Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism

Journal of Biological Chemistry

Volumn 282, Issue 21, 2007, Pages 15799-15811

  Holst, Birgitte ^a   Mokrosinski, Jacek ^a   Lang, Manja ^b   Brandt, Erik ^a   Nygaard, Rie ^c   Frimurer, Thomas M ^c   Beck Sickinger, Annette G ^b   Schwartz, Thue W ^a,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c 7TM Pharma A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN RECEPTOR; INVERSE AGONISM; MUTATIONS; N TERMINUS;

AMIDES; BINDING SITES; CARBOXYLATION; LIGANDS; SUBSTITUTION REACTIONS;

PEPTIDES;

AROMATIC COMPOUND; DEXTROTRYTOPHYLPHENYLALANINE DEXTROTRYPTOPHYLLEUCYLLEUCINE; G PROTEIN COUPLED RECEPTOR; GHRELIN; HORMONE RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; LIGAND; MEMBRANE PROTEIN; PARTIAL AGONIST; PEPTIDE; UNCLASSIFIED DRUG; GROWTH HORMONE SECRETAGOGUE RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR MODEL; MOLECULAR PROBE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; SOLID PHASE SYNTHESIS; SUBSTITUTION REACTION; AMINO ACID SUBSTITUTION; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG POTENTIATION; GENETICS; MISSENSE MUTATION; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTATION, MISSENSE; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34447530948     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609796200     Document Type: Article

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