. 55: 2277-2285. (Pubitemid 44743625)
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2277-2285
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 20
    • 0036732527 scopus 로고    scopus 로고
    • Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans
    • Olusi, S. O. 2002. Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans. Int. J. Obes.Relat. Metab. Disord. 26: 1159-1164.
    • (2002) Int. J. Obes.Relat. Metab. Disord. , vol.26 , pp. 1159-1164
    • Olusi, S.O.1
  • 21
    • 38449098785 scopus 로고    scopus 로고
    • Plasma protein carbonyl and thiol stress before and after laparascopic gastric banding in morbidly obese patients
    • Uzun, H., D. Konukoglu, R. Gelisgen, K. Zemgin, and T. Mustafa. 2007. Plasma protein carbonyl and thiol stress before and after laparascopic gastric banding in morbidly obese patients. Obes. Surg. 17: 1367-1373.
    • (2007) Obes. Surg. , vol.17 , pp. 1367-1373
    • Uzun, H.1    Konukoglu, D.2    Gelisgen, R.3    Zemgin, K.4    Mustafa, T.5
  • 22
    • 77951666172 scopus 로고    scopus 로고
    • Pericardial fat volume correlates with inflammatory markers: The Framingham Heart Study
    • Tadros, T. M., J. M. Massaro, G. A. Rosito, U. Hoffmann, et al. 2010. Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study. Obesity (Silver Spring). 18: 1039-1045.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 1039-1045
    • Tadros, T.M.1    Massaro, J.M.2    Rosito, G.A.3    Hoffmann, U.4
  • 24
    • 2442421194 scopus 로고    scopus 로고
    • Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin Resistance, Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis Revisited
    • DOI 10.1161/01.ATV.0000122852.22604.78
    • Ceriello, A., and E. Motz. 2004. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler. Thromb. Vasc. Biol. 24: 816-823. (Pubitemid 38620857)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.5 , pp. 816-823
    • Ceriello, A.1    Motz, E.2
  • 25
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis, N., E. D. Rosen, and E. S. Lander. 2006. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature. 440: 944-948.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 26
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • DOI 10.1038/414813a
    • Brownlee, M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature. 414: 813-820. (Pubitemid 34000785)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 813-820
    • Brownlee, M.1
  • 27
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    • DOI 10.1007/BF00280883
    • Matthews, D. R., J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner. 1985. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28: 412-419. (Pubitemid 15018832)
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3
  • 28
    • 0035710746 scopus 로고    scopus 로고
    • -Delta DeltaCT method
    • DOI 10.1006/meth.2001.1262
    • Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25: 402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 29
    • 27444443876 scopus 로고    scopus 로고
    • Diagnosis and management of the metabolic syndrome: An AHA/NHLBI scientifi c statement
    • Grundy, S. M., J. I. Cleeman, S. R. Daniels, et al. 2005. Diagnosis and management of the metabolic syndrome: an AHA/NHLBI scientifi c statement. Circulation. 112: 2735-2752.
    • (2005) Circulation , vol.112 , pp. 2735-2752
    • Grundy, S.M.1    Cleeman, J.I.2    Daniels, S.R.3
  • 30
    • 0029910018 scopus 로고    scopus 로고
    • Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
    • DOI 10.1074/jbc.271.44.27879
    • Hawley, S. A., M. Davison, A. Woods, S. P. Davies, R. K. Beri, D. Carling, and D. G. Hardie. 1996. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J. Biol. Chem. 271: 27879-27887. (Pubitemid 26367365)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.44 , pp. 27879-27887
    • Hawley, S.A.1    Davison, M.2    Woods, A.3    Davies, S.P.4    Beri, R.K.5    Carling, D.6    Hardie, D.G.7
  • 31
    • 0031967987 scopus 로고    scopus 로고
    • Angiotensinogen levels and obesity in four black populations
    • DOI 10.1097/00004872-199816050-00003
    • Cooper, R., T. Forrester, O. Ogunbiyi, and J. J. Muffinda. 1998. Angiotensinogen levels and obesity in four black populations. ICSHIB Investigators. J. Hypertens. 16: 571-575. (Pubitemid 28230544)
    • (1998) Journal of Hypertension , vol.16 , Issue.5 , pp. 571-575
    • Cooper, R.1    Forrester, T.2    Ogunbiyi, O.3    Muffinda, J.4
  • 34
    • 70450277113 scopus 로고    scopus 로고
    • Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway
    • McGillicuddy, F. C., E. H. Chiguoine, C. C. Hinkle, R. J. Kim, R. Shah, H. M. Roche, E. M. Smyth, and M. P. Reilly. 2009. Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J. Biol. Chem. 284: 31936-31944.
    • (2009) J. Biol. Chem. , vol.284 , pp. 31936-31944
    • McGillicuddy, F.C.1    Chiguoine, E.H.2    Hinkle, C.C.3    Kim, R.J.4    Shah, R.5    Roche, H.M.6    Smyth, E.M.7    Reilly, M.P.8
  • 35
    • 43049096860 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in obesity
    • Kola, B., A. B. Grossman, and M. Korbonits. 2008. The role of AMP-activated protein kinase in obesity. Front. Horm. Res. 36: 198-211.
    • (2008) Front. Horm. Res. , vol.36 , pp. 198-211
    • Kola, B.1    Grossman, A.B.2    Korbonits, M.3
  • 36
    • 33747139670 scopus 로고    scopus 로고
    • Nampt/PBEF/Visfatin: A regulator of mammalian health and longevity?
    • DOI 10.1016/j.exger.2006.06.003, PII S0531556506001793
    • Yang, H., S. Lavu, and D. A. Sinclair. 2006. Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity? Exp. Gerontol. 41: 718-726. (Pubitemid 44223900)
    • (2006) Experimental Gerontology , vol.41 , Issue.8 , pp. 718-726
    • Yang, H.1    Lavu, S.2    Sinclair, D.A.3
  • 37
    • 0034504237 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome
    • DOI 10.1210/er.21.6.697
    • Wajchenberg, B. L. 2000. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr. Rev. 21: 697-738. (Pubitemid 32113289)
    • (2000) Endocrine Reviews , vol.21 , Issue.6 , pp. 697-738
    • Wajchenberg, B.L.1
  • 38
    • 0026691717 scopus 로고
    • Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells
    • Hellmér, J., C. Marcus, T. Sonnenfeld, and P. Arner. 1992. Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells. J. Clin. Endocrinol. Metab. 75: 15-20.
    • (1992) J. Clin. Endocrinol. Metab. , vol.75 , pp. 15-20
    • Hellmér, J.1    Marcus, C.2    Sonnenfeld, T.3    Arner, P.4
  • 39
    • 70350228797 scopus 로고    scopus 로고
    • Depot-specific differences in adipogenic progenitor abundance and proliferative response to high-fat diet
    • Joe, A. W. B., L. Yi, Y. Even, A. W. Vogl, and F. M. V. Rossi. 2009. Depot-specific differences in adipogenic progenitor abundance and proliferative response to high-fat diet. Stem Cells. 27: 2563-2570.
    • (2009) Stem Cells , vol.27 , pp. 2563-2570
    • Joe, A.W.B.1    Yi, L.2    Even, Y.3    Vogl, A.W.4    Rossi, F.M.V.5
  • 41
    • 33744951039 scopus 로고    scopus 로고
    • Inflammation and the metabolic syndrome: Role of angiotensin II and oxidative stress
    • Ferder, L., F. Inserra, and M. Martinez-Maldonado. 2006. Inflammation and the metabolic syndrome: role of angiotensin II and oxidative stress. Curr. Hypertens. Rep. 8: 191-198. (Pubitemid 43853445)
    • (2006) Current Hypertension Reports , vol.8 , Issue.3 , pp. 191-198
    • Ferder, L.1    Inserra, F.2    Martinez-Maldonado, M.3
  • 44
    • 34248343425 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1, adipose tissue and insulin resistance
    • DOI 10.1097/MOL.0b013e32814e6d29, PII 0004143320070600000003
    • Alessi, M. C., M. Poggi, and I. Juhan-Vague. 2007. Plasminogen activator inhibitor-1, adipose tissue and insulin resistance. Curr. Opin. Lipidol. 18: 240-245. (Pubitemid 46743045)
    • (2007) Current Opinion in Lipidology , vol.18 , Issue.3 , pp. 240-245
    • Alessi, M.-C.1    Poggi, M.2    Juhan-Vague, I.3
  • 46
    • 77953517927 scopus 로고    scopus 로고
    • Macrophage alph1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1
    • Yang, Z., B. B. Kahn, H. Shi, and B. Z. Xue. 2010. Macrophage alph1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J. Biol. Chem. 285: 19051-19059.
    • (2010) J. Biol. Chem. , vol.285 , pp. 19051-19059
    • Yang, Z.1    Kahn, B.B.2    Shi, H.3    Xue, B.Z.4
  • 47
    • 67650882500 scopus 로고    scopus 로고
    • AMPKα1 regulates the antioxidant status of vascular endothelial cells
    • Colombo, S. L., and S. Moncada. 2009. AMPKα1 regulates the antioxidant status of vascular endothelial cells. Biochem. J. 421: 163-169.
    • (2009) Biochem. J. , vol.421 , pp. 163-169
    • Colombo, S.L.1    Moncada, S.2
  • 49
    • 79959705713 scopus 로고    scopus 로고
    • AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: A randomised glycaemia-controlled crossover study
    • Boyle, J. G., P. J. Logan, G. C. Jones, M. Small, N. Sattar, J. M. Connell, S. J. Cleland, and I. P. Salt. 2011. AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study. Diabetologia. 54: 1799-1809.
    • (2011) Diabetologia , vol.54 , pp. 1799-1809
    • Boyle, J.G.1    Logan, P.J.2    Jones, G.C.3    Small, M.4    Sattar, N.5    Connell, J.M.6    Cleland, S.J.7    Salt, I.P.8
  • 50
    • 0023655369 scopus 로고
    • Protein damage and degradation by oxygen radicals
    • Davies, K. J. 1987. Protein damage and degradation by oxygen radicals. J. Biol. Chem. 262: 9895-9901.
    • (1987) J. Biol. Chem. , vol.262 , pp. 9895-9901
    • Davies, K.J.1
  • 52
  • 54
    • 58149316660 scopus 로고    scopus 로고
    • Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress
    • Rongvaux, A., M. Galli, S. Denanglaire, F. Van Gool, P. L. Dreze, C. Szpirer, F. Bureau, F. Andris, and O. Leo. 2008. Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress. J. Immunol. 181: 4685-4695.
    • (2008) J. Immunol. , vol.181 , pp. 4685-4695
    • Rongvaux, A.1    Galli, M.2    Denanglaire, S.3    Van Gool, F.4    Dreze, P.L.5    Szpirer, C.6    Bureau, F.7    Andris, F.8    Leo, O.9
  • 56
    • 43049121395 scopus 로고    scopus 로고
    • Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
    • DOI 10.1016/j.devcel.2008.02.004, PII S1534580708000749
    • Fulco, M., Y. Cen, P. Zhao, E. P. Hoffman, M. W. McBurney, A. A. Sauve, and V. Sartorelli. 2008. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPKmediated regulation of Nampt. Dev. Cell. 14: 661-673. (Pubitemid 351622608)
    • (2008) Developmental Cell , vol.14 , Issue.5 , pp. 661-673
    • Fulco, M.1    Cen, Y.2    Zhao, P.3    Hoffman, E.P.4    McBurney, M.W.5    Sauve, A.A.6    Sartorelli, V.7
  • 57
    • 77953285326 scopus 로고    scopus 로고
    • SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis
    • Costa, C. S., T. O. Hammes, F. Rohden, R. Margis, J. W. Bortolotto, A. V. Padoin, C. C. Mottin, and R. M. Guaragna. 2010. SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis. Obes. Surg. 20: 633-639.
    • (2010) Obes. Surg. , vol.20 , pp. 633-639
    • Costa, C.S.1    Hammes, T.O.2    Rohden, F.3    Margis, R.4    Bortolotto, J.W.5    Padoin, A.V.6    Mottin, C.C.7    Guaragna, R.M.8
  • 58
    • 47749085114 scopus 로고    scopus 로고
    • AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: Potential mechanism and physiological relevance
    • Gauthier, M. S., H. Miyoshi, S. C. Souza, J. M. Cacicedo, A. K. Saha, A. S. Greenberg, and N. B. Ruderman. 2008. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J. Biol. Chem. 283: 16514-16524.
    • (2008) J. Biol. Chem. , vol.283 , pp. 16514-16524
    • Gauthier, M.S.1    Miyoshi, H.2    Souza, S.C.3    Cacicedo, J.M.4    Saha, A.K.5    Greenberg, A.S.6    Ruderman, N.B.7
  • 59
    • 14344257169 scopus 로고    scopus 로고
    • AMPK inhibits fatty acid-induced increases in NF-kB transactivation in cultured human umbilical vein endothelial cells
    • DOI 10.1016/j.bbrc.2004.09.177
    • Cacicedo, J. M., N. Yagihashi, J. F. Keaney Jr, N. B. Ruderman, and Y. Ido. 2004. AMPK inhibits fatty acid-induced increases in NF-kB transactivation in cultured human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 324: 1204-1209. (Pubitemid 40292150)
    • (2004) Biochemical and Biophysical Research Communications , vol.324 , Issue.4 , pp. 1204-1209
    • Cacicedo, J.M.1    Yagihashi, N.2    Keaney Jr., J.F.3    Ruderman, N.B.4    Ido, Y.5
  • 60
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag, D., D. Carling, R. D. Stout, and J. Suttles. 2008. Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J. Immunol. 181: 8633-8641.
    • (2008) J. Immunol. , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 62
    • 34248199965 scopus 로고    scopus 로고
    • Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase
    • DOI 10.1074/jbc.M608310200
    • Wu, Y., P. Song, J. Xu, M. Zhang, and M-H. Zou. 2007. Activation of protein phosphatase 2a by palmitate inhibits AMP-activated protein kinase. J. Biol. Chem. 282: 9777-9788. (Pubitemid 47104626)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.13 , pp. 9777-9788
    • Wu, Y.1    Song, P.2    Xu, J.3    Zhang, M.4    Zou, M.-H.5
  • 63
    • 77957078371 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and inflammation in obesity and diabetes
    • Hummasti, S., and G. S. Hotamisligil. 2010. Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ. Res. 107: 579-591.
    • (2010) Circ. Res. , vol.107 , pp. 579-591
    • Hummasti, S.1    Hotamisligil, G.S.2


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