IL-1 family in breast cancer: Potential interplay with leptin and other adipocytokines

FEBS Letters

Volumn 583, Issue 2, 2009, Pages 259-265

  Perrier, Stéphane ^a   Caldefie Chézet, Florence ^b   Vasson, Marie Paule ^b,c  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

^c CENTRE JEAN PERRIN   (France)

Author keywords

Adipocytokine; Breast cancer; IL 1; Leptin; Obesity

Indexed keywords

ADIPOCYTOKINE; BASIC FIBROBLAST GROWTH FACTOR; ESTROGEN RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; LEPTIN RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 1; RESISTIN; TRANSCRIPTION FACTOR AP 1; VASCULOTROPIN;

ADIPOCYTE; ADIPOSE TISSUE; BREAST CANCER; CANCER GROWTH; CANCER RISK; CYTOKINE RELEASE; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HUMAN; MULTIGENE FAMILY; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROGNOSIS; SHORT SURVEY;

ADIPOKINES; BREAST NEOPLASMS; FEMALE; HUMANS; INTERLEUKIN-1; LEPTIN; OBESITY;

EID: 58249106120     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.12.030     Document Type: Short Survey

References (90)

1. Lorincz A.M., and Sukumar S. Molecular links between obesity and breast cancer. Endocr. Relat. Cancer 13 (2006) 279-292
2. Tilg H., and Moshen A.R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 6 (2006) 772-783
3. Rose D.P., Komninou D., and Stephenson G.D. Obesity, adipocytokines, and insulin resistance in breast cancer. Obes. Rev. 5 (2004) 153-165
4. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 115 (2005) 911-919
5. Dinarello C.A. Biologic basis for interleukin-1 in disease. Blood 87 (1996) 2095-2147
6. Köck A., Schwarz T., Urbanski A., Peng Z., Vetterlein M., Micksche M., Ansel J.C., Kung H.F., and Luger T.A. Expression and release of interleukin-1 by different human melanoma cell lines. J. Natl. Cancer Inst. 81 (1989) 36-42
7. Chen Z., Colon I., Ortiz N., Callister M., Dong G., Pegram M.Y., Arosarena O., Strome S., Nicholson J.C., and Van Waes C. Effects of interleukin-1alpha, interleukin-1 receptor antagonist, and neutralizing antibody on proinflammatory cytokine expression by human squamous cell carcinoma lines. Cancer Res. 58 (1998) 3668-3676
8. Gemma A., Takenaka K., Hosoya Y., Matuda K., Seike M., Kurimoto F., Ono Y., Uematsu K., Takeda Y., Hibino S., Yoshimura A., Shibuya M., and Kudoh S. Altered expression of several genes in highly metastatic subpopulations of a human pulmonary adenocarcinoma cell line. Eur. J. Cancer 37 (2001) 1554-1561
9. Elaraj D.M., Weinreich D.M., Varghese S., Puhlmann M., Hewitt S.M., Carroll N.M., Feldman E.D., Turner E.M., and Alexander H.R. The role of interleukin 1 in growth and metastasis of human cancer xenografts. Clin. Cancer Res. 12 (2006) 1088-1096
10. Singer C.F., Kronsteiner N., Hudelist G., Marton E., Walter I., Kubista M., Czerwenka K., Schreiber M., Seifert M., and Kubista E. Interleukin 1 system and sex steroid receptor expression in human breast cancer: interleukin 1alpha protein secretion is correlated with malignant phenotype. Clin. Cancer Res. 9 (2003) 4877-4883
11. Pantschenko A.G., Pushkar I., Anderson K.H., Wang Y., Miller L.J., Kurtzman S.H., Barrows G., and Kreutzer D.L. The interleukin-1 family of cytokines and receptors in human breast cancer: implications for tumor progression. Int. J. Oncol. 23 (2003) 269-284
12. Juge-Aubry C.E., Somm E., Giusti V., Pernin A., Chicheportiche R., Verdumo C., Rohner-Jeanrenaud F., Burger D., Dayer J.M., and Meier C.A. Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation. Diabetes 52 (2003) 1104-1110
13. Chavey C., Bibeau F., Gourgou-Bourgade S., Burlinchon S., Boissière F., Laune D., Roques S., and Lazennec G. Oestrogen receptor negative breast cancers exhibit high cytokine content. Breast Cancer Res. 9 (2007) R15
14. Lewis A.M., Varghese S., Xu H., and Alexander H.R. Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment. J. Trans. Med. 4 (2006) 48
15. Apte R.N., Krelin Y., Song X., Dotan S., Recih E., Elkabets M., Carmi Y., Dvorkin T., White R.M., Gayvoronsky L., Segal S., and Voronov E. Effects of micro-environment- and malignant cell-derived interleukin-1 in carcinogenesis, tumour invasiveness and tumour-host interactions. Eur. J. Cancer 42 (2006) 751-759
16. Faggioni R., Fantuzzi G., Fuller J., Dinarello C.A., Feingold K.R., and Grunfeld C. IL-1 beta mediates leptin induction during inflammation. Am. J. Physiol. 274 (1998) 204-208
17. O'brien S.N., Welter B.H., and Price T.M. Presence of leptin in breast cell lines and breast tumors. Biochem. Biophys. Res. Commun. 259 (1999) 695-698
18. Iguchi M., Aiba S., Yoshino Y., and Tagami H. Human follicular papilla cells carry out nonadipose tissue production of leptin. J. Invest. Dermatol. 117 (2001) 1349-1356
19. Kumar S., Kishimoto H., Chua H.L., Badve S., Miller K.D., Bigsby R.M., and Nakshatri H. Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancer. Am. J. Pathol. 163 (2003) 2531-2541
20. Ueland T., Kristo C., Godang K., Aukrust P., and Bollerslev J. Interleukin-1 receptor antagonist is associated with fat distribution in endogenous Cushing's syndrome: a longitudinal study. J. Clin. Endocrinol. Metab. 88 (2003) 1492-1496
21. Ljung L., Olsson T., Engstrand S., Wållberg-Jonsson S., Söderberg S., and Rantapää-Dahlqvist S. Interleukin-1 receptor antagonist is associated with both lipid metabolism and inflammation in rheumatoid arthritis. Clin. Exp. Rheumatol. 25 (2007) 617-620
22. Perrier S., Darakhshan F., and Hajduch E. IL-1 receptor antagonist in metabolic diseases: Dr. Jekyll or Mr. Hyde?. Febs Lett. 580 (2006) 6289-6294
23. Arend W.P. The balance between IL-1 and IL-1ra in disease. Cytokine Growth Factor Rev. 13 (2002) 323-340
24. Arend W.P., Malyak M., Guthridge C.J., and Gabay C. Interleukin-1 receptor antagonist: role in biology. Annu. Rev. Immunol. 16 (1998) 27-55
25. Vamvakopoulos J., Green C., and Metcalfe S. Genetic control of IL-1beta bioactivity through differential regulation of the IL-1 receptor antagonist. Eur. J. Immunol. 32 (2002) 2988-2996
26. Bower J.E., Ganz P.A., Aziz N., and Fahey J.L. Fatigue and proinflammatory cytokine activity in breast cancer survivors. Psychosom. Med. 64 (2002) 604-611
27. Dubost J.J., Perrier S., Afane M., Viallard J.L., Roux-Lombard P., Baudet-Pommel M., Begue C., Kemeny J.L., and Sauvezie B. IL-1 receptor antagonist in saliva; characterization in normal saliva and reduced concentration in Sjogren's syndrome (SS). Clin. Exp. Immunol. 106 (1996) 237-242
28. Waugh J., and Perry C.M. Anakinra: a review of its use in the management of rheumatoid arthritis. BioDrugs 19 (2005) 189-202
29. Larsen C.M., Faulenbach M., Vaag A., Vølund A., Ehses J.A., Seifert B., Mandrup-Poulsen T., and Donath M.Y. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med. 356 (2007) 1517-1526
30. Ricci S., Macchia G., Ruggiero P., Maggi T., Bossù P., Xu L., Medaglini D., Tagliabue A., Hammarström L., Pozzi G., and Boraschi D. In vivo mucosal delivery of bioactive human interleukin 1 receptor antagonist produced by Streptococcus gordonii. BMC Biotechnol. 3 (2003) 15
31. Lavi G., Voronov E., Dinarello C.A., Apte R.N., and Cohen S. Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases. J. Control Release 123 (2007) 123-130
32. Bar D., Apte R.N., Voronov E., Dinarello C.A., and Cohen S. A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development. FASEB J. 18 (2004) 161-163
33. Rambaldi A., Torcia M., Bettoni S., Vannier E., Barbui T., Shaw A.R., Dinarello C.A., and Cozzolino F. Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells. Blood 78 (1991) 3248-3253
34. Schirò R., Longoni D., Rossi V., Maglia O., Doni A., Arsura M., Carrara G., Masera G., Vannier E., Dinarello C.A., Rambaldi A., and Biondi A. Suppression of juvenile chronic myelogenous leukemia colony growth by interleukin-1 receptor antagonist. Blood 83 (1994) 460-465
35. Nicolini A., Carpi A., and Rossi G. Cytokines in breast cancer. Cytokine Growth Factor Rev. 17 (2006) 325-337
36. Liu L., and Gudas L.J. Retinoic acid induces expression of the interleukin-1beta gene in cultured normal human mammary epithelial cells and in human breast carcinoma lines. J. Cell Physiol. 193 (2002) 244-252
37. Jin L., Yuan R.Q., Fuchs A., Yao Y., Joseph A., Schwall R., Schnitt S.J., Guida A., Hastings H.M., Andres J., Turkel G., Polverini P.J., Goldberg I.D., and Rosen E.M. Expression of interleukin-1beta in human breast carcinoma. Cancer 80 (1997) 421-434
38. Kurtzman S.H., Anderson K.H., Wang Y., Miller L.J., Renna M., Stankus M., Lindquist R.R., Barrows G., and Kreutzer D.L. Cytokines in human breast cancer: IL-1alpha and IL-1beta expression. Oncol. Rep. 6 (1999) 65-70
39. Miller L.J., Kurtzman S.H., Anderson K., Wang Y., Stankus M., Renna M., Lindquist R., Barrows G., and Kreutzer D.L. Interleukin-1 family expression in human breast cancer: interleukin-1 receptor antagonist. Cancer Invest. 18 (2000) 293-302
40. Honma S., Shimodaira K., Shimizu Y., Tsuchiya N., Saito H., Yanaihara T., and Okai T. The influence of inflammatory cytokines on estrogen production and cell proliferation in human breast cancer cells. Endocr. J. 49 (2002) 371-377
41. Purohit A., Wang D.Y., Ghilchik M.W., and Reed M.J. Regulation of aromatase and sulphatase in breast tumour cells. J. Endocrinol. 150 (1996) S65-S71
42. Danforth Jr. D.N., and Sgagias M.K. Interleukin 1 alpha blocks estradiol-stimulated growth and down-regulates the estrogen receptor in MCF-7 breast cancer cells in vitro. Cancer Res. 51 (1991) 1488-1493
43. Singer C.F., Hudelist G., Gschwantler-Kaulich D., Fink-Retter A., Mueller R., Walter I., Czerwenka K., and Kubista E. Interleukin-1alpha protein secretion in breast cancer is associated with poor differentiation and estrogen receptor alpha negativity. Int. J. Gynecol. Cancer 16 Suppl. 2 (2006) 556-559
44. Fuksiewicz M., Kaminska J., Kotowicz B., Kowalska M., Rubach M., and Pienkowski T. Serum cytokine levels and the expression of estrogen and progesterone receptors in breast cancer patients. Clin. Chem. Lab. Med. 44 (2006) 1092-1097
45. Lee K.M., Park S.K., Hamajima N., Tajima K., Choi J.Y., Noh D.Y., Ahn S.H., Yoo K.Y., Hirvonen A., and Kang D. Genetic polymorphisms of interleukin-1 beta (IL-1B) and IL-1 receptor antagonist (IL-1RN) and breast cancer risk in Korean women. Breast Cancer Res. Treat. 96 (2006) 197-202
46. Perrier S., Coussediere C., Dubost J.J., Albuisson E., and Sauvezie B. IL-1 receptor antagonist (IL-1RA) gene polymorphism in Sjogren's syndrome and rheumatoid arthritis. Clin. Immunol. Immunopathol. 87 (1998) 309-313
47. Otero M., Lago R., Gomez R., Lago F., Gomez-Reino J.J., and Gualillo O. Leptin: a metabolic hormone that functions like a proinflammatory adipokine. Drug News Perspect. 19 (2006) 21-26
48. Dieudonne M.N., Machinal-Quelin F., Serazin-Leroy V., Leneveu M.C., Pecquery R., and Giudicelli Y. Leptin mediates a proliferative response in human MCF7 breast cancer cells. Biochem. Biophys. Res. Commun. 293 (2002) 622-628
49. Hu X., Juneja S.C., Maihle N.J., and Cleary M.P. Leptin - a growth factor in normal and malignant breast cells and for normal mammary gland development. J. Natl. Cancer Inst. 94 (2002) 1704-1711
50. Somasundar P., McFadden D.W., Hileman S.M., and Vona-Davis L. Leptin is a growth factor in cancer. J. Surg. Res. 116 (2004) 337-349
51. Chen C., Chang Y.C., Liu C.L., Chang K.J., and Guo I.C. Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1. Breast Cancer Res. Treat. 98 (2006) 121-132
52. Laud K., Gourdou I., Pessemesse L., Peyrat J.P., and Djiane J. Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line. Mol. Cell Endocrinol. 188 (2002) 219-226
53. Caldefie-Chézet F., Guerry M., de Latour M., Farges M.C., Penault-Llorca F., Guillot J., and Vasson M.P. Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line. Nutr. Clin. Metabol. 22 Suppl. 1 (2003) S42
54. Caldefie-Chézet F., Damez M., de Latour M., Konska G., Mishellani F., Fusillier C., Guerry M., Penault-Llorca F., Guillot J., and Vasson M.P. Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. Biochem. Biophys. Res. Commun. 334 (2005) 737-741
55. Jardé T., Caldefie-Chézet F., Damez M., Mishellany F., Penault-Llorca F., Guillot J., and Vasson M.P. Leptin and leptin receptor involvement in cancer development: a study on human primary breast carcinoma. Oncol. Rep. 19 (2008) 905-911
56. Ishikawa M., Kitayama J., and Nagawa H. Enhanced expression of leptin and leptin receptor (ObR) in human breast cancer. Clin. Cancer Res. 10 (2004) 4325-4331
57. Garofalo C., Koda M., Cascio S., Sulkowska M., Kanczuga-Koda L., Golaszewska J., Russo A., Sulkowski S., and Surmacz E. Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin. Cancer Res. 12 (2006) 1447-1453
58. Miyoshi Y., Funahashi T., Tanaka S., Taguchi T., Tamaki Y., Shimomura I., and Noguchi S. High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. Int. J. Cancer 118 (2006) 1414-1419
59. Catalano S., Marsico S., Giordano C., Mauro L., Rizza P., Panno M.L., and Andò S. Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line. J. Biol. Chem. 278 (2003) 28668-28676
60. Bamberger A.M., Methner C., Lisboa B.W., Städtler C., Schulte H.M., Löning T., and Milde-Langosch K. Expression pattern of the AP-1 family in breast cancer: association of fosB expression with a well-differentiated, receptor-positive tumor phenotype. Int. J. Cancer 84 (1999) 533-538
61. Magoffin D.A., Weitsman S.R., Aagarwal S.K., and Jakimiuk A.J. Leptin regulation of aromatase activity in adipose stromal cells from regularly cycling women. Ginekol. Pol. 70 (1999) 1-7
62. Matarese G., Moschos S., and Mantzoros C.S. Leptin in immunology. J. Immunol. 173 (2005) 3137-3142
63. Martín-Romero C., Santos-Alvarez J., Goberna R., and Sánchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol. 199 (2000) 15-24
64. Zhao Y., Sun R., You L., Gao C., and Tian Z. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem. Biophys. Res. Commun. 300 (2003) 247-252
65. Fujita Y., Murakami M., Ogawa Y., Masuzaki H., Tanaka M., Ozaki S., Nakao K., and Mimori T. Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin. Exp. Immunol. 128 (2002) 21-26
66. Caldefie-Chezet F., Poulin A., Tridon A., Sion B., and Vasson M.P. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?. J. Leukoc. Biol. 69 (2001) 414-418
67. Caldefie-Chezet F., Poulin A., and Vasson M.P. Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radic. Res. 37 (2003) 809-814
68. Johnston A., Arnadottir S., Gudjonsson J.E., Aphale A., Sigmarsdottir A.A., Gunnarsson S.I., Steinsson J.T., Elder J.T., and Valdimarsson H. Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation. Br. J. Dermatol. 159 (2008) 342-350
69. Reichlin S., Chen G., and Nicolson M. Blood to brain transfer of leptin in normal and interleukin-1beta-treated male rats. Endocrinology 141 (2000) 1951-1954
70. Maedler K., Sergeev P., Ehses J.A., Mathe Z., Bosco D., Berney T., Dayer J.M., Reinecke M., Halban P.A., and Donath M.Y. Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets. Proc. Natl. Acad. Sci. USA 101 (2004) 8138-8143
71. Gabay C., Dreyer M., Pellegrinelli N., Chicheportiche R., and Meier C.A. Leptin directly induces the secretion of interleukin 1 receptor antagonist in human monocytes. J. Clin. Endocrinol. Metab. 86 (2001) 783-791
72. Faggioni R., Fantuzzi G., Gabay C., Moser A., Dinarello C.A., Feingold K.R., and Grunfeld C. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am. J. Physiol. 276 (1999) 136-142
73. Dreyer M.G., Juge-Aubry C.E., Gabay C., Lang U., Rohner-Jeanrenaud F., Dayer J.M., and Meier C.A. Leptin activates the promoter of the interleukin-1 receptor antagonist through p42/44 mitogen-activated protein kinase and a composite nuclear factor kappa B/PU.1 binding site. Biochem. J. 370 (2003) 591-599
74. Simons P.J., van den Pangaart P.S., van Roomen C.P., Aerts J.M., and Boon L. Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: evidence that tumor necrosis factor-alpha- and interleukin-1beta-treated human preadipocytes are potent leptin producers. Cytokine 32 (2005) 94-103
75. Juge-Aubry C.E., and Meier C.A. Immunomodulatory actions of leptin. Mol. Cell. Endocrinol. 194 (2002) 1-7
76. Vona-Davis L., and Rose D.P. Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr. Relat. Cancer 14 (2007) 189-206
77. Jardé, T., Caldefie-Chézet, F., Damez, M., Mishellany, F., Buechler, C., Bernard-Gallon, D., Penault-Llorca, F., Guillot, J. and Vasson, M.P. (2008) Antagonistic proliferative activities of adiponectin and leptin in breast cancer: study on MCF7 cells. Proc. Nutr. Soc. 67(OCE), E184.
78. Jardé T., Caldefie-Chézet F., Damez M., Mishellany F., Perrone D., Penault-Llorca F., Guillot J., and Vasson M.P. Adiponectin and leptin expression in primary breast ductal cancer and in adjacent healthy epithelial and myoepithelial tissue. Histopathology 53 (2008) 484-487
79. Kang J.H., Lee Y.Y., Yu B.Y., Yang B.S., Cho K.H., Yoon D.K., and Roh Y.K. Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell. Arch. Pharm. Res. 28 (2005) 1263-1269
80. Dieudonne M.N., Bussiere M., Dos Santos E., Leneveu M.C., Giudicelli Y., and Pecquery R. Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochem. Biophys. Res. Commun. 345 (2006) 271-279
81. Hou, W.K., Xu, Y.X., Yu, T., Zhang, L., Zhang, W.W., Fu, C.L., Sun, Y., Wu, Q. and Chen, L. (2007) Adipocytokines and breast cancer risk. Chin. Med. J. (Engl.) 120, 1592-1596.
82. Wolf A.M., Wolf D., Rumpold H., Enrich B., and Tilg H. Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem. Biophys. Res. Commun. 323 (2004) 630-635
83. Miyoshi Y., Funahashi T., Kihara S., Taguchi T., Tamaki Y., Matsuzawa Y., and Noguchi S. Association of serum adiponectin levels with breast cancer risk. Clin. Cancer Res. 9 (2003) 5699-5704
84. Rafiq S., Stevens K., Hurst A.J., Murray A., Henley W., Weedon M.N., Bandinelli S., Corsi A.M., Guralnik J.M., Ferruci L., Melzer D., and Frayling T.M. Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun. 8 (2007) 344-351
85. Karaduman M., Bilici A., Ozet A., Sengul A., Musabak U., and Alomeroglu M. Tissue levels of adiponectin in breast cancer patients. Med. Oncol. 24 (2007) 361-366
86. Polyak K., and Hu M. Do myoepithelial cells hold the key for breast tumor progression?. J. Mammary Gland Biol. Neoplasia 10 (2005) 231-247
87. Stattin P., Söderberg S., Biessy C., Lenner P., Hallmans G., Kaaks R., and Olsson T. Plasma leptin and breast cancer risk: a prospective study in northern Sweden. Breast Cancer Res. Treat. 86 (2004) 191-196
88. Meier C.A., Bobbioni E., Gabay C., Assimacopoulos-Jeannet F., Golay A., and Dayer J.M. IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin?. J. Clin. Endocrinol. Metab. 87 (2002) 1184-1188
89. Juge-Aubry C.E., Somm E., Chicheportiche R., Burger D., Pernin A., Cuenod-Pittet B., Quinodoz P., Giusti V., Dayer J.M., and Meier C.A. Regulatory effects of interleukin (IL)-1, interferon-beta, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissue. J. Clin. Endocrinol. Metab. 89 (2004) 2652-2658
90. Perera C.N., Spalding H.S., Mohammed S.I., and Camarillo I.G. Identification of proteins secreted from leptin stimulated MCF-7 breast cancer cells: a dual proteomic approach. Exp. Biol. Med. 233 (2008) 708-720