Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: Synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety

Journal of Medicinal Chemistry

Volumn 43, Issue 10, 2000, Pages 2049-2063

  Shiraishi, Mitsuru ^a   Aramaki, Yoshio ^a   Seto, Masaki ^a   Imoto, Hiroshi ^a   Nishikawa, Youichi ^a   Kanzaki, Naoyuki ^a   Okamoto, Mika ^a   Sawada, Hidekazu ^b   Nishimura, Osamu ^b   Baba, Masanori ^a   Fujino, Masahiko ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANILIDE; ANTIVIRUS AGENT; CHEMOKINE RECEPTOR CCR5; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; QUATERNARY AMMONIUM DERIVATIVE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

AMIDES; ANIMALS; ANTI-HIV AGENTS; CELL LINE; CHEMOKINE CCL2; CHEMOKINES, CC; CHO CELLS; CRICETINAE; CYTOKINES; HIV-1; IODINE RADIOISOTOPES; MACROPHAGES; MOLECULAR STRUCTURE; QUATERNARY AMMONIUM COMPOUNDS; RANTES; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 0034117636     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9906264     Document Type: Article

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