Structural and molecular interactions of CCR5 inhibitors with CCR5

Journal of Biological Chemistry

Volumn 281, Issue 18, 2006, Pages 12688-12698

  Maeda, Kenji ^a,b   Das, Debananda ^b   Ogata Aoki, Hiromi ^a   Nakata, Hirotomo ^a   Miyakawa, Toshikazu ^a   Tojo, Yasushi ^a   Norman, Rachael ^b   Takaoka, Yoshikazu ^c   Ding, Jianping ^d   Arnold, Gail F ^d   Arnold, Eddy ^d   Mitsuya, Hiroaki ^a,b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c ONO PHARMACEUTICAL CO   (Japan)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOELECTRIC POTENTIALS; CELLS; IMMUNOLOGY; LIPIDS; MOLECULAR DYNAMICS; MUTAGENESIS; VIRUSES;

APLAVIROC (AVC); CC-CHEMOKINE RECEPTOR 5 (CCR5); CELLULAR ENTRY; STRUCTURAL ANALYSES;

ENZYME INHIBITION;

APLAVIROC; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; GLYCOPROTEIN GP 120; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; SCH C; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; HAMSTER; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; IN VIVO STUDY; INFECTION SENSITIVITY; MOLECULAR INTERACTION; NONHUMAN; OVARY CELL; PRIORITY JOURNAL; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; KINETICS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CCR5;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33744954776     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512688200     Document Type: Article

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