Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry

Journal of Virology

Volumn 81, Issue 5, 2007, Pages 2359-2371

  Westby, Mike ^a   Smith Burchnell, Caroline ^a   Mori, Julie ^a   Lewis, Marilyn ^a   Mosley, Michael ^a   Stockdale, Mark ^a   Dorr, Patrick ^a   Ciaramella, Giuseppe ^a   Perros, Manos ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); APLAVIROC; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4; EFAVIRENZ; ENFUVIRTIDE; GLYCOPROTEIN GP 120; MARAVIROC; SAQUINAVIR;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SENSITIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REVERTANT; SITE DIRECTED MUTAGENESIS; VIRUS ENVELOPE; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL LINE; CYCLOHEXANES; DRUG RESISTANCE, VIRAL; GENES, ENV; HIV ENVELOPE PROTEIN GP120; HIV FUSION INHIBITORS; HIV INFECTIONS; HIV-1; HUMANS; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PHENOTYPE; RECEPTORS, CCR5; RECEPTORS, CXCR4; TRIAZOLES; VARIATION (GENETICS); VIRUS CULTIVATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33847237614     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02006-06     Document Type: Article

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