메뉴 건너뛰기




Volumn 187, Issue 11, 2011, Pages 6094-6107

Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma

Author keywords

[No Author keywords available]

Indexed keywords

ALPHAVBETA5 INTEGRIN; COLLAGEN TYPE 1; CYTOCHALASIN D; FORMOTEROL; LYSOPHOSPHATIDIC ACID; MESSENGER RNA; METHACHOLINE; TRANSFORMING GROWTH FACTOR BETA;

EID: 82755189233     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003507     Document Type: Article
Times cited : (117)

References (60)
  • 2
    • 0032558685 scopus 로고    scopus 로고
    • A 15-year follow-up study of ventilatory function in adults with asthma
    • Lange, P., J. Parner, J. Vestbo, P. Schnohr, and G. Jensen. 1998. A 15-year follow-up study of ventilatory function in adults with asthma. N. Engl. J. Med. 339: 1194-1200.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1194-1200
    • Lange, P.1    Parner, J.2    Vestbo, J.3    Schnohr, P.4    Jensen, G.5
  • 5
    • 30744470159 scopus 로고    scopus 로고
    • The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma
    • DOI 10.1183/09031936.06.00130004
    • Boxall, C., S. T. Holgate, and D. E. Davies. 2006. The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur. Respir. J. 27: 208-229. (Pubitemid 43092684)
    • (2006) European Respiratory Journal , vol.27 , Issue.1 , pp. 208-229
    • Boxall, C.B.1    Holgate, S.T.2    Davies, D.E.3
  • 7
    • 41449112762 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 increases fibronectin deposition through integrin receptor alpha 5 beta 1 on human airway smooth muscle
    • Moir, L. M., J. K. Burgess, and J. L. Black. 2008. Transforming growth factor beta 1 increases fibronectin deposition through integrin receptor alpha 5 beta 1 on human airway smooth muscle. J. Allergy Clin. Immunol. 121: 1034-1039. e1034.
    • (2008) J. Allergy Clin. Immunol. , vol.121
    • Moir, L.M.1    Burgess, J.K.2    Black, J.L.3
  • 8
    • 0034651234 scopus 로고    scopus 로고
    • TGF-beta1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine- specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2
    • DOI 10.1006/abbi.1999.1625
    • Kucich, U., J. C. Rosenbloom, G. Shen, W. R. Abrams, A. D. Hamilton, S. M. Sebti, and J. Rosenbloom. 2000. TGF-beta1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2. Arch. Biochem. Biophys. 374: 313-324. (Pubitemid 30120268)
    • (2000) Archives of Biochemistry and Biophysics , vol.374 , Issue.2 , pp. 313-324
    • Kucich, U.1    Rosenbloom, J.C.2    Shen, G.3    Abrams, W.R.4    Hamilton, A.D.5    Sebti, S.M.6    Rosenbloom, J.7
  • 9
    • 17844400081 scopus 로고    scopus 로고
    • Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: Effect on the Smad signaling pathway
    • McMillan, S. J., G. Xanthou, and C. M. Lloyd. 2005. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway. J. Immunol. 174: 5774-5780. (Pubitemid 40593221)
    • (2005) Journal of Immunology , vol.174 , Issue.9 , pp. 5774-5780
    • McMillan, S.J.1    Xanthou, G.2    Lloyd, C.M.3
  • 10
    • 77956628834 scopus 로고    scopus 로고
    • Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25
    • Gregory, L. G., S. A. Mathie, S. A. Walker, S. Pegorier, C. P. Jones, and C. M. Lloyd. 2010. Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25. Am. J. Respir. Crit. Care Med. 182: 143-154.
    • (2010) Am. J. Respir. Crit. Care Med. , vol.182 , pp. 143-154
    • Gregory, L.G.1    Mathie, S.A.2    Walker, S.A.3    Pegorier, S.4    Jones, C.P.5    Lloyd, C.M.6
  • 12
    • 0037439630 scopus 로고    scopus 로고
    • Making sense of latent TGFbeta activation
    • DOI 10.1242/jcs.00229
    • Annes, J. P., J. S. Munger, and D. B. Rifkin. 2003. Making sense of latent TGFbeta activation. J. Cell Sci. 116: 217-224. (Pubitemid 36163863)
    • (2003) Journal of Cell Science , vol.116 , Issue.2 , pp. 217-224
    • Annes, J.P.1    Munger, J.S.2    Rifkin, D.B.3
  • 13
    • 0025215307 scopus 로고
    • Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin
    • Lyons, R. M., L. E. Gentry, A. F. Purchio, and H. L. Moses. 1990. Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin. J. Cell Biol. 110: 1361-1367.
    • (1990) J. Cell Biol. , vol.110 , pp. 1361-1367
    • Lyons, R.M.1    Gentry, L.E.2    Purchio, A.F.3    Moses, H.L.4
  • 14
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • Yu, Q., and I. Stamenkovic. 2000. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev. 14: 163-176. (Pubitemid 30070982)
    • (2000) Genes and Development , vol.14 , Issue.2 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 15
    • 42249092990 scopus 로고    scopus 로고
    • Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis
    • Tatler, A. L., J. Porte, A. Knox, G. Jenkins, and L. Pang. 2008. Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis. Biochem. Biophys. Res. Commun. 370: 239-242.
    • (2008) Biochem. Biophys. Res. Commun. , vol.370 , pp. 239-242
    • Tatler, A.L.1    Porte, J.2    Knox, A.3    Jenkins, G.4    Pang, L.5
  • 16
    • 0024994691 scopus 로고
    • Physicochemical activation of recombinant latent transforming growth factor-beta's 1,2 and 3
    • Brown, P. D., L. M. Wakefield, A. D. Levinson, and M. B. Sporn. 1990. Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3. Growth Factors 3: 35-43. (Pubitemid 20265013)
    • (1990) Growth Factors , vol.3 , Issue.1 , pp. 35-43
    • Brown, P.D.1    Wakefield, L.M.2    Levinson, A.D.3    Sporn, M.B.4
  • 17
    • 0033532054 scopus 로고    scopus 로고
    • The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta
    • Ribeiro, S. M., M. Poczatek, S. Schultz-Cherry, M. Villain, and J. E. Murphy-Ullrich. 1999. The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta. J. Biol. Chem. 274: 13586-13593.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13586-13593
    • Ribeiro, S.M.1    Poczatek, M.2    Schultz-Cherry, S.3    Villain, M.4    Murphy-Ullrich, J.E.5
  • 18
    • 34147214101 scopus 로고    scopus 로고
    • Expression and activation of TGF-beta isoforms in acute allergen-induced remodelling in asthma
    • DOI 10.1136/thx.2006.063487
    • Torrego, A., M. Hew, T. Oates, M. Sukkar, and K. Fan Chung. 2007. Expression and activation of TGF-beta isoforms in acute allergen-induced remodelling in asthma. Thorax 62: 307-313. (Pubitemid 46580573)
    • (2007) Thorax , vol.62 , Issue.4 , pp. 307-313
    • Torrego, A.1    Hew, M.2    Oates, T.3    Sukkar, M.4    Kian, F.C.5
  • 22
    • 0034995590 scopus 로고    scopus 로고
    • Activation of paracrine TGF-beta1 signaling upon stimulation and degranulation of rat serosal mast cells: A novel function for chymase
    • DOI 10.1096/fj.00-0273com
    • Lindstedt, K. A., Y. Wang, N. Shiota, J. Saarinen, M. Hyytiäinen, J. O. Kokkonen, J. Keski-Oja, and P. T. Kovanen. 2001. Activation of paracrine TGF-beta1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase. FASEB J. 15: 1377-1388. (Pubitemid 32531815)
    • (2001) FASEB Journal , vol.15 , Issue.8 , pp. 1377-1388
    • Lindstedt, K.A.1    Wang, Y.2    Shiota, N.3    Saarinen, J.4    Hyytiainen, M.5    Kokkonen, J.O.6    Keski-Oja, J.7    Kovanen, P.T.8
  • 24
    • 33947265169 scopus 로고    scopus 로고
    • Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice
    • DOI 10.1083/jcb.200611044
    • Yang, Z., Z. Mu, B. Dabovic, V. Jurukovski, D. Yu, J. Sung, X. Xiong, and J. S. Munger. 2007. Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. J. Cell Biol. 176: 787-793. (Pubitemid 46425539)
    • (2007) Journal of Cell Biology , vol.176 , Issue.6 , pp. 787-793
    • Yang, Z.1    Mu, Z.2    Dabovic, B.3    Jurukovski, V.4    Yu, D.5    Sung, J.6    Xiong, X.7    Munger, J.S.8
  • 25
    • 61949349656 scopus 로고    scopus 로고
    • Mice that lack activity of alphavbeta6- And alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice
    • Aluwihare, P., Z. Mu, Z. Zhao, D. Yu, P. H.Weinreb, G. S. Horan, S. M. Violette, and J. S. Munger. 2009. Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice. J. Cell Sci. 122: 227-232.
    • (2009) J. Cell Sci. , vol.122 , pp. 227-232
    • Aluwihare, P.1    Mu, Z.2    Zhao, Z.3    Yu, D.4    Weinreb, P.H.5    Horan, G.S.6    Violette, S.M.7    Munger, J.S.8
  • 26
    • 79959993129 scopus 로고    scopus 로고
    • Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β
    • Kitamura, H., S. Cambier, S. Somanath, T. Barker, S. Minagawa, J. Markovics, A. Goodsell, J. Publicover, L. Reichardt, D. Jablons, et al. 2011. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β. J. Clin. Invest. 121: 2863-2875.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2863-2875
    • Kitamura, H.1    Cambier, S.2    Somanath, S.3    Barker, T.4    Minagawa, S.5    Markovics, J.6    Goodsell, A.7    Publicover, J.8    Reichardt, L.9    Jablons, D.10
  • 29
    • 28244449083 scopus 로고    scopus 로고
    • 3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts
    • Asano, Y., H. Ihn, K. Yamane, M. Jinnin, Y. Mimura, and K. Tamaki. 2005. Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts. J. Immunol. 175: 7708-7718. (Pubitemid 41713471)
    • (2005) Journal of Immunology , vol.175 , Issue.11 , pp. 7708-7718
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 30
    • 37249044357 scopus 로고    scopus 로고
    • Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix
    • DOI 10.1083/jcb.200704042
    • Wipff, P. J., D. B. Rifkin, J. J. Meister, and B. Hinz. 2007. Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J. Cell Biol. 179: 1311-1323. (Pubitemid 350277747)
    • (2007) Journal of Cell Biology , vol.179 , Issue.6 , pp. 1311-1323
    • Wipff, P.-J.1    Rifkin, D.B.2    Meister, J.-J.3    Hinz, B.4
  • 32
    • 65349145784 scopus 로고    scopus 로고
    • Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein Galphaq
    • Xu, M. Y., J. Porte, A. J. Knox, P. H. Weinreb, T. M. Maher, S. M. Violette, R. J. McAnulty, D. Sheppard, and R. G. Jenkins. 2009. Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein Galphaq. Am. J. Pathol. 174: 1264-1279.
    • (2009) Am. J. Pathol. , vol.174 , pp. 1264-1279
    • Xu, M.Y.1    Porte, J.2    Knox, A.J.3    Weinreb, P.H.4    Maher, T.M.5    Violette, S.M.6    McAnulty, R.J.7    Sheppard, D.8    Jenkins, R.G.9
  • 33
    • 25444501226 scopus 로고    scopus 로고
    • Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts
    • DOI 10.1002/art.21246
    • Asano, Y., H. Ihn, K. Yamane, M. Jinnin, Y. Mimura, and K. Tamaki. 2005. Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts. Arthritis Rheum. 52: 2897-2905. (Pubitemid 41369121)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.9 , pp. 2897-2905
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 35
    • 0030927344 scopus 로고    scopus 로고
    • Effect of interleukin-1beta, tumour necrosis factor-alpha and interferon-gamma on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells
    • DOI 10.1038/sj.bjp.0701152
    • Pang, L., and A. J. Knox. 1997. Effect of interleukin-1 beta, tumour necrosis factor-alpha and interferon-gamma on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells. Br. J. Pharmacol. 121: 579-587. (Pubitemid 27226313)
    • (1997) British Journal of Pharmacology , vol.121 , Issue.3 , pp. 579-587
    • Pang, L.1    Knox, A.J.2
  • 37
    • 33745809878 scopus 로고    scopus 로고
    • WAF1 mRNA in human colon cancer HT-29 cells treated with inositol hexaphosphate
    • Weglarz, L., I. Molin, A. Orchel, B. Parfiniewicz, and Z. Dzierzewicz. 2006. Quantitative analysis of the level of p53 and p21(WAF1) mRNA in human colon cancer HT-29 cells treated with inositol hexaphosphate. Acta Biochim. Pol. 53: 349-356. (Pubitemid 44033933)
    • (2006) Acta Biochimica Polonica , vol.53 , Issue.2 , pp. 349-356
    • Weglarz, L.1    Molin, I.2    Orchel, A.3    Parfiniewicz, B.4    Dzierzewicz, Z.5
  • 38
    • 58149100136 scopus 로고    scopus 로고
    • Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1: Requirement for Smads, (beta)-CATENIN, and GSK3(beta)
    • Clifford, R. L., K. Deacon, and A. J. Knox. 2008. Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1: requirement for Smads, (beta)-CATENIN, AND GSK3(beta). J. Biol. Chem. 283: 35337-35353.
    • (2008) J. Biol. Chem. , vol.283 , pp. 35337-35353
    • Clifford, R.L.1    Deacon, K.2    Knox, A.J.3
  • 39
    • 70449723400 scopus 로고    scopus 로고
    • Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter
    • John, A. E., Y. M. Zhu, C. E. Brightling, L. Pang, and A. J. Knox. 2009. Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter. J. Immunol. 183: 4682-4692.
    • (2009) J. Immunol. , vol.183 , pp. 4682-4692
    • John, A.E.1    Zhu, Y.M.2    Brightling, C.E.3    Pang, L.4    Knox, A.J.5
  • 40
    • 0033982574 scopus 로고    scopus 로고
    • Normal development, wound healing, and adenovirus susceptibility in beta5- deficient mice
    • DOI 10.1128/MCB.20.3.755-759.2000
    • Huang, X., M. Griffiths, J. Wu, R. V. Farese, Jr., and D. Sheppard. 2000. Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice. Mol. Cell. Biol. 20: 755-759. (Pubitemid 30044211)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.3 , pp. 755-759
    • Huang, X.1    Griffiths, M.2    Wu, J.3    Farese Jr., R.V.4    Sheppard, D.5
  • 42
    • 33947192116 scopus 로고    scopus 로고
    • Small airway changes in healthy and ovalbumin-treated mice during quasi-static lung inflation
    • DOI 10.1016/j.resp.2006.11.006, PII S1569904806003119
    • Sera, T., K. Uesugi, R. Himeno, and N. Yagi. 2007. Small airway changes in healthy and ovalbumin-treated mice during quasi-static lung inflation. Respir. Physiol. Neurobiol. 156: 304-311. (Pubitemid 46436604)
    • (2007) Respiratory Physiology and Neurobiology , vol.156 , Issue.3 , pp. 304-311
    • Sera, T.1    Uesugi, K.2    Himeno, R.3    Yagi, N.4
  • 44
    • 33144458448 scopus 로고    scopus 로고
    • Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts
    • DOI 10.2353/ajpath.2006.041306
    • Asano, Y., H. Ihn, K. Yamane, M. Jinnin, and K. Tamaki. 2006. Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts. Am. J. Path. 168: 499-510. (Pubitemid 43271148)
    • (2006) American Journal of Pathology , vol.168 , Issue.2 , pp. 499-510
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Tamaki, K.5
  • 45
    • 0030810597 scopus 로고    scopus 로고
    • Lysophosphatidic acid enhances contractility of isolated airway smooth muscle
    • Toews, M. L., E. E. Ustinova, and H. D. Schultz. 1997. Lysophosphatidic acid enhances contractility of isolated airway smooth muscle. J. Appl. Physiol. 83: 1216-1222. (Pubitemid 27433090)
    • (1997) Journal of Applied Physiology , vol.83 , Issue.4 , pp. 1216-1222
    • Toews, M.L.1    Ustinova, E.E.2    Schultz, H.D.3
  • 46
    • 0038526427 scopus 로고    scopus 로고
    • Theophylline and cAMP inhibit lysophosphatidic acid-induced hyperresponsiveness of bovine tracheal smooth muscle cells
    • DOI 10.1113/jphysiol.2003.039024
    • Sakai, J., M. Oike, M. Hirakawa, and Y. Ito. 2003. Theophylline and cAMP inhibit lysophosphatidic acid-induced hyperresponsiveness of bovine tracheal smooth muscle cells. J. Physiol. 549: 171-180. (Pubitemid 36626406)
    • (2003) Journal of Physiology , vol.549 , Issue.1 , pp. 171-180
    • Sakai, J.1    Oike, M.2    Hirakawa, M.3    Ito, Y.4
  • 47
    • 67049115820 scopus 로고    scopus 로고
    • The contribution of Ca2+ signaling and Ca2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice
    • Bai, Y., and M. J. Sanderson. 2009. The contribution of Ca2+ signaling and Ca2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 296: L947-L958.
    • (2009) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.296
    • Bai, Y.1    Sanderson, M.J.2
  • 48
    • 0033213922 scopus 로고    scopus 로고
    • The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation
    • Calderwood, D. A., R. Zent, R. Grant, D. J. Rees, R. O. Hynes, and M. H. Ginsberg. 1999. The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J. Biol. Chem. 274: 28071-28074.
    • (1999) J. Biol. Chem. , vol.274 , pp. 28071-28074
    • Calderwood, D.A.1    Zent, R.2    Grant, R.3    Rees, D.J.4    Hynes, R.O.5    Ginsberg, M.H.6
  • 49
    • 27644538315 scopus 로고    scopus 로고
    • Integrin-mediated activation of latent transforming growth factor beta
    • DOI 10.1007/s10555-005-5131-6
    • Sheppard, D. 2005. Integrin-mediated activation of latent transforming growth factor beta. Cancer Metastasis Rev. 24: 395-402. (Pubitemid 41569979)
    • (2005) Cancer and Metastasis Reviews , vol.24 , Issue.3 , pp. 395-402
    • Sheppard, D.1
  • 51
    • 0028353880 scopus 로고
    • Hypothesis: Excessive bronchoconstriction in asthma is due to decreased airway elastance
    • Bramley, A. M., R. J. Thomson, C. R. Roberts, and R. R. Schellenberg. 1994. Hypothesis: excessive bronchoconstriction in asthma is due to decreased airway elastance. Eur. Respir. J. 7: 337-341. (Pubitemid 24138002)
    • (1994) European Respiratory Journal , vol.7 , Issue.2 , pp. 337-341
    • Bramley, A.M.1    Thomson, R.J.2    Roberts, C.R.3    Schellenberg, R.R.4
  • 54
    • 77749324374 scopus 로고    scopus 로고
    • The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma
    • Dekkers, B. G., I. S. Bos, R. Gosens, A. J. Halayko, J. Zaagsma, and H. Meurs. 2010. The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. Am. J. Respir. Crit. Care Med. 181: 556-565.
    • (2010) Am. J. Respir. Crit. Care Med. , vol.181 , pp. 556-565
    • Dekkers, B.G.1    Bos, I.S.2    Gosens, R.3    Halayko, A.J.4    Zaagsma, J.5    Meurs, H.6
  • 57
    • 0030814301 scopus 로고    scopus 로고
    • Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine
    • Boulet, L. P., M. Laviolette, H. Turcotte, A. Cartier, M. Dugas, J. L. Malo, and M. Boutet. 1997. Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine. Chest 112: 45-52. (Pubitemid 27343598)
    • (1997) Chest , vol.112 , Issue.1 , pp. 45-52
    • Boulet, L.-P.1    Laviolette, M.2    Turcotte, H.3    Cartier, A.4    Dugas, M.5    Malo, J.-L.6    Boutet, M.7
  • 58
    • 18644380685 scopus 로고    scopus 로고
    • Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling
    • DOI 10.1164/rccm.200409-1249OC
    • Gosens, R., I. S. Bos, J. Zaagsma, and H. Meurs. 2005. Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling. Am. J. Respir. Crit. Care Med. 171: 1096-1102. (Pubitemid 40663720)
    • (2005) American Journal of Respiratory and Critical Care Medicine , vol.171 , Issue.10 , pp. 1096-1102
    • Gosens, R.1    Bos, I.S.T.2    Zaagsma, J.3    Meurs, H.4
  • 60
    • 33751173229 scopus 로고    scopus 로고
    • Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling
    • Leung, S. Y., A. Niimi, A. Noble, T. Oates, A. S. Williams, S. Medicherla, A. A. Protter, and K. F. Chung. 2006. Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling. J. Pharmacol. Exp. Ther. 319: 586-594.
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 586-594
    • Leung, S.Y.1    Niimi, A.2    Noble, A.3    Oates, T.4    Williams, A.S.5    Medicherla, S.6    Protter, A.A.7    Chung, K.F.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.