Leptin and leptin receptor involvement in cancer development: A study on human primary breast carcinoma

Oncology Reports

Volumn 19, Issue 4, 2008, Pages 905-911

  Jardé, Thierry ^a,d   Caldefie Chézet, Florence ^a   Damez, Mireille ^a   Mishellany, Florence ^b   Penault Llorca, Frédérique ^b   Guillot, Jean ^a   Vasson, Marie Paule ^a,c  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b Laboratoire d'Anatomopathologie   (France)

^c CENTRE JEAN PERRIN   (France)

^d Lab de Biochimie/Biol Moleculaire   (France)

Author keywords

Breast; Breast cancer; Ductal carcinoma; Leptin; Leptin receptor; Lobular carcinoma; Oestrogen receptor; Prognostic; Tumour size

Indexed keywords

ESTROGEN RECEPTOR; KI 67 ANTIGEN; LEPTIN; LEPTIN RECEPTOR; PROGESTERONE RECEPTOR;

ADULT; AGED; ARTICLE; AUTOCRINE EFFECT; BREAST CANCER; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER GRADING; CANCER SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HISTOPATHOLOGY; HORMONE ACTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; BREAST TUMOR; CHEMISTRY; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY;

ADULT; AGED; BREAST NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LEPTIN; MIDDLE AGED; RECEPTORS, LEPTIN;

EID: 43849103666     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.19.4.905     Document Type: Article

References (63)

1. Allison DB, Fontaine KR, Manson JE, Stevens J and van Itallie TB: Annual deaths attributable to obesity in the United States. JAMA 282: 1530-1538, 1999.
2. Klein S, Wadden T and Sugerman HJ: AGA technical review on obesity. Gastroenterology 123: 882-932, 2002.
3. Chu SY, Lee NC, Wingo PA, Senie RT, Greenberg RS and Peterson HB: The relationship between body mass and breast cancer among women enrolled in the Cancer and Steroid Hormone Study. J Clin Epidemiol 44: 1197-1206, 1991.
4. Lahmann PH, Hoffmann K, Allen N, et al: Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC). Int J Cancer 111: 762-771, 2004.
5. Chlebowski RT, Aiello E and McTiernan A: Weight loss in breast cancer patient management. J Clin Oncol 20: 1128-1143, 2002.
6. Key TJ, Allen NE, Verkasalo PK and Banks E: Energy balance and cancer: the role of sex hormones. Proc Nutr Soc 60: 81-89, 2001.
7. Dizdar O and Alyamac E: Obesity: an endocrine tumor? Med Hypotheses 63: 790-792, 2004.
8. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L and Friedman J: Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.
9. Hoggard N, Haggarty P, Thomas L and Lea RG: Leptin expression in placental and fetal tissues: does leptin have a functional role? Biochem Soc Trans 29: 57-63, 2001.
10. Gainsford T, Willson TA, Metcalf D, et al: Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 93: 14564-14568, 1996.
11. Mounzih K, Lu R and Chehab FF: Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology 138: 1190-1193, 1997.
12. Caldefie-Chezet F, Poulin A and Vasson MP: Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radic Res 37: 809-814, 2003.
13. Caldefie-Chezet F, Poulin A, Farges MC, Walrand S and Vasson MP: Implication of leptin in the non-specific immune response of stressed rats. Eur J Clin Invest 36: 668-669, 2006.
14. Soyupek S, Armagan A, Serel TA, Hoscan MB, Perk H, Karaoz E and Candir O: Leptin expression in the testicular tissue of fertile and infertile men. Arch Androl 51: 239-246, 2005.
15. Loffler S, Aust G, Kohler U and Spanel-Borowski K: Evidence of leptin expression in normal and polycystic human ovaries. Mol Hum Reprod 7: 1143-1149, 2001.
16. Masuzaki H, Ogawa Y, Sagawa N, et al: Non-adipose tissue production of leptin: leptin as a novel placenta-derived hormones in humans. Nat Med 3: 1029-1033, 1997.
17. Morroni M, De Matteis R, Palumbo C, et al: In vivo leptin expression in cartilage and bone cells of growing rats and adult humans. J Anat 205: 291-296, 2004.
18. Solberg R, Aas V, Thoresen GH, Kase ET, Drevon CA, Rustan AC and Reseland JE: Leptin expression in human primary skeletal muscle cells is reduced during differentiation. J Cell Biochem 96: 89-96, 2005.
19. Mix H, Widjaja A, Jandl O, et al: Expression of leptin and leptin receptor isoforms in the human stomach. Gut 47: 481-486, 2000.
20. Somasundar P, McFadden DW, Hileman SM and Vona-Davis L: Leptin is a growth factor in cancer. J Surg Res 116: 337-349, 2004.
21. Tartaglia LA, Dembski M, Weng X, et al: Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271, 1995.
22. Caldefie-Chezet F, Poulin A, Tridon A, Sion B and Vasson MP: Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action? J Leukoc Biol 69: 414-418, 2001.
23. Ebenbichler CF, Kaser S, Laimer M, Wolf HJ, Patsch JR and Illsley NP: Polar expression and phosphorylation of human leptin receptor isoforms in paired, syncytial, microvillous and basal membranes from human term placenta. Placenta 23: 516-521, 2002.
24. Kitawaki J, Koshiba H, Ishihara H, Kusuki I, Tsukamoto K and Honjo H: Expression of leptin receptor in human endometrium and fluctuation during the menstrual cycle. J Clin Endocrinol Metab 85: 1946-1950, 2000.
25. Breidert M, Miehlke S, Glasow A, et al: Leptin and its receptor in normal human gastric mucosa and in Helicobacter pylori-associated gastritis. Scand J Gastroenterol 34: 954-961, 1999.
26. Tsuchiya T, Shimizu H, Horie T and Mori M: Expression of leptin receptor in lung: leptin as a growth factor. Eur J Pharmacol 365: 273-279, 1999.
27. Konopleva M, Mikhail A, Estrov Z, et al: Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 93: 1668-1676, 1999.
28. Knerr I, Schuster S, Nomikos P, et al: Gene expression of adrenomedullin, leptin, their receptors and neuropeptide Y in hormone-secreting and non-functioning pituitary adenomas, meningiomas and malignant intracranial tumours in humans. Neuropathol Appl Neurobiol 27: 215-222, 2001.
29. Shimon I, Yan X, Magoffin DA, Friedman TC and Melmed S: Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion. J Clin Endocrinol Metab 83: 4059-4064, 1998.
30. Wang XJ, Yuan SL, Lu Q, Lu YR, Zhang J, Liu Y and Wang WD: Potential involvement of leptin in carcinogenesis of hepatocellular carcinoma. World J Gastroenterol 10: 2478-2481, 2004.
31. Ishikawa M, Kitayama J and Nagawa H: Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 10: 4325-4331, 2004.
32. Garofalo C, Koda M, Cascio S, et al: Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 12: 1447-1453, 2006.
33. Bouloumie A, Drexler HC, Lafontan M and Busse R: Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 83: 1059-1066, 1998.
34. Rouet-Benzineb P, Aparicio T, Guilmeau S, Pouzet C, Descatoire V, Buyse M and Bado A: Leptin counteracts sodium butyrate-induced apoptosis in human colon cancer HT-29 cells via NF-kappaB signaling. J Biol Chem 279: 16495-16502, 2004.
35. Onuma M, Bub JD, Rummel TL and Iwamoto Y: Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase. J Biol Chem 278: 42660-42667, 2003.
36. Somasundar P, Riggs D, Jackson B, Vona-Davis L and McFadden DW: Leptin stimulates esophageal adenocarcinoma growth by non-apoptotic mechanisms. Am J Surg 186: 575-578, 2003.
37. Pai R, Lin C, Tran T and Tarnawski A: Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation. Biochem Biophys Res Commun 331: 984-992, 2005.
38. Dieudonne MN, Machinal-Quelin F, Serazin-Leroy V, Leneveu MC, Pecquery R and Giudicelli Y: Leptin mediates a proliferative response in human MCF7 breast cancer cells. Biochem Biophys Res Commun 293: 622-628, 2002.
39. Hu X, Juneja SC, Maihle NJ and Cleary MP: Leptin: a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst 94: 1704-1711, 2002.
40. Chen C, Chang YC, Liu CL, Chang KJ and Guo IC: Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1. Breast Cancer Res Treat 98: 121-132, 2006.
41. Caldefie-Chezet F, Damez M, De Latour M, et al: Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. Biochem Biophys Res Commun 334: 737-741, 2005.
42. Tessitore L, Vizio B, Jenkins O, et al: Leptin expression in colorectal and breast cancer patients. Int J Mol Med 5: 421-426, 2000.
43. Penault-Llorca F, Cayre A, Bouchet MF, et al: Induction chemotherapy for breast carcinoma: predictive markers and relation with outcome. Int J Oncol 22: 1319-1325, 2003.
44. Elston CW and Ellis IO: Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19: 403-410, 1991.
45. Chen DC, Chung YF, Yeh YT, et al: Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett 237: 109-114, 2005.
46. Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I and Noguchi S: High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptun levels. Int J Cancer 118: 1414-1419, 2006.
47. O'Brien SN, Welter BH and Price TM: Presence of leptin in breast cell lines and breast tumors. Biochem Biophys Res Commun 259: 695-698, 1999.
48. Onetti-Muda A, Crescenzi A, Pujia N, Faraggiana T and Marinozzi V: Demonstration of oestrogen and progesterone receptors in freeze-dried, paraffin-embedded sections of breast cancer. Histopathology 18: 511-516, 1991.
49. Cohen C, Unger ER, Sgoutas D, Bradley N and Chenggis M: Automated immunohistochemical estrogen receptor in fixed embedded breast carcinomas. Comparison with manual immunohistochemistry on frozen tissues. Am J Clin Pathol 92: 669-672, 1989.
50. Révillion F, Charlier M, Lhotellier V, et al: Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers. Clin Cancer Res 12: 2088-2094, 2006.
51. Yin N, Wang D, Zhang H, et al: Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res 64: 5870-5875, 2004.
52. Catalano S, Marsico S, Giordano C, Mauro L, Pizza P, Panno ML and Ando S: Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line. J Biol Chem 278: 28668-28676, 2003.
53. Magoffin DA, Weitsman SR, Aagarwal SK and Jakimiuk AJ: Leptin regulation of aromatase activity in adipose stromal cells from regularly cycling women. Ginekol Pol 70: 1-7, 1999.
54. Catalano S, Mauro L, Marsico S, et al: Leptin induces, via ERK1/ ERK2 signal, functional acfivation of estrogen receptor alpha in MCF-7 cells. J Biol Chem 279: 19908-19915, 2004.
55. Casabiell X, Pineiro V, Peino R, et al: Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women, but not in men. J Clin Endocrinol Metab 83: 2149-2155, 1998.
56. Machinal-Quelin F, Dieudonne MN, Pecquery R, Leneveu MC and Giudicelli Y: Direct in vitro effects of androgens and estrogens on oh gene expression and leptin secretion in human adipose tissue. Endocrine 18: 179-184, 2002.
57. Shimizu H, Shimomura Y, Nakanishi Y, Futawatari T, Ohtani K, Sato N and Mori M: Estrogen increases in vivo leptin production in rats and human subjects. J Endocrinol 154: 285-292, 1997.
58. Garofalo C, Sisci D and Surmacz E: Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells. Clin Cancer Res 10: 6466-6475, 2004.
59. Marttunen MB, Andersson S, Hietanen P, et al: Antiestrogenic tamoxifen and toremifene increase serum leptin levels in post-menopausal breast cancer patients. Maturitas 35: 175-179, 2000.
60. Ozet A, Arpaci F, Yilmaz MI, et al: Effects of tamoxifen on the serum leptin level in patients with breast cancer. Jpn J Clin Oncol 31: 424-427, 2001.
61. Cleary MP, Juneja SC, Phillips FC, Hu X, Grande JP and Maihle NJ: Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Exp Biol Med 229: 182-193, 2004.
62. Cleary MP, Phillips FC, Getzin SC, et al: Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors. Breast Cancer Res Treat 77: 205-215, 2003.
63. Gonzalez RR, Cherfils S, Escobar M, et al: Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J Biol Chem 281: 26320-26328, 2006.