Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7

Journal of Biological Chemistry

Volumn 288, Issue 18, 2013, Pages 12511-12521

  Steen, Anne ^a   Thiele, Stefanie ^a   Guo, Dong ^b   Hansen, Lærke S ^a   Frimurer, Thomas M ^c   Rosenkilde, Mette M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LEIDEN UNIVERSITY   (Netherlands)

^c Capital Region   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; AROMATIC AMINO ACID; CHANGE ORIENTATIONS; CHEMOKINE RECEPTORS; COMPUTATIONAL MODELING; EQUILIBRIUM STATE; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE HELICES;

ACTIVATION ANALYSIS; AMINO ACIDS; PROTEINS;

SIGNALING;

4 [(4 BROMOPHENYL)(ETHOXYIMINO)METHYL] 1' [(2,4 DIMETHYL 3 PYRIDINYL)CARBONYL] 4' METHYL 1,4' BIPIPERIDINE; APLAVIROC; BETA ARRESTIN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; GLYCINE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; PHENYLALANINE; TRYPTOPHAN; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; GENE MUTATION; IC 50; MATHEMATICAL MODEL; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STEREOSPECIFICITY;

7-HELIX RECEPTOR; BIASED SIGNALING; CHEMOKINES; G PROTEIN-COUPLED RECEPTORS (GPCR); G PROTEINS; PHARMACOLOGY; RECEPTOR STRUCTURE-FUNCTION; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CCR5; SIGNAL TRANSDUCTION;

EID: 84877131386     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.449587     Document Type: Article

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