-
1
-
-
33747750597
-
The mechanisms, diagnosis, and management of severe asthma in adults
-
S.T. Holgate, and R. Polosa The mechanisms, diagnosis, and management of severe asthma in adults Lancet 368 2006 780 793
-
(2006)
Lancet
, vol.368
, pp. 780-793
-
-
Holgate, S.T.1
Polosa, R.2
-
2
-
-
76149146032
-
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
-
W.C. Moore Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program Am. J. Respir. Crit. Care Med. 181 2010 315 323
-
(2010)
Am. J. Respir. Crit. Care Med.
, vol.181
, pp. 315-323
-
-
Moore, W.C.1
-
3
-
-
79551505136
-
Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome
-
J. Lötvall Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome J. Allergy Clin. Immunol. 127 2011 355 360
-
(2011)
J. Allergy Clin. Immunol.
, vol.127
, pp. 355-360
-
-
Lötvall, J.1
-
4
-
-
70449649943
-
BTS/SIGN British guideline on management of asthma
-
British Thoracic Society Scottish Intercollegiate Guidelines Network
-
British Thoracic Society Scottish Intercollegiate Guidelines Network BTS/SIGN British guideline on management of asthma Thorax 63 Suppl. 4 2008 1 121
-
(2008)
Thorax
, vol.63
, Issue.SUPPL. 4
, pp. 1-121
-
-
-
5
-
-
39449103632
-
An overview of chronic severe asthma
-
R. Polosa An overview of chronic severe asthma Intern. Med. J. 38 2008 190 198
-
(2008)
Intern. Med. J.
, vol.38
, pp. 190-198
-
-
Polosa, R.1
-
6
-
-
0030876380
-
A national estimate of the economic costs of asthma
-
D.H. Smith A national estimate of the economic costs of asthma Am. J. Respir. Crit. Care Med. 156 1997 787 793
-
(1997)
Am. J. Respir. Crit. Care Med.
, vol.156
, pp. 787-793
-
-
Smith, D.H.1
-
7
-
-
0036151024
-
Costs of asthma are correlated with severity: A 1-yr prospective study
-
P. Godard Costs of asthma are correlated with severity: a 1-yr prospective study Eur. Respir. J. 19 2002 61 67
-
(2002)
Eur. Respir. J.
, vol.19
, pp. 61-67
-
-
Godard, P.1
-
8
-
-
2442474468
-
Asthma severity and medical resource utilization
-
L. Antoncelli Asthma severity and medical resource utilization Eur. Respir. J. 23 2004 723 729
-
(2004)
Eur. Respir. J.
, vol.23
, pp. 723-729
-
-
Antoncelli, L.1
-
9
-
-
34249912039
-
Severe asthma in adults: What are the important questions?
-
P. Chanez Severe asthma in adults: what are the important questions? J. Allergy Clin. Immunol. 119 2007 1337 1348
-
(2007)
J. Allergy Clin. Immunol.
, vol.119
, pp. 1337-1348
-
-
Chanez, P.1
-
10
-
-
62749196135
-
Managing patients with chronic severe asthma: Rise to the challenge
-
R. Polosa, and G.T. Benfatto Managing patients with chronic severe asthma: rise to the challenge Eur. J. Intern. Med. 20 2009 114 124
-
(2009)
Eur. J. Intern. Med.
, vol.20
, pp. 114-124
-
-
Polosa, R.1
Benfatto, G.T.2
-
11
-
-
62549165245
-
Difficult to treat asthma in adults
-
G.P. Currie Difficult to treat asthma in adults BMJ 338 2009 494
-
(2009)
BMJ
, vol.338
, pp. 494
-
-
Currie, G.P.1
-
12
-
-
84993706094
-
Recommendation for optimal management of severe refractory asthma
-
J.B. Morjaria, and R. Polosa Recommendation for optimal management of severe refractory asthma J. Asthma Allergy 3 2010 43 56
-
(2010)
J. Asthma Allergy
, vol.3
, pp. 43-56
-
-
Morjaria, J.B.1
Polosa, R.2
-
13
-
-
40049092917
-
Treatment strategies for allergy and asthma
-
S.T. Holgate, and R. Polosa Treatment strategies for allergy and asthma Nat. Rev. Immunol. 8 2008 218 230
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 218-230
-
-
Holgate, S.T.1
Polosa, R.2
-
14
-
-
0026610142
-
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
-
D. Robinson Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma N. Engl. J. Med. 326 1992 298 304
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 298-304
-
-
Robinson, D.1
-
15
-
-
33746713752
-
Anti-TNF-alfa and Th1 cytokine-directed therapies for the treatment of asthma
-
M. Cazzola, and R. Polosa Anti-TNF-alfa and Th1 cytokine-directed therapies for the treatment of asthma Curr. Opin. Allergy Clin. Immunol. 6 2006 43 50
-
(2006)
Curr. Opin. Allergy Clin. Immunol.
, vol.6
, pp. 43-50
-
-
Cazzola, M.1
Polosa, R.2
-
16
-
-
78149274601
-
Harnessing regulatory T cells to suppress asthma: From potential to therapy
-
A. Thorburn, and P. Hansbro Harnessing regulatory T cells to suppress asthma: from potential to therapy Am. J. Respir. Cell. Mol. Biol. 43 2010 511 519
-
(2010)
Am. J. Respir. Cell. Mol. Biol.
, vol.43
, pp. 511-519
-
-
Thorburn, A.1
Hansbro, P.2
-
17
-
-
77956929721
-
Potential therapeutic targets for steroid-resistant asthma
-
W. Wang Potential therapeutic targets for steroid-resistant asthma Curr. Drug Targets 11 2010 957 970
-
(2010)
Curr. Drug Targets
, vol.11
, pp. 957-970
-
-
Wang, W.1
-
18
-
-
0037235949
-
Engineered antibodies
-
P.J. Hudson, and C. Souriau Engineered antibodies Nat. Med. 9 2003 129 134
-
(2003)
Nat. Med.
, vol.9
, pp. 129-134
-
-
Hudson, P.J.1
Souriau, C.2
-
19
-
-
0001871568
-
Therapeutic applications of monoclonal antibodies for human disease
-
J.R. Birch, E.S. Lennox, Wiley-Liss New York
-
D.A. Scheinberg, and P.B. Chapman Therapeutic applications of monoclonal antibodies for human disease J.R. Birch, E.S. Lennox, Monoclonal Antibodies, Principles and Practice 1995 Wiley-Liss New York 45 105
-
(1995)
Monoclonal Antibodies, Principles and Practice
, pp. 45-105
-
-
Scheinberg, D.A.1
Chapman, P.B.2
-
21
-
-
17644441947
-
The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: Efficacy, safety and pharmacokinetics
-
J. Corne The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety and pharmacokinetics J. Clin. Invest. 99 1997 879 887
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 879-887
-
-
Corne, J.1
-
22
-
-
38149126990
-
Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps
-
J. Patou Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps J. Allergy Clin. Immunol. 121 2008 110 115
-
(2008)
J. Allergy Clin. Immunol.
, vol.121
, pp. 110-115
-
-
Patou, J.1
-
23
-
-
69949123296
-
Off-label use of omalizumab in non-asthma conditions: New opportunities
-
J.B. Morjaria, and R. Polosa Off-label use of omalizumab in non-asthma conditions: new opportunities Expert Rev. Resp. Med. 3 2009 299 308
-
(2009)
Expert Rev. Resp. Med.
, vol.3
, pp. 299-308
-
-
Morjaria, J.B.1
Polosa, R.2
-
24
-
-
63449107848
-
Anti-IgE therapy: Clinical utility beyond asthma
-
T.B. Casale, and J. Stokes Anti-IgE therapy: clinical utility beyond asthma J. Allergy Clin. Immunol. 123 2009 770 771
-
(2009)
J. Allergy Clin. Immunol.
, vol.123
, pp. 770-771
-
-
Casale, T.B.1
Stokes, J.2
-
25
-
-
0029076544
-
Inhibition of allergic reactions with antibodies to IgE
-
R.L. Shields Inhibition of allergic reactions with antibodies to IgE Int. Arch. Allergy Immunol. 107 1995 308 312
-
(1995)
Int. Arch. Allergy Immunol.
, vol.107
, pp. 308-312
-
-
Shields, R.L.1
-
27
-
-
33745019865
-
Anti-IgE for chronic asthma in adults and children (update)
-
S. Walker Anti-IgE for chronic asthma in adults and children (update) Cochrane Database Syst. Rev. 2 2006 CD003559
-
(2006)
Cochrane Database Syst. Rev.
, vol.2
, pp. 003559
-
-
Walker, S.1
-
28
-
-
71249102935
-
Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma
-
B. Lanier Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma J. Allergy Clin. Immunol. 124 2009 1210 1216
-
(2009)
J. Allergy Clin. Immunol.
, vol.124
, pp. 1210-1216
-
-
Lanier, B.1
-
30
-
-
78650324258
-
Omalizumab in the management of oral corticosteroid-dependent IGE-mediated asthma patients
-
C. Domingo Omalizumab in the management of oral corticosteroid-dependent IGE-mediated asthma patients Curr. Med. Res. Opin. 27 2011 45 53
-
(2011)
Curr. Med. Res. Opin.
, vol.27
, pp. 45-53
-
-
Domingo, C.1
-
31
-
-
77950297895
-
Regulation of Syk kinase and FcRbeta expression in human basophils during treatment with omalizumab
-
A.K. Zaidi Regulation of Syk kinase and FcRbeta expression in human basophils during treatment with omalizumab J. Allergy Clin. Immunol. 125 2010 902 908
-
(2010)
J. Allergy Clin. Immunol.
, vol.125
, pp. 902-908
-
-
Zaidi, A.K.1
-
32
-
-
0042736310
-
Allergic asthma and an anti-CD23 mAb (IDEC-152): Results of a phase I, single-dose, dose-escalating clinical trial
-
L.J. Rosenwasser Allergic asthma and an anti-CD23 mAb (IDEC-152): results of a phase I, single-dose, dose-escalating clinical trial J. Allergy Clin. Immunol. 112 2003 563 570
-
(2003)
J. Allergy Clin. Immunol.
, vol.112
, pp. 563-570
-
-
Rosenwasser, L.J.1
-
33
-
-
23644437708
-
TNF-alpha as a promising therapeutic target in chronic asthma: A lesson from rheumatoid arthritis
-
C. Russo, and R. Polosa TNF-alpha as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis Clin. Sci. 109 2005 135 142
-
(2005)
Clin. Sci.
, vol.109
, pp. 135-142
-
-
Russo, C.1
Polosa, R.2
-
34
-
-
77952548792
-
Biologic and pharmacologic therapies in clinical development for the inflammatory response in COPD
-
J.B. Morjaria Biologic and pharmacologic therapies in clinical development for the inflammatory response in COPD Drug Discov. Today 15 2010 396 405
-
(2010)
Drug Discov. Today
, vol.15
, pp. 396-405
-
-
Morjaria, J.B.1
-
35
-
-
33749438560
-
The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma
-
E. Erin The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma Am. J. Respir. Crit. Care Med. 174 2006 753 762
-
(2006)
Am. J. Respir. Crit. Care Med.
, vol.174
, pp. 753-762
-
-
Erin, E.1
-
36
-
-
62549084077
-
A randomized, double-blind, placebo-controlled study of tumor necrosis factoralpha blockade in severe persistent asthma
-
S.E. Wenzel A randomized, double-blind, placebo-controlled study of tumor necrosis factoralpha blockade in severe persistent asthma Am. J. Respir. Crit. Care Med. 179 2009 549 558
-
(2009)
Am. J. Respir. Crit. Care Med.
, vol.179
, pp. 549-558
-
-
Wenzel, S.E.1
-
37
-
-
28244479315
-
Tumour necrosis factor (TNF{alpha}) as a novel therapeutic target in symptomatic corticosteroid-dependent asthma
-
P.H. Howarth Tumour necrosis factor (TNF{alpha}) as a novel therapeutic target in symptomatic corticosteroid-dependent asthma Thorax 60 2005 1012 1018
-
(2005)
Thorax
, vol.60
, pp. 1012-1018
-
-
Howarth, P.H.1
-
38
-
-
32644490529
-
Evidence of a role of tumor necrosis factor alpha in refractory asthma
-
M.A. Berry Evidence of a role of tumor necrosis factor alpha in refractory asthma N. Engl. J. Med. 354 2006 697 708
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 697-708
-
-
Berry, M.A.1
-
39
-
-
47049130758
-
The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: A double blind, randomised placebo-controlled trial
-
J.B. Morjaria The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised placebo-controlled trial Thorax 63 2008 584 591
-
(2008)
Thorax
, vol.63
, pp. 584-591
-
-
Morjaria, J.B.1
-
40
-
-
79957987328
-
Efficacy/safety of etanercept in moderate-to-severe asthma: A randomised, controlled trial
-
S.T. Holgate Efficacy/safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial Eur. Respir. J. 37 2011 1352 1359
-
(2011)
Eur. Respir. J.
, vol.37
, pp. 1352-1359
-
-
Holgate, S.T.1
-
42
-
-
85047693849
-
Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
-
P. Flood-Page Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics J. Clin. Invest. 112 2003 1029 1036
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1029-1036
-
-
Flood-Page, P.1
-
43
-
-
3042714189
-
Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice
-
H. Tanaka Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice Am. J. Respir. Cell. Mol. Biol. 31 2004 62 68
-
(2004)
Am. J. Respir. Cell. Mol. Biol.
, vol.31
, pp. 62-68
-
-
Tanaka, H.1
-
44
-
-
0026643596
-
Interleukin-5, eosinophils, and disease
-
C.J. Sanderson Interleukin-5, eosinophils, and disease Blood 79 1992 3101 3109
-
(1992)
Blood
, vol.79
, pp. 3101-3109
-
-
Sanderson, C.J.1
-
45
-
-
36749065556
-
A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
-
P. Flood-Page A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma Am. J. Respir. Crit. Care Med. 176 2007 1062 1071
-
(2007)
Am. J. Respir. Crit. Care Med.
, vol.176
, pp. 1062-1071
-
-
Flood-Page, P.1
-
46
-
-
0037438409
-
Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
-
P.T. Flood-Page Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway Am. J. Respir. Crit. Care Med. 167 2003 199 204
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.167
, pp. 199-204
-
-
Flood-Page, P.T.1
-
47
-
-
6644229440
-
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
-
M.J. Leckie Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response Lancet 356 2000 2144 2148
-
(2000)
Lancet
, vol.356
, pp. 2144-2148
-
-
Leckie, M.J.1
-
48
-
-
61849155730
-
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
-
P. Nair Mepolizumab for prednisone-dependent asthma with sputum eosinophilia N. Engl. J. Med. 360 2009 985 993
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 985-993
-
-
Nair, P.1
-
49
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
P. Haldar Mepolizumab and exacerbations of refractory eosinophilic asthma N. Engl. J. Med. 360 2009 973 984
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 973-984
-
-
Haldar, P.1
-
50
-
-
55649109417
-
Immunomodulatory and biologic therapies for severe refractory asthma
-
R. Polosa, and J. Morjaria Immunomodulatory and biologic therapies for severe refractory asthma Respir. Med. 102 2008 1499 1510
-
(2008)
Respir. Med.
, vol.102
, pp. 1499-1510
-
-
Polosa, R.1
Morjaria, J.2
-
51
-
-
77952683218
-
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase i study of subjects with mild asthma
-
W.W. Busse Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma J. Allergy Clin. Immunol. 125 2010 1237 1244
-
(2010)
J. Allergy Clin. Immunol.
, vol.125
, pp. 1237-1244
-
-
Busse, W.W.1
-
52
-
-
77649198441
-
Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma
-
C.K. Oh Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma Eur. Respir. Rev. 19 2010 46 54
-
(2010)
Eur. Respir. Rev.
, vol.19
, pp. 46-54
-
-
Oh, C.K.1
-
53
-
-
0032881604
-
Differential responses of human monocytes and macrophages to IL-4 and IL-13
-
P. Hart Differential responses of human monocytes and macrophages to IL-4 and IL-13 J. Leukoc. Biol. 66 1999 575 578
-
(1999)
J. Leukoc. Biol.
, vol.66
, pp. 575-578
-
-
Hart, P.1
-
54
-
-
0037393323
-
IL-13 receptors and signaling pathways: An evolving web
-
G.K. Hershey IL-13 receptors and signaling pathways: an evolving web J. Allergy Clin. Immunol. 111 2003 677 690
-
(2003)
J. Allergy Clin. Immunol.
, vol.111
, pp. 677-690
-
-
Hershey, G.K.1
-
55
-
-
0033454115
-
Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo controlled trial
-
L.C. Borish Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo controlled trial Am. J. Respir. Crit. Care Med. 160 1999 1816 1823
-
(1999)
Am. J. Respir. Crit. Care Med.
, vol.160
, pp. 1816-1823
-
-
Borish, L.C.1
-
56
-
-
0034995872
-
Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
-
L.C. Borish Efficacy of soluble IL-4 receptor for the treatment of adults with asthma J. Allergy Clin. Immunol. 107 2001 963 970
-
(2001)
J. Allergy Clin. Immunol.
, vol.107
, pp. 963-970
-
-
Borish, L.C.1
-
57
-
-
0036379740
-
Preclinical efficacy and safety of pascolizumab (SB 240683): A humanized antiinterleukin-4 antibody with therapeutic potential in asthma
-
T.K. Hart Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized antiinterleukin-4 antibody with therapeutic potential in asthma Clin. Exp. Immunol. 130 2002 93 100
-
(2002)
Clin. Exp. Immunol.
, vol.130
, pp. 93-100
-
-
Hart, T.K.1
-
58
-
-
58849101739
-
The effects of IMA-638 on allergen induced airway responses in subjects with mild atopic asthma
-
G.M. Gauvreau The effects of IMA-638 on allergen induced airway responses in subjects with mild atopic asthma Eur. Respir. J. 32 Suppl. 52 2008 827
-
(2008)
Eur. Respir. J.
, vol.32
, Issue.SUPPL. 52
, pp. 827
-
-
Gauvreau, G.M.1
-
59
-
-
79954583416
-
Effects of Interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
-
G.M. Gauvreau Effects of Interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma Am. J. Respir. Crit. Care Med. 183 2011 1007 1014
-
(2011)
Am. J. Respir. Crit. Care Med.
, vol.183
, pp. 1007-1014
-
-
Gauvreau, G.M.1
-
60
-
-
71749097206
-
Effects of anti-IL-13 (Novartis QAX576) on inflammatory responses following nasal allergen challenge (NAC)
-
H.H. Kariyawasam Effects of anti-IL-13 (Novartis QAX576) on inflammatory responses following nasal allergen challenge (NAC) Am. J. Respir. Crit. Care Med. 179 2009 3642
-
(2009)
Am. J. Respir. Crit. Care Med.
, vol.179
, pp. 3642
-
-
Kariyawasam, H.H.1
-
61
-
-
76749141384
-
A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma
-
D. Singh A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma BMC Pulm. Med. 10 2010 3
-
(2010)
BMC Pulm. Med.
, vol.10
, pp. 3
-
-
Singh, D.1
-
62
-
-
80053084755
-
Lebrikizumab treatment in adults with asthma
-
J. Corren Lebrikizumab treatment in adults with asthma N. Engl. J. Med. 365 2011 1088 1098
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 1088-1098
-
-
Corren, J.1
-
63
-
-
2442671439
-
Preclinical evaluation of BAY 16-9996 a dual IL-4/IL-13 receptor antagonist
-
N. Fitch Preclinical evaluation of BAY 16-9996 a dual IL-4/IL-13 receptor antagonist J. Allergy Clin. Immunol. 107 Suppl. 2001 331 339
-
(2001)
J. Allergy Clin. Immunol.
, vol.107
, Issue.SUPPL.
, pp. 331-339
-
-
Fitch, N.1
-
64
-
-
35348909044
-
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies
-
S. Wenzel Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies Lancet 370 2007 1422 1431
-
(2007)
Lancet
, vol.370
, pp. 1422-1431
-
-
Wenzel, S.1
-
65
-
-
73049109006
-
Randomized, double-blind, placebo controlled first in human study of inhaled AIR645, an IL-4Rα oligonucleotide, in healthy volunteers
-
M.R. Hodges Randomized, double-blind, placebo controlled first in human study of inhaled AIR645, an IL-4Rα oligonucleotide, in healthy volunteers Am. J. Respir. Crit. Care Med. 179 2009 3640
-
(2009)
Am. J. Respir. Crit. Care Med.
, vol.179
, pp. 3640
-
-
Hodges, M.R.1
-
66
-
-
77953039047
-
A randomized, controlled, phase 2 study of AMG 317, an IL-4Rα antagonist, in patients with asthma
-
J. Corren A randomized, controlled, phase 2 study of AMG 317, an IL-4Rα antagonist, in patients with asthma Am. J. Respir. Crit. Care Med. 181 2010 788 796
-
(2010)
Am. J. Respir. Crit. Care Med.
, vol.181
, pp. 788-796
-
-
Corren, J.1
-
67
-
-
0033024432
-
IL-9 pathway in asthma: New therapeutic targets for allergic inflammatory disorders
-
R.C. Levitt IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders J. Allergy Clin. Immunol. 103 1999 485 491
-
(1999)
J. Allergy Clin. Immunol.
, vol.103
, pp. 485-491
-
-
Levitt, R.C.1
-
68
-
-
79958219647
-
Biology of IL-9 pathway and its therapeutic potential for the treatment of asthma
-
C.K. Oh Biology of IL-9 pathway and its therapeutic potential for the treatment of asthma Inflamm. Allergy Drug Targets 10 2011 180 186
-
(2011)
Inflamm. Allergy Drug Targets
, vol.10
, pp. 180-186
-
-
Oh, C.K.1
-
69
-
-
79955448185
-
Randomized, double-blind, placebo-controlled, multicenter Phase 2A study to evaluate the effect of a humanized Interleukin-9 monoclonal antibody (MEDI-528) on exercise-induced bronchospasm
-
J. Parker Randomized, double-blind, placebo-controlled, multicenter Phase 2A study to evaluate the effect of a humanized Interleukin-9 monoclonal antibody (MEDI-528) on exercise-induced bronchospasm Am. J. Respir. Crit. Care Med. 181 2010 5394
-
(2010)
Am. J. Respir. Crit. Care Med.
, vol.181
, pp. 5394
-
-
Parker, J.1
-
70
-
-
36849046819
-
OX40-OX40L interactions: A promising therapeutic target for allergic diseases?
-
Y.H. Wang, and Y.J. Liu OX40-OX40L interactions: a promising therapeutic target for allergic diseases? J. Clin. Invest. 117 2007 3655 3657
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3655-3657
-
-
Wang, Y.H.1
Liu, Y.J.2
-
71
-
-
0038068126
-
Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma
-
A. Hoshino Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma Eur. J. Immunol. 33 2003 861 869
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 861-869
-
-
Hoshino, A.1
-
72
-
-
0034906753
-
The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ Tcells in asthma
-
O.M. Kon The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ Tcells in asthma Eur. Respir. J. 18 2001 45 52
-
(2001)
Eur. Respir. J.
, vol.18
, pp. 45-52
-
-
Kon, O.M.1
-
73
-
-
0032480574
-
Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma
-
O.M. Kon Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma Lancet 352 1998 1109 1113
-
(1998)
Lancet
, vol.352
, pp. 1109-1113
-
-
Kon, O.M.1
-
74
-
-
0026871242
-
T lymphocytes and activated eosinophils in airway mucosa in fatal asthma and cystic fibrosis
-
M. Azzawi T lymphocytes and activated eosinophils in airway mucosa in fatal asthma and cystic fibrosis Am. Rev. Respir. Dis. 145 1992 1477 1482
-
(1992)
Am. Rev. Respir. Dis.
, vol.145
, pp. 1477-1482
-
-
Azzawi, M.1
-
75
-
-
57349179165
-
Daclizumab improves asthma control in patients with moderate to severe persistent asthma: A randomized, controlled trial
-
W.W. Busse Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial Am. J. Respir. Crit. Care Med. 178 2008 1002 1008
-
(2008)
Am. J. Respir. Crit. Care Med.
, vol.178
, pp. 1002-1008
-
-
Busse, W.W.1
|