Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach

Journal of Biological Chemistry

Volumn 286, Issue 43, 2011, Pages 37543-37554

  Thiele, Stefanie ^a   Steen, Anne ^a   Jensen, Pia C ^a   Mokrosinski, Jacek ^a   Frimurer, Thomas M ^b   Rosenkilde, Mette M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATORS; ALLOSTERIC SITE; CHEMOKINE RECEPTORS; CHEMOKINES; CHIMERIC RECEPTORS; CLASS A; DRUG DEVELOPMENT; EXTRACELLULAR; EXTRACELLULAR REGION; HIGH AFFINITY; HIGH AFFINITY BINDING; LARGE SIZES; MODEL SYSTEM; RECEPTOR INTERACTION; SIGNALING UNITS; SMALL MOLECULES; TRANSMEMBRANE HELICES; TRANSMEMBRANE REGIONS; TRANSMEMBRANES; TROJAN HORSE;

ACTIVE NETWORKS; MOLECULAR INTERACTIONS; MOLECULAR STRUCTURE; PEPTIDES;

MOLECULES;

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; COMPLEMENT COMPONENT C7; INOSITOL PHOSPHATE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; AMIDES; ANIMALS; BENZOATES; CERCOPITHECUS AETHIOPS; CHEMOKINES; COS CELLS; CYCLIC N-OXIDES; HUMANS; PIPERAZINES; PIPERIDINES; PYRIDINES; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, CCR2; RECEPTORS, CCR5; RECOMBINANT FUSION PROTEINS; SPIRO COMPOUNDS;

EQUIDAE;

EID: 80054804698     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.243808     Document Type: Article

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