Activation of nuclear factor-kappa B signalling promotes cellular senescence

Oncogene

Volumn 30, Issue 20, 2011, Pages 2356-2366

  Rovillain, E ^a   Mansfield, L ^a   Caetano, C ^a   Alvarez Fernandez, M ^b   Caballero, O L ^c   Medema, R H ^b   Hummerich, H ^a   Jat, P S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

Author keywords

cellular senescence; conditional immortalisation; differential expression; NF B signalling; senescence bypass

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAMIN; PROTEIN P16; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB;

ARTICLE; CELL CYCLE ARREST; CELL IMMORTALIZATION; DOWN REGULATION; FIBROBLAST; GENE EXPRESSION PROFILING; GENETIC COMPLEMENTATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; ONCOGENE; OXIDATIVE STRESS; PRIORITY JOURNAL; SENESCENCE; SIGNAL TRANSDUCTION; TELOMERE; UPREGULATION;

CELL AGING; CELL LINE, TRANSFORMED; FIBROBLASTS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, P16; GENES, P53; GENETIC COMPLEMENTATION TEST; HUMANS; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 79956148168     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.611     Document Type: Article

References (54)

1. Adams PD. (2009). Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell 36: 2-14.
2. Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY. (2007). Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev 21: 3244-3257. (Pubitemid 350277752)
3. Aggarwal BB, Totpal K, LaPushin R, Chaturvedi MM, Pereira-Smith OM, Smith JR. (1995). Diminished responsiveness of senescent normal human fibroblasts to TNF-dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B. Exp Cell Res 218: 381-388.
4. Barsotti AM, Prives C. (2009). Pro-proliferative FoxM1 is a target of p53-mediated repression. Oncogene 28: 4295-4305.
5. Batsi C, Markopoulou S, Vartholomatos G, Georgiou I, Kanavaros P, Gorgoulis VG et al. (2009). Chronic NF-kappaB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response. Mech Ageing Dev 130: 409-419.
6. Berns K, Hijmans EM, Mullenders J, Brummelkamp TR, Velds A, Heimerikx M et al. (2004). A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428: 431-437. (Pubitemid 38419689)
7. Ben-Porath I, Weinberg RA. (2005). The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 37: 961-976. (Pubitemid 40311739)
8. Besnier C, Ylinen L, Strange B, Lister A, Takeuchi Y, Goff SP et al. (2003). Characterization of murine leukemia virus restriction in mammals. J Virol 77: 13403-13406. (Pubitemid 37494335)
9. Campisi J, d'Adda di Fagagna F. (2007). Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8: 729-740. (Pubitemid 47312822)
10. Collado M, Blasco MA, Serrano M. (2007). Cellular senescence in cancer and aging. Cell 130: 223-233. (Pubitemid 47081143)
11. Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM et al. (1998). Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci USA 95: 14723-14728. (Pubitemid 29003697)
12. Dimri GP, Campisi J. (1994). Altered profile of transcription factor-binding activities in senescent human fibroblasts. Exp Cell Res 212: 132-140. (Pubitemid 24167367)
13. Dodeller F, Gottar M, Huesken D, Iourgenko V, Cenni B. (2008). The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways. J Biol Chem 283: 21487-21494.
14. Gonos ES, Burns JS, Mazars GR, Kobrna A, Riley TE, Barnett SC et al. (1996). Rat embryo fibroblasts immortalized with simian virus 40 large T antigen undergo senescence upon its inactivation. Mol Cell Biol 16: 5127-5138. (Pubitemid 26272166)
15. Gorman SD, Cristofalo VJ. (1985). Reinitiation of cellular DNA synthesis in BrdU-selected nondividing senescent WI-38 cells by simian virus 40 infection. J Cell Physiol 125: 122-126. (Pubitemid 15012077)
16. Hanahan D, Weinberg RA. (2000). The hallmarks of cancer. Cell 100: 57-70. (Pubitemid 30046295)
17. Hardy K, Mansfield L, Mackay A, Benvenuti S, Ismail S, Arora P et al. (2005). Transcriptional networks and cellular senescence in human mammary fibroblasts. Mol Biol Cell 16: 943-953. (Pubitemid 40165583)
18. Hayden MS, Ghosh S. (2008). Shared principles in NF-kappaB signaling. Cell 132: 344-362.
19. Hayflick L, Moorhead PS. (1961). The serial cultivation of human diploid cell strains. Exp Cell Res 25: 585-621.
20. He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y et al. (2007). A microRNA component of the p53 tumour suppressor network. Nature 447: 1130-1134. (Pubitemid 47014436)
21. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U et al. (2003). Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249-264.
22. Jensen LJ, Kuhn M, Stark M, Chaffron S, Creevey C, Muller J et al. (2009). STRING 8-a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res 37: D412-D416.
23. Karin M. (2009). NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol 1: a000141.
24. Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ. (1998). Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396: 84-88. (Pubitemid 28520454)
25. Kriete A, Mayo KL, Yalamanchili N, Beggs W, Bender P, Kari C et al. (2008). Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity. Immun Ageing 5: 5.
26. Kriete A, Mayo KL. (2009). Atypical pathways of NF-kappaB activation and aging. Exp Gerontol 44: 250-255.
27. Kuilman T, Michaloglou C, Vredeveld LC, Douma S, Van Doorn R, Desmet CJ et al. (2008). Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133: 1019-1031. (Pubitemid 351787746)
28. Kuilman T, Peeper DS. (2009). Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer 9: 81-94.
29. Laoukili J, Alvarez M, Meijer LA, Stahl M, Mohammed S, Kleij L et al. (2008a). Activation of FoxM1 during G2 requires cyclin A/ Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain. Mol Cell Biol 28: 3076-3087. (Pubitemid 351556538)
30. Laoukili J, Alvarez-Fernandez M, Stahl M, Medema RH. (2008b). FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner. Cell Cycle 7: 2720-2726.
31. Laoukili J, Stahl M, Medema RH. (2007). FoxM1: at the crossroads of ageing and cancer. Biochim Biophys Acta 1775: 92-102. (Pubitemid 44881197)
32. Ly DH, Lockhart DJ, Lerner RA, Schultz PG. (2000). Mitotic misregulation and human aging. Science 287: 2486-2492. (Pubitemid 30185444)
33. Mansfield LV. (2006). Dissecting the Telomere-Independent Pathways Underlying Human Cellular Senescence, PhD thesis. University of London, London, UK.
34. Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y et al. (2003). Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22: 3307-3318. (Pubitemid 36712943)
35. Micheau O, Lens S, Gaide O, Alevizopoulos K, Tschopp J. (2001). NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol 21: 5299-5305. (Pubitemid 32702435)
36. Momand J, Zambetti GP, Olson DC, George D, Levine AJ. (1992). The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69: 1237-1245.
37. O'Hare MJ, Bond J, Clarke C, Takeuchi Y, Atherton AJ, Berry C et al. (2001). Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells. Proc Natl Acad Sci USA 98: 646-651. (Pubitemid 32105097)
38. Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J. (2009). Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci USA 106: 17031-17036.
39. Ossovskaya VS, Mazo IA, Chernov MV, Chernova OB, Strezoska Z, Kondratov R et al. (1996). Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains. Proc Natl Acad Sci USA 93: 10309-10314. (Pubitemid 26314618)
40. Park HJ, Wang Z, Costa RH, Tyner A, Lau LF, Raychaudhuri P. (2008). An N-terminal inhibitory domain modulates activity of FoxM1 during cell cycle. Oncogene 27: 1696-1704. (Pubitemid 351380268)
41. Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ et al (2010). Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol 6: 347.
42. Penzo M, Massa PE, Olivotto E, Bianchi F, Borzi RM, Hanidu A et al. (2009). Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1. J Cell Physiol 218: 215-227.
43. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S et al. (2004). NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431: 461-466. (Pubitemid 39329586)
44. Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D et al. (2004). Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci USA 101: 9309-9314. (Pubitemid 38812872)
45. Rowland BD, Denissov SG, Douma S, Stunnenberg HG, Bernards R, Peeper DS. (2002). E2F transcriptional repressor complexes are critical downstream targets of p19 (ARF)/p53-induced proliferative arrest. Cancer Cell 2: 55-65. (Pubitemid 41043988)
46. Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. (2008). Activation of innate immunity system during aging: NF-kB signalling is the molecular culprit of inflamm-aging. Ageing Res Rev 7: 83-105. (Pubitemid 351418294)
47. Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D et al. (2003). Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13: 2498-2504. (Pubitemid 37428274)
48. Shelton DN, Chang E, Whittier PS, Choi D, Funk WD. (1999). Microarray analysis of replicative senescence. Curr Biol 9: 939-945. (Pubitemid 29442477)
49. Taganov KD, Boldin MP, Chang KJ, Baltimore D. (2006). NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 103: 12481-12486. (Pubitemid 44267285)
50. Walia V, Ding M, Kumar S, Nie D, Premkumar LS, Elble RC. (2009). hCLCA2 is a p53-inducible inhibitor of breast cancer cell proliferation. Cancer Res 69: 6624-6632.
51. Wang IC, Chen YJ, Hughes D, Petrovic V, Major ML, Park HJ et al. (2005). Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol 25: 10875-10894. (Pubitemid 41747132)
52. Whitfield ML, Sherlock G, Saldanha AJ, Murray JI, Ball CA, Alexander KE et al. (2002). Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell 13: 1977-2000. (Pubitemid 34651487)
53. Yamakuchi M, Ferlito M, Lowenstein CJ. (2008). miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci USA 105: 13421-13426.
54. Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA et al. (2004). Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23: 2369-2380. (Pubitemid 38954844)