Obesity, adipocytokines and cancer

Translational Oncogenomics

Volumn 2008, Issue 3, 2008, Pages 45-52

  Masaki, Takayuki ^a   Yoshimatsu, Hironobu ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Adiponectin; Cancer; Leptin; Obesity; Visceral adiposity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; GLUCOSE; INSULIN; LEPTIN; LIPID; TRIACYLGLYCEROL;

BREAST CANCER; CANCER RESEARCH; CARCINOGENESIS; COLON CANCER; CYTOKINE RELEASE; DISEASE ASSOCIATION; ENDOMETRIUM CANCER; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; HYPERTENSION; INSULIN BLOOD LEVEL; INTRAABDOMINAL FAT; LIPID BLOOD LEVEL; LIPID STORAGE; LIPOGENESIS; MEAL; METABOLIC DISORDER; NEOPLASM; OBESITY; PREVALENCE; PROSTATE CANCER; REVIEW; STOMACH CANCER; WHITE ADIPOSE TISSUE;

EID: 77953465497     PISSN: None     EISSN: 11772727     Source Type: Journal    
DOI: None     Document Type: Review

References (89)

1. Ahima, R.S., Prabakaran, D., Mantzoros, C. et al. 1996. Role of leptin in the neuroendocrine response to fasting. Nature, 382:250-2.
2. Arita, Y., Kihara, S., Ouchi, N. et al. 1999. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun., 257:79-83.
3. Arpaci, F., Yilmaz, M.I., Ozet, A. et al. 2002. Low serum leptin level in colon cancer patients without significant weight loss. Tumori, 88:147-9.
4. Aparicio, T., Kotelevets, L., Tsocas, A. et al. 2005. Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice nor intestinal tumourigenesis in APcMin/+ Mice. Gut., 54:1136-45.
5. Attoub, S., Noe, V., Pirola, L. et al. 2000. Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase, rho-, and rac-dcpendent signaling pathways. Faseb J., 14:2329-38.
6. Barb, D., Neuwirth, A., Mantzoros, C.S. et al. 2007. Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway. Endocr. Relat. Cancer, 14:995-1005.
7. Berg, A.H., Combs, T.P., Du, X. et al. 2001. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med., 7:947-53.
8. Bergstrom, A., Pisani, P. and Tenet, V. 2001. Overweight as an avoidable cause of cancer in Europe. Int. J. Cancer, 91:421-30.
9. Bray, G.A. 2004. Medical consequences of obesity. J. Clin. Endocrinol. Metab., 89:2583-9.
10. Bub, J.D., Miyazaki, T. and Iwamoto, Y. 2006. Adiponectin as a growth inhibitor in prostate cancer cells. Biochem. Biophys. Res. Commun., 340:1158-66.
11. Calle, E.E. and Thun, M.J. 2004. Obesity and cancer. Oncogene, 23:6365-78.
12. Calle, E.E., Rodriguez, C., Walker-Thurmond, K. et al. 2003. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med., 348:1625-38.
13. Carroll, K.K. 1998. Obesity as a risk factor for certain types of cancer. Lipids, 1998; 33:1055-9.
14. Chang, S, Buzdar, A.U. and Hursting, S.D. 1998. Inflammatory breast cancer and body mass index. J. Clin. Oncol., 16:3731-5.
15. Cong, L., Gasser, J., Zhao, J. et al. 2007. Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2. Endocr. Relat. Cancer, 14:713-20.
16. Cust, A.E., Kaaks, R., Friedenreich, C. et al: 2007. Plasma adiponectin levels and endometrial cancer risk in pre- and postmenopausal women. J. Clin. Endocrinol. Metab., 92:255-63.
17. Dal Maso, L., Augustin, L.S., Karalis, A. et al. 2004. Circulating adiponectin and endometrial cancer risk. J. Clin. Endocrinol. Metab., 89:1160-3.
18. Dieudonne, M.N., Bussiere, M., Dos Santos, E. et al. 2006. Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochem. Biophys. Res. Commun., 345:271-9.
19. Enriori, P.J., Evans, A.E. and Sinnayah, P. 2006. Leptin resistance and obesity. Obesity (Silver Spring), 5:254S-8S.
20. Ferroni, P., Palmirotta, R., Spila, A. et al. 2007. Prognostic significance of adiponectin levels in non-metastatic colorectal cancer. Anticancer Res., 27:483-9.
21. Frederich, R.C., Lollmann, B., Hamann, A. et al. 1995. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J. Clin. Invest., 96:1658-63.
22. Frezza, E.E., Wachtel, M.S. and Chiriva-Internati, M. 2006. Influence of obesity on the risk of developing colon cancer. Gut., 55:285-91.
23. Friedman, J.M. and Halaas, J.L. 1998. Leptin and the regulation of body weight in mammals. Nature, 395:763-70.
24. Friedman, J.M. 2000. Obesity in the new millennium. Nature, 404:632-4.
25. Garofalo, C., Sisci, D. and Surmacz, E. 2004. Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells. Clin. Cancer Res., 10:6466-75.
26. Garofalo, C. and Surmacz, E. 2006. Leptin and cancer. J. Cell. Physiol., 207:12-22.
27. Giovannucci, E., Ascherio, A., Rimm, E.B. et al. 1995. Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann. Intern. Med., 122:327-34.
28. Gonzalez, R.R., Cherfils, S., Escobar, M. et al. 2006. Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R.2). J. Biol. Chem., 281:26320-8.
29. Hardwick, J.C., Van Den Brink, G.R., Offerhaus, G.J. et al. 2001. Leptin is a growth factor for colonic epithelial cells. Gastroenterology, 121:79-90.
30. Harvie, M., Hooper, L. and Howell, A.H. 2003. Central obesity and breast cancer risk: A systematic review. Obes. Rev., 4: 157-73.
31. Hirose, Y., Hata, K., Kuno, T. et al. 2004. Enhancement of development of azoxymethane-induced colonic premalignant lesions in C57BL/KsJ.-db/db mice. Carcinogenesis, 25:821-5.
32. Hotta, K., Funahashi, T. and Arita, Y. 2000. Plasma concentrations of a novel, adipose-specific protein, adiponcetin, in type 2 diabetic patients. Arterioscler. Thromb. Vasc. Biol., 20:1595-9.
33. Housa, D., Housova, J., Vernerova, Z. et al. 2006. Adipocytokines and cancer. Physiol. Res., 55:233-44.
34. Hu, E., Liang, P. and Spiegelman, B.M. 1996. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem., 271:10697-703.
35. Hu, X., Juneja, S.C., Maihle, N.J. et al. 2002. Leptin - A growth factor in normal and malignant breast cells and for normal mammary gland development. J. Natl. Cancer Inst., 94:1704-11.
36. Hubbard, J. S., Rohrmann, S. and Landis, P.K. 2004. Association of prostate cancer risk with insulin, glucose, and anthropometry in the Baltimore longitudinal study of aging. Urology, 63:253-8.
37. Ishikawa, M., Kitayama, J. and Nagawa, H. 2004. Enhanced expression of leptin and leptin receptor (OB-R.) in human breast cancer. Clin. Cancer Res., 10:4325-31.
38. Ishikawa, M., Kitayama, J., Yamauchi, et al. 2007. Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2. Cancer Sci., 98:1120-7.
39. Jónsson, F., Wolk, A., Pedersen, N.L. et al. 2003. Obesity and hormone-dependent tumors: cohort and co-twin control studies based on the Swedish Twin Registry. Int. J. Cancer, 106:594-9.
40. Kadowaki, T. and Yamauchi, T. 2005. Adiponectin and adiponectin receptors. Endocr. Rev., 26:439-51.
41. Kadowaki, T., Yamauchi, T., Kubota, N. et al. 2006. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest., 116:1784-92.
42. Kang, J.H., Lee, Y.Y., Yu, B.Y. et al. 2005. Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell. Arch. Pharm. Res., 28:1263-9.
43. Kershaw, E.E. and Flier, J.S. 2004. Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metab., 89:2548-56.
44. Koda, M., Sulkowska, M., Wincewicz, A. et al. 2007. Expression of leptin, leptin receptor, and hypoxia-inducible factor 1 alpha in human endometrial cancer. Ann. N. Y. Acad. Sci., 1095:90-8.
45. Korner, A., Pazaitou-Panayiotou, K., Kelesidis, T. et al. 2007. Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies, J. Clin. Endocrinol. Metab., 92:1041-8.
46. Kubota, N., Terauchi, Y. and Yamauchi, T. 2002. Disruption of adiponectin causes insulin resistance and neointimal formation. J. Biol. Chem., 277:25863-6.
47. Laoiou, P., Signorello, L.B., Trichopoulos, D. et al. 1998. Leptin in relation to prostate cancer and benign prostatic hyperplasia. Int. J. Cancer, 76:25-8.
48. Lago, F., Dieguez, C. and Gómez-Reino, J. 2007. Adipokines as emerging mediators of immune response and inflammation. Nat. Clin. Pract Rheumatol., 3:716-24.
49. Liu, Z., Uesaka, T., Watanabe, H. et al. 2001. High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin. Int. J. Oncol., 19:1009-14.
50. Maeda, K, Okubo, K., Shimomura, I. etal. 1996. cDNA cloning and expression of a novel adipose specific collagen-like fdctor, apM1 (AdiPose Most abundant Gene transcript. Biochem Biophys. Res. Commun., 221:286-9.
51. Maeda, N, Shimomura, I., Kishida, K. et al. 2602. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat. Med., 8:731-7.
52. Mantzoros, C.S., Bolhke, K., Moschos, S. and Cramer, D.W. 1999. Leptin in relation to carcinoma in situ of the breast: a study of pre-menopausal cases and controls. Int. J. Cancer, 80:523-6.
53. Mantzoros, C., Petridou, E., Dessypris, N. et al. 2004. Adiponcetin and breast cancer risk J. Clin. Endocrinol. Metab., 89:1102-7.
54. Maffei, M., Halaas, J., Ravussin, E. et al. 1995. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med., 1: 1155-61.
55. Matsuzawa, Y. 2005. White adipose tissue and cardiovascular disease. Best Pract Res. Clin. Endocrinol. Metab., 19:637-47.
56. Matsuzawa, Y. 2006. Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat. Clim Pract Cardiovasc Med., 3:35-42.
57. Miyoshi, Y., Funahashi, T., Kiliara, S. et al. 2003. Association of serum adiponectin levils with b6ast cancer risk. Clin. Cancer Res., 2003; 9:5699-704.
58. O'Brien, S.N., Welter, B.N. and Price, T.M. 1999. Presence of leptin in breast cell lines and breast tumors. Biochem. Biophys. Res. Commun., 259:695-8.
59. Okumura, M., Yamamoto, M., Sakuma, H. et al. 2002. Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: Reciprocal involvement of PKC-alpha and PPAR. expression. Biochim. Biophys. Acta., 1592:107-16.
60. Petridou, E., Papadiamantis, Y., Markopoulos, C. et al. 2000. Leptin and insulin growth factor I in relation to breast cancer (Greece). Cancer Causes Control, 11:383-8.
61. Petridou, E., Belechri, M., Dessypris, N. et al. 2002. Leptin and body mass index in relation to endometrial cancer risk. Ann. Nutr. Metab., 46:147-51.
62. Petridou, E., Mautzoros, C., Dessypris, N. et al. 2003. Plasma adiponectin concentrations in relation to epdometrial cancer: a case-control study in Greece. J. Clin. Endocrinol. Metab., 88:993-7.
63. Ray, A., Nkhata, K.J. and Cleary, M.P. 2007. Effect of leptin on human breast cancer cell lifes in relationship catrogen receptor and HER.2 status. Int. J. Oncol., 30:1499-509.
64. Ribeiro, R., Vasconcelos, A., Costa, S. et al. 2004. Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease. Prostate, 59:268-74.
65. Rouet-Benzineb, P., Apariio, T., Guilmeau, S. et al. 2004. Leptin counter-acts sodium butyrate-induced apoptosis in human colon cancer HT-29 cells via NF-kB. signaling. J. Biol. Chem., 279:16495-502.
66. Saglam, K., Aydur, E., Yilmaz, M. et al. 2003. Leptin influences cellular differentiation and progression in prostate cancer. J. Urol., 169:1308-11.
67. Sauter, E.R., Garofalo, C., Hewett, J. et al. 2004. Leptin expression in breast nipple aspirate fluid (NAF) and serum is influenced by body mass index (BMI) but not by the presence of breast cancer. Horm Metab. Res., 36:336-40.
68. Saladin, R., De Vos, P., Guerre-Millo, M. et al. 1995. Transient increase in obese gcne expression after food intake or insulin administration. Nature, 377:527-9.
69. Scherer, P.E., Williams, S., Fogliano, M. et al. 1995. A novel serum protein similar to Clq, produced exclusively in adipocytes. J. Biol. Chem., 270:26746-9.
70. Schuurman, A.G., Goldbohm, R.A., Dorant, E. et al. 2000. Anthropometry in relation to prostate cancer risk in the Netherlands Cohort Study. Am. J. Epidemiol., 151:541-9.
71. Sharma, D., Saxena, N.K., Vertino, P.M. et al. 2006. Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways. Endocr. Relat. Cancer, 13:629-40.
72. Somasundar, P., Frankenberry, K.A., Skinner, H. et al. 2004. Prostate cancer cell proliferation is influenced by leptin. J. Surg. Res., 118:71-82.
73. Spiegelman, B.M. and Flier, J.S. 1996. Adipogenesis and obesity: rounding out the big picture. Cell., 87:377-89.
74. Stattin, P., Soderberg, S., Hallmans, G. et al. 2001. Leptin is associated with increased prostate cancer risk: a nested case-referent study. J. Clin. Endocrinol. Metab., 86:1341-5.
75. Stattin, P., Kaaks, R., Johansson, R. et al. 2003. Plasma leptin is not associated with prostate cancer risk. Cancer Epidemiol. Biomarkers Prev., 12:474-5.
76. Stattin, P., Palmqvist, R., Soderberg, S. et al. 2003b. Plasma leptin and colorectal cancer risk: A prospective study in Northern Sweden. Oncol. Rep., 10:2015-21.
77. Takahata, C., Miyoshi, Y., Irahara, N. et al. 2007. Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells. Cancer Lett., 250:229-36.
78. Takemura, Y., Osuga, Y., Yamauchi, T. et al. 2006. Expression of adiponectin receptors and its possible implication in the human endometrium. Endocrinology, 147:3203-10.
79. Terry, P., Giovannucci, E., Bergkvist, L. et al. 2001. Body weight and colorectal cancer risk in a cohort of Swedish women: relation varies by age and cancer site. Br. J. Cancer, 85:346-9.
80. Terry, P., Miller, A. and Rohan, T. 2002. Obesity and colorectal cancer risk in women. Gut., 51:191-4.
81. Tessitore, L., Vizio, B., Jenkins, O. et al. 2006. Leptin expression in colorectal and breast cancer patients. Int. J. Mol. Med., 5:421-6.
82. Vona-Davis, L., Howard-McNatt, M. and Rose, D.P. 2007. Adiposity, type 2 diabetes and the metabolic syndrome in breastcancer. Obes. Rev., 8:395-408.
83. Yamauchi, t., Kamon, J., Waki, H. et al. 2001. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med., 7:941-6.
84. Yamauchi, T., Kamon, J., Minokoshi, Y. et al. 2002. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinasc. Nat. Med., 8:1288-95.
85. Yamauchi, T., Kamon, J., Ito, Y. et al. 2003. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature, 423:762-9.
86. Yang, W.S., Lee, W.J., Funahashi, T. et al. 2002. Plasma adiponectin levels in ovorweight and obesc Asians. Obes. Res., 2002; 10:1104-10.
87. Yin, N., Wang, D., Zhang, H. et al. 2004. Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res., 64:5870-5.
88. Yuan, S.S., Tsai, K.B., Chung, Y.F. et al. 2004. Aberrant expression and possible involvement of the leptin receptor in endometrial cancer. Gynecol. Oncol., 92:769-75.
89. Zhang, Y., Proenca, R., Maffei, M. et al. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature, 372:425-32.