Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 300, Issue 5, 2011, Pages

  Ma, Lan ^a   Brown, Melanie ^a   Kogut, Paul ^a   Serban, Karina ^a   Li, Xiaojing ^a   Mcconville, John ^a   Chen, Bohao ^a   Bentley, J Kelley ^b   Hershenson, Marc B ^b   Dulin, Nickolai ^a   Solway, Julian ^a   Camoretti Mercado, Blanca ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Airway hyperresponsiveness; Airway remodeling; Asthma; Bronchial; Proliferation

Indexed keywords

CONTRACTILE PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; PROTEIN KINASE B; PROTEIN P70;

AIRWAY SMOOTH MUSCLE HYPERTROPHY; ARTICLE; ASTHMA; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MUSCLE HYPERTROPHY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA TRANSLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER;

ACTINS; ANIMALS; ASTHMA; CELL PROLIFERATION; CONTRACTILE PROTEINS; DOGS; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYPERTROPHY; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TRACHEA;

EID: 79955762960     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00119.2009     Document Type: Article

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