메뉴 건너뛰기




Volumn 114, Issue 7, 2013, Pages 834-843

Airway smooth muscle in the pathophysiology and treatment of asthma

Author keywords

Airflow obstruction; Airway remodeling; Inflammation

Indexed keywords

ARTICLE; ASTHMA; BIOLOGICAL MODEL; HUMAN; LUNG; PATHOLOGY; PATHOPHYSIOLOGY; SMOOTH MUSCLE;

EID: 84878580085     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00950.2012     Document Type: Article
Times cited : (136)

References (151)
  • 4
    • 33746718743 scopus 로고    scopus 로고
    • How does exercise cause asthma attacks?
    • DOI 10.1097/01.all.0000199797.02423.78, PII 0013083220060200000008
    • Anderson SD. How does exercise cause asthma attacks? Curr Opin Allergy Clin Immunol 6:37-42, 2006. (Pubitemid 44517807)
    • (2006) Current Opinion in Allergy and Clinical Immunology , vol.6 , Issue.1 , pp. 37-42
    • Anderson, S.D.1
  • 5
    • 80053018467 scopus 로고    scopus 로고
    • Biochemical basis of asthma therapy
    • Barnes PJ. Biochemical basis of asthma therapy. J Biol Chem 286:32899-32905, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 32899-32905
    • Barnes, P.J.1
  • 9
    • 36749095585 scopus 로고    scopus 로고
    • Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma
    • DOI 10.1136/thx.2006.073429
    • Berry M, Morgan A, Shaw DE, Parker D, Green R, Brightling C, Bradding P, Wardlaw AJ, Pavord ID. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax 62:1043-1049, 2007. (Pubitemid 350206195)
    • (2007) Thorax , vol.62 , Issue.12 , pp. 1043-1049
    • Berry, M.1    Morgan, A.2    Shaw, D.E.3    Parker, D.4    Green, R.5    Brightling, C.6    Bradding, P.7    Wardlaw, A.J.8    Pavord, I.D.9
  • 10
    • 77249157385 scopus 로고    scopus 로고
    • Chronic activation in shortened airway smooth muscle: A synergistic combination underlying airway hyperresponsiveness?
    • Bosse Y, Chin LY, Pare PD, Seow CY. Chronic activation in shortened airway smooth muscle: a synergistic combination underlying airway hyperresponsiveness? Am J Respir Cell Mol Biol 42:341-348, 2010.
    • (2010) Am J Respir Cell Mol Biol , vol.42 , pp. 341-348
    • Bosse, Y.1    Chin, L.Y.2    Pare, P.D.3    Seow, C.Y.4
  • 11
    • 77956821305 scopus 로고    scopus 로고
    • Bronchial hyperresponsiveness in the assessment of asthma control: Airway hyperresponsiveness in asthma: Its measurement and clinical significance
    • Brannan JD. Bronchial hyperresponsiveness in the assessment of asthma control: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 138:11S-17S, 2010.
    • (2010) Chest , vol.138
    • Brannan, J.D.1
  • 13
    • 84856680087 scopus 로고    scopus 로고
    • Muscarinic receptor antagonists: Effects on pulmonary function
    • Buels KS, Fryer AD. Muscarinic receptor antagonists: effects on pulmonary function. Hand Exp Pharmacol 208:317-341, 2012.
    • (2012) Hand Exp Pharmacol , vol.208 , pp. 317-341
    • Buels, K.S.1    Fryer, A.D.2
  • 15
    • 84873367468 scopus 로고    scopus 로고
    • Use of continuous positive airway pressure reduces airway reactivity in adults with asthma
    • Busk M, Busk N, Puntenney P, Hutchins J, Yu Z, Gunst SJ, Tepper RS. Use of continuous positive airway pressure reduces airway reactivity in adults with asthma. Eur Respir J 41:317-322, 2013.
    • (2013) Eur Respir J , vol.41 , pp. 317-322
    • Busk, M.1    Busk, N.2    Puntenney, P.3    Hutchins, J.4    Yu, Z.5    Gunst, S.J.6    Tepper, R.S.7
  • 17
    • 33748475192 scopus 로고    scopus 로고
    • Reflex regulation of airway smooth muscle tone
    • DOI 10.1152/japplphysiol.00313.2006
    • Canning BJ. Reflex regulation of airway smooth muscle tone. J Appl Physiol 101:971-985, 2006. (Pubitemid 44352315)
    • (2006) Journal of Applied Physiology , vol.101 , Issue.3 , pp. 971-985
    • Canning, B.J.1
  • 19
    • 78649424607 scopus 로고    scopus 로고
    • RhoA, a possible target for treatment of airway hyperresponsiveness in bronchial asthma
    • Chiba Y, Matsusue K, Misawa M. RhoA, a possible target for treatment of airway hyperresponsiveness in bronchial asthma. J Pharm Sci 114:239-247, 2010.
    • (2010) J Pharm Sci , vol.114 , pp. 239-247
    • Chiba, Y.1    Matsusue, K.2    Misawa, M.3
  • 23
    • 0032808099 scopus 로고    scopus 로고
    • Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1β and TNFα: Effects of IL-10 and corticosteroids
    • DOI 10.1038/sj.bjp.0702660
    • Chung KF, Patel HJ, Fadlon EJ, Rousell J, Haddad EB, Jose PJ, Mitchell J, Belvisi M. Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1beta and TNFalpha: effects of IL-10 and corticosteroids. Br J Pharmacol 127:1145-1150, 1999. (Pubitemid 29326637)
    • (1999) British Journal of Pharmacology , vol.127 , Issue.5 , pp. 1145-1150
    • Fan Chung, K.1    Patel, H.J.2    Fadlon, E.J.3    Rousell, J.4    Haddad, E.-B.5    Jose, P.J.6    Mitchell, J.7    Belvisi, M.8
  • 30
    • 77953280084 scopus 로고    scopus 로고
    • P70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression
    • Deng H, Hershenson MB, Lei J, Bitar KN, Fingar DC, Solway J, Bentley JK. p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression. Am J Respir Cell Mol Biol 42:744-752, 2010.
    • (2010) Am J Respir Cell Mol Biol , vol.42 , pp. 744-752
    • Deng, H.1    Hershenson, M.B.2    Lei, J.3    Bitar, K.N.4    Fingar, D.C.5    Solway, J.6    Bentley, J.K.7
  • 31
    • 78650790075 scopus 로고    scopus 로고
    • Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo
    • Dillon PF, Root-Bernstein R, Robinson NE, Abraham WM, Berney C. Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. PLos One 5:e15130, 2010.
    • (2010) PLos One , vol.5
    • Dillon, P.F.1    Root-Bernstein, R.2    Robinson, N.E.3    Abraham, W.M.4    Berney, C.5
  • 37
    • 0027181166 scopus 로고
    • Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: A 3-D morphometric study
    • Ebina M, Takahashi T, Chiba T, Motomiya M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am Rev Respir Dis 148:720-726, 1993. (Pubitemid 23263786)
    • (1993) American Review of Respiratory Disease , vol.148 , Issue.3 , pp. 720-726
    • Ebina, M.1    Takahashi, T.2    Chiba, T.3    Motomiya, M.4
  • 38
    • 34247348118 scopus 로고    scopus 로고
    • A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans
    • DOI 10.1002/gepi.20210
    • Flores C, Ma SF, Maresso K, Ober C, Garcia JG. A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans. Genet Epidemiol 31:296-305, 2007. (Pubitemid 46642094)
    • (2007) Genetic Epidemiology , vol.31 , Issue.4 , pp. 296-305
    • Flores, C.1    Ma, S.-F.2    Maresso, K.3    Ober, C.4    Garcia, J.G.N.5
  • 39
    • 0030028768 scopus 로고    scopus 로고
    • Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    • DOI 10.1084/jem.183.1.195
    • Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med 183:195-201, 1996. (Pubitemid 26028759)
    • (1996) Journal of Experimental Medicine , vol.183 , Issue.1 , pp. 195-201
    • Foster, P.S.1    Hogan, S.P.2    Ramsay, A.J.3    Matthaei, K.I.4    Young, I.G.5
  • 42
    • 80155180513 scopus 로고    scopus 로고
    • Relationship between polymorphisms in the 5' leader cistron, positions 16 and 27 of the adrenergic beta2 receptor gene and asthma in a Han population from southwest China
    • Fu WP, Zhao ZH, Zhong L, Sun C, Fang LZ, Liu L, Zhang JQ, Wang L, Shu JK, Wang XM, Dai LM. Relationship between polymorphisms in the 5' leader cistron, positions 16 and 27 of the adrenergic beta2 receptor gene and asthma in a Han population from southwest China. Respirology 16:1221-1227, 2011.
    • (2011) Respirology , vol.16 , pp. 1221-1227
    • Fu, W.P.1    Zhao, Z.H.2    Zhong, L.3    Sun, C.4    Fang, L.Z.5    Liu, L.6    Zhang, J.Q.7    Wang, L.8    Shu, J.K.9    Wang, X.M.10    Dai, L.M.11
  • 44
    • 0026783671 scopus 로고
    • Airway cooling and rewarming. The second reaction sequence in exercise-induced asthma
    • Gilbert IA, McFadden ER Jr. Airway cooling and rewarming. The second reaction sequence in exercise-induced asthma. J Clin Invest 90:699-704, 1992.
    • (1992) J Clin Invest , vol.90 , pp. 699-704
    • Gilbert, I.A.1    Mcfadden Jr., E.R.2
  • 47
    • 0029339086 scopus 로고
    • Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells
    • Green SA, Turki J, Bejarano P, Hall IP, Liggett SB. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 13:25-33, 1995.
    • (1995) Am J Respir Cell Mol Biol , vol.13 , pp. 25-33
    • Green, S.A.1    Turki, J.2    Bejarano, P.3    Hall, I.P.4    Liggett, S.B.5
  • 49
    • 0035140711 scopus 로고    scopus 로고
    • Selected contribution: Plasticity of airway smooth muscle stiffness and extensibility: Role of length-adaptive mechanisms
    • Gunst SJ, Wu MF. Selected contribution: plasticity of airway smooth muscle stiffness and extensibility: role of length-adaptive mechanisms. J Appl Physiol 90:741-749, 2001. (Pubitemid 32118938)
    • (2001) Journal of Applied Physiology , vol.90 , Issue.2 , pp. 741-749
    • Gunst, S.J.1    Wu, M.-F.2
  • 50
    • 0024040764 scopus 로고
    • Down-regulation of beta-adrenergic receptors: Agonist-induced reduction in receptor mRNA levels
    • Hadcock JR, Malbon CC. Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels. Proc Natl Acad Sci USA 85:5021-5025, 1988.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 5021-5025
    • Hadcock, J.R.1    Malbon, C.C.2
  • 52
    • 0032699292 scopus 로고    scopus 로고
    • Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle
    • Hakonarson H, Maskeri N, Carter C, Chuang S, Grunstein MM. Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle. J Clin Invest 104:657-667, 1999.
    • (1999) J Clin Invest , vol.104 , pp. 657-667
    • Hakonarson, H.1    Maskeri, N.2    Carter, C.3    Chuang, S.4    Grunstein, M.M.5
  • 56
    • 42149196003 scopus 로고    scopus 로고
    • Targeting airway inflammation in asthma: Current and future therapies
    • DOI 10.1378/chest.07-0829
    • Hanania NA. Targeting airway inflammation in asthma: current and future therapies. Chest 133:989-998, 2008. (Pubitemid 351536877)
    • (2008) Chest , vol.133 , Issue.4 , pp. 989-998
    • Hanania, N.A.1
  • 57
    • 33751325028 scopus 로고    scopus 로고
    • Recovery from bronchoconstriction and bronchodilator tolerance
    • DOI 10.1385/CRIAI:31:2:181, PII CRIAI312181
    • Haney S, Hancox RJ. Recovery from bronchoconstriction and bronchodilator tolerance. Clin Rev Allergy Immunol 31:181-196, 2006. (Pubitemid 44804947)
    • (2006) Clinical Reviews in Allergy and Immunology , vol.31 , Issue.2-3 , pp. 181-196
    • Haney, S.1    Hancox, R.J.2
  • 59
    • 0029915964 scopus 로고    scopus 로고
    • PDGF isoform-induced proliferation and receptor expression in human cultured airway smooth muscle cells
    • Hirst SJ, Barnes PJ, Twort CH. PDGF isoform-induced proliferation and receptor expression in human cultured airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 270:L415-L428, 1996.
    • (1996) Am J Physiol Lung Cell Mol Physiol , vol.270
    • Hirst, S.J.1    Barnes, P.J.2    Twort, C.H.3
  • 60
    • 53149123285 scopus 로고    scopus 로고
    • Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: Cooperative roles for CADM1, stem cell factor, and IL-6
    • Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol 181:2772-2780, 2008.
    • (2008) J Immunol , vol.181 , pp. 2772-2780
    • Hollins, F.1    Kaur, D.2    Yang, W.3    Cruse, G.4    Saunders, R.5    Sutcliffe, A.6    Berger, P.7    Ito, A.8    Brightling, C.E.9    Bradding, P.10
  • 61
    • 76149084817 scopus 로고    scopus 로고
    • An official research policy statement of the American Thoracic Society/European Respiratory Society: Standards for quantitative assessment of lung structure
    • Hsia CC, Hyde DM, Ochs M, Weibel ER. An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure. Am J Respir Crit Care Med 181:394-418, 2010.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 394-418
    • Hsia, C.C.1    Hyde, D.M.2    Ochs, M.3    Weibel, E.R.4
  • 63
    • 0034077676 scopus 로고    scopus 로고
    • Airway smooth muscle in health and disease; methods of measurement and relation to function
    • DOI 10.1034/j.1399-3003.2000.15d25.x
    • James A, Carroll N. Airway smooth muscle in health and disease; methods of measurement and relation to function. Eur Respir J 15:782-789, 2000. (Pubitemid 30196310)
    • (2000) European Respiratory Journal , vol.15 , Issue.4 , pp. 782-789
    • James, A.1    Carroll, N.2
  • 67
    • 84860902418 scopus 로고    scopus 로고
    • A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in beta2-adrenergic receptor internalization and down-regulation
    • Jiang X, Pan H, Nabhan JF, Krishnan R, Koziol-White C, Panettieri RA, Lu Q. A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in beta2-adrenergic receptor internalization and down-regulation. FASEB J 26:1995-2007, 2012.
    • (2012) FASEB J , vol.26 , pp. 1995-2007
    • Jiang, X.1    Pan, H.2    Nabhan, J.F.3    Krishnan, R.4    Koziol-White, C.5    Panettieri, R.A.6    Lu, Q.7
  • 68
    • 0031568394 scopus 로고    scopus 로고
    • Human airway smooth muscle cells express and release rantes in response to t helper 1 cytokines: Regulation by t helper 2 cytokines and corticosteroids
    • John M, Hirst SJ, Jose PJ, Robichaud A, Berkman N, Witt C, Twort CH, Barnes PJ, Chung KF. Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids. J Immunol 158:1841-1847, 1997. (Pubitemid 127469542)
    • (1997) Journal of Immunology , vol.158 , Issue.4 , pp. 1841-1847
    • John, M.1    Hirst, S.J.2    Jose, P.J.3    Robichaud, A.4    Berkman, N.5    Witt, C.6    Twort, C.H.C.7    Barnes, P.J.8    Chung, K.F.9
  • 69
    • 29544449036 scopus 로고    scopus 로고
    • Molecular mechanisms of beta (2)-adrenergic receptor function, response, and regulation
    • Johnson M. Molecular mechanisms of beta (2)-adrenergic receptor function, response, and regulation. J Allergy Clin Immunol 117:18-25, 2006.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 18-25
    • Johnson, M.1
  • 72
    • 0032480574 scopus 로고    scopus 로고
    • Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma
    • DOI 10.1016/S0140-6736(97)12261-9
    • Kon OM, Sihra BS, Compton CH, Leonard TB, Kay AB, Barnes NC. Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma. Lancet 352:1109-1113, 1998. (Pubitemid 28448517)
    • (1998) Lancet , vol.352 , Issue.9134 , pp. 1109-1113
    • Kon, O.M.1    Sihra, B.S.2    Compton, C.H.3    Leonard, T.B.4    Kay, A.B.5    Barnes, N.C.6
  • 74
    • 80053542412 scopus 로고    scopus 로고
    • Phosphodiesterase type 4D gene polymorphism: Association with the response to short-acting bronchodilators in paediatric asthma patients
    • Labuda M, Laberge S, Briere J, Berube D, Beaulieu P, Pastinen T, Krajinovic M. Phosphodiesterase type 4D gene polymorphism: association with the response to short-acting bronchodilators in paediatric asthma patients. Med Inf (Lond) 2011:301695, 2011.
    • (2011) Med Inf (Lond) , vol.2011 , pp. 301695
    • Labuda, M.1    Laberge, S.2    Briere, J.3    Berube, D.4    Beaulieu, P.5    Pastinen, T.6    Krajinovic, M.7
  • 81
    • 0027994066 scopus 로고
    • T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis
    • DOI 10.1084/jem.180.3.807
    • Lazaar AL, Albelda SM, Pilewski JM, Brennan B, Pure E, Panettieri RA Jr. T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis. J Exp Med 180:807-816, 1994. (Pubitemid 24256594)
    • (1994) Journal of Experimental Medicine , vol.180 , Issue.3 , pp. 807-816
    • Lazaar, A.L.1    Albelda, S.M.2    Pilewski, J.M.3    Brennan, B.4    Pure, E.5    Panettieri Jr., R.A.6
  • 83
    • 33751173229 scopus 로고    scopus 로고
    • Effect of transforming growth factor-beta receptor I kinase inhibitor 2, 4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling
    • Leung SY, Niimi A, Noble A, Oates T, Williams AS, Medicherla S, Protter AA, Chung KF. Effect of transforming growth factor-beta receptor I kinase inhibitor 2, 4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling. J Pharmacol Exp Ther 319:586-594, 2006.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 586-594
    • Leung, S.Y.1    Niimi, A.2    Noble, A.3    Oates, T.4    Williams, A.S.5    Medicherla, S.6    Protter, A.A.7    Chung, K.F.8
  • 84
    • 0036185622 scopus 로고    scopus 로고
    • High resolution computed tomographic assessment of airway wall thickness in chronic asthma: Reproducibility and relationship with lung function and severity
    • DOI 10.1136/thorax.57.3.247
    • Little SA, Sproule MW, Cowan MD, Macleod KJ, Robertson M, Love JG, Chalmers GW, McSharry CP, Thomson NC. High resolution computed tomographic assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity. Thorax 57:247-253, 2002. (Pubitemid 34214412)
    • (2002) Thorax , vol.57 , Issue.3 , pp. 247-253
    • Little, S.A.1    Sproule, M.W.2    Cowan, M.D.3    Macleod, K.J.4    Robertson, M.5    Love, J.G.6    Chalmers, G.W.7    McSharry, C.P.8    Thomson, N.C.9
  • 88
    • 17844400081 scopus 로고    scopus 로고
    • Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-β antibody: Effect on the Smad signaling pathway
    • McMillan SJ, Xanthou G, Lloyd CM. Manipulation of allergeninduced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway. J Immunol 174:5774-5780, 2005. (Pubitemid 40593221)
    • (2005) Journal of Immunology , vol.174 , Issue.9 , pp. 5774-5780
    • McMillan, S.J.1    Xanthou, G.2    Lloyd, C.M.3
  • 90
    • 21844445318 scopus 로고    scopus 로고
    • A prospective feasibility study of bronchial thermoplasty in the human airway
    • Miller JD, Cox G, Vincic L, Lombard CM, Loomas BE, Danek CJ. A prospective feasibility study of bronchial thermoplasty in the human airway. Chest 127:1999-2006, 2005.
    • (2005) Chest , vol.127 , pp. 1999-2006
    • Miller, J.D.1    Cox, G.2    Vincic, L.3    Lombard, C.M.4    Loomas, B.E.5    Danek, C.J.6
  • 91
    • 84860010929 scopus 로고    scopus 로고
    • Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor
    • Molfino NA, Gossage D, Kolbeck R, Parker JM, Geba GP. Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor. Clin Exp Allergy 42:712-737, 2012.
    • (2012) Clin Exp Allergy , vol.42 , pp. 712-737
    • Molfino, N.A.1    Gossage, D.2    Kolbeck, R.3    Parker, J.M.4    Geba, G.P.5
  • 96
    • 77953295635 scopus 로고    scopus 로고
    • Recent advances in the pathophysiology of asthma
    • Murphy DM, O'Byrne PM. Recent advances in the pathophysiology of asthma. Chest 137:1417-1426, 2010.
    • (2010) Chest , vol.137 , pp. 1417-1426
    • Murphy, D.M.1    O'Byrne, P.M.2
  • 98
    • 72949152214 scopus 로고
    • Effect of a previous deep inspiration on airway resistance in man
    • Nadel JA, Tierney DF. Effect of a previous deep inspiration on airway resistance in man. J Appl Physiol 16:717-719, 1961.
    • (1961) J Appl Physiol , vol.16 , pp. 717-719
    • Nadel, J.A.1    Tierney, D.F.2
  • 101
    • 80355142109 scopus 로고    scopus 로고
    • Insights into the initiation of type 2 immune responses
    • Oliphant CJ, Barlow JL, McKenzie AN. Insights into the initiation of type 2 immune responses. Immunology 134:378-385, 2011.
    • (2011) Immunology , vol.134 , pp. 378-385
    • Oliphant, C.J.1    Barlow, J.L.2    McKenzie, A.N.3
  • 103
    • 0029874376 scopus 로고    scopus 로고
    • Endothelin-1-induced potentiation of human airway smooth muscle proliferation: An ETA receptor-mediated phenomenon
    • Panettieri RA Jr, Goldie RG, Rigby PJ, Eszterhas AJ, Hay DW. Endothelin-1-induced potentiation of human airway smooth muscle proliferation: an ETA receptor-mediated phenomenon. Br J Pharmacol 118:191-197, 1996.
    • (1996) Br J Pharmacol , vol.118 , pp. 191-197
    • Panettieri Jr., R.A.1    Goldie, R.G.2    Rigby, P.J.3    Eszterhas, A.J.4    Hay, D.W.5
  • 106
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
    • Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, Ortega H, Chanez P. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 380:651-659, 2012.
    • (2012) Lancet , vol.380 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3    Bleecker, E.R.4    Buhl, R.5    Keene, O.N.6    Ortega, H.7    Chanez, P.8
  • 108
    • 84861596408 scopus 로고    scopus 로고
    • Monoclonal antibodies for chronic refractory asthma and pipeline developments
    • Polosa R, Casale T. Monoclonal antibodies for chronic refractory asthma and pipeline developments. Drug Discov Today 17:591-599, 2012.
    • (2012) Drug Discov Today , vol.17 , pp. 591-599
    • Polosa, R.1    Casale, T.2
  • 113
    • 0027564307 scopus 로고
    • Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects
    • Reihsaus E, Innis M, MacIntyre N, Liggett SB. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 8:334-339, 1993.
    • (1993) Am J Respir Cell Mol Biol , vol.8 , pp. 334-339
    • Reihsaus, E.1    Innis, M.2    MacIntyre, N.3    Liggett, S.B.4
  • 115
    • 78649868199 scopus 로고    scopus 로고
    • The role of the T cell in asthma
    • Robinson DS. The role of the T cell in asthma. J Allergy Clin Immunol 126:1081-1093, 2010.
    • (2010) J Allergy Clin Immunol , vol.126 , pp. 1081-1093
    • Robinson, D.S.1
  • 117
    • 0035014034 scopus 로고    scopus 로고
    • Regulation of α-smooth muscle actin gene expression in myofibroblast differentiation from rat lung fibroblasts
    • DOI 10.1016/S1357-2725(01)00041-3, PII S1357272501000413
    • Roy SG, Nozaki Y, Phan SH. Regulation of alpha-smooth muscle actin gene expression in myofibroblast differentiation from rat lung fibroblasts. Int J Biochem Cell Biol 33:723-734, 2001. (Pubitemid 32520968)
    • (2001) International Journal of Biochemistry and Cell Biology , vol.33 , Issue.7 , pp. 723-734
    • Roy, S.G.1    Nozaki, Y.2    Phan, S.H.3
  • 121
    • 33749433631 scopus 로고    scopus 로고
    • Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction
    • Schaafsma D, Bos IS, Zuidhof AB, Zaagsma J, Meurs H. Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction. Respir Res 7:121, 2006.
    • (2006) Respir Res , vol.7 , pp. 121
    • Schaafsma, D.1    Bos, I.S.2    Zuidhof, A.B.3    Zaagsma, J.4    Meurs, H.5
  • 122
    • 49049090820 scopus 로고    scopus 로고
    • The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation
    • Schaafsma D, Bos IS, Zuidhof AB, Zaagsma J, Meurs H. The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation. Am J Physiol Lung Cell Mol Physiol 295:L214-L219, 2008.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295
    • Schaafsma, D.1    Bos, I.S.2    Zuidhof, A.B.3    Zaagsma, J.4    Meurs, H.5
  • 123
    • 7544221330 scopus 로고    scopus 로고
    • Allergic sensitization enhances the contribution of Rho-kinase to airway smooth muscle contraction
    • DOI 10.1038/sj.bjp.0705903
    • Schaafsma D, Gosens R, Bos IS, Meurs H, Zaagsma J, Nelemans SA. Allergic sensitization enhances the contribution of Rho-kinase to airway smooth muscle contraction. Br J Pharmacol 143:477-484, 2004. (Pubitemid 39452215)
    • (2004) British Journal of Pharmacology , vol.143 , Issue.4 , pp. 477-484
    • Schaafsma, D.1    Gosens, R.2    Bos, I.S.T.3    Meurs, H.4    Zaagsma, J.5    Nelemans, S.A.6
  • 125
    • 79954613106 scopus 로고    scopus 로고
    • Emergence of airway smooth muscle functions related to structural malleability
    • Seow CY, Fredberg JJ. Emergence of airway smooth muscle functions related to structural malleability. J Appl Physiol 110:1130-1135, 2011.
    • (2011) J Appl Physiol , vol.110 , pp. 1130-1135
    • Seow, C.Y.1    Fredberg, J.J.2
  • 126
    • 79951670027 scopus 로고    scopus 로고
    • The multiple dimensions of airways disease: Targeting treatment to clinical phenotypes
    • Shirtcliffe P, Weatherall M, Travers J, Beasley R. The multiple dimensions of airways disease: targeting treatment to clinical phenotypes. Curr Opin Pulm Med 17:72-78, 2011.
    • (2011) Curr Opin Pulm Med , vol.17 , pp. 72-78
    • Shirtcliffe, P.1    Weatherall, M.2    Travers, J.3    Beasley, R.4
  • 127
    • 0028817013 scopus 로고
    • Airway hyperresponsiveness in asthma: A problem of limited smooth muscle relaxation with inspiration
    • Skloot G, Permutt S, Togias A. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. J Clin Invest 96:2393-2403, 1995.
    • (1995) J Clin Invest , vol.96 , pp. 2393-2403
    • Skloot, G.1    Permutt, S.2    Togias, A.3
  • 128
    • 0041506933 scopus 로고    scopus 로고
    • Pharmacology and physiology of human adrenergic receptor polymorphisms
    • DOI 10.1146/annurev.pharmtox.43.100901.135823
    • Small KM, McGraw DW, Liggett SB. Pharmacology and physiology of human adrenergic receptor polymorphisms. Ann Rev Pharmacol Toxicol 43:381-411, 2003. (Pubitemid 37372647)
    • (2003) Annual Review of Pharmacology and Toxicology , vol.43 , pp. 381-411
    • Small, K.M.1    McGraw, D.W.2    Liggett, S.B.3
  • 129
    • 34047118039 scopus 로고    scopus 로고
    • Airway smooth muscle as a target for asthma therapy
    • DOI 10.1056/NEJMe078005
    • Solway J, Irvin CG. Airway smooth muscle as a target for asthma therapy. N Engl J Med 356:1367-1369, 2007. (Pubitemid 46513306)
    • (2007) New England Journal of Medicine , vol.356 , Issue.13 , pp. 1367-1369
    • Solway, J.1    Irvin, C.G.2
  • 134
    • 0032979945 scopus 로고    scopus 로고
    • Interleukin 5 release into asthmatic airways 4 and 24 hours after endobronchial allergen challenge: Its relationship with eosinophil recruitment
    • DOI 10.1006/cyto.1998.0457
    • Teran LM, Carroll MP, Shute JK, Holgate ST. Interleukin 5 release into asthmatic airways 4 and 24 hours after endobronchial allergen challenge: its relationship with eosinophil recruitment. Cytokine 11:518-522, 1999. (Pubitemid 29317415)
    • (1999) Cytokine , vol.11 , Issue.7 , pp. 518-522
    • Teran, L.M.1    Carroll, M.P.2    Shute, J.K.3    Holgate, S.T.4
  • 136
    • 34147214101 scopus 로고    scopus 로고
    • Expression and activation of TGF-β isoforms in acute allergen-induced remodelling in asthma
    • DOI 10.1136/thx.2006.063487
    • Torrego A, Hew M, Oates T, Sukkar M, Fan Chung K. Expression and activation of TGF-beta isoforms in acute allergen-induced remodelling in asthma. Thorax 62:307-313, 2007. (Pubitemid 46580573)
    • (2007) Thorax , vol.62 , Issue.4 , pp. 307-313
    • Torrego, A.1    Hew, M.2    Oates, T.3    Sukkar, M.4    Kian, F.C.5
  • 138
    • 0033797030 scopus 로고    scopus 로고
    • Indirect bronchial hyperresponsiveness in asthma: Mechanisms, pharmacology and implications for clinical research
    • Van Schoor J, Joos GF, Pauwels RA. Indirect bronchial hyperresponsiveness in asthma: mechanisms, pharmacology and implications for clinical research. Eur Respir J 16:514-533, 2000.
    • (2000) Eur Respir J , vol.16 , pp. 514-533
    • Van Schoor, J.1    Joos, G.F.2    Pauwels, R.A.3
  • 140
    • 84878569577 scopus 로고    scopus 로고
    • Physiology in Medicine-Déjà vu all over again
    • doi:10.1152/japplphysiol.00028.2013
    • Wagner PD. Physiology in Medicine-Déjà vu all over again. J Appl Physiol; doi:10.1152/japplphysiol.00028.2013.
    • J Appl Physiol
    • Wagner, P.D.1
  • 141
    • 84858014511 scopus 로고    scopus 로고
    • Bronchial thermoplasty for severe asthma
    • Wahidi MM, Kraft M. Bronchial thermoplasty for severe asthma. Am J Respir Crit Care Med 185:709-714, 2012.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 709-714
    • Wahidi, M.M.1    Kraft, M.2
  • 148
    • 36448960164 scopus 로고    scopus 로고
    • ERK1/2 signaling pathway modulates the airway smooth muscle cell phenotype in the rat model of chronic asthma
    • DOI 10.1159/000108783
    • Xie M, Liu XS, Xu YJ, Zhang ZX, Bai J, Ni W, Chen SX. ERK1/2 signaling pathway modulates the airway smooth muscle cell phenotype in the rat model of chronic asthma. Respiration 74:680-690, 2007. (Pubitemid 350164515)
    • (2007) Respiration , vol.74 , Issue.6 , pp. 680-690
    • Xie, M.1    Liu, X.-S.2    Xu, Y.-J.3    Zhang, Z.-X.4    Bai, J.5    Ni, W.6    Chen, S.-X.7
  • 149
    • 80051775437 scopus 로고    scopus 로고
    • Chronic continuous positive airway pressure (CPAP) reduces airway reactivity in vivo in an allergen-induced rabbit model of asthma
    • Xue Z, Yu Y, Gao H, Gunst SJ, Tepper RS. Chronic continuous positive airway pressure (CPAP) reduces airway reactivity in vivo in an allergen-induced rabbit model of asthma. J Appl Physiol 111:353-357, 2011.
    • (2011) J Appl Physiol , vol.111 , pp. 353-357
    • Xue, Z.1    Yu, Y.2    Gao, H.3    Gunst, S.J.4    Tepper, R.S.5
  • 150
    • 41549146179 scopus 로고    scopus 로고
    • Chronic inflation of ferret lungs with CPAP reduces airway smooth muscle contractility in vivo and in vitro
    • DOI 10.1152/japplphysiol.00241.2007
    • Xue Z, Zhang L, Liu Y, Gunst SJ, Tepper RS. Chronic inflation of ferret lungs with CPAP reduces airway smooth muscle contractility in vivo and in vitro. J Appl Physiol 104:610-615, 2008. (Pubitemid 351468787)
    • (2008) Journal of Applied Physiology , vol.104 , Issue.3 , pp. 610-615
    • Xue, Z.1    Zhang, L.2    Liu, Y.3    Gunst, S.J.4    Tepper, R.S.5
  • 151
    • 30744445698 scopus 로고    scopus 로고
    • Human lung mast cells adhere to human airway smooth , in part, via tumor suppressor in lung cancer
    • Yang W, Kaur D, Okayama Y, Ito A, Wardlaw AJ, Brightling CE, Bradding P. Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol 176:1238-1243, 2006. (Pubitemid 43099728)
    • (2006) Journal of Immunology , vol.176 , Issue.2 , pp. 1238-1243
    • Yang, W.1    Kaur, D.2    Okayama, Y.3    Ito, A.4    Wardlaw, A.J.5    Brightling, C.E.6    Bradding, P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.