Leptin: Involvement in the pathophysiology of breast cancer;Leptine: Implication dans la physiopathologie du cancer du sein

Annales d'Endocrinologie

Volumn 74, Issue 2, 2013, Pages 90-101

  Caldefie Chézet, Florence ^a,b   Dubois, Virginie ^a,b   Delort, Laetitia ^a,b   Rossary, Adrien ^a,b   Vasson, Marie Paule ^a,b,c  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CRNH AUVERGNE   (France)

^c CENTRE JEAN PERRIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; LEPTIN;

ADIPOCYTE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL; HUMAN; INFLAMMATION; OBESITY; PATHOPHYSIOLOGY; RISK FACTOR; TUMOR VASCULARIZATION; ANIMAL; BREAST TUMOR; CELL TRANSFORMATION; COMPLICATION; FEMALE; METABOLISM; MORTALITY; PATHOLOGY; PHYSIOLOGY; REVIEW;

ADIPOCYTES; ANIMALS; BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; HUMANS; LEPTIN; OBESITY;

EID: 84877602952     PISSN: 00034266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ando.2013.03.005     Document Type: Article

References (147)

1. Ronti T., Lupattelli G., Mannarino E. The endocrine function of adipose tissue: an update. Clin Endocrinol (Oxf) 2006, 64:355-365.
2. Prolo P., Wong M.L., Licinio J. Leptin. Int J Biochem Cell Biol 1998, 30:1285-1290.
3. Lam Q.L., Lu L. Role of leptin in immunity. Cell Mol Immunol 2007, 4:1-13.
4. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995, 83:1263-1271.
5. Galic S., Oakhill J.S., Steinberg G.R. Adipose tissue as an endocrine organ. Mol Cell Endocrinol 2010, 316:129-139.
6. Lee G.H., Proenca R., Montez J.M., Carroll K.M., Darvishzadeh J.G., Lee J.I., et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996, 379:632-635.
7. Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
8. Tartaglia L.A. The leptin receptor. J Biol Chem 1997, 272:6093-6096.
9. Morris D.L., Rui L. Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab 2009, 297:E1247-E1259.
10. Harris R.B. Leptin - much more than a satiety signal. Annu Rev Nutr 2000, 20:45-75.
11. Rayner D.V., Trayhurn P. Regulation of leptin production: sympathetic nervous system interactions. J Mol Med (Berl) 2001, 79:8-20.
12. Trayhurn P., Beattie J.H. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 2001, 60:329-339.
13. Cinti S., Matteis R.D., Pico C., Ceresi E., Obrador A., Maffeis C., et al. Secretory granules of endocrine and chief cells of human stomach mucosa contain leptin. Int J Obes Relat Metab Disord 2000, 24:789-793.
14. Wang Y., Lam K.S., Yau M.H., Xu A. Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J 2008, 409:623-633.
15. Vazquez-Vela M.E., Torres N., Tovar A.R. White adipose tissue as endocrine organ and its role in obesity. Arch Med Res 2008, 39:715-728.
16. Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem J 2006, 393:7-20.
17. Ahima R.S., Flier J.S. Adipose tissue as an endocrine organ. Trends Endocrinol Metab 2000, 11:327-332.
18. Lonnqvist F., Nordfors L., Jansson M., Thorne A., Schalling M., Arner P. Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression. J Clin Invest 1997, 99:2398-2404.
19. Fain J.N., Madan A.K., Hiler M.L., Cheema P., Bahouth S.W. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 2004, 145:2273-2282.
20. Wajchenberg B.L. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000, 21:697-738.
21. Kershaw E.E., Flier J.S. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004, 89:2548-2556.
22. Rosenbaum M., Leibel R.L. The role of leptin in human physiology. N Engl J Med 1999, 341:913-915.
23. Chapman I.M., Wittert G.A., Norman R.J. Circulating leptin concentrations in polycystic ovary syndrome: relation to anthropometric and metabolic parameters. Clin Endocrinol (Oxf) 1997, 46:175-181.
24. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996, 334:292-295.
25. Silha J.V., Krsek M., Skrha J.V., Sucharda P., Nyomba B.L., Murphy L.J. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol 2003, 149:331-335.
26. Hancke K., Grubeck D., Hauser N., Kreienberg R., Weiss J.M. Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients. Breast Cancer Res Treat 2010, 119:367-377.
27. Martin S.S., Qasim A., Reilly M.P. Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol 2008, 52:1201-1210.
28. Devos R., Guisez Y., Van der Heyden J., White D.W., Kalai M., Fountoulakis M., et al. Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. J Biol Chem 1997, 272:18304-18310.
29. Banks A.S., Davis S.M., Bates S.H., Myers M.G. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000, 275:14563-14572.
30. Gao F.B., Kohwi M., Brenman J.E., Jan L.Y., Jan Y.N. Control of dendritic field formation in Drosophila: the roles of flamingo and competition between homologous neurons. Neuron 2000, 28:91-101.
31. Cirillo D., Rachiglio A.M., la Montagna R., Giordano A., Normanno N. Leptin signaling in breast cancer: an overview. J Cell Biochem 2008, 105:956-964.
32. Guo X., Roberts M.R., Becker S.M., Podd B., Zhang Y., Chua S.C., et al. Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica. Mucosal Immunol 2011, 4:294-303.
33. Athyros V.G., Tziomalos K., Karagiannis A., Anagnostis P., Mikhailidis D.P. Should adipokines be considered in the choice of the treatment of obesity-related health problems?. Curr Drug Targets 2010, 11:122-135.
34. Ahima R.S., Osei S.Y. Leptin signaling. Physiol Behav 2004, 81:223-241.
35. Stephens T.W., Basinski M., Bristow P.K., Bue-Valleskey J.M., Burgett S.G., Craft L., et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995, 377:530-532.
36. Kristensen P., Judge M.E., Thim L., Ribel U., Christjansen K.N., Wulff B.S., et al. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 1998, 393:72-76.
37. Elias C.F., Lee C., Kelly J., Aschkenasi C., Ahima R.S., Couceyro P.R., et al. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 1998, 21:1375-1385.
38. Mizuno T.M., Kleopoulos S.P., Bergen H.T., Roberts J.L., Priest C.A., Mobbs C.V. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 1998, 47:294-297.
39. El-Haschimi K., Pierroz D.D., Hileman S.M., Bjorbaek C., Flier J.S. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 2000, 105:1827-1832.
40. Cowley M.A., Smart J.L., Rubinstein M., Cerdan M.G., Diano S., Horvath T.L., et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001, 411:480-484.
41. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., Baskin D.G. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996, 98:1101-1106.
42. Takahashi K.A., Cone R.D. Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons. Endocrinology 2005, 146:1043-1047.
43. Paraskevas K.I., Liapis C.D., Mikhailidis D.P. Leptin: a promising therapeutic target with pleiotropic action besides body weight regulation. Curr Drug Targets 2006, 7:761-771.
44. Wang M.Y., Lee Y., Unger R.H. Novel form of lipolysis induced by leptin. J Biol Chem 1999, 274:17541-17544.
45. Muoio D.M., Dohm G.L., Fiedorek F.T., Tapscott E.B., Coleman R.A. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 1997, 46:1360-1363.
46. Minokoshi Y., Kim Y.B., Peroni O.D., Fryer L.G., Muller C., Carling D., et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002, 415:339-343.
47. Rondinone C.M. Adipocyte-derived hormones, cytokines, and mediators. Endocrine 2006, 29:81-90.
48. Toyoshima Y., Gavrilova O., Yakar S., Jou W., Pack S., Asghar Z., et al. Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes. Endocrinology 2005, 146:4024-4035.
49. Kahn B.B., Alquier T., Carling D., Hardie D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005, 1:15-25.
50. Emilsson V., Liu Y.L., Cawthorne M.A., Morton N.M., Davenport M. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 1997, 46:313-316.
51. Kulkarni R.N., Wang Z.L., Wang R.M., Hurley J.D., Smith D.M., Ghatei M.A., et al. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest 1997, 100:2729-2736.
52. Harle P., Straub R.H. Leptin is a link between adipose tissue and inflammation. Ann N Y Acad Sci 2006, 1069:454-462.
53. Caldefie-Chezet F., Poulin A., Tridon A., Sion B., Vasson M.P. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?. J Leukoc Biol 2001, 69:414-418.
54. Dardeno T.A., Chou S.H., Moon H.S., Chamberland J.P., Fiorenza C.G., Mantzoros C.S. Leptin in human physiology and therapeutics. Front Neuroendocrinol 2010, 31:377-393.
55. Huang L., Li C. Leptin: a multifunctional hormone. Cell Res 2000, 10:81-92.
56. Curado M.P. Breast cancer in the world: incidence and mortality. Salud Publica Mex 2011, 53:372-384.
57. Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010, 127:2893-2917.
58. Renehan A.G., Soerjomataram I., Leitzmann M.F. Interpreting the epidemiological evidence linking obesity and cancer: a framework for population-attributable risk estimations in Europe. Eur J Cancer 2010, 46:2581-2592.
59. http://www.roche.fr/fmfiles/re7199006/enquete_obepi_2012/obepi_2012.pdf.
60. Research WCRFAIfC, food, nutrition, physical activity, and the prevention of cancer: a global perspective 2007, AICR, Washington DC, 517 pages.
61. Gonzalez C.A., Riboli E. Diet and cancer prevention: contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Cancer 2010, 46:2555-2562.
62. Chlebowski R.T., Aiello E., McTiernan A. Weight loss in breast cancer patient management. J Clin Oncol 2002, 20:1128-1143.
63. Maccio A., Madeddu C., Mantovani G. Adipose tissue as target organ in the treatment of hormone-dependent breast cancer: new therapeutic perspectives. Obes Rev 2009, 10:660-670.
64. Dirat B., Bochet L., Dabek M., Daviaud D., Dauvillier S., Majed B., et al. Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res 2011, 71:2455-2465.
65. Tan J., Buache E., Chenard M.P., Dali-Youcef N., Rio M.C. Adipocyte is a non-trivial, dynamic partner of breast cancer cells. Int J Dev Biol 2011, 5:851-859.
66. Heber D., Ashley J., Bagga D. Stromal-epithelial cell interactions in breast cancer. Adv Exp Med Biol 1996, 399:41-51.
67. Ruohola J.K., Viitanen T.P., Valve E.M., Seppanen J.A., Loponen N.T., Keskitalo J.J., et al. Enhanced invasion and tumor growth of fibroblast growth factor 8b-overexpressing MCF-7 human breast cancer cells. Cancer Res 2001, 61:4229-4237.
68. Manabe Y., Toda S., Miyazaki K., Sugihara H. Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions. J Pathol 2003, 201:221-228.
69. Chamras H., Bagga D., Elstner E., Setoodeh K., Koeffler H.P., Heber D. Preadipocytes stimulate breast cancer cell growth. Nutr Cancer 1998, 32:59-63.
70. Grisouard J., Dembinski K., Mayer D., Keller U., Muller B., Christ-Crain M. Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation. Diabetol Metab Syndr 2011, 3:16.
71. Tessitore L., Vizio B., Pesola D., Cecchini F., Mussa A., Argiles J.M., et al. Adipocyte expression and circulating levels of leptin increase in both gynaecological and breast cancer patients. Int J Oncol 2004, 24:1529-1535.
72. Ozet A., Arpaci F., Yilmaz M.I., Ayta H., Ozturk B., Komurcu S., et al. Effects of tamoxifen on the serum leptin level in patients with breast cancer. Jpn J Clin Oncol 2001, 31:424-427.
73. Chen C., Chang Y.C., Liu C.L., Chang K.J., Guo I.C. Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1. Breast Cancer Res Treat 2006, 98:121-132.
74. Hou W.K., Xu Y.X., Yu T., Zhang L., Zhang W.W., Fu C.L., et al. Adipocytokines and breast cancer risk. Chin Med J (Engl) 2007, 120:1592-1596.
75. Han C.Z., Du L.L., Jing J.X., Zhao X.W., Tian F.G., Shi J., et al. Associations among lipids, leptin, and leptin receptor gene Gin223Arg polymorphisms and breast cancer in China. Biol Trace Elem Res 2008, 126:38-48.
76. Korner A., Kratzsch J., Gausche R., Schaab M., Erbs S., Kiess W. New predictors of the metabolic syndrome in children - role of adipocytokines. Pediatr Res 2007, 61:640-645.
77. Mantzoros C.S., Bolhke K., Moschos S., Cramer D.W. Leptin in relation to carcinoma in situ of the breast: a study of pre-menopausal cases and controls. Int J Cancer 1999, 80:523-526.
78. Woo H.Y., Park H., Ki C.S., Park Y.L., Bae W.G. Relationships among serum leptin, leptin receptor gene polymorphisms, and breast cancer in Korea. Cancer Lett 2006, 237:137-142.
79. Maccio A., Madeddu C., Gramignano G., Mulas C., Floris C., Massa D., et al. Correlation of body mass index and leptin with tumor size and stage of disease in hormone-dependent postmenopausal breast cancer: preliminary results and therapeutic implications. J Mol Med (Berl) 2010, 88:677-686.
80. Carroll P.A., Healy L., Lysaght J., Boyle T., Reynolds J.V., Kennedy M.J., et al. Influence of the metabolic syndrome on leptin and leptin receptor in breast cancer. Mol Carcinog 2011, 50:643-651.
81. Chen D.C., Chung Y.F., Yeh Y.T., Chaung H.C., Kuo F.C., Fu O.Y., et al. Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett 2006, 237:109-114.
82. Han C., Zhang H.T., Du L., Liu X., Jing J., Zhao X., et al. Serum levels of leptin, insulin, and lipids in relation to breast cancer in china. Endocrine 2005, 26:19-24.
83. Aliustaoglu M., Bilici A., Gumus M., Colak A.T., Baloglu G., Irmak R., et al. Preoperative serum leptin levels in patients with breast cancer. Med Oncol 2010, 27:388-391.
84. Miyoshi Y., Funahashi T., Tanaka S., Taguchi T., Tamaki Y., Shimomura I., et al. High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. Int J Cancer 2006, 118:1414-1419.
85. Caldefie-Chezet F., Damez M., de Latour M., Konska G., Mishellani F., Fusillier C., et al. Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. Biochem Biophys Res Commun 2005, 334:737-741.
86. Jarde T., Caldefie-Chezet F., Damez M., Mishellany F., Penault-Llorca F., Guillot J., et al. Leptin and leptin receptor involvement in cancer development: a study on human primary breast carcinoma. Oncol Rep 2008, 19:905-911.
87. O'Brien S.N., Welter B.H., Price T.M. Presence of leptin in breast cell lines and breast tumors. Biochem Biophys Res Commun 1999, 259:695-698.
88. Laud K., Gourdou I., Pessemesse L., Peyrat J.P., Djiane J. Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line. Mol Cell Endocrinol 2002, 188:219-226.
89. Ishikawa M., Kitayama J., Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 2004, 10:4325-4331.
90. Hu X., Juneja S.C., Maihle N.J., Cleary M.P. Leptin - a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst 2002, 94:1704-1711.
91. Garofalo C., Koda M., Cascio S., Sulkowska M., Kanczuga-Koda L., Golaszewska J., et al. Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 2006, 12:1447-1453.
92. Revillion F., Charlier M., Lhotellier V., Hornez L., Giard S., Baranzelli M.C., et al. Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers. Clin Cancer Res 2006, 12:2088-2094.
93. Kim Y., Kim S.Y., Lee J.J., Seo J., Kim Y.W., Koh S.H., et al. Effects of the expression of leptin and leptin receptor (OBR) on the prognosis of early-stage breast cancers. Cancer Res Treat 2006, 38:126-132.
94. Koda M., Sulkowska M., Kanczuga-Koda L., Jarzabek K., Sulkowski S. Expression of leptin and its receptor in female breast cancer in relation with selected apoptotic markers. Folia Histochem Cytobiol 2007, 45(Suppl. 1):S187-S191.
95. Kim H.S. Leptin and leptin receptor expression in breast cancer. Cancer Res Treat 2009, 41:155-163.
96. Masaki T., Yoshimatsu H. Obesity, adipocytokines and cancer. Transl Oncogenomics 2008, 3:45-52.
97. Koda M., Kanczuga-Koda L., Sulkowska M., Surmacz E., Sulkowski S. Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapy. BMC Cancer 2010, 10:320.
98. Jeong Y.J., Bong J.G., Park S.H., Choi J.H., Oh H.K. Expression of leptin, leptin receptor, adiponectin, and adiponectin receptor in ductal carcinoma in situ and invasive breast cancer. J Breast Cancer 2011, 14:96-103.
99. Fiorio E., Mercanti A., Terrasi M., Micciolo R., Remo A., Auriemma A., et al. Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis. BMC Cancer 2008, 8:305.
100. Jarde T., Caldefie-Chezet F., Goncalves-Mendes N., Mishellany F., Buechler C., Penault-Llorca F., et al. Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies. Endocr Relat Cancer 2009, 16:1197-1210.
101. Fusco R., Galgani M., Procaccini C., Franco R., Pirozzi G., Fucci L., et al. Cellular and molecular crosstalk between leptin receptor and estrogen receptor-{alpha} in breast cancer: molecular basis for a novel therapeutic setting. Endocr Relat Cancer 2010, 17:373-382.
102. Dubois V., Delort L., Mishellany F., Jarde T., Billard H., Lequeux C., et al. Zinc-alpha2-glycoprotein: a new biomarker of breast cancer?. Anticancer Res 2010, 30:2919-2925.
103. Perrier S., Caldefie-Chezet F., Vasson M.P. IL-1 family in breast cancer: potential interplay with leptin and other adipocytokines. FEBS Lett 2009, 583:259-265.
104. Cleary M.P., Phillips F.C., Getzin S.C., Jacobson T.L., Jacobson M.K., Christensen T.A., et al. Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors. Breast Cancer Res Treat 2003, 77:205-215.
105. Cleary M.P., Juneja S.C., Phillips F.C., Hu X., Grande J.P., Maihle N.J. Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Exp Biol Med (Maywood) 2004, 229:182-193.
106. Zheng Q., Dunlap S.M., Zhu J., Downs-Kelly E., Rich J., Hursting S.D., et al. Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival. Endocr Relat Cancer 2011, 18:491-503.
107. Mauro L., Catalano S., Bossi G., Pellegrino M., Barone I., Morales S., et al. Evidences that leptin up-regulates E-cadherin expression in breast cancer: effects on tumor growth and progression. Cancer Res 2007, 67:3412-3421.
108. Gonzalez R.R., Cherfils S., Escobar M., Yoo J.H., Carino C., Styer A.K., et al. Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J Biol Chem 2006, 281:26320-26328.
109. Gonzalez-Perez R.R., Xu Y., Guo S., Watters A., Zhou W., Leibovich S.J. Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkappaB/HIF-1alpha activation. Cell Signal 2010, 22:1350-1362.
110. Cleary M.P., Grande J.P., Juneja S.C., Maihle N.J. Diet-induced obesity and mammary tumor development in MMTV-neu female mice. Nutr Cancer 2004, 50:174-180.
111. Nachat-Kappes R., Pinel A., Combe K., Lamas B., Farges M.C., Rossary A., et al. Effects of enriched environment on COX-2. Leptin and eicosanoids in a mouse model of breast cancer. PLoS One 2012, 7:e51525.
112. Dieudonne M.N., Machinal-Quelin F., Serazin-Leroy V., Leneveu M.C., Pecquery R., Giudicelli Y. Leptin mediates a proliferative response in human MCF7 breast cancer cells. Biochem Biophys Res Commun 2002, 293:622-628.
113. Yin N., Wang D., Zhang H., Yi X., Sun X., Shi B., et al. Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res 2004, 64:5870-5875.
114. Garofalo C., Sisci D., Surmacz E. Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells. Clin Cancer Res 2004, 10:6466-6475.
115. Saxena N.K., Vertino P.M., Anania F.A., Sharma D. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J Biol Chem 2007, 282:13316-13325.
116. Ray A., Nkhata K.J., Cleary M.P. Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status. Int J Oncol 2007, 30:1499-1509.
117. Soma D., Kitayama J., Yamashita H., Miyato H., Ishikawa M., Nagawa H. Leptin augments proliferation of breast cancer cells via transactivation of HER2. J Surg Res 2008, 149:9-14.
118. Frankenberry K.A., Skinner H., Somasundar P., McFadden D.W., Vona-Davis L.C. Leptin receptor expression and cell signaling in breast cancer. Int J Oncol 2006, 28:985-993.
119. Taliaferro-Smith L., Nagalingam A., Knight B.B., Oberlick E., Saxena N.K., Sharma D. Integral role of PTP1B in adiponectin-mediated inhibition of oncogenic actions of leptin in breast carcinogenesis. Neoplasia 2013, 15:23-38.
120. Housa D., Housova J., Vernerova Z., Haluzik M. Adipocytokines and cancer. Physiol Res 2006, 55:233-244.
121. Okumura M., Yamamoto M., Sakuma H., Kojima T., Maruyama T., Jamali M., et al. Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression. Biochim Biophys Acta 2002, 1592:107-116.
122. Perera C.N., Chin H.G., Duru N., Camarillo I.G. Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression. J Endocrinol 2008, 199:221-233.
123. Somasundar P., Yu A.K., Vona-Davis L., McFadden D.W. Differential effects of leptin on cancer in vitro. J Surg Res 2003, 113:50-55.
124. Naviglio S., Di Gesto D., Romano M., Sorrentino A., Illiano F., Sorvillo L., et al. Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells. Cancer Biol Ther 2009, 8:1183-1190.
125. McCormack D., Schneider J., McDonald D., McFadden D. The antiproliferative effects of pterostilbene on breast cancer in vitro are via inhibition of constitutive and leptin-induced Janus kinase/signal transducer and activator of transcription activation. Am J Surg 2011, 202:541-544.
126. Perera C.N., Spalding H.S., Mohammed S.I., Camarillo I.G. Identification of proteins secreted from leptin stimulated MCF-7 breast cancer cells: a dual proteomic approach. Exp Biol Med (Maywood) 2008, 233:708-720.
127. Binai N.A., Damert A., Carra G., Steckelbroeck S., Lower J., Lower R., et al. Expression of estrogen receptor alpha increases leptin-induced STAT3 activity in breast cancer cells. Int J Cancer 2010, 127:55-66.
128. Xu P., Ye W., Li H., Lin S.H., Kuo C.T., Feng E., et al. Zeranol enhances leptin-induced proliferation in primary cultured human breast cancer epithelial cells. Mol Med Report 2010, 3:795-800.
129. Jiang H., Yu J., Guo H., Song H., Chen S. Upregulation of survivin by leptin/STAT3 signaling in MCF-7 cells. Biochem Biophys Res Commun 2008, 368:1-5.
130. Jarde T., Perrier S., Vasson M.P., Caldefie-Chezet F. Molecular mechanisms of leptin and adiponectin in breast cancer. Eur J Cancer 2011, 47:33-43.
131. Bjorbaek C., El-Haschimi K., Frantz J.D., Flier J.S. The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 1999, 274:30059-30065.
132. Catalano S., Mauro L., Marsico S., Giordano C., Rizza P., Rago V., et al. Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells. J Biol Chem 2004, 279:19908-19915.
133. Williams J.A., Phillips D.H. Mammary expression of xenobiotic metabolizing enzymes and their potential role in breast cancer. Cancer Res 2000, 60:4667-4677.
134. Mitrunen K., Hirvonen A. Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism. Mutat Res 2003, 544:9-41.
135. Lamas B., Goncalves-Mendes N., Nachat-Kappes R., Rossary A., Caldefie-Chezet F., Vasson M.P., et al. Leptin modulates dose-dependently the metabolic and cytolytic activities of NK-92 cells. J Cell Physiol 2012, 10.1002/jcp.24273.
136. Basu S., Nachat-Kappes R., Caldefie-Chezet F., Vasson M.P. Eicosanoids and adipokines in breast cancer: from molecular mechanisms to clinical considerations. Antioxid Redox Signal 2012, 18:323-360.
137. Sierra-Honigmann M.R., Nath A.K., Murakami C., Garcia-Cardena G., Papapetropoulos A., Sessa W.C., et al. Biological action of leptin as an angiogenic factor. Science 1998, 281:1683-1686.
138. Park H.Y., Kwon H.M., Lim H.J., Hong B.K., Lee J.Y., Park B.E., et al. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med 2001, 33:95-102.
139. Dubois V, Obésité et cancer mammaire: implication du microenvironnement adipocytaire et des adipokines ? Thèse d'université 2012, université d'Auvergne, p. 225.
140. Artwohl M., Roden M., Holzenbein T., Freudenthaler A., Waldhausl W., Baumgartner-Parzer S.M. Modulation by leptin of proliferation and apoptosis in vascular endothelial cells. Int J Obes Relat Metab Disord 2002, 26:577-580.
141. Goetze S., Bungenstock A., Czupalla C., Eilers F., Stawowy P., Kintscher U., et al. Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands. Hypertension 2002, 40:748-754.
142. Aronis K.N., Diakopoulos K.N., Fiorenza C.G., Chamberland J.P., Mantzoros C.S. Leptin administered in physiological or pharmacological doses does not regulate circulating angiogenesis factors in humans. Diabetologia 2011, 54:2358-2367.
143. Saxena N.K., Taliaferro-Smith L., Knight B.B., Merlin D., Anania F.A., O'Regan R.M., et al. Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor. Cancer Res 2008, 68:9712-9722.
144. Dubois V., Delort L., Billard H., Perrier S., Vasson M., Caldefie-Chezet F. Adiponectin: a "counter-regulator" in the angiogenesis process in breast cancer related to obesity?. Bull Cancer 2011, 98:S95.
145. Marttunen M.B., Andersson S., Hietanen P., Karonen S.L., Koistinen H.A., Koivisto V.A., et al. Antiestrogenic tamoxifen and toremifene increase serum leptin levels in postmenopausal breast cancer patients. Maturitas 2000, 35:175-179.
146. Nunez N.P., Jelovac D., Macedo L., Berrigan D., Perkins S.N., Hursting S.D., et al. Effects of the antiestrogen tamoxifen and the aromatase inhibitor letrozole on serum hormones and bone characteristics in a preclinical tumor model for breast cancer. Clin Cancer Res 2004, 10:5375-5380.
147. Chen X., Zha X., Chen W., Zhu T., Qiu J., Roe O.D., et al. Leptin attenuates the anti-estrogen effect of tamoxifen in breast cancer. Biomed Pharmacother 2012, [doi:pii: S0753-3322(12)00093-5].