메뉴 건너뛰기




Volumn 52, Issue 15, 2008, Pages 1201-1210

Leptin Resistance. A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular Disease

Author keywords

atherosclerosis; cardiovascular disease; inflammation; leptin resistance; obesity

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CYTOKINE; INSULIN; INTERLEUKIN 18; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 52949129178     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2008.05.060     Document Type: Review
Times cited : (421)

References (133)
  • 1
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 3
    • 0032059793 scopus 로고    scopus 로고
    • Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men
    • Mantzoros C.S., Liolios A.D., Tritos N.A., et al. Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men. Obes Res 6 (1998) 179-186
    • (1998) Obes Res , vol.6 , pp. 179-186
    • Mantzoros, C.S.1    Liolios, A.D.2    Tritos, N.A.3
  • 4
    • 0032862037 scopus 로고    scopus 로고
    • Leptin is associated with increased risk of myocardial infarction
    • Soderberg S., Ahren B., Jansson J.H., et al. Leptin is associated with increased risk of myocardial infarction. J Intern Med 246 (1999) 409-418
    • (1999) J Intern Med , vol.246 , pp. 409-418
    • Soderberg, S.1    Ahren, B.2    Jansson, J.H.3
  • 5
    • 0035909997 scopus 로고    scopus 로고
    • Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS)
    • Wallace A.M., McMahon A.D., Packard C.J., et al. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation 104 (2001) 3052-3056
    • (2001) Circulation , vol.104 , pp. 3052-3056
    • Wallace, A.M.1    McMahon, A.D.2    Packard, C.J.3
  • 7
    • 4043077647 scopus 로고    scopus 로고
    • Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes
    • Reilly M.P., Iqbal N., Schutta M., et al. Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab 89 (2004) 3872-3878
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3872-3878
    • Reilly, M.P.1    Iqbal, N.2    Schutta, M.3
  • 8
    • 34249697436 scopus 로고    scopus 로고
    • Role of leptin in immunity
    • Lam Q.L., and Lu L. Role of leptin in immunity. Cell Mol Immunol 4 (2007) 1-13
    • (2007) Cell Mol Immunol , vol.4 , pp. 1-13
    • Lam, Q.L.1    Lu, L.2
  • 9
    • 33645746168 scopus 로고    scopus 로고
    • Induction of leptin resistance through direct interaction of C-reactive protein with leptin
    • Chen K., Li F., Li J., et al. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med 12 (2006) 425-432
    • (2006) Nat Med , vol.12 , pp. 425-432
    • Chen, K.1    Li, F.2    Li, J.3
  • 10
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and coronary artery disease
    • Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352 (2005) 1685-1695
    • (2005) N Engl J Med , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 11
    • 0000736325 scopus 로고
    • Obese, a new mutation in the house mouse
    • Ingalls A.M., Dickie M.M., and Snell G.D. Obese, a new mutation in the house mouse. J Hered 41 (1950) 317-318
    • (1950) J Hered , vol.41 , pp. 317-318
    • Ingalls, A.M.1    Dickie, M.M.2    Snell, G.D.3
  • 12
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman D.L. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9 (1973) 294-298
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 13
  • 14
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter M.A., Cullen M.J., Baker M.B., et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269 (1995) 540-543
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3
  • 15
    • 0030884355 scopus 로고    scopus 로고
    • Relationship between concentration of serum leptin and fetal growth
    • Harigaya A., Nagashima K., Nako Y., and Morikawa A. Relationship between concentration of serum leptin and fetal growth. J Clin Endocrinol Metab 82 (1997) 3281-3284
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3281-3284
    • Harigaya, A.1    Nagashima, K.2    Nako, Y.3    Morikawa, A.4
  • 16
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • Considine R.V., Sinha M.K., Heiman M.L., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334 (1996) 292-295
    • (1996) N Engl J Med , vol.334 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 17
    • 0030936047 scopus 로고    scopus 로고
    • The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure
    • Kennedy A., Gettys T.W., Watson P., et al. The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab 82 (1997) 1293-1300
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1293-1300
    • Kennedy, A.1    Gettys, T.W.2    Watson, P.3
  • 18
    • 0029131574 scopus 로고
    • Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity
    • Frederich R.C., Lollmann B., Hamann A., et al. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest 96 (1995) 1658-1663
    • (1995) J Clin Invest , vol.96 , pp. 1658-1663
    • Frederich, R.C.1    Lollmann, B.2    Hamann, A.3
  • 19
    • 0030977992 scopus 로고    scopus 로고
    • Crystal structure of the obese protein leptin-E100
    • Zhang F., Basinski M.B., Beals J.M., et al. Crystal structure of the obese protein leptin-E100. Nature 387 (1997) 206-209
    • (1997) Nature , vol.387 , pp. 206-209
    • Zhang, F.1    Basinski, M.B.2    Beals, J.M.3
  • 20
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: mediators linking adipose tissue, inflammation and immunity
    • Tilg H., and Moschen A.R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6 (2006) 772-783
    • (2006) Nat Rev Immunol , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 22
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia L.A., Dembski M., Weng X., et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 83 (1995) 1263-1271
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3
  • 23
    • 0029776030 scopus 로고    scopus 로고
    • The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
    • Baumann H., Morella K.K., White D.W., et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci U S A 93 (1996) 8374-8378
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 8374-8378
    • Baumann, H.1    Morella, K.K.2    White, D.W.3
  • 24
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal splicing of the leptin receptor in diabetic mice
    • Lee G.H., Proenca R., Montez J.M., et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379 (1996) 632-635
    • (1996) Nature , vol.379 , pp. 632-635
    • Lee, G.H.1    Proenca, R.2    Montez, J.M.3
  • 25
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjorbaek C., Uotani S., da Silva B., and Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 272 (1997) 32686-32695
    • (1997) J Biol Chem , vol.272 , pp. 32686-32695
    • Bjorbaek, C.1    Uotani, S.2    da Silva, B.3    Flier, J.S.4
  • 26
    • 0031577546 scopus 로고    scopus 로고
    • Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and, e in different mouse tissues
    • Lollmann B., Gruninger S., Stricker-Krongrad A., and Chiesi M. Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and, e in different mouse tissues. Biochem Biophys Res Commun 238 (1997) 648-652
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 648-652
    • Lollmann, B.1    Gruninger, S.2    Stricker-Krongrad, A.3    Chiesi, M.4
  • 27
    • 0033569730 scopus 로고    scopus 로고
    • The role of SOCS-3 in leptin signaling and leptin resistance
    • Bjorbaek C., El-Haschimi K., Frantz J.D., and Flier J.S. The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 274 (1999) 30059-30065
    • (1999) J Biol Chem , vol.274 , pp. 30059-30065
    • Bjorbaek, C.1    El-Haschimi, K.2    Frantz, J.D.3    Flier, J.S.4
  • 28
    • 0030764045 scopus 로고    scopus 로고
    • Evidence that plasma leptin and insulin levels are associated with body adiposity via different mechanisms
    • Schwartz M.W., Prigeon R.L., Kahn S.E., et al. Evidence that plasma leptin and insulin levels are associated with body adiposity via different mechanisms. Diabetes Care 20 (1997) 1476-1481
    • (1997) Diabetes Care , vol.20 , pp. 1476-1481
    • Schwartz, M.W.1    Prigeon, R.L.2    Kahn, S.E.3
  • 29
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial
    • Heymsfield S.B., Greenberg A.S., Fujioka K., et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282 (1999) 1568-1575
    • (1999) JAMA , vol.282 , pp. 1568-1575
    • Heymsfield, S.B.1    Greenberg, A.S.2    Fujioka, K.3
  • 30
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    • Chen H., Charlat O., Tartaglia L.A., et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84 (1996) 491-495
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3
  • 31
    • 0029020677 scopus 로고
    • Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity
    • Considine R.V., Considine E.L., Williams C.J., et al. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 95 (1995) 2986-2988
    • (1995) J Clin Invest , vol.95 , pp. 2986-2988
    • Considine, R.V.1    Considine, E.L.2    Williams, C.J.3
  • 32
    • 33745197808 scopus 로고    scopus 로고
    • The role of leptin in leptin resistance and obesity
    • Zhang Y., and Scarpace P.J. The role of leptin in leptin resistance and obesity. Physiol Behav 88 (2006) 249-256
    • (2006) Physiol Behav , vol.88 , pp. 249-256
    • Zhang, Y.1    Scarpace, P.J.2
  • 33
    • 0035800015 scopus 로고    scopus 로고
    • Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats
    • Scarpace P.J., Matheny M., and Tumer N. Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats. Neuroscience 104 (2001) 1111-1117
    • (2001) Neuroscience , vol.104 , pp. 1111-1117
    • Scarpace, P.J.1    Matheny, M.2    Tumer, N.3
  • 34
    • 2942556882 scopus 로고    scopus 로고
    • Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression
    • Wilsey J., and Scarpace P.J. Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression. J Endocrinol 181 (2004) 297-306
    • (2004) J Endocrinol , vol.181 , pp. 297-306
    • Wilsey, J.1    Scarpace, P.J.2
  • 35
    • 0036831235 scopus 로고    scopus 로고
    • Hypothalamic delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and physiological responses
    • Wilsey J., Zolotukhin S., Prima V., Shek E.W., Matheny M.K., and Scarpace P.J. Hypothalamic delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and physiological responses. Gene Ther 9 (2002) 1492-1499
    • (2002) Gene Ther , vol.9 , pp. 1492-1499
    • Wilsey, J.1    Zolotukhin, S.2    Prima, V.3    Shek, E.W.4    Matheny, M.K.5    Scarpace, P.J.6
  • 36
    • 0036226005 scopus 로고    scopus 로고
    • Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats
    • Scarpace P.J., Matheny M., Zhang Y., et al. Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats. Neuropharmacology 42 (2002) 548-561
    • (2002) Neuropharmacology , vol.42 , pp. 548-561
    • Scarpace, P.J.1    Matheny, M.2    Zhang, Y.3
  • 37
    • 21344466081 scopus 로고    scopus 로고
    • Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats
    • Scarpace P.J., Matheny M., Tumer N., Cheng K.Y., and Zhang Y. Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats. Diabetologia 48 (2005) 1075-1083
    • (2005) Diabetologia , vol.48 , pp. 1075-1083
    • Scarpace, P.J.1    Matheny, M.2    Tumer, N.3    Cheng, K.Y.4    Zhang, Y.5
  • 38
    • 0031761385 scopus 로고    scopus 로고
    • Expression of leptin receptor isoforms in rat brain microvessels
    • Bjorbaek C., Elmquist J.K., Michl P., et al. Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology 139 (1998) 3485-3491
    • (1998) Endocrinology , vol.139 , pp. 3485-3491
    • Bjorbaek, C.1    Elmquist, J.K.2    Michl, P.3
  • 39
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • Banks W.A., Kastin A.J., Huang W., Jaspan J.B., and Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides 17 (1996) 305-311
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.3    Jaspan, J.B.4    Maness, L.M.5
  • 40
    • 0030807358 scopus 로고    scopus 로고
    • Diet-induced obese mice develop peripheral, but not central, resistance to leptin
    • Van Heek M., Compton D.S., France C.F., et al. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 99 (1997) 385-390
    • (1997) J Clin Invest , vol.99 , pp. 385-390
    • Van Heek, M.1    Compton, D.S.2    France, C.F.3
  • 41
    • 0029881125 scopus 로고    scopus 로고
    • Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans
    • Schwartz M.W., Peskind E., Raskind M., Boyko E.J., and Porte Jr. D. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 2 (1996) 589-593
    • (1996) Nat Med , vol.2 , pp. 589-593
    • Schwartz, M.W.1    Peskind, E.2    Raskind, M.3    Boyko, E.J.4    Porte Jr., D.5
  • 42
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., and Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1 (1998) 619-625
    • (1998) Mol Cell , vol.1 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 43
    • 0036228770 scopus 로고    scopus 로고
    • Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
    • Cheng A., Uetani N., Simoncic P.D., et al. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell 2 (2002) 497-503
    • (2002) Dev Cell , vol.2 , pp. 497-503
    • Cheng, A.1    Uetani, N.2    Simoncic, P.D.3
  • 44
    • 0030792590 scopus 로고    scopus 로고
    • A family of cytokine-inducible inhibitors of signalling
    • Starr R., Willson T.A., Viney E.M., et al. A family of cytokine-inducible inhibitors of signalling. Nature 387 (1997) 917-921
    • (1997) Nature , vol.387 , pp. 917-921
    • Starr, R.1    Willson, T.A.2    Viney, E.M.3
  • 45
    • 0033001325 scopus 로고    scopus 로고
    • Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues
    • Emilsson V., Arch J.R., de Groot R.P., Lister C.A., and Cawthorne M.A. Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues. FEBS Lett 455 (1999) 170-174
    • (1999) FEBS Lett , vol.455 , pp. 170-174
    • Emilsson, V.1    Arch, J.R.2    de Groot, R.P.3    Lister, C.A.4    Cawthorne, M.A.5
  • 46
    • 0030839112 scopus 로고    scopus 로고
    • A new protein containing an SH2 domain that inhibits JAK kinases
    • Endo T.A., Masuhara M., Yokouchi M., et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387 (1997) 921-924
    • (1997) Nature , vol.387 , pp. 921-924
    • Endo, T.A.1    Masuhara, M.2    Yokouchi, M.3
  • 47
    • 0030755934 scopus 로고    scopus 로고
    • Structure and function of a new STAT-induced STAT inhibitor
    • Naka T., Narazaki M., Hirata M., et al. Structure and function of a new STAT-induced STAT inhibitor. Nature 387 (1997) 924-929
    • (1997) Nature , vol.387 , pp. 924-929
    • Naka, T.1    Narazaki, M.2    Hirata, M.3
  • 48
    • 33846055719 scopus 로고    scopus 로고
    • Is leptin an important physiological regulator of CRP?
    • Zhao A. Is leptin an important physiological regulator of CRP?. Nat Med 13 (2007) 19-21
    • (2007) Nat Med , vol.13 , pp. 19-21
    • Zhao, A.1
  • 49
    • 0034805384 scopus 로고    scopus 로고
    • Soluble leptin receptor represents the main leptin binding activity in human blood
    • Lammert A., Kiess W., Bottner A., Glasow A., and Kratzsch J. Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun 283 (2001) 982-988
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 982-988
    • Lammert, A.1    Kiess, W.2    Bottner, A.3    Glasow, A.4    Kratzsch, J.5
  • 50
    • 0348141022 scopus 로고    scopus 로고
    • The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data
    • Zastrow O., Seidel B., Kiess W., et al. The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data. Int J Obes Relat Metab Disord 27 (2003) 1472-1478
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 1472-1478
    • Zastrow, O.1    Seidel, B.2    Kiess, W.3
  • 51
    • 0037318484 scopus 로고    scopus 로고
    • High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130
    • Pignatti P., Ciapponi L., Galle P., et al. High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130. Clin Exp Immunol 131 (2003) 355-363
    • (2003) Clin Exp Immunol , vol.131 , pp. 355-363
    • Pignatti, P.1    Ciapponi, L.2    Galle, P.3
  • 52
    • 0141459376 scopus 로고    scopus 로고
    • C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol
    • Kazumi T., Kawaguchi A., Hirano T., and Yoshino G. C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol. Metabolism 52 (2003) 1113-1116
    • (2003) Metabolism , vol.52 , pp. 1113-1116
    • Kazumi, T.1    Kawaguchi, A.2    Hirano, T.3    Yoshino, G.4
  • 53
    • 2442581240 scopus 로고    scopus 로고
    • Independent association between plasma leptin and C-reactive protein in healthy humans
    • Shamsuzzaman A.S., Winnicki M., Wolk R., et al. Independent association between plasma leptin and C-reactive protein in healthy humans. Circulation 109 (2004) 2181-2185
    • (2004) Circulation , vol.109 , pp. 2181-2185
    • Shamsuzzaman, A.S.1    Winnicki, M.2    Wolk, R.3
  • 54
    • 0035431169 scopus 로고    scopus 로고
    • The effects of leptin administration in non-obese human subjects
    • Mackintosh R.M., and Hirsch J. The effects of leptin administration in non-obese human subjects. Obes Res 9 (2001) 462-469
    • (2001) Obes Res , vol.9 , pp. 462-469
    • Mackintosh, R.M.1    Hirsch, J.2
  • 55
    • 1942440850 scopus 로고    scopus 로고
    • Leptin and the proinflammatory state associated with human obesity
    • Hukshorn C.J., Lindeman J.H., Toet K.H., et al. Leptin and the proinflammatory state associated with human obesity. J Clin Endocrinol Metab 89 (2004) 1773-1778
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1773-1778
    • Hukshorn, C.J.1    Lindeman, J.H.2    Toet, K.H.3
  • 57
    • 33846083468 scopus 로고    scopus 로고
    • Is leptin an important physiological regulator of CRP?
    • Farooqi I.S., and O'Rahilly S. Is leptin an important physiological regulator of CRP?. Nat Med 13 (2007) 16-17
    • (2007) Nat Med , vol.13 , pp. 16-17
    • Farooqi, I.S.1    O'Rahilly, S.2
  • 59
    • 33846107585 scopus 로고    scopus 로고
    • Is leptin an important physiological regulator of CRP?
    • Gertler A., Niv-Spector L., and Reicher S. Is leptin an important physiological regulator of CRP?. Nat Med 13 (2007) 18-19
    • (2007) Nat Med , vol.13 , pp. 18-19
    • Gertler, A.1    Niv-Spector, L.2    Reicher, S.3
  • 60
    • 0033575993 scopus 로고    scopus 로고
    • Effects of recombinant leptin therapy in a child with congenital leptin deficiency
    • Farooqi I.S., Jebb S.A., Langmack G., et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 341 (1999) 879-884
    • (1999) N Engl J Med , vol.341 , pp. 879-884
    • Farooqi, I.S.1    Jebb, S.A.2    Langmack, G.3
  • 61
    • 33748970803 scopus 로고    scopus 로고
    • Leptin and atherosclerosis
    • Beltowski J. Leptin and atherosclerosis. Atherosclerosis 189 (2006) 47-60
    • (2006) Atherosclerosis , vol.189 , pp. 47-60
    • Beltowski, J.1
  • 62
    • 0017737576 scopus 로고
    • Dissociation of obesity, hypercholesterolemia and diabetes from atherosclerosis in ob/ob mice
    • Yen T.T., Allan J.A., Pearson D.V., and Schinitsky M.R. Dissociation of obesity, hypercholesterolemia and diabetes from atherosclerosis in ob/ob mice. Experientia 33 (1977) 995-996
    • (1977) Experientia , vol.33 , pp. 995-996
    • Yen, T.T.1    Allan, J.A.2    Pearson, D.V.3    Schinitsky, M.R.4
  • 63
    • 0034136240 scopus 로고    scopus 로고
    • Expression of leptin receptor (Ob-R) in human atherosclerotic lesions: potential role in intimal neovascularization
    • Kang S.M., Kwon H.M., Hong B.K., et al. Expression of leptin receptor (Ob-R) in human atherosclerotic lesions: potential role in intimal neovascularization. Yonsei Med J 41 (2000) 68-75
    • (2000) Yonsei Med J , vol.41 , pp. 68-75
    • Kang, S.M.1    Kwon, H.M.2    Hong, B.K.3
  • 64
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • Farooqi I.S., Matarese G., Lord G.M., et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110 (2002) 1093-1103
    • (2002) J Clin Invest , vol.110 , pp. 1093-1103
    • Farooqi, I.S.1    Matarese, G.2    Lord, G.M.3
  • 65
    • 0029863684 scopus 로고    scopus 로고
    • Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters
    • Grunfeld C., Zhao C., Fuller J., et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest 97 (1996) 2152-2157
    • (1996) J Clin Invest , vol.97 , pp. 2152-2157
    • Grunfeld, C.1    Zhao, C.2    Fuller, J.3
  • 66
    • 0037469232 scopus 로고    scopus 로고
    • Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association
    • Pearson T.A., Mensah G.A., Alexander R.W., et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107 (2003) 499-511
    • (2003) Circulation , vol.107 , pp. 499-511
    • Pearson, T.A.1    Mensah, G.A.2    Alexander, R.W.3
  • 68
    • 0031769566 scopus 로고    scopus 로고
    • Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion
    • Bornstein S.R., Licinio J., Tauchnitz R., et al. Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion. J Clin Endocrinol Metab 83 (1998) 280-283
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 280-283
    • Bornstein, S.R.1    Licinio, J.2    Tauchnitz, R.3
  • 69
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • Lord G.M., Matarese G., Howard J.K., Baker R.J., Bloom S.R., and Lechler R.I. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394 (1998) 897-901
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3    Baker, R.J.4    Bloom, S.R.5    Lechler, R.I.6
  • 70
    • 0035816639 scopus 로고    scopus 로고
    • Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A
    • Yamagishi S.I., Edelstein D., Du X.L., Kaneda Y., Guzman M., and Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 276 (2001) 25096-25100
    • (2001) J Biol Chem , vol.276 , pp. 25096-25100
    • Yamagishi, S.I.1    Edelstein, D.2    Du, X.L.3    Kaneda, Y.4    Guzman, M.5    Brownlee, M.6
  • 71
    • 0037044831 scopus 로고    scopus 로고
    • Glucose-dependent regulation of cholesterol ester metabolism in macrophages by insulin and leptin
    • O'Rourke L., Gronning L.M., Yeaman S.J., and Shepherd P.R. Glucose-dependent regulation of cholesterol ester metabolism in macrophages by insulin and leptin. J Biol Chem 277 (2002) 42557-42562
    • (2002) J Biol Chem , vol.277 , pp. 42557-42562
    • O'Rourke, L.1    Gronning, L.M.2    Yeaman, S.J.3    Shepherd, P.R.4
  • 72
    • 0034681920 scopus 로고    scopus 로고
    • Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    • Ridker P.M., Rifai N., Stampfer M.J., and Hennekens C.H. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101 (2000) 1767-1772
    • (2000) Circulation , vol.101 , pp. 1767-1772
    • Ridker, P.M.1    Rifai, N.2    Stampfer, M.J.3    Hennekens, C.H.4
  • 73
    • 0034625079 scopus 로고    scopus 로고
    • Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction
    • Ridker P.M., Rifai N., Pfeffer M., Sacks F., Lepage S., and Braunwald E. Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation 101 (2000) 2149-2153
    • (2000) Circulation , vol.101 , pp. 2149-2153
    • Ridker, P.M.1    Rifai, N.2    Pfeffer, M.3    Sacks, F.4    Lepage, S.5    Braunwald, E.6
  • 74
    • 34047183090 scopus 로고    scopus 로고
    • Plasma cytokines, metabolic syndrome, and atherosclerosis in humans
    • Reilly M.P., Rohatgi A., McMahon K., et al. Plasma cytokines, metabolic syndrome, and atherosclerosis in humans. J Invest Med 55 (2007) 26-35
    • (2007) J Invest Med , vol.55 , pp. 26-35
    • Reilly, M.P.1    Rohatgi, A.2    McMahon, K.3
  • 75
    • 10344231441 scopus 로고    scopus 로고
    • Inflammatory markers and the risk of coronary heart disease in men and women
    • Pai J.K., Pischon T., Ma J., et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 351 (2004) 2599-2610
    • (2004) N Engl J Med , vol.351 , pp. 2599-2610
    • Pai, J.K.1    Pischon, T.2    Ma, J.3
  • 77
    • 0142087611 scopus 로고    scopus 로고
    • Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells
    • Calabro P., Willerson J.T., and Yeh E.T. Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation 108 (2003) 1930-1932
    • (2003) Circulation , vol.108 , pp. 1930-1932
    • Calabro, P.1    Willerson, J.T.2    Yeh, E.T.3
  • 78
    • 46249084673 scopus 로고    scopus 로고
    • Adipokines, insulin resistance and coronary artery calcification
    • Qasim A., Mehta N., Tadesse M.G., et al. Adipokines, insulin resistance and coronary artery calcification. J Am Coll Cardiol 52 (2008) 231-236
    • (2008) J Am Coll Cardiol , vol.52 , pp. 231-236
    • Qasim, A.1    Mehta, N.2    Tadesse, M.G.3
  • 79
    • 0034956457 scopus 로고    scopus 로고
    • Plasma leptin is independently associated with the intima-media thickness of the common carotid artery
    • Ciccone M., Vettor R., Pannacciulli N., et al. Plasma leptin is independently associated with the intima-media thickness of the common carotid artery. Int J Obes Relat Metab Disord 25 (2001) 805-810
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. 805-810
    • Ciccone, M.1    Vettor, R.2    Pannacciulli, N.3
  • 82
    • 0242610329 scopus 로고    scopus 로고
    • Determination of endothelial function and early atherosclerotic changes in healthy obese women
    • Oflaz H., Ozbey N., Mantar F., et al. Determination of endothelial function and early atherosclerotic changes in healthy obese women. Diabetes Nutr Metab 16 (2003) 176-181
    • (2003) Diabetes Nutr Metab , vol.16 , pp. 176-181
    • Oflaz, H.1    Ozbey, N.2    Mantar, F.3
  • 83
    • 0344959452 scopus 로고    scopus 로고
    • Leptin is a risk marker for first-ever hemorrhagic stroke in a population-based cohort
    • Soderberg S., Ahren B., Stegmayr B., et al. Leptin is a risk marker for first-ever hemorrhagic stroke in a population-based cohort. Stroke 30 (1999) 328-337
    • (1999) Stroke , vol.30 , pp. 328-337
    • Soderberg, S.1    Ahren, B.2    Stegmayr, B.3
  • 84
    • 3242884800 scopus 로고    scopus 로고
    • Leptin, but not adiponectin, predicts stroke in males
    • Soderberg S., Stegmayr B., Stenlund H., et al. Leptin, but not adiponectin, predicts stroke in males. J Intern Med 256 (2004) 128-136
    • (2004) J Intern Med , vol.256 , pp. 128-136
    • Soderberg, S.1    Stegmayr, B.2    Stenlund, H.3
  • 85
    • 0242381316 scopus 로고    scopus 로고
    • Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting
    • Piatti P., Di Mario C., Monti L.D., et al. Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting. Circulation 108 (2003) 2074-2081
    • (2003) Circulation , vol.108 , pp. 2074-2081
    • Piatti, P.1    Di Mario, C.2    Monti, L.D.3
  • 86
    • 0031735742 scopus 로고    scopus 로고
    • Leptinemia is not a risk factor for ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study
    • Couillard C., Lamarche B., Mauriege P., et al. Leptinemia is not a risk factor for ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Diabetes Care 21 (1998) 782-786
    • (1998) Diabetes Care , vol.21 , pp. 782-786
    • Couillard, C.1    Lamarche, B.2    Mauriege, P.3
  • 87
    • 10744232583 scopus 로고    scopus 로고
    • Fasting plasma leptin, tumor necrosis factor-alpha receptor 2, and monocyte chemoattracting protein 1 concentration in a population of glucose-tolerant and glucose-intolerant women: impact on cardiovascular mortality
    • Piemonti L., Calori G., Mercalli A., et al. Fasting plasma leptin, tumor necrosis factor-alpha receptor 2, and monocyte chemoattracting protein 1 concentration in a population of glucose-tolerant and glucose-intolerant women: impact on cardiovascular mortality. Diabetes Care 26 (2003) 2883-2889
    • (2003) Diabetes Care , vol.26 , pp. 2883-2889
    • Piemonti, L.1    Calori, G.2    Mercalli, A.3
  • 88
    • 0033304576 scopus 로고    scopus 로고
    • Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
    • Ozata M., Ozdemir I.C., and Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 84 (1999) 3686-3695
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3686-3695
    • Ozata, M.1    Ozdemir, I.C.2    Licinio, J.3
  • 89
    • 33644840217 scopus 로고    scopus 로고
    • Rethinking leptin and insulin action: therapeutic opportunities for diabetes
    • Yildiz B.O., and Haznedaroglu I.C. Rethinking leptin and insulin action: therapeutic opportunities for diabetes. Int J Biochem Cell Biol 38 (2006) 820-830
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 820-830
    • Yildiz, B.O.1    Haznedaroglu, I.C.2
  • 91
    • 0029819643 scopus 로고    scopus 로고
    • Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss
    • Havel P.J., Kasim-Karakas S., Mueller W., Johnson P.R., Gingerich R.L., and Stern J.S. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab 81 (1996) 4406-4413
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 4406-4413
    • Havel, P.J.1    Kasim-Karakas, S.2    Mueller, W.3    Johnson, P.R.4    Gingerich, R.L.5    Stern, J.S.6
  • 92
    • 0030883332 scopus 로고    scopus 로고
    • Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects
    • Boden G., Chen X., Kolaczynski J.W., and Polansky M. Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J Clin Invest 100 (1997) 1107-1113
    • (1997) J Clin Invest , vol.100 , pp. 1107-1113
    • Boden, G.1    Chen, X.2    Kolaczynski, J.W.3    Polansky, M.4
  • 94
    • 0034750119 scopus 로고    scopus 로고
    • Plasma leptin concentrations during extended fasting and graded glucose infusions: relationships with changes in glucose, insulin, and FFA
    • Sonnenberg G.E., Krakower G.R., Hoffmann R.G., Maas D.L., Hennes M.M., and Kissebah A.H. Plasma leptin concentrations during extended fasting and graded glucose infusions: relationships with changes in glucose, insulin, and FFA. J Clin Endocrinol Metab 86 (2001) 4895-4900
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4895-4900
    • Sonnenberg, G.E.1    Krakower, G.R.2    Hoffmann, R.G.3    Maas, D.L.4    Hennes, M.M.5    Kissebah, A.H.6
  • 95
    • 0031665979 scopus 로고    scopus 로고
    • Increased OB gene expression leads to elevated plasma leptin concentrations in patients with chronic primary hyperinsulinemia
    • D'Adamo M., Buongiorno A., Maroccia E., et al. Increased OB gene expression leads to elevated plasma leptin concentrations in patients with chronic primary hyperinsulinemia. Diabetes 47 (1998) 1625-1629
    • (1998) Diabetes , vol.47 , pp. 1625-1629
    • D'Adamo, M.1    Buongiorno, A.2    Maroccia, E.3
  • 96
    • 0033044994 scopus 로고    scopus 로고
    • Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus
    • Seufert J., Kieffer T.J., Leech C.A., et al. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab 84 (1999) 670-676
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 670-676
    • Seufert, J.1    Kieffer, T.J.2    Leech, C.A.3
  • 97
    • 0030847432 scopus 로고    scopus 로고
    • Acute stimulation of glucose metabolism in mice by leptin treatment
    • Kamohara S., Burcelin R., Halaas J.L., Friedman J.M., and Charron M.J. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389 (1997) 374-377
    • (1997) Nature , vol.389 , pp. 374-377
    • Kamohara, S.1    Burcelin, R.2    Halaas, J.L.3    Friedman, J.M.4    Charron, M.J.5
  • 98
    • 0033306791 scopus 로고    scopus 로고
    • Differential effects of leptin in regulation of tissue glucose utilization in vivo
    • Wang J.L., Chinookoswong N., Scully S., Qi M., and Shi Z.Q. Differential effects of leptin in regulation of tissue glucose utilization in vivo. Endocrinology 140 (1999) 2117-2124
    • (1999) Endocrinology , vol.140 , pp. 2117-2124
    • Wang, J.L.1    Chinookoswong, N.2    Scully, S.3    Qi, M.4    Shi, Z.Q.5
  • 99
    • 0030784253 scopus 로고    scopus 로고
    • Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action
    • Rossetti L., Massillon D., Barzilai N., et al. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem 272 (1997) 27758-27763
    • (1997) J Biol Chem , vol.272 , pp. 27758-27763
    • Rossetti, L.1    Massillon, D.2    Barzilai, N.3
  • 100
    • 0035937174 scopus 로고    scopus 로고
    • Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia
    • Lee Y., Wang M.Y., Kakuma T., et al. Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J Biol Chem 276 (2001) 5629-5635
    • (2001) J Biol Chem , vol.276 , pp. 5629-5635
    • Lee, Y.1    Wang, M.Y.2    Kakuma, T.3
  • 101
    • 12144289998 scopus 로고    scopus 로고
    • Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    • Licinio J., Caglayan S., Ozata M., et al. Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci U S A 101 (2004) 4531-4536
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4531-4536
    • Licinio, J.1    Caglayan, S.2    Ozata, M.3
  • 102
    • 0037148928 scopus 로고    scopus 로고
    • Leptin-replacement therapy for lipodystrophy
    • Oral E.A., Simha V., Ruiz E., et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med 346 (2002) 570-578
    • (2002) N Engl J Med , vol.346 , pp. 570-578
    • Oral, E.A.1    Simha, V.2    Ruiz, E.3
  • 103
    • 34548639473 scopus 로고    scopus 로고
    • Obesity-induced inflammation: a metabolic dialogue in the language of inflammation
    • Ferrante Jr. A.W. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med 262 (2007) 408-414
    • (2007) J Intern Med , vol.262 , pp. 408-414
    • Ferrante Jr., A.W.1
  • 104
    • 34548033748 scopus 로고    scopus 로고
    • A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women
    • Liu S., Tinker L., Song Y., et al. A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Arch Intern Med 167 (2007) 1676-1685
    • (2007) Arch Intern Med , vol.167 , pp. 1676-1685
    • Liu, S.1    Tinker, L.2    Song, Y.3
  • 105
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan A.D., Manson J.E., Rifai N., Buring J.E., and Ridker P.M. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286 (2001) 327-334
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4    Ridker, P.M.5
  • 106
    • 0036833814 scopus 로고    scopus 로고
    • Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study
    • Han T.S., Sattar N., Williams K., Gonzalez-Villalpando C., Lean M.E., and Haffner S.M. Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study. Diabetes Care 25 (2002) 2016-2021
    • (2002) Diabetes Care , vol.25 , pp. 2016-2021
    • Han, T.S.1    Sattar, N.2    Williams, K.3    Gonzalez-Villalpando, C.4    Lean, M.E.5    Haffner, S.M.6
  • 107
    • 0031714508 scopus 로고    scopus 로고
    • Relationship between angiotensinogen, leptin and blood pressure levels in young normotensive men
    • Schorr U., Blaschke K., Turan S., Distler A., and Sharma A.M. Relationship between angiotensinogen, leptin and blood pressure levels in young normotensive men. J Hypertens 16 (1998) 1475-1480
    • (1998) J Hypertens , vol.16 , pp. 1475-1480
    • Schorr, U.1    Blaschke, K.2    Turan, S.3    Distler, A.4    Sharma, A.M.5
  • 108
    • 0032421732 scopus 로고    scopus 로고
    • The obese gene product, leptin: possible role in obesity-related hypertension in adolescents
    • Hirose H., Saito I., Tsujioka M., Mori M., Kawabe H., and Saruta T. The obese gene product, leptin: possible role in obesity-related hypertension in adolescents. J Hypertens 16 (1998) 2007-2012
    • (1998) J Hypertens , vol.16 , pp. 2007-2012
    • Hirose, H.1    Saito, I.2    Tsujioka, M.3    Mori, M.4    Kawabe, H.5    Saruta, T.6
  • 109
    • 0030699352 scopus 로고    scopus 로고
    • High plasma immunoreactive leptin level in essential hypertension
    • Agata J., Masuda A., Takada M., et al. High plasma immunoreactive leptin level in essential hypertension. Am J Hypertens 10 (1997) 1171-1174
    • (1997) Am J Hypertens , vol.10 , pp. 1171-1174
    • Agata, J.1    Masuda, A.2    Takada, M.3
  • 110
    • 0037735382 scopus 로고    scopus 로고
    • Plasma leptin and blood pressure in men: graded association independent of body mass and fat pattern
    • Barba G., Russo O., Siani A., et al. Plasma leptin and blood pressure in men: graded association independent of body mass and fat pattern. Obes Res 11 (2003) 160-166
    • (2003) Obes Res , vol.11 , pp. 160-166
    • Barba, G.1    Russo, O.2    Siani, A.3
  • 111
    • 0036867369 scopus 로고    scopus 로고
    • Relationship between changes in serum leptin levels and blood pressure after weight loss
    • Itoh K., Imai K., Masuda T., et al. Relationship between changes in serum leptin levels and blood pressure after weight loss. Hypertens Res 25 (2002) 881-886
    • (2002) Hypertens Res , vol.25 , pp. 881-886
    • Itoh, K.1    Imai, K.2    Masuda, T.3
  • 112
    • 26044452059 scopus 로고    scopus 로고
    • Role of leptin in obesity-related hypertension
    • Haynes W.G. Role of leptin in obesity-related hypertension. Exp Physiol 90 (2005) 683-688
    • (2005) Exp Physiol , vol.90 , pp. 683-688
    • Haynes, W.G.1
  • 113
    • 4644340686 scopus 로고    scopus 로고
    • Obesity-related hypertension: is there a role for selective leptin resistance?
    • Correia M.L., and Haynes W.G. Obesity-related hypertension: is there a role for selective leptin resistance?. Curr Hypertens Rep 6 (2004) 230-235
    • (2004) Curr Hypertens Rep , vol.6 , pp. 230-235
    • Correia, M.L.1    Haynes, W.G.2
  • 114
    • 33646360219 scopus 로고    scopus 로고
    • Role of leptin in blood pressure regulation and arterial hypertension
    • Beltowski J. Role of leptin in blood pressure regulation and arterial hypertension. J Hypertens 24 (2006) 789-801
    • (2006) J Hypertens , vol.24 , pp. 789-801
    • Beltowski, J.1
  • 116
    • 0036628739 scopus 로고    scopus 로고
    • Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications
    • Mark A.L., Correia M.L., Rahmouni K., and Haynes W.G. Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. J Hypertens 20 (2002) 1245-1250
    • (2002) J Hypertens , vol.20 , pp. 1245-1250
    • Mark, A.L.1    Correia, M.L.2    Rahmouni, K.3    Haynes, W.G.4
  • 117
    • 0036066483 scopus 로고    scopus 로고
    • The concept of selective leptin resistance: evidence from agouti yellow obese mice
    • Correia M.L., Haynes W.G., Rahmouni K., Morgan D.A., Sivitz W.I., and Mark A.L. The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes 51 (2002) 439-442
    • (2002) Diabetes , vol.51 , pp. 439-442
    • Correia, M.L.1    Haynes, W.G.2    Rahmouni, K.3    Morgan, D.A.4    Sivitz, W.I.5    Mark, A.L.6
  • 118
    • 21344432100 scopus 로고    scopus 로고
    • Role of selective leptin resistance in diet-induced obesity hypertension
    • Rahmouni K., Morgan D.A., Morgan G.M., Mark A.L., and Haynes W.G. Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes 54 (2005) 2012-2018
    • (2005) Diabetes , vol.54 , pp. 2012-2018
    • Rahmouni, K.1    Morgan, D.A.2    Morgan, G.M.3    Mark, A.L.4    Haynes, W.G.5
  • 119
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • Munzberg H., Flier J.S., and Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145 (2004) 4880-4889
    • (2004) Endocrinology , vol.145 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 120
    • 0037012483 scopus 로고    scopus 로고
    • Effect of leptin on arterial thrombosis following vascular injury in mice
    • Bodary P.F., Westrick R.J., Wickenheiser K.J., Shen Y., and Eitzman D.T. Effect of leptin on arterial thrombosis following vascular injury in mice. JAMA 287 (2002) 1706-1709
    • (2002) JAMA , vol.287 , pp. 1706-1709
    • Bodary, P.F.1    Westrick, R.J.2    Wickenheiser, K.J.3    Shen, Y.4    Eitzman, D.T.5
  • 121
    • 0035179087 scopus 로고    scopus 로고
    • Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity
    • Konstantinides S., Schafer K., Koschnick S., and Loskutoff D.J. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 108 (2001) 1533-1540
    • (2001) J Clin Invest , vol.108 , pp. 1533-1540
    • Konstantinides, S.1    Schafer, K.2    Koschnick, S.3    Loskutoff, D.J.4
  • 122
    • 0032971218 scopus 로고    scopus 로고
    • Leptin promotes aggregation of human platelets via the long form of its receptor
    • Nakata M., Yada T., Soejima N., and Maruyama I. Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes 48 (1999) 426-429
    • (1999) Diabetes , vol.48 , pp. 426-429
    • Nakata, M.1    Yada, T.2    Soejima, N.3    Maruyama, I.4
  • 123
    • 12144291060 scopus 로고    scopus 로고
    • Interactions between fibrinolysis, lipoproteins and leptin related to a first myocardial infarction
    • Thogersen A.M., Soderberg S., Jansson J.H., et al. Interactions between fibrinolysis, lipoproteins and leptin related to a first myocardial infarction. Eur J Cardiovasc Prev Rehabil 11 (2004) 33-40
    • (2004) Eur J Cardiovasc Prev Rehabil , vol.11 , pp. 33-40
    • Thogersen, A.M.1    Soderberg, S.2    Jansson, J.H.3
  • 124
    • 0032816875 scopus 로고    scopus 로고
    • Plasma plasminogen activator inhibitor-I is associated with plasma leptin irrespective of body mass index, body fat mass, and plasma insulin and metabolic parameters in premenopausal women
    • De Mitrio V., De Pergola G., Vettor R., et al. Plasma plasminogen activator inhibitor-I is associated with plasma leptin irrespective of body mass index, body fat mass, and plasma insulin and metabolic parameters in premenopausal women. Metabolism 48 (1999) 960-964
    • (1999) Metabolism , vol.48 , pp. 960-964
    • De Mitrio, V.1    De Pergola, G.2    Vettor, R.3
  • 125
    • 0032930738 scopus 로고    scopus 로고
    • Plasma leptin levels are associated with abnormal fibrinolysis in men and postmenopausal women
    • Soderberg S., Olsson T., Eliasson M., Johnson O., and Ahren B. Plasma leptin levels are associated with abnormal fibrinolysis in men and postmenopausal women. J Intern Med 245 (1999) 533-543
    • (1999) J Intern Med , vol.245 , pp. 533-543
    • Soderberg, S.1    Olsson, T.2    Eliasson, M.3    Johnson, O.4    Ahren, B.5
  • 126
    • 0034907012 scopus 로고    scopus 로고
    • Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men
    • Chu N.F., Spiegelman D., Hotamisligil G.S., Rifai N., Stampfer M., and Rimm E.B. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis 157 (2001) 495-503
    • (2001) Atherosclerosis , vol.157 , pp. 495-503
    • Chu, N.F.1    Spiegelman, D.2    Hotamisligil, G.S.3    Rifai, N.4    Stampfer, M.5    Rimm, E.B.6
  • 127
    • 4444253877 scopus 로고    scopus 로고
    • Leptin increase is associated with markers of the hemostatic system in obese healthy women
    • Guagnano M.T., Romano M., Falco A., et al. Leptin increase is associated with markers of the hemostatic system in obese healthy women. J Thromb Haemost 1 (2003) 2330-2334
    • (2003) J Thromb Haemost , vol.1 , pp. 2330-2334
    • Guagnano, M.T.1    Romano, M.2    Falco, A.3
  • 128
    • 0036875194 scopus 로고    scopus 로고
    • Relationship between IL-6, leptin and adiponectin and variables of fibrinolysis in overweight and obese hypertensive patients
    • Skurk T., van Harmelen V., Lee Y.M., Wirth A., and Hauner H. Relationship between IL-6, leptin and adiponectin and variables of fibrinolysis in overweight and obese hypertensive patients. Horm Metab Res 34 (2002) 659-663
    • (2002) Horm Metab Res , vol.34 , pp. 659-663
    • Skurk, T.1    van Harmelen, V.2    Lee, Y.M.3    Wirth, A.4    Hauner, H.5
  • 129
    • 0036420550 scopus 로고    scopus 로고
    • Leptin correlates with some hemostatic parameters in CAPD patients
    • Malyszko J., Wolczynski S., Malyszko J., and Mysliwiec M. Leptin correlates with some hemostatic parameters in CAPD patients. Nephron 92 (2002) 721-724
    • (2002) Nephron , vol.92 , pp. 721-724
    • Malyszko, J.1    Wolczynski, S.2    Malyszko, J.3    Mysliwiec, M.4
  • 130
    • 34748877708 scopus 로고    scopus 로고
    • Leptin signaling and obesity: cardiovascular consequences
    • Yang R., and Barouch L.A. Leptin signaling and obesity: cardiovascular consequences. Circ Res 101 (2007) 545-559
    • (2007) Circ Res , vol.101 , pp. 545-559
    • Yang, R.1    Barouch, L.A.2
  • 131
    • 0032707747 scopus 로고    scopus 로고
    • Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin-resistant men
    • Paolisso G., Tagliamonte M.R., Galderisi M., et al. Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin-resistant men. Hypertension 34 (1999) 1047-1052
    • (1999) Hypertension , vol.34 , pp. 1047-1052
    • Paolisso, G.1    Tagliamonte, M.R.2    Galderisi, M.3
  • 133
    • 34547700630 scopus 로고    scopus 로고
    • Leptin and high-sensitivity C-reactive protein and their interaction in the metabolic syndrome in middle-aged subjects
    • Ukkola O., and Kesaniemi Y.A. Leptin and high-sensitivity C-reactive protein and their interaction in the metabolic syndrome in middle-aged subjects. Metabolism 56 (2007) 1221-1227
    • (2007) Metabolism , vol.56 , pp. 1221-1227
    • Ukkola, O.1    Kesaniemi, Y.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.