Associations among lipids, leptin, and leptin receptor gene gin223arg polymorphisms and breast cancer in China

Biological Trace Element Research

Volumn 126, Issue 1-3, 2008, Pages 38-48

  Han, Cun Zhi ^a   Du, Li Li ^a   Jing, Jie Xian ^a   Zhao, Xian Wen ^a   Tian, Fu Guo ^a   Shi, Jing ^b   Tian, Bao Guo ^a   Liu, Xiu Ying ^a   Zhang, Li Jiao ^a  

^a SHANXI CANCER HOSPITAL   (China)

^b SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; Insulin; Leptin; Leptin receptor gene polymorphism; Lipids

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; ARGININE; DNA; GLUTAMINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LEPTIN RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; LEPTIN RECEPTOR, HUMAN; LIPID;

ADULT; AGED; ARTICLE; BODY MASS; BREAST CANCER; CANCER RISK; CHINA; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIETARY INTAKE; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE FREQUENCY; GENOTYPE; HERITABILITY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INSULIN BLOOD LEVEL; LIFESTYLE; MAJOR CLINICAL STUDY; OBESITY; PHYSICAL ACTIVITY; POLYMERASE CHAIN REACTION; PROTEIN BLOOD LEVEL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; WAIST HIP RATIO; BLOOD; BREAST TUMOR; FEMALE; GENETIC POLYMORPHISM; GENETICS; MIDDLE AGED;

ADULT; AGED; BODY MASS INDEX; BREAST NEOPLASMS; CHINA; FEMALE; GENOTYPE; HUMANS; LEPTIN; LIFE STYLE; LIPIDS; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, LEPTIN; WAIST-HIP RATIO;

EID: 64849109418     PISSN: 01634984     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12011-008-8182-z     Document Type: Article

References (51)

1. Xu GW (2005) Chinese breast cancer deaths jump 40% since one child abortion policy. Life Site News, October 13 (Beijing)
2. X Shu F Jin Q Dai J Rong JR Shi JD Potter LA Brinton JR Hebert ZX Ruan YT Gao W Zheng 2001 Association of body size and fat distribution with risk breast cancer among Chinese women Int J Cancer 94 499 454 (Pubitemid 32906080)
3. AM Lorincz S Sukumar 2006 Molecular links between obesity and breast cancer Endocr Relat Cancer 13 279 292 (Pubitemid 43886659)
4. G Berclaz S Li KN Price 2004 Body mass index as a prognostic feature in operable breast cancer: the International Breast Cancer Study Group experience Ann Oncol 15 875 884 (Pubitemid 39004342)
5. A Asseryanis E Ruecklinger M Hellan E Kubista CF Singer 2004 Breast cancer size in postmenopausal women is correlated with body mass index and androgen serum levels Gynecol Endocrinol 18 29 36 (Pubitemid 38134761)
6. EE Calle C Rodriguez K Walker-Thurmond MJ Thun 2003 Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults N Engl J Med 348 1625 1638 (Pubitemid 36459468)
7. X Hu SC Juneja NJ Maihle MP Cleary 2002 Leptin-a growth factor in normal and malignant breast cells and for normal mammary gland development J Natl Cancer Inst 94 1704 1711 (Pubitemid 35446839)
8. K Laud I Gourdou L Pessemesse JP Peyrat J Djiane 2002 Identification of leptin receptor in human breast cancer: functional activity in the T47-D breast cancer cell line Mol Cell Endocrinol 188 219 226 (Pubitemid 34242679)
9. SN O'Brien BH Welter TM Price U Clemson SG Glemson 1999 Presence of leptin in breast cell lines and breast tumors Biochem Biophys Res Commun 259 695 698 (Pubitemid 29335596)
10. CZ Han XT Zhang LL Du XY Lui JX Jing XW Zhao X Yang BG Tian 2005 Serum levels of leptin, insulin, and lipids in relation to breast cancer in China Endocrine 26 19 24 (Pubitemid 41271112)
11. L Tessitore B Vizio O Jenkins I De Stefano 2000 Leptin expression in colorectal and breast cancer patients Int J Mol Med 5 421 426
12. P Stattin A Lukanova C Biessy S Soderberg R Palmqvist R Kaaks T Olsson E Jellum 2004 Obesity and colon cancer: does leptin provide a link? Int J Cancer 109 149 152 (Pubitemid 38160676)
13. R Ribeiro C Lopes R Medeiros 2006 The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives Prostate Cancer Prostatic Dis 9 19 24 (Pubitemid 43378863)
14. KF Malik WS Young 3rd 1996 Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice Endocrinology 137 1497 500 (Pubitemid 26098619)
15. T Tsuchiya H Shimizu T Hori M Mori 1999 Expression of leptin receptor in lung: leptin as a growth factor Eur J Pharmacol 365 273 279 (Pubitemid 29070774)
16. H Mix A Widjaja O Jandl M Cornberg A Kaul M Goke W Beil M Kuske G Brabant MP Manns S Wagner 2000 Expression of leptin receptor isoforms in the human stomach Gut 47 481 486
17. M Hino T Nakano T Yamane K Ohta T Takubo N Tatsumi 2000 Leptin receptor and leukemia Leuk Lymphoma 36 457 461 (Pubitemid 30103169)
18. JC Hardwick GR Van Den Brink GJ Offerhaus SJ Van Deventer MP Peppelenbosch 2001 Leptin is a growth factor for colonic epithelial cells Gastroenterology 121 79 90 (Pubitemid 32591517)
19. S Attoub V Noe L Pirola E Bruyneel E Chastre M Mareel MP Wymann C Gespach 2000 Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-and rac-dependent signaling pathways FASEB J 14 2329 2338
20. M Isono R Inoue T Kamida H Kobayashi J Matsuyama 2003 Significance of leptin expression in invasive potential of pituitary adenomas Clin Neurol Neurosurg 105 111 116 (Pubitemid 36411679)
21. YM Zheng KS Xiang R Zhang WP Jia JS Lu JL Tong 1999 Association of Gln223Arg variant in leptin receptor gene with metabolic abnormalities and hypertension in type 2 diabetes in Shanghai "Han" population Chinese Journal of Endocrinology and metabolism 38 174 178
22. EE Calle C Rodriguez K Walker-Thurmond MJ Thun 2003 Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults N Engl J Med 348 1625 1638 (Pubitemid 36459468)
23. F Bianchini R Kaaks H Vainio 2002 Overweight, obesity, and cancer risk Lancet Oncol 3 565 574
24. L Tessitore B Visio D Pesola F Cecchini A Mussa JM Argiles C Benedetto 2004 Adipocytes expression and circulating levels of leptin increase in both gynaecological and breast cancer patients Int J Cancer 24 1529 1535
25. A Ozet F Arpaci M Yilmaz llker H Ayta B Ozturk S Komurcu AA Yavuz Y Tezcan C Acikel 2001 Effect of tamoxifen on the serum leptin level in patients with breast cancer Jpn J Clin Oncol 31 424 427 (Pubitemid 33039749)
26. S Christo K Bolhke S Moschos W Cramer 1999 Leptin in relation to carcinoma in situ of the breast: a study of pre-menopausal cases and controls Int J Cancer 80 523 526 (Pubitemid 29047515)
27. I Makoto K Joji N Hirokazu 2004 Enhanced expression of leptin and leptin receptor (LEPR) in human breast cancer Clin Cancer Res 10 4325 4331 (Pubitemid 38878870)
28. SM Smith-Kirwin DM O'Connor J Johnston E de Lancy SG Hassink VL Funanage 1998 Leptin expression in human mammary epithelial cells and breast milk J Clin Endocrinol Metab 83 1810 1813 (Pubitemid 28501064)
29. SH Waxler P Taber LP Melcher 1953 Obesity and the time of appearance of spontaneous mammary carcinoma in C3H mice Cancer Res 13 276 278
30. WE Heston G Vlahakis 1962 Genetic obesity and neoplasia J Natl Cancer Inst (Bethesda) 29 197 209
31. MP Cleary FC Phillip SC Getzin TL Jacobson MK Jacobson TA Christensen SC Juneja JP Grande NJ Maihle 2003 Genetically obese MMTV-TGF-alph/Lep(ob) Lep(ob) female mice do not develop mammary tumors Breast Cancer Res Treat 77 205 215 (Pubitemid 36197635)
32. CS Mantzoros K Bolhke S Moschos CS Cramer 1999 Leptin in relation to carcinoma in situ of the breast: a study of pre-menopausal cases and controls Int J Cancer 80 523 526 (Pubitemid 29047515)
33. E Petridou Y Papadiamantis C Markopoulos E Spanos N Dessypris D Trichopoulos 2000 Leptin and insulin growth factor I in relation to breast cancer Cancer Causes Control 11 383 388 (Pubitemid 30345235)
34. JM Friedman RL Leibel DS Siegel J Walsh N Bahary 1991 Molecular mapping of the mouse ob mutation Genomics 11 1054 1062
35. DL Coleman 1978 Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice Diabetologia 14 141 148 (Pubitemid 8286141)
36. Y Zhang R Proenca M Maffei M Barone L Leopold JM Friedman 1994 Positional cloning of the mouse obese gene and its human homologue Nature 372 425 432 (Pubitemid 24365442)
37. O Mammes D Betoulle R Aubert B Herbeth G Siest F Fumeron 2000 Association of the G-2548A polymorphism in the 5¢ region of the LEP gene with overweight Ann Hum Genet 64 391 394 (Pubitemid 32055730)
38. VS Mattevi VM Zembrzuski MH Hutz 2002 Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil Int J Obes Relat Metab Disord 26 1179 1185
39. J Hager K Clement S Francke J Raison N Lahlou N Rich V Pelloux A Basdevant B GuyGrand M North P Froguel 1998 A polymorphism in the 5¢ untranslated region of the human ob gene is associated with low leptin levels Int J Obes Relat Metab Disord 22 200 205 (Pubitemid 28112018)
40. O Lamas A Marti JA Martinez 2002 Obesity and immunocompetence Eur J Clin Nutr 56 3 S42 S45
41. T Gotoda BS Manning AP Goldstone H Imrie AL Evans AD Strosberg PM McKeigue J Scott TJ Aitman 1997 Leptin receptor gene variation and obesity: lack of association in a white British male population Hum Mol Genet 6 869 876 (Pubitemid 27239070)
42. N Yiannakouris M Yannakoulia L Melistas JL Chan D Klimis-Zacas CS Mantzoros 2001 The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability J Clin Endocrinol Metab 86 4434 4439 (Pubitemid 32848571)
43. J Hoffstedt P Eriksson S Mottagui-Tabar P Arner 2002 A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin Horm Metab Res 34 355 359
44. K Snoussi AD Strosberg N Bouaouina SB Ahmed AN Helal L Chouchane 2006 Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma BMC Cancer 6 38 51 (Pubitemid 43380715)
45. HY Woo H Park CS Ki YL Park WG Bae 2005 Relationships among serum leptin, leptin receptor gene polymorphisms, and breast cancer in Korea Cancer Lett 9 1 6
46. L Jerome L Shiry JB Leyland 2004 Anti-insulin-like growth factor strategies in breast cancer Semin Oncol 31 54 63 (Pubitemid 38543940)
47. NE Allen PN Appleby R Kaaks S Rinaldi GK Davey TJ Key 2003 Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women Cancer Causes Control 14 65 74 (Pubitemid 36403271)
48. R Zefang C Qiuyin S Xiao-Ou C Hui LI Chun YU Herbert G Yu-Tang Z Wei 2004 Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP3 protein levels among Chinese women Cancer Epidemiol Biomark Prev 13 1290 1295 (Pubitemid 39071551)
49. A Takahashi Yasuno H Masuzaki T Miyawaki Y Ogawa N Matsuaka K Hosoda G Inoue Y Yoshimasa K Nakao 2003 Leptin receptor polymorphism is association with serum lipids levels and impairment of cholesterol lowering effect in Japanese men Diabetes Res Clin Pract 62 169 175 (Pubitemid 37414983)
50. U Coskun N Gunel FB Torunner 2003 Serum leptin, prolactin and vascular endothelial growth factor (VEGF) levels in patients with breast cancer Neoplasma 50 41 46 (Pubitemid 36458939)
51. L-L Du C-Z Han X-Y Liu 2006 Relationship between serum leptin level BMI and breast cancer incidence Cancer Res Clin 18 307 310