-
1
-
-
0141567744
-
RecQ helicases: suppressors of tumorigenesis and premature aging
-
Bachrati C.Z., and Hickson I.D. RecQ helicases: suppressors of tumorigenesis and premature aging. Biochem. J. 374 (2003) 577-606
-
(2003)
Biochem. J.
, vol.374
, pp. 577-606
-
-
Bachrati, C.Z.1
Hickson, I.D.2
-
2
-
-
4444281968
-
What can progeroid syndromes tell us about human aging?
-
Kipling D., Davis T., Ostler E.L., and Faragher R.G.A. What can progeroid syndromes tell us about human aging?. Science 305 (2004) 1426-1431
-
(2004)
Science
, vol.305
, pp. 1426-1431
-
-
Kipling, D.1
Davis, T.2
Ostler, E.L.3
Faragher, R.G.A.4
-
3
-
-
14644442350
-
Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing?
-
Puzianowska-Kuznicka M., and Kuznicki J. Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing?. Int. J. Biochem. Cell Biol. 37 (2005) 947-960
-
(2005)
Int. J. Biochem. Cell Biol.
, vol.37
, pp. 947-960
-
-
Puzianowska-Kuznicka, M.1
Kuznicki, J.2
-
5
-
-
34247390746
-
Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid syndromes
-
Kudlow B.A., Kennedy B.K., and Monnat Jr. R.J. Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid syndromes. Nat. Rev. Mol. Cell Biol. 8 (2007) 394-404
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 394-404
-
-
Kudlow, B.A.1
Kennedy, B.K.2
Monnat Jr., R.J.3
-
6
-
-
15844409553
-
Positional cloning of the Werner's syndrome gene
-
Yu C.-E., Oshima J., Fu Y.-H., Wijsman E.M., Hisama F., Alisch R., Matthews S., Nakura J., Miki T., Ouais S., Martin G.M., Mulligan J., and Schellenberg G.D. Positional cloning of the Werner's syndrome gene. Science 272 (1996) 258-262
-
(1996)
Science
, vol.272
, pp. 258-262
-
-
Yu, C.-E.1
Oshima, J.2
Fu, Y.-H.3
Wijsman, E.M.4
Hisama, F.5
Alisch, R.6
Matthews, S.7
Nakura, J.8
Miki, T.9
Ouais, S.10
Martin, G.M.11
Mulligan, J.12
Schellenberg, G.D.13
-
7
-
-
24044441918
-
Deficient DNA repair in the human progeroid disorders, Werner syndrome
-
Bohr V.A. Deficient DNA repair in the human progeroid disorders, Werner syndrome. Mutat. Res. 577 (2005) 252-259
-
(2005)
Mutat. Res.
, vol.577
, pp. 252-259
-
-
Bohr, V.A.1
-
8
-
-
33845286555
-
Human laminopathies: nuclei gone genetically awry
-
Capell B.C., and Collins F.S. Human laminopathies: nuclei gone genetically awry. Nature Rev. Genet. 7 (2006) 940-952
-
(2006)
Nature Rev. Genet.
, vol.7
, pp. 940-952
-
-
Capell, B.C.1
Collins, F.S.2
-
9
-
-
0037202608
-
Recombinational DNA repair and human disease
-
Thompson L.H., and Schild D. Recombinational DNA repair and human disease. Mutat. Res. 509 (2002) 49-78
-
(2002)
Mutat. Res.
, vol.509
, pp. 49-78
-
-
Thompson, L.H.1
Schild, D.2
-
10
-
-
34249993770
-
Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells
-
Ariyoshi K., Suzuki K., Goto M., Watanabe M., and Kodama S. Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells. J. Radiat Res. (Tokyo) 48 (2007) 219-231
-
(2007)
J. Radiat Res. (Tokyo)
, vol.48
, pp. 219-231
-
-
Ariyoshi, K.1
Suzuki, K.2
Goto, M.3
Watanabe, M.4
Kodama, S.5
-
11
-
-
33745016642
-
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
-
Shumaker D.K., Dechat T., Kohlmaier A., Adam S.A., Bozowsky M.R., Erdos M.R., Eriksson M., Goldman A.E., Khuon S., Collins F.S., Jenuwein T., and Goldman R.D. Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc. Natl. Acad. Sci. USA 103 (2006) 8703-8708
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 8703-8708
-
-
Shumaker, D.K.1
Dechat, T.2
Kohlmaier, A.3
Adam, S.A.4
Bozowsky, M.R.5
Erdos, M.R.6
Eriksson, M.7
Goldman, A.E.8
Khuon, S.9
Collins, F.S.10
Jenuwein, T.11
Goldman, R.D.12
-
12
-
-
33746883839
-
Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci
-
Manju K., Muralikrishna B., and Parnaik V.K. Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci. J. Cell Sci. 119 (2006) 2704-2714
-
(2006)
J. Cell Sci.
, vol.119
, pp. 2704-2714
-
-
Manju, K.1
Muralikrishna, B.2
Parnaik, V.K.3
-
14
-
-
28944447430
-
PIDD mediates NF-κB activation in response to DNA damage
-
Janssens S., Tinel A., Lippens S., and Tschopp J. PIDD mediates NF-κB activation in response to DNA damage. Cell 123 (2005) 1079-1092
-
(2005)
Cell
, vol.123
, pp. 1079-1092
-
-
Janssens, S.1
Tinel, A.2
Lippens, S.3
Tschopp, J.4
-
15
-
-
33749249590
-
NF-κB activation by double-strand breaks
-
Habraken Y., and Piette J. NF-κB activation by double-strand breaks. Biochem. Pharmacol. 72 (2006) 1132-1141
-
(2006)
Biochem. Pharmacol.
, vol.72
, pp. 1132-1141
-
-
Habraken, Y.1
Piette, J.2
-
16
-
-
33646006734
-
Signals from within: the DNA-damage-induced NF-κB response
-
Janssens S., and Tschopp J. Signals from within: the DNA-damage-induced NF-κB response. Cell Death Differ. 13 (2006) 773-784
-
(2006)
Cell Death Differ.
, vol.13
, pp. 773-784
-
-
Janssens, S.1
Tschopp, J.2
-
17
-
-
33750312876
-
Posttranslational modifications of NEMO and its partners in NF-κB signaling
-
Sebban H., Yamaoka S., and Courtois G. Posttranslational modifications of NEMO and its partners in NF-κB signaling. Trends Cell Biol. 16 (2006) 569-577
-
(2006)
Trends Cell Biol.
, vol.16
, pp. 569-577
-
-
Sebban, H.1
Yamaoka, S.2
Courtois, G.3
-
18
-
-
0026970404
-
Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review)
-
Schreck R., Albermann K., and Baeuerle P.A. Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Rad. Res. Commun. 17 (1992) 221-237
-
(1992)
Free Rad. Res. Commun.
, vol.17
, pp. 221-237
-
-
Schreck, R.1
Albermann, K.2
Baeuerle, P.A.3
-
19
-
-
33845768987
-
Integrating cell-signalling pathways with NF-kappaB and IKK function
-
Perkins N.D. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat. Rev. Mol. Cell Biol. 8 (2007) 49-62
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 49-62
-
-
Perkins, N.D.1
-
20
-
-
4444376712
-
Signaling to NF-kappaB
-
Hayden M.S., and Ghosh S. Signaling to NF-kappaB. Genes Dev. 18 (2004) 2195-2224
-
(2004)
Genes Dev.
, vol.18
, pp. 2195-2224
-
-
Hayden, M.S.1
Ghosh, S.2
-
21
-
-
25844459154
-
NF-kappaB: linking inflammation and immunity to cancer development and progression
-
Karin M., and Greten F.R. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nature Rev. Immunol. 5 (2005) 749-759
-
(2005)
Nature Rev. Immunol.
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
22
-
-
33750443289
-
IkB kinase complexes: gateways to NF-κB activation and transcription
-
Scheidereit C. IkB kinase complexes: gateways to NF-κB activation and transcription. Oncogene 25 (2006) 6685-6705
-
(2006)
Oncogene
, vol.25
, pp. 6685-6705
-
-
Scheidereit, C.1
-
24
-
-
33644538632
-
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
-
Wu Z.-H., Shi Y., Tibbetts R.S., and Miyamoto S. Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science 311 (2006) 1141-1146
-
(2006)
Science
, vol.311
, pp. 1141-1146
-
-
Wu, Z.-H.1
Shi, Y.2
Tibbetts, R.S.3
Miyamoto, S.4
-
25
-
-
33846783142
-
NF-kappaB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage
-
Wuerzberger-Davis S.M., Nakamura Y., Seufzer B.J., and Miyamoto S. NF-kappaB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage. Oncogene 26 (2007) 641-651
-
(2007)
Oncogene
, vol.26
, pp. 641-651
-
-
Wuerzberger-Davis, S.M.1
Nakamura, Y.2
Seufzer, B.J.3
Miyamoto, S.4
-
26
-
-
33748188499
-
PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress
-
Mabb A.M., Wuerzberger-Davis S.M., and Miyamoto S. PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress. Nat. Cell Biol. 8 (2006) 986-993
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 986-993
-
-
Mabb, A.M.1
Wuerzberger-Davis, S.M.2
Miyamoto, S.3
-
27
-
-
0344305376
-
Sequential modification of NEMO/IKKγ by SUMO-1 and ubiquitin mediates NF-κB activation by genotoxic stress
-
Huang T.T., Wuerzberger-Davis S.M., Wu Z.-H., and Miyamoto S. Sequential modification of NEMO/IKKγ by SUMO-1 and ubiquitin mediates NF-κB activation by genotoxic stress. Cell 115 (2003) 565-576
-
(2003)
Cell
, vol.115
, pp. 565-576
-
-
Huang, T.T.1
Wuerzberger-Davis, S.M.2
Wu, Z.-H.3
Miyamoto, S.4
-
29
-
-
34447548569
-
Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents
-
Haince J.-F., Kozlov S., Dawson V.L., Hendzel M.J., Lavin M.F., and Poirier G.G. Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. J. Biol. Chem. 282 (2007) 16441-16453
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 16441-16453
-
-
Haince, J.-F.1
Kozlov, S.2
Dawson, V.L.3
Hendzel, M.J.4
Lavin, M.F.5
Poirier, G.G.6
-
30
-
-
0036710459
-
The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders
-
Hassa P.O., and Hottiger M.O. The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. Cell. Mol. Life Sci. 59 (2002) 1534-1553
-
(2002)
Cell. Mol. Life Sci.
, vol.59
, pp. 1534-1553
-
-
Hassa, P.O.1
Hottiger, M.O.2
-
31
-
-
0034733928
-
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
-
Shall S., and de Murcia G. Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?. Mutat. Res. 460 (2000) 1-15
-
(2000)
Mutat. Res.
, vol.460
, pp. 1-15
-
-
Shall, S.1
de Murcia, G.2
-
32
-
-
33750735356
-
DNA repair and PARP in aging
-
Burkle A. DNA repair and PARP in aging. Free Rad. Res. 40 (2006) 1295-1302
-
(2006)
Free Rad. Res.
, vol.40
, pp. 1295-1302
-
-
Burkle, A.1
-
33
-
-
34047248402
-
Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB
-
Huang W.-C., Ju T.-K., Hung M.-C., and Chen C.-C. Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB. Mol. Cell 26 (2007) 75-87
-
(2007)
Mol. Cell
, vol.26
, pp. 75-87
-
-
Huang, W.-C.1
Ju, T.-K.2
Hung, M.-C.3
Chen, C.-C.4
-
34
-
-
0033975869
-
Innate immune recognition: mechanisms and pathways
-
Medzhitov R., and Janeway Jr. C. Innate immune recognition: mechanisms and pathways. Immunol. Rev. 173 (2000) 89-97
-
(2000)
Immunol. Rev.
, vol.173
, pp. 89-97
-
-
Medzhitov, R.1
Janeway Jr., C.2
-
35
-
-
34547605613
-
IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
-
Lee D.-F., Kuo H.-P., Chen C.-T., Hsu J.-M., Chou C.-K., Wei Y., Sun H.-L., Li L.-Y., Ping B., Huang W.C., He X., Hung J.-Y., Lai C.-C., Ding Q., Su J.-L., Yang J.-Y., Sahin A.A., Hortobagyi G.N., Tsai F.-J., Tsai C.-H., and Hung M.-C. IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 130 (2007) 440-455
-
(2007)
Cell
, vol.130
, pp. 440-455
-
-
Lee, D.-F.1
Kuo, H.-P.2
Chen, C.-T.3
Hsu, J.-M.4
Chou, C.-K.5
Wei, Y.6
Sun, H.-L.7
Li, L.-Y.8
Ping, B.9
Huang, W.C.10
He, X.11
Hung, J.-Y.12
Lai, C.-C.13
Ding, Q.14
Su, J.-L.15
Yang, J.-Y.16
Sahin, A.A.17
Hortobagyi, G.N.18
Tsai, F.-J.19
Tsai, C.-H.20
Hung, M.-C.21
more..
-
36
-
-
33746727619
-
Werner syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome?
-
Davis T., and Kipling D. Werner syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome?. Rejuvenation Res. 9 (2006) 402-407
-
(2006)
Rejuvenation Res.
, vol.9
, pp. 402-407
-
-
Davis, T.1
Kipling, D.2
-
37
-
-
0033793152
-
The network and the remodeling theories of aging: historical background and new perspectives
-
Franceschi C., Valesin S., Bonafe M., Paolisso G., Yashin A.I., Monti D., and De Benedictis G. The network and the remodeling theories of aging: historical background and new perspectives. Exp. Gerontol. 35 (2000) 879-896
-
(2000)
Exp. Gerontol.
, vol.35
, pp. 879-896
-
-
Franceschi, C.1
Valesin, S.2
Bonafe, M.3
Paolisso, G.4
Yashin, A.I.5
Monti, D.6
De Benedictis, G.7
-
38
-
-
40949123149
-
-
A. Salminen, J. Huuskonen, J. Ojala, A. Kauppinen, K. Kaarniranta, T. Suuronen, Activation of innate immunity system during aging: NF-κB signaling is the molecular culprit of inflamm-aging. Aging Res. Rev. doi:10.1016/j.arr.2007.
-
A. Salminen, J. Huuskonen, J. Ojala, A. Kauppinen, K. Kaarniranta, T. Suuronen, Activation of innate immunity system during aging: NF-κB signaling is the molecular culprit of inflamm-aging. Aging Res. Rev. doi:10.1016/j.arr.2007.
-
-
-
-
39
-
-
28544439444
-
The role of the immune system in the pathophysiology of osteoporosis
-
Clowes J.A., Riggs B.L., and Khosla S. The role of the immune system in the pathophysiology of osteoporosis. Immunol. Rev. 208 (2005) 207-227
-
(2005)
Immunol. Rev.
, vol.208
, pp. 207-227
-
-
Clowes, J.A.1
Riggs, B.L.2
Khosla, S.3
-
40
-
-
5444262078
-
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
-
Cai D., Frantz J.D., Tawa Jr N.E., Melendez P.A., Oh B.-C., Lidov H.G.W., Hasselgren P.-O., Frontera W.R., Lee J., Glass D.J., and Shoelson S.E. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell 119 (2004) 285-298
-
(2004)
Cell
, vol.119
, pp. 285-298
-
-
Cai, D.1
Frantz, J.D.2
Tawa Jr, N.E.3
Melendez, P.A.4
Oh, B.-C.5
Lidov, H.G.W.6
Hasselgren, P.-O.7
Frontera, W.R.8
Lee, J.9
Glass, D.J.10
Shoelson, S.E.11
-
41
-
-
8444252436
-
TLR signaling: an emerging bridge from innate immunity to atherogenesis
-
Michelsen K.S., Doherty T.M., Shah P.K., and Arditi M. TLR signaling: an emerging bridge from innate immunity to atherogenesis. J. Immunol. 173 (2004) 5901-5907
-
(2004)
J. Immunol.
, vol.173
, pp. 5901-5907
-
-
Michelsen, K.S.1
Doherty, T.M.2
Shah, P.K.3
Arditi, M.4
-
42
-
-
33745840859
-
Hyaluronan fragments act as an endogenous danger signal by engaging TLR2
-
Scheibner K.A., Lutz M.A., Boodoo S., Fenton M.J., Powell J.D., and Horton M.R. Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J. Immunol. 177 (2006) 1272-1281
-
(2006)
J. Immunol.
, vol.177
, pp. 1272-1281
-
-
Scheibner, K.A.1
Lutz, M.A.2
Boodoo, S.3
Fenton, M.J.4
Powell, J.D.5
Horton, M.R.6
|