Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry

Journal of Virology

Volumn 77, Issue 9, 2003, Pages 5201-5208

  Tsamis, Fotini ^a   Gavrilov, Svetlana ^a   Kajumo, Francis ^a   Seibert, Christoph ^b   Kuhmann, Shawn ^c   Ketas, Tom ^c   Trkola, Alexandra ^d   Palani, Anadan ^e   Clader, John W ^e   Tagat, Jayaram R ^e   McCombie, Stuart ^e   Baroudy, Bahige ^e   Moore, John P ^c   Sakmar, Thomas P ^b   Dragic, Tatjana ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(4 BROMOPHENYL)(ETHOXYIMINO)METHYL] 1' [(2,4 DIMETHYL 3 PYRIDINYL)CARBONYL] 4' METHYL 1,4' BIPIPERIDINE; 4 [1 [(2,4 DIMETHYL 3 PYRIDINYL)CARBONYL] 4 METHYL 4 PIPERIDINYL] 2 METHYL 1 [1 [4 (TRIFLUOOROMETHYL)PHENYL]ETHYL]PIPERAZINE; CHEMOKINE RECEPTOR CCR5; EPITOPE; GLYCOPROTEIN GP 120; MONOCLONAL ANTIBODY; PIPERIDINE DERIVATIVE; PROTEIN INHIBITOR;

ARTICLE; CELL LINE; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTE; MOLECULAR DYNAMICS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYCLIC N-OXIDES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MEMBRANE FUSION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PIPERIDINES; PYRIDINES; RECEPTORS, CCR5; VIRUS REPLICATION;

EID: 0037404511     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.9.5201-5208.2003     Document Type: Article

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