Leptin-regulated gene expression in MCF-7 breast cancer cells: Mechanistic insights into leptin-regulated mammary tumor growth and progression

Journal of Endocrinology

Volumn 199, Issue 2, 2008, Pages 221-233

  Perera, Candida N ^a   Chin, Hwei G ^a   Duru, Nadire ^a   Camarillo, Ignacio G ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b Purdue University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD147 ANTIGEN; CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN G; CYCLINE; LEPTIN; PROTEIN BCL 2; PROTEIN P16; PROTEIN P21; PROTEIN P27; SURVIVIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VILLIN; VILLIN 2;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST TUMOR; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; NICK END LABELING; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; TUMOR GROWTH; UNINDEXED SEQUENCE; UPREGULATION;

APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU NICK-END LABELING; LEPTIN; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION;

EID: 56849130281     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0215     Document Type: Article

References (60)

1. Barnett JB 2003 The relationship between obesity and breast cancer risk and mortality. Nutrition Reviews 61 73-76.
2. Bay BH, Jin R, Huang J & Tan PH 2006 Metallothionein as a prognostic biomarker in breast cancer. Experimental Biology and Medicine 231 1516-1521.
3. Bose N & Masellis AM 2005 Secretory products of breast cancer cells upregulate hyaluronan production in a human osteoblast cell line. Clinical and Experimental Metastasis 22 629-642.
4. Buck MB & Knabbe C 2006 TGF-beta signaling in breast cancer. Annals of the New York Academy of Sciences 1089 119-126.
5. Calle EE & Kaaks R 2004 Overweight, obesity and cancer: epidemiological evidence and proposed mechanisums. Nature Reviews. Cancer 4 579-591.
6. Carmichael AR 2006 Obesity as a risk factor for development and poor prognosis of breast cancer. British Journal of Obstetrics and Gynaecology 113 1160-1166
7. Casrellucci M, De Matteis R, Meisser A, Cancello R, Monsurro V, Islami D, Sarzani R, Marzioni D, Cinti S & Bischof P 2000 Leptin modulates extracellular matrix molecules and metalloproteinases: possible implications for trophoblast invasion. Molecular Human Reproduction 10 951-958.
8. Catalano S, Marsico S, Giordano C, Mauro L, Rizza P, Panno ML & Ando S 2003 Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line. Journal of Biological Chemistry 278 28668-28676.
9. Catalano S, Mauro L, Marsico S, Giordano C, Rizza P, Rago V, Montanaro D, Maggiolini M, Panno ML & Ando S 2004 Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells. Journal of Bioligical Chemistry 279 19908-19915.
10. Chen Y, Dougherty ER & Bittner ML 1997 Ratio-based decisions and the quantitative analysis of cDNA microarray images. Journal of Biomedical Optics 2 364-374.
11. Cleary MP, Phillips FC, Getzin SC, Jacobson TL, Jacobson MK, Christensen TA, Juneja SC, Grande JP & Maihle NJ 2003 Genetically obese MMTV-TGF alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors. Breast Cancer Research and Treatment 77 205-215.
12. Cleary MP, Juneja SC, Phillips FC, Hu X, Grande JP & Maihle NJ 2004 Leptin receptor-deficient MMTV-TGF alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Experimental Biology and Medicine 229 182-193.
13. Dieudonne MN, Machinal-Quelin F, Serazin-Leroy V, Leneveu MC, Pecquery R & Giudicelli Y 2002 Leptin mediates a proliferative response in human MCF7 breast cancer cells. Biochemical and Biophysical Research Communications 293 622-628.
14. Eckhardt BL, Parker BS, van Larr RK, Restall CM, Natoli AL, Tavaria MD, Stanley KL, Sloan EK, Moseley JM & Anderson RL 2005 Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix. Molecular Cancer Research 3 1-13.
15. Elliott BE, Meens JA, SenGupta SK, Louvard D & Arpin M 2005 The membrane cyroskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Research 7 R365-R373.
16. Frommer KW, Reichenmiller K, Schutt BS, Hoeflich A, Ranke MB, Dodt G & Elmlinger MW 2006 IGF-independent effects of IGFBP-2 on the human breast cancer cell line Hs578T. Journal of Molecular Endocrinology 37 13-23.
17. Fruhbeck G 2006 Intracellular signalling pathways activated by leptin. Biochemical Journal 393 7-20.
18. Garofalo C & Surmacz E 2006 Leptin and cancer. Journal of Cellular Physiology 207 12-22.
19. Garofalo C, Koda M, Cascio S, Sulkowska M, Kanczuga-Koda L, Golaszewska J, Russo A, Sulkowski S & Surmacz E 2006 Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clinical Cancer Research 12 1447-1453.
20. Gonzalez RR, Cherfils S, Escobar M, Yon JH, Carino C, Styer AK, Sullivan BT, Sakamoto H, Olawaiye A & Serikawa T 2006 Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). Journal of Biological Chemistry 281 26320-26328.
21. Han DC, Isono M, Chen S, Casaretto A, Hong SW, Wolf G & Ziyadeh FN 2001 Leptin stimulates type I collagen production in db/db mesangial cells: glucose uptake and TGF-beta type II receptor expression. Kidney International 59 1315-1321
22. Hanahan D & Weinberg RA 2000 The hallmarks of cancer. Cell 100 57-70.
23. Hardee ME, Rabbam ZN, Arcasoy MO, Kirkpatrick JF, Vujaskovic Z, Dewhirst MW & Blackwell KL 2006 Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity. Molecular Cancer Therapeutics 5 356-561.
24. Hegyi K, Fulop K, Kovacs K, Toth S & Falus A 2004 Leptin-induced signal transduction pathways. Cell Biology International 28 159-169.
25. Henson MC & Castracane VD 2000 Leptin in pregnancy. Biology of Reproduction 63 1219-1228.
26. Hu X, Juneja SC, Maihle NJ & Cleary MP 2002 Leptin - a growth factor in normal and malignant breast cells and for normal mammary gland development. Journal of the National Cancer Institute 94 1704-1711.
27. Kaaks R 2001 Plasma insulin, IGF-I and breast cancer. Gynécologie, Obstétrique and Fertilité 29 185-191.
28. Kibbey MM, Jameson MJ, Eaton EM & Rosenzweig SA 2006 Insuhn-like growth factor binding protein-2: contributions of the C-terminal domain to insulin-like growth factor-1 binding. Molecular Pharmacology 69 833-845.
29. Kondo S, Shimo T, Nishida T, Yosimichi G, Eguchi T, Sugahara T & Takigawa M 2002 Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases. Carcinogenesis 23 769-776.
30. Laud K, Gourdou I, Belair L, Keisler DH & Djiane J 1999 Detection and regulation of leptin receptor mRNA in ovine mammary epithelial cells during pregnancy and lactation. FEBS Letters 463 194-198.
31. Le TT, Rehrer CW, Huff TB, Nichols MB, Camarillo IG & Cheng JX 2007 Nonlinear optical imaging to evaluate the impact of obesity on mammary gland and tumor stroma. Molecular Imaging 6 205-211.
32. Lester RD, Jo M, Campana WM & Gonias SL 2005 Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia. Journal of Biological Chemistry 280 39273-39277.
33. Li Q, Wu L, Oelschlager DK, Wan M, Stockard CR, Grizzle WE, Wang N, Chen H, Sun Y & Cao X 2005 Smad4 inhibits tumor growth by inducing apoptosis in estrogen receptor-alpha-positive breast cancer cells. Journal of Biological Chemistry 280 27022-27028.
34. De Longgueville F, Meneses-Lorente G, Surry D, Bertholet V, Le bourdlles B & Remacle J 2002 Gene expression profilling of drug metabolism and toxicology markers using a low density DNA microarray. Biochemical Pharmacology 64 137-149.
35. Lorincz AM & Sukumar S 2006 Molecular links between obesity and breast cancer. Endocrine-Related Cancer 13 279-292.
36. Martinez-Arribas F, Alvarez T, Del Val G, Martin-Garabato E, Nunez-Villar MJ, Lucas R, Sanchez J, Tejerina A & Schneider J 2007 Bcl-2 expression in breast cancer: a comparative study at the mRNA and protein level. Anticancer Research 27 219-222.
37. Mauro L, Catalano S, Bossi G, Pellegrino M, Barone I, Morales S, Giordano C, Bartella V, Casaburi I & Ando S 2007 Evidences that leptin up-regulates E-cadherin expression in breast cancer: effects on tumor growth and progression. Cancer Research 67 3412-3421.
38. Milde-Langosch K, Bamberger AM, Rieck G, Kelp B & Loning T 2001 Overexpression of the p16 cell cycle inhibitor inbreast cancer is associated with a more malignant phenotype. Breast Cancer Research and Treatment 67 61-70.
39. Minn AJ, Kang Y, Serganova I, Gupta GP, Giri DD, Doubrovin M, Ponomarev V, Gerald WL, Blasberg R & Massague J 2005 Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. Journal of Clinical Investigation 115 44-55.
40. Nam SY, Lee EJ, Kim KR, Cha BS, Song YD, Lim SK, Lee HC & Huh KB 1997 Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone. International Journal of Obesity and Related Metabolic Disorders 21 355-359.
41. Ogunwobi OO & Beales IL 2006 The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. International Journal of Colorectal Disease 22 401-409.
42. Okumura M, Yamamoto M, Sakuma H, Kojima T, Maruyama T, Jamali M, Cooper DR & Yasuda K 2002 Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression. Biochimica et Biophysica Acta 1592 107-116.
43. Pereira JJ, Mayer T, Docherty SE, Reid HH, Marshall J, Thompson EW, Rossjohn J & Price JT 2004 Bimolecular interaction of insulin-like growth factor (IGF) binding protein-2 with alphavbeta3 negatively modulates IGF-I-mediated migration and tumor growth. Cancer Research 64 977-984.
44. Perera CN, Spalding H, Mohammed SI & Camarillo IG 2008 Identification of proteins secreted from leptin stimulated MCF-7 breast cancer cells: a dual proteomic approach. Experimental Biology and Medicine 233 708-720.
45. Saxena NK, Saliba G, Floyd JJ & Anania FA 2003 Leptin induces increased alpha2(I) collagen gene expression in cultured rat hepatic stellate cells. Journal of Cellular Biochemistry 89 311-320.
46. Saxena NK, Titus MA, Ding X, Floyd J, Srinivasan S, Sitaraman SV & Anania FA 2004 Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation. FASEB Journal 3 1612-1614.
47. Sens MA, Somji S, Garrett SH, Beall CL & Sens DA 2001 Metallothionein isoform 3 overexpression is associated with breast cancers having a poor prognosis. American Journal of Pathology 159 21-26.
48. Sherr C & Roberts JM 1999 Inhibitors: positive and negative regulators of G1-phase progression. Genes and Development 13 1501-1512.
49. Somasundar P, Yu AK, Vona-Davis L & McFadden DW 2003 Differential effects of leptin on cancer in vitro. Journal of Surgical Research 113 50-55.
50. Souchelnytskyi S 2005 Proteomics of TGF-beta signaling and its impact on breast cancer. Expert Review of Proteomics 2 925-935.
51. Stefańczyk-Krzymowska S, Grzegorzewski W, Wasowska B, Skipor J & Krzymowski T 1998 Local increase of ovarian steroid hormone concentration in blood supplying the oviduct and uterus during early pregnancy of sows. Theriogenology 50 1071-1080.
52. Surmacz S 2007 Obesity hormone leptin: a new target in breast cancer? Breast Cancer Research 9 301.
53. Sweeney G 2002 Leptin signalling. Cellular Signalling 14 655-663.
54. Tlsty TD & Coussens LM 2006 Tumor stroma and regulation of cancer development. Annual Review of Pathology 1 119-150.
55. Tobin SW, Brown MK, Douville K, Payne DC, Eastman A & Arrick BA 2001 Inhibition of transforming growth factor beta signaling in MCF-7 cells results in resistance to tumor necrosis factor alpha: a role for Bc1-2. Cell Growth and Diferentiation 12 109-117.
56. Wajant H, Pfizenmaier K & Scheurich P 2003 Tumor necrosis factor signaling. Cell Death and Differentiation 10 45-65.
57. Weiss RH, Marshall D, Howard L, Corbacho AM, Cheung AT & Sawai ET 2003 Suppression of breast cancer growth and angiogenesis by an antisense oligodeoxynucleotide to p21 (Waf1/Cip1). Cancer Letters 189 39-48.
58. Xia W, Bisi J, Strum J, Liu L, Carrick K, Graham KM, Treece AL, Hardwicke MA, Dush M, Liao Q et al. 2006 Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers. Cancer Research 66 1640-1647.
59. Yang JM, Neill PO, Jin W, Foty R, Medina DJ, Xu Z, Lomas M, Arndt GM, Tang Y, Nakada M et al. 2006 Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. Journal of Biological Chemistry 28 9719-9727.
60. Zhang M, Yang J & Li F 2006 Transcriptional and post-transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment. Journal of Experimental and Clinical Cancer Research 25 391-402.