A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in β2-adrenergic receptor internalization and down-regulation

FASEB Journal

Volumn 26, Issue 5, 2012, Pages 1995-2007

  Jiang, Xiaofeng ^a   Pan, Hui ^a   Nabhan, Joseph F ^a   Krishnan, Ramaswamy ^b   Koziol White, Cynthia ^c   Panettieri, Reynold A ^c   Lu, Quan ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

agonist; Alendronate; Genetic screen; Shorthairpin RNA

Indexed keywords

ALENDRONIC ACID; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; COMPLEMENTARY DNA; CYCLIC AMP; DNA; G PROTEIN COUPLED RECEPTOR; GENOMIC DNA; GERANYLTRANSFERASE; GUANOSINE TRIPHOSPHATASE; ISOPRENALINE; LENTIVIRUS VECTOR; PLASMID DNA; RAB PROTEIN; SHORT HAIRPIN RNA;

ADRENERGIC SYSTEM; AIRWAY; ARTICLE; ASTHMA; DRUG TARGETING; ENZYME PHOSPHORYLATION; EXPRESSED SEQUENCE TAG; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOFLUORESCENCE MICROSCOPY; INTERNALIZATION; LUNG; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RNA INTERFERENCE; SMOOTH MUSCLE FIBER;

BASE SEQUENCE; CELL LINE; DNA PRIMERS; DOWN-REGULATION; ENDOCYTOSIS; EXPRESSED SEQUENCE TAGS; FLOW CYTOMETRY; GERANYLTRANSTRANSFERASE; HUMANS; MICROSCOPY, FLUORESCENCE; POLYMERASE CHAIN REACTION; RECEPTORS, ADRENERGIC, BETA-2; RNA INTERFERENCE;

EID: 84860902418     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-193870     Document Type: Article

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