Leptin mediates a proliferative response in human MCF7 breast cancer cells

Biochemical and Biophysical Research Communications

Volumn 293, Issue 1, 2002, Pages 622-628

  Dieudonne, Marie Noelle ^a   Machinal Quelin, Florence ^a   Serazin Leroy, Valérie ^a   Leneveu, Marie Christine ^a   Pecquery, René ^a   Giudicelli, Yves ^a  

^a CENTRE HOSPITALIER INTERCOMMUNAL   (France)

Author keywords

Leptin; Leptin receptors; MCF 7 proliferation; Signal transduction

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P42; PROTEIN P44; STAT3 PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER RISK; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HORMONE ACTION; HUMAN; HUMAN CELL; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACUTE-PHASE PROTEINS; ADIPOCYTES; BREAST NEOPLASMS; CELL DIVISION; DNA, NEOPLASM; DNA-BINDING PROTEINS; FEMALE; HUMANS; LEPTIN; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; OBESITY; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; STAT3 TRANSCRIPTION FACTOR; THYMIDINE; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0036289490     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00205-X     Document Type: Article

References (35)

1. Body fat distribution and breast cancer in the Framingham study
2. Obesity and body fat distribution and breast cancer prognosis
3. Adipose tissue as an endocrine organ
4. Leptin and the regulation of body weight in mammals
5. Clinical review 94: What's in a name? In search of leptin's physiologic role
6. Effects of gender, body composition, and menopause on plasma concentrations of leptin
7. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
8. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
9. Rat insulinoma-derived pancreatic beta-cells express a functional leptin receptor that mediates a proliferative response
10. Biological action of leptin as an angiogenic factor
11. Expression of leptin receptor in lung: Leptin as a growth factor
12. Leptin mediates a proliferative response in human gastric mucosa cells with functional receptor
13. A novel keratinocyte mitogen: Regulation of leptin and its functional receptor in skin repair
14. In vitro proadipogenic effect of leptin on rat preadipocytes: Activation of mitogen-activated protein kinase and of STAT3 signaling pathways
15. Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization
16. The leptin receptor
17. One-hour downward alkaline capillary transfer for blotting of DNA and RNA
18. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
19. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
20. Leptin signaling in the hypothalamus of normal rats in vivo
21. Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1/2 cells
22. Identification of a novel inhibitor of mitogen-activated protein kinase
23. Detection and regulation of leptin receptor mRNA in ovine mammary epithelial cells during pregnancy and lactation
24. Expression of functional leptin receptors in rodent Leydig cells
25. The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man
26. Leptin increases the viability of isolated rat pancreatic islets by suppressing apoptosis
27. Specific, nongenomic actions of steroid hormones
28. Rapid nongenomic E2 effects on p42/44 MAPK, AP-1, and cAMP response element binding protein in rat white adipocytes
29. Effects of estrogen on leptin gene promoter activation in MCF-7 breast cancer and JEG-3 choriocarcinoma cells: Selective regulation via estrogen receptors alpha and beta
30. Control of aromatase activity in breast tumours: The role of the immune system
31. Tumor necrosis factor-alpha stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4
32. Transcriptional regulation of CYP19 gene (aromatase) expression in adipose stromal cells in primary culture
33. Leptin directly stimulates aromatase activity in human luteinized granulosa cells
34. Leptin regulation of aromatase activity in adipose stromal cells from regularly cycling women
35. The direct proliferative stimulus of dehydroepiandrosterone on MCF7 breast cancer cells is potentiated by overexpression of aromatase