T cells localize with proliferating smooth muscle α-actin+ cell compartments in asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 182, Issue 3, 2010, Pages 317-324

  Ramos Barbón, David ^a,b   Fraga Iriso, Rebeca ^a   Brienza, Nadia S ^a   Montero Martínez, Carmen ^a   Verea Hernando, Héctor ^a   Olivenstein, Ron ^b   Lemiere, Catherine ^c   Ernst, Pierre ^b   Hamid, Qutayba A ^b   Martin, James G ^b  

^a UNIVERSITY OF A CORUÑA   (Spain)

^b MCGILL UNIVERSITY   (Canada)

^c HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

Author keywords

Cell proliferation; Inflammation; T lymphocytes; Vascular cell adhesion molecule 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CYCLINE; VASCULAR CELL ADHESION MOLECULE 1; ACTIN;

ARTICLE; ASTHMA; BRONCHUS BIOPSY; CELL DIFFERENTIATION; CELL INFILTRATION; CELL INTERACTION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; DISEASE SEVERITY; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; T LYMPHOCYTE; UPREGULATION; AIRWAY REMODELING; BIOPSY; BRONCHUS; CASE CONTROL STUDY; CYTOLOGY; HOSPITALIZATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; SMOOTH MUSCLE;

ACTINS; AIRWAY REMODELING; ASTHMA; BIOPSY; BRONCHI; CASE-CONTROL STUDIES; CELL PROLIFERATION; HUMANS; MUSCLE, SMOOTH; PROLIFERATING CELL NUCLEAR ANTIGEN; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 77956635183     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200905-0745OC     Document Type: Article

References (45)

1. Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, Carter R, Wong HH, Cadbury PS, Fahy JV. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med 2004;169:1001-1006.
2. Wiggs BR, Moreno R, Hogg JC, Hilliam C, Pare PD. A model of the mechanics of airway narrowing. J Appl Physiol 1990;69:849-860.
3. Lambert RK, Wiggs BR, Kuwano K, Hogg JC, Pare PD. Functional significance of increased airway smooth muscle in asthma and COPD. J Appl Physiol 1993;74:2771-2781.
4. Sapienza S, Du T, Eidelman DH, Wang NS, Martin JG. Structural changes in the airways of sensitized Brown Norway rats after antigen challenge. Am Rev Respir Dis 1991;144:423-427.
5. Henderson WR Jr, Tang LO, Chu SJ, Tsao SM, Chiang GK, Jones F, Jonas M, Pae C, Wang H, Chi EY. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med 2002;165:108-116. (Pubitemid 34053366)
6. Shinagawa K, Kojima M. Mouse model of airway remodeling: strain differences. Am J Respir Crit Care Med 2003;168:959-967.
7. Fixman ED, Stewart A, Martin JG. Basic mechanisms of development of airway structural changes in asthma. Eur Respir J 2007;29:379-389.
8. Boxall C, Holgate ST, Davies DE. The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur Respir J 2006;27:208-229.
9. Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma: from bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000;161:1720-1745.
10. + T cells drive airway smooth muscle remodeling in experimental asthma. J Clin Invest 2005;115:1580-1589.
11. Halayko AJ, Salari H, Ma X, Stephens NL. Markers of airway smooth muscle cell phenotype. Am J Physiol 1996;270:L1040-L1051. (Pubitemid 26299672)
12. Singh SR, Hall IP. Airway myofibroblasts and their relationship with airway myocytes and fibroblasts. Proc Am Thorac Soc 2008;5:127-132.
13. Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 2003;171:380-389.
14. Saunders R, Siddiqui S, Kaur D, Doe C, Sutcliffe A, Hollins F, Bradding P, Wardlaw A, Brightling CE. Fibrocyte localization to the airway smooth muscle is a feature of asthma. J Allergy Clin Immunol 2009;123:376-384.
15. Lazaar AL, Albelda SM, Pilewski JM, Brennan B, Pure E, Panettieri RA Jr. T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis. J Exp Med 1994;180:807-816.
16. + cells in asthma [abstract]. Am J Respir Crit Care Med 2008;177:A825.
17. + en el asma [abstract]. Arch Bronconeumol 2008;44:3-4.
18. + cells suggests T cell-myocyte/myofibroblast contact as a mechanism of airway smooth muscle (ASM) growth in asthma [abstract]. Eur Respir J 2008;32:289s.
19. Ramos-Barbón D, Fraga-Iriso R, Brienza N, Montero-Martínez C, Verea H, Olivenstein R, Lemiere C, Ernst P, Hamid Q, Martin JG. Mecanismos de remodelación bronquial en el asma I: Desarrollo de un compartimento de "non-organized airway contractile elements" (NOACE) [abstract]. Arch Bronconeumol 2009;45:10.
20. + se yuxtaponen a compartimentos proliferativos de músculo liso bronquial y "non-organized airway contractile elements" (NOACE) [abstract]. Arch Bronconeumol 2009;45:10-11.
21. Ramos-Barbón D, Fraga-Iriso R, Brienza N, Montero-Martínez C, Verea H, Olivenstein R, Lemiere C, Ernst P, Hamid Q, Martin JG. T cells juxtapose proliferating airway smooth muscle (ASM) and nonorganized airway contractile elements (NOACE) [abstract]. Eur Respir J 2009;34:226s.
22. Ramos-Barbón D, Fraga-Iriso R, Brienza N, Montero-Martínez C, Verea H, Olivenstein R, Lemiere C, Ernst P, Hamid Q, Martin JG. Asthmatics develop a bronchial compartment of proliferating, nonorganized airway contractile elements (NOACE) [abstract]. Eur Respir J 2009;34:565s.
23. American Thoracic Society. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 2000;162:2341-2351.
24. Pepe C, Foley S, Shannon J, Lemiere C, Olivenstein R, Ernst P, Ludwig MS, Martin JG, Hamid Q. Differences in airway remodeling between subjects with severe and moderate asthma. J Allergy Clin Immunol 2005;116:544-549.
25. National Institutes of Health - National Heart, Lung, and Blood Institute and National Institute of Allergy and Infectious Diseases, American Academy of Allergy and Immunology, American College of Chest Physicians, and American Thoracic Society. Workshop summary and guidelines: investigative use of bronchoscopy, lavage, and bronchial biopsies in asthma and other airway diseases. J Allergy Clin Immunol 1991;88:808-814.
26. Hordijk PL. Endothelial signalling events during leukocyte transmigration. FEBS J 2006;273:4408-4415.
27. Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID. Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med 2002;346:1699-1705.
28. Begueret H, Berger P, Vernejoux JM, Dubuisson L, Marthan R, Tuñón-de-Lara JM. Inflammation of bronchial smooth muscle in allergic asthma. Thorax 2007;62:8-15.
29. Deshpande DA, White TA, Dogan S, Walseth TF, Panettieri RA, Kannan MS. CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2005;288:L773-L788.
30. Moynihan B, Tolloczko B, Michoud MC, Tamaoka M, Ferraro P,Martin JG. MAP kinases mediate interleukin-13 effects on calcium signaling in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2008;295:L171-L177.
31. Goldsmith AM, Bentley JK, Zhou L, Jia Y, Bitar KN, Fingar DC, Hershenson MB. Transforming growth factor-beta induces airway smooth muscle hypertrophy. Am J Respir Cell Mol Biol 2006;34:247-254.
32. Hirota JA, Nguyen TT, Schaafsma D, Sharma P, Tran T. Airway smooth muscle in asthma: phenotype plasticity and function. Pulm Pharmacol Ther 2009;22:370-378.
33. Lobb RR, Abraham WM, Burkly LC, Gill A, Ma W, Knight JA, Leone DR, Antognetti G, Pepinsky RB. Pathophysiologic role of alpha 4 integrins in the lung. Ann N Y Acad Sci 1996;796:113-123.
34. Muller WA. Mechanisms of transendothelial migration of leukocytes. Circ Res 2009;105:223-230.
35. Zhang W, Liu HT. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 2002;12:9-18.
36. Salmon M, Walsh DA, Koto H, Barnes PJ, Chung KF. Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling. Eur Respir J 1999;14:633-641.
37. Johnson PR, Roth M, Tamm M, Hughes M, Ge Q, King G, Burgess JK, Black JL. Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med 2001;164:474-477.
38. Ebina M, Takahashi T, Chiba T, Motomiya M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am Rev Respir Dis 1993;148:720-726.
39. Halayko AJ, Tran T, Ji SY, Yamasaki A, Gosens R. Airway smooth muscle phenotype and function: interactions with current asthma therapies. Curr Drug Targets 2006;7:525-540.
40. Moir LM, Leung SY, Eynott PR, McVicker CG, Ward JP, Chung KF, Hirst SJ. Repeated allergen inhalation induces phenotypic modulation of smooth muscle in bronchioles of sensitized rats. Am J Physiol Lung Cell Mol Physiol 2003;284:L148-L159.
41. Beresford MJ, Wilson GD, Makris A. Measuring proliferation in breast cancer: practicalities and applications. Breast Cancer Res 2006;8:216.
42. Moldovan GL, Pfander B, Jentsch S. PCNA, the maestro of the replication fork. Cell 2007;129:665-679.
43. Brewster CE, Howarth PH, Djukanovic R, Wilson J, Holgate ST, Roche WR. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1990;3:507-511.
44. Gizycki MJ, Adelroth E, Rogers AV, O'Byrne PM, Jeffery PK. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma. Am J Respir Cell Mol Biol 1997;16:664-673.
45. Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003;167:1360-1368.