MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle

European Respiratory Journal

Volumn 36, Issue 3, 2010, Pages 630-637

  Dowell, M L ^a   Lavoie, T L ^a   Lakser, O J ^a   Dulin, N O ^a   Fredberg, J J ^b   Gerthoffer, W T ^c   Seow, C Y ^d   Mitchell, R W ^a   Solway, J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF SOUTH ALABAMA   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Airway smooth muscle; Asthma; Bronchoconstriction; Smooth muscle mechanics; Tidal breathing

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CALDESMON; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MYOSIN LIGHT CHAIN;

ANIMAL TISSUE; ARTICLE; BREATHING MECHANICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR WEIGHT; MUSCLE FORCE; MUSCLE ISOTONIC CONTRACTION; MUSCLE LENGTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRACHEA MUSCLE;

ANIMALS; BUTADIENES; DEPSIPEPTIDES; DOGS; ENZYME INHIBITORS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NITRILES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIDAL VOLUME; TISSUE DISTRIBUTION; TRACHEA;

EID: 77956573560     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00160209     Document Type: Article

References (54)

1. Oliver MN, Fabry B, Marinkovic A, et al. Airway hyperresponsiveness, remodeling, and smooth muscle mass: right answer, wrong reason? Am J Respir Cell Mol Biol 2007; 37: 264-272.
2. Fredberg JJ. Bronchospasm and its biophysical basis in airway smooth muscle. Respir Res 2004; 5: 2.
3. Fredberg JJ, Inouye D, Miller B, et al. Airway smooth muscle, tidal stretches, and dynamically determined contractile states. Am J Respir Crit Care Med 1997; 156: 1752-1759. (Pubitemid 28011778)
4. Fredberg JJ, Inouye DS, Mijailovich SM, et al. Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Respir Crit Care Med 1999; 159: 959-967.
5. Gerthoffer WT, Gunst SJ. Invited review: focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle. J Appl Physiol 2001; 91: 963-972.
6. Gunst SJ, Fredberg JJ. The first three minutes: smooth muscle contraction, cytoskeletal events, and soft glasses. J Appl Physiol 2003; 95: 413-425.
7. Gunst SJ, Shen X, Ramchandani R, et al. Bronchoprotective and bronchodilatory effects of deep inspiration in rabbits subjected to bronchial challenge. J Appl Physiol 2001; 91: 2511-2516. (Pubitemid 33108011)
8. Latourelle J, Fabry B, Fredberg JJ. Dynamic equilibration of airway smooth muscle contraction during physiological loading. J Appl Physiol 2002; 92: 771-779. (Pubitemid 34671047)
9. Salerno FG, Shinozuka N, Fredberg JJ, et al. Tidal volume amplitude affects the degree of induced bronchoconstriction in dogs. J Appl Physiol 1999; 87: 1674-1677.
10. Shen X, Gunst SJ, Tepper RS. Effect of tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits. J Appl Physiol 1997; 83: 1202-1208. (Pubitemid 27433088)
11. Freedman S, Lane R, Gillett MK, et al. Abolition of methacholine induced bronchoconstriction by the hyperventilation of exercise or volition. Thorax 1988; 43: 631-636.
12. Gump A, Haughney L, Fredberg J. Relaxation of activated airway smooth muscle: relative potency of isoproterenol vs. tidal stretch. J Appl Physiol 2001; 90: 2306-2310. (Pubitemid 32467425)
13. Murphy TM, Ray DW, Alger LE, et al. Ontogeny of dry gas hyperpnea-induced bronchoconstriction in guinea pigs. J Appl Physiol 1994; 76: 1150-1155.
14. Skloot G, Permutt S, Togias A. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. J Clin Invest 1995; 96: 2393-2403.
15. Lakser OJ, Lindeman RP, Fredberg JJ. Inhibition of the p38 MAP kinase pathway destabilizes smooth muscle length during physiological loading. Am J Physiol Lung Cell Mol Physiol 2002; 282: L1117-L1121.
16. Dowell ML, Lakser OJ, Gerthoffer WT, et al. Latrunculin B increases force fluctuation-induced relengthening of ACh-contracted, isotonically shortened canine tracheal smooth muscle. J Appl Physiol 2005; 98: 489-497.
17. Yamboliev IA, Hedges JC, Mutnick JL, et al. Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway. Am J Physiol Heart Circ Physiol 2000; 278: H1899-H1907.
18. Cao W, Sohn UD, Bitar KN, et al. MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Physiol Gastrointest Liver Physiol 2003; 285: G86-G95. (Pubitemid 36736392)
19. Gerthoffer WT, Yamboliev IA, Shearer M, et al. Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle. J Physiol 1996; 495: 597-609. (Pubitemid 26329108)
20. Kim HR, Hai CM. Mechanisms of mechanical strain memory in airway smooth muscle. Can J Physiol Pharmacol 2005; 83: 811-815. (Pubitemid 43235404)
21. Gerthoffer WT. Signal-transduction pathways that regulate visceral smooth muscle function. III. Coupling of muscarinic receptors to signaling kinases and effector proteins in gastrointestinal smooth muscles. Am J Physiol Gastrointest Liver Physiol 2005; 288: G849-G853.
22. 2+-independent smooth muscle contraction. A novel function for integrin-linked kinase. J Biol Chem 2001; 276: 16365-16373.
23. Harnett KM, Biancani P. Calcium-dependent and calcium-independent contractions in smooth muscles. Am J Med 2003; 115: Suppl. 3A, 24S-30S.
24. 2 muscarinic receptors to ERK MAP kinases and caldesmon phosphorylation in colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol 2000; 278: G429-G437.
25. D'Angelo G, Graceffa P, Wang CA, et al. Mammal-specific, ERK-dependent, caldesmon phosphorylation in smooth muscle. Quantitation using novel anti-phosphopeptide antibodies. J Biol Chem 1999; 274: 30115-30121. (Pubitemid 29483396)
26. Hedges JC, Oxhorn BC, Carty M, et al. Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle. Am J Physiol Cell Physiol 2000; 278: C718-C726. (Pubitemid 30211304)
27. Li Y, Je HD, Malek S, et al. ERK1/2-mediated phosphorylation of myometrial caldesmon during pregnancy and labor. Am J Physiol Regul Integr Comp Physiol 2003; 284: R192-R199.
28. Mitchell RW, Antonissen LA, Kepron W, et al. Effect of atropine on the hyperresponsiveness of ragweed-sensitized canine tracheal smooth muscle. J Pharmacol Exp Ther 1986; 236: 803-809. (Pubitemid 16080084)
29. Lakser OJ, Dowell ML, Hoyte FL, et al. Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma. Eur Respir J 2008; 32: 1224-1230.
30. 3 receptors in contractile cultured airway myocytes. Am J Physiol Lung Cell Mol Physiol 2000; 278: L1091-L1100.
31. Lagaud GJ, Lam E, Lui A, et al. Nonspecific inhibition of myogenic tone by PD98059, a MEK1 inhibitor, in rat middle cerebral arteries. Biochem Biophys Res Commun 1999; 257: 523-527. (Pubitemid 29301475)
32. Pearce WJ, Williams JM, Chang MM, et al. ERK inhibition attenuates 5-HT-induced contractions in fetal and adult ovine carotid arteries. Arch Physiol Biochem 2003; 111: 36-44.
33. Xiao D, Pearce WJ, Longo LD, et al. ERK-mediated uterine artery contraction: role of thick and thin filament regulatory pathways. Am J Physiol Heart Circ Physiol 2004; 286: H1615-H1622.
34. Xiao D, Zhang L. ERK MAP kinases regulate smooth muscle contraction in ovine uterine artery: effect of pregnancy. Am J Physiol Heart Circ Physiol 2002; 282: H292-H300.
35. D'Angelo G, Adam LP. Inhibition of ERK attenuates force development by lowering myosin light chain phosphorylation. Am J Physiol Heart Circ Physiol 2002; 282: H602-H610.
36. Earley JJ, Su X, Moreland RS. Caldesmon inhibits active cross-bridges in unstimulated vascular smooth muscle: an antisense oligodeoxynucleotide approach. Circ Res 1998; 83: 661-667. (Pubitemid 28427750)
37. Gorenne I, Su X, Moreland RS. Caldesmon phosphorylation is catalyzed by two kinases in permeabilized and intact vascular smooth muscle. J Cell Physiol 2004; 198: 461-469. (Pubitemid 38235041)
38. erk mitogen-activated protein kinase in vitro and demonstration of another caldesmon kinase in intact gizzard smooth muscle. FEBS Lett 1999; 452: 254-258.
39. cdc2 kinase. Identification of phosphorylation sites. J Biol Chem 1991; 266: 19971-19975.
40. 2+ sensitivity of smooth muscle contraction. J Biol Chem 2000; 275: 1959-1965.
41. McFawn PK, Shen L, Vincent SG, et al. Calcium-independent contraction and sensitization of airway smooth muscle by p21-activated protein kinase. Am J Physiol Lung Cell Mol Physiol 2003; 284: L863-L870.
42. Vorotnikov AV, Gusev NB, Hua S, et al. Identification of casein kinase II as a major endogeneous caldesmon kinase in sheep aorta smooth muscle. FEBS Lett 1993; 334: 18-22. (Pubitemid 23323029)
43. 2+/calmodulin-dependent multifunctional protein kinase. J Biol Chem 1990; 265: 8975-8978.
44. Houle F, Rousseau S, Morrice N, et al. Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing. Mol Biol Cell 2003; 14: 1418-1432. (Pubitemid 36547411)
45. Dulin NO, Fernandes DJ, Dowell M, et al. What evidence implicates airway smooth muscle in the cause of BHR? Clin Rev Allergy Immunol 2003; 24: 73-84.
46. Solway J, Bellam S, Dowell M, et al. Actin dynamics. A potential integrator of smooth muscle (dys-)function and contractile apparatus gene expression in asthma. Parker B. Francis lecture. Chest 2003; 123: 392S-398S.
47. Huang R, Li L, Guo H, et al. Caldesmon binding to actin is regulated by calmodulin and phosphorylation via different mechanisms. Biochemistry 2003; 42: 2513-2523. (Pubitemid 36330604)
48. Kulikova N, Avrova SV, Borovikov YS. Caldesmon inhibits the rotation of smooth actin subdomain-1 and alters its mobility during the ATP hydrolysis cycle. Biochem Biophys Res Commun 2009; 390: 125-129.
49. 2 synthesis in endothelium. Am J Physiol Cell Physiol 2001; 281: C1266-C1276.
50. Kurosawa M, Numazawa S, Tani Y, et al. ERK signaling mediates the induction of inflammatory cytokines by bufalin in human monocytic cells. Am J Physiol Cell Physiol 2000; 278: C500-508. (Pubitemid 30154929)
51. Liu Q, Hofmann PA. Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes. Am J Physiol Heart Circ Physiol 2004; 286: H2204-H2212.
52. Xiao YQ, Malcolm K, Worthen GS, et al. Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-β. J Biol Chem 2002; 277: 14884-14893. (Pubitemid 34952562)
53. Burgess JK, Lee JH, Ge Q, et al. Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: differences in asthma. J Cell Physiol 2008; 216: 673-679.
54. Duan W, Chan JH, Wong CH, et al. Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model. J Immunol 2004; 172: 7053-7059. (Pubitemid 38669147)