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Volumn 33, Issue 4, 2013, Pages 181-188

STAT activation in malignancies: Roles in tumor progression and in the generation of antineoplastic effects of IFNs

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CAVEOLIN 1; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 21; INTERLEUKIN 6; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STAT5A PROTEIN; STAT5B PROTEIN; STAT6 PROTEIN;

EID: 84876155664     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2012.0154     Document Type: Review
Times cited : (8)

References (119)
  • 1
    • 0032934156 scopus 로고    scopus 로고
    • Functional roles of STAT family proteins: Lessons from knockout mice
    • Akira S. 1999. Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 17(3):138-146.
    • (1999) Stem Cells , vol.17 , Issue.3 , pp. 138-146
    • Akira, S.1
  • 2
    • 0034657958 scopus 로고    scopus 로고
    • Roles of STAT3 defined by tissue-specific gene targeting
    • Akira S. 2000. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene 19(21):2607-2611.
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2607-2611
    • Akira, S.1
  • 3
    • 0035393595 scopus 로고    scopus 로고
    • Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in downregulation of Bcl-2 and sensitization to cytotoxic drugs
    • Alas S, Bonavida B. 2001. Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in downregulation of Bcl-2 and sensitization to cytotoxic drugs. Cancer Res 61(13):5137-5144.
    • (2001) Cancer Res , vol.61 , Issue.13 , pp. 5137-5144
    • Alas, S.1    Bonavida, B.2
  • 4
    • 0034894958 scopus 로고    scopus 로고
    • Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis
    • Alas S, Emmanouilides C, Bonavida B. 2001. Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis. Clin Cancer Res 7(3):709-723.
    • (2001) Clin Cancer Res , vol.7 , Issue.3 , pp. 709-723
    • Alas, S.1    Emmanouilides, C.2    Bonavida, B.3
  • 6
    • 27544479318 scopus 로고    scopus 로고
    • Role of tyrosine kinase inhibitors in cancer therapy
    • Arora A, Scholar EM. 2005. Role of tyrosine kinase inhibitors in cancer therapy. J Pharmacol Exp Ther 315(3):971-979.
    • (2005) J Pharmacol Exp Ther , vol.315 , Issue.3 , pp. 971-979
    • Arora, A.1    Scholar, E.M.2
  • 7
    • 33750135226 scopus 로고    scopus 로고
    • Receptor-mediated tobacco toxicity: Cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes
    • Arredondo J, Chernyavsky AI, Jolkovsky DL, Pinkerton KE, Grando SA. 2006. Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes. FASEB J 20(12):2093-2101.
    • (2006) FASEB J , vol.20 , Issue.12 , pp. 2093-2101
    • Arredondo, J.1    Chernyavsky, A.I.2    Jolkovsky, D.L.3    Pinkerton, K.E.4    Grando, S.A.5
  • 8
    • 33847019644 scopus 로고    scopus 로고
    • Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3
    • Aziz MH, Manoharan HT, Verma AK. 2007. Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. Cancer Res 67(3):1385-1394.
    • (2007) Cancer Res , vol.67 , Issue.3 , pp. 1385-1394
    • Aziz, M.H.1    Manoharan, H.T.2    Verma, A.K.3
  • 10
    • 4243156987 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines
    • Barton BE, Karras JG, Murphy TF, Barton A, Huang HF. 2004. Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: direct STAT3 inhibition induces apoptosis in prostate cancer lines. Mol Cancer Ther 3(1):11-20.
    • (2004) Mol Cancer Ther , vol.3 , Issue.1 , pp. 11-20
    • Barton, B.E.1    Karras, J.G.2    Murphy, T.F.3    Barton, A.4    Huang, H.F.5
  • 11
    • 70349323403 scopus 로고    scopus 로고
    • Targeting signal transducer and activator of transcription signaling pathway in leukemias
    • Benekli M, Baumann H, Wetzler M. 2009. Targeting signal transducer and activator of transcription signaling pathway in leukemias. J Clin Oncol 27(26):4422-4432.
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4422-4432
    • Benekli, M.1    Baumann, H.2    Wetzler, M.3
  • 12
    • 0036093058 scopus 로고    scopus 로고
    • Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival
    • Benekli M, Xia Z, Donohue KA, Ford LA, Pixley LA, Baer MR, Baumann H, Wetzler M. 2002. Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival. Blood 99(1):252-257.
    • (2002) Blood , vol.99 , Issue.1 , pp. 252-257
    • Benekli, M.1    Xia, Z.2    Donohue, K.A.3    Ford, L.A.4    Pixley, L.A.5    Baer, M.R.6    Baumann, H.7    Wetzler, M.8
  • 13
    • 55749116156 scopus 로고    scopus 로고
    • Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance
    • Bewry NN, Nair RR, Emmons MF, Boulware D, Pinilla-Ibarz J, Hazlehurst LA. 2008. Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance. Mol Cancer Ther 7(10):3169-3175.
    • (2008) Mol Cancer Ther , vol.7 , Issue.10 , pp. 3169-3175
    • Bewry, N.N.1    Nair, R.R.2    Emmons, M.F.3    Boulware, D.4    Pinilla-Ibarz, J.5    Hazlehurst, L.A.6
  • 15
    • 32644434424 scopus 로고    scopus 로고
    • The role of constitutively active Stat6 in leukemia and lymphoma
    • Bruns HA, Kaplan MH. 2006. The role of constitutively active Stat6 in leukemia and lymphoma. Crit Rev Oncol Hematol 57(3):245-253.
    • (2006) Crit Rev Oncol Hematol , vol.57 , Issue.3 , pp. 245-253
    • Bruns, H.A.1    Kaplan, M.H.2
  • 16
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB, Jove R. 2002. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8(4):945-954.
    • (2002) Clin Cancer Res , vol.8 , Issue.4 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 19
    • 0030043695 scopus 로고    scopus 로고
    • A functionally defective allele of TAP1 results in loss of MHC class i antigen presentation in a human lung cancer
    • Chen HL, Gabrilovich D, Tampe R, Girgis KR, Nadaf S, Carbone DP. 1996. A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer. Nat Genet 13(2):210-213.
    • (1996) Nat Genet , vol.13 , Issue.2 , pp. 210-213
    • Chen, H.L.1    Gabrilovich, D.2    Tampe, R.3    Girgis, K.R.4    Nadaf, S.5    Carbone, D.P.6
  • 20
    • 0032577678 scopus 로고    scopus 로고
    • Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
    • Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE, Jr., Kuriyan J. 1998. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93(5):827-839.
    • (1998) Cell , vol.93 , Issue.5 , pp. 827-839
    • Chen, X.1    Vinkemeier, U.2    Zhao, Y.3    Jeruzalmi, D.4    Darnell Jr., J.E.5    Kuriyan, J.6
  • 21
    • 67249144899 scopus 로고    scopus 로고
    • Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes
    • Cheon H, Stark GR. 2009. Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes. Proc Natl Acad Sci U S A 106(23):9373-9378.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.23 , pp. 9373-9378
    • Cheon, H.1    Stark, G.R.2
  • 22
    • 79960393173 scopus 로고    scopus 로고
    • Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition
    • Chiu WT, Lee HT, Huang FJ, Aldape KD, Yao J, Steeg PS, Chou CY, Lu Z, Xie K, Huang S. 2011. Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res 71(14):4932- 4943.
    • (2011) Cancer Res , vol.71 , Issue.14 , pp. 4932-4943
    • Chiu, W.T.1    Lee, H.T.2    Huang, F.J.3    Aldape, K.D.4    Yao, J.5    Steeg, P.S.6    Chou, C.Y.7    Lu, Z.8    Xie, K.9    Huang, S.10
  • 23
    • 0345305266 scopus 로고    scopus 로고
    • Localization of IFN-gamma-activated Stat1 and IFN regulatory factors 1 and 2 in breast cancer cells
    • Connett JM, Hunt SR, Hickerson SM, Wu SJ, Doherty GM. 2003. Localization of IFN-gamma-activated Stat1 and IFN regulatory factors 1 and 2 in breast cancer cells. J Interferon Cytokine Res 23(11):621-630.
    • (2003) J Interferon Cytokine Res , vol.23 , Issue.11 , pp. 621-630
    • Connett, J.M.1    Hunt, S.R.2    Hickerson, S.M.3    Wu, S.J.4    Doherty, G.M.5
  • 24
    • 68649104728 scopus 로고    scopus 로고
    • Substantially reduced expression of PIAS1 is associated with colon cancer development
    • Coppola D, Parikh V, Boulware D, Blanck G. 2009. Substantially reduced expression of PIAS1 is associated with colon cancer development. J Cancer Res Clin Oncol 135(9):1287-1291.
    • (2009) J Cancer Res Clin Oncol , vol.135 , Issue.9 , pp. 1287-1291
    • Coppola, D.1    Parikh, V.2    Boulware, D.3    Blanck, G.4
  • 26
    • 35148822215 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-6 (STAT6) is a constitutively expressed survival factor in human prostate cancer
    • Das S, Roth CP, Wasson LM, Vishwanatha JK. 2007. Signal transducer and activator of transcription-6 (STAT6) is a constitutively expressed survival factor in human prostate cancer. Prostate 67(14):1550-1564.
    • (2007) Prostate , vol.67 , Issue.14 , pp. 1550-1564
    • Das, S.1    Roth, C.P.2    Wasson, L.M.3    Vishwanatha, J.K.4
  • 29
    • 38949165127 scopus 로고    scopus 로고
    • Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas
    • Ding BB, Yu JJ, Yu RY, Mendez LM, Shaknovich R, Zhang Y, Cattoretti G, Ye BH. 2008. Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood 111(3): 1515-1523.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1515-1523
    • Ding, B.B.1    Yu, J.J.2    Yu, R.Y.3    Mendez, L.M.4    Shaknovich, R.5    Zhang, Y.6    Cattoretti, G.7    Ye, B.H.8
  • 40
    • 33744920357 scopus 로고    scopus 로고
    • Role of STAT3 in type i interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation
    • Ho HH, Ivashkiv LB. 2006. Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation. J Biol Chem 281(20):14111-14118.
    • (2006) J Biol Chem , vol.281 , Issue.20 , pp. 14111-14118
    • Ho, H.H.1    Ivashkiv, L.B.2
  • 42
    • 23744481633 scopus 로고    scopus 로고
    • Evaluation of potential Stat3- regulated genes in human breast cancer
    • Hsieh FC, Cheng G, Lin J. 2005. Evaluation of potential Stat3- regulated genes in human breast cancer. Biochem Biophys Res Commun 335(2):292-299.
    • (2005) Biochem Biophys Res Commun , vol.335 , Issue.2 , pp. 292-299
    • Hsieh, F.C.1    Cheng, G.2    Lin, J.3
  • 44
    • 78649854047 scopus 로고    scopus 로고
    • Administration of interferon for two or more years decreases early stage hepatocellular carcinoma recurrence rate after radical ablation: A retrospective study of hepatitis C virus-related liver cancer
    • Ikeda K, Kobayashi M, Seko Y, Imai N, Hirakawa M, Kawamura Y, Sezaki H, Hosaka T, Akuta N, Saitoh S, Suzuki F, Suzuki Y, Arase Y, Kumada H. 2010. Administration of interferon for two or more years decreases early stage hepatocellular carcinoma recurrence rate after radical ablation: A retrospective study of hepatitis C virus-related liver cancer. Hepatol Res 40(12):1168-1175.
    • (2010) Hepatol Res , vol.40 , Issue.12 , pp. 1168-1175
    • Ikeda, K.1    Kobayashi, M.2    Seko, Y.3    Imai, N.4    Hirakawa, M.5    Kawamura, Y.6    Sezaki, H.7    Hosaka, T.8    Akuta, N.9    Saitoh, S.10    Suzuki, F.11    Suzuki, Y.12    Arase, Y.13    Kumada, H.14
  • 45
    • 24944444235 scopus 로고    scopus 로고
    • Rapid inhibition of MAPK signaling and antiproliferation effect via JAK/STAT signaling by interferonalpha in hepatocellular carcinoma cell lines
    • Inamura K, Matsuzaki Y, Uematsu N, Honda A, Tanaka N, Uchida K. 2005. Rapid inhibition of MAPK signaling and antiproliferation effect via JAK/STAT signaling by interferonalpha in hepatocellular carcinoma cell lines. Biochim Biophys Acta 1745(3):401-410.
    • (2005) Biochim Biophys Acta , vol.1745 , Issue.3 , pp. 401-410
    • Inamura, K.1    Matsuzaki, Y.2    Uematsu, N.3    Honda, A.4    Tanaka, N.5    Uchida, K.6
  • 47
    • 22944438723 scopus 로고    scopus 로고
    • Rational drug design of G-quartet DNA as anti-cancer agents
    • Jing N, Sha W, Li Y, Xiong W, Tweardy DJ. 2005. Rational drug design of G-quartet DNA as anti-cancer agents. Curr Pharm Des 11(22):2841-2854.
    • (2005) Curr Pharm des , vol.11 , Issue.22 , pp. 2841-2854
    • Jing, N.1    Sha, W.2    Li, Y.3    Xiong, W.4    Tweardy, D.J.5
  • 48
    • 84872320115 scopus 로고    scopus 로고
    • Repression of STAT3, STAT5A, and STAT5B expressions in chronic myelogenous leukemia cell line K-562 with unmodified or chemically modified siRNAs and induction of apoptosis
    • Epub ahead of print]. DOI: 10.1007/s00277-012-1575-2
    • Kaymaz BT, Selvi N, Gunduz C, Aktan C, Dalmizrak A, Saydam G, Kosova B. 2012. Repression of STAT3, STAT5A, and STAT5B expressions in chronic myelogenous leukemia cell line K-562 with unmodified or chemically modified siRNAs and induction of apoptosis. Ann Hematol 2012 [Epub ahead of print]. DOI: 10.1007/s00277-012-1575-2.
    • (2012) Ann Hematol , vol.2012
    • Kaymaz, B.T.1    Selvi, N.2    Gunduz, C.3    Aktan, C.4    Dalmizrak, A.5    Saydam, G.6    Kosova, B.7
  • 49
    • 44949128833 scopus 로고    scopus 로고
    • The effect of azacitidine on interleukin-6 signaling and nuclear factor-kappaB activation and its in vitro and in vivo activity against multiple myeloma
    • Khong T, Sharkey J, Spencer A. 2008. The effect of azacitidine on interleukin-6 signaling and nuclear factor-kappaB activation and its in vitro and in vivo activity against multiple myeloma. Haematologica 93(6):860-869.
    • (2008) Haematologica , vol.93 , Issue.6 , pp. 860-869
    • Khong, T.1    Sharkey, J.2    Spencer, A.3
  • 50
    • 0037138370 scopus 로고    scopus 로고
    • Signaling through the JAK/STAT pathway, recent advances and future challenges
    • Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. 2002. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285(1-2):1-24.
    • (2002) Gene , vol.285 , Issue.1-2 , pp. 1-24
    • Kisseleva, T.1    Bhattacharya, S.2    Braunstein, J.3    Schindler, C.W.4
  • 51
    • 78449258706 scopus 로고    scopus 로고
    • Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden
    • Klover PJ, Muller WJ, Robinson GW, Pfeiffer RM, Yamaji D, Hennighausen L. 2010. Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden. Neoplasia 12(11):899-905.
    • (2010) Neoplasia , vol.12 , Issue.11 , pp. 899-905
    • Klover, P.J.1    Muller, W.J.2    Robinson, G.W.3    Pfeiffer, R.M.4    Yamaji, D.5    Hennighausen, L.6
  • 52
  • 55
    • 33646973354 scopus 로고    scopus 로고
    • Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines
    • Kovarik A, Fojtova M, Boudny V, Adamkova L, Lauerova L, Kovarik J. 2005. Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines. Melanoma Res 15(6):481-488.
    • (2005) Melanoma Res , vol.15 , Issue.6 , pp. 481-488
    • Kovarik, A.1    Fojtova, M.2    Boudny, V.3    Adamkova, L.4    Lauerova, L.5    Kovarik, J.6
  • 58
    • 3943103442 scopus 로고    scopus 로고
    • RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells
    • Lee SO, Lou W, Qureshi KM, Mehraein-Ghomi F, Trump DL, Gao AC. 2004. RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. Prostate 60(4):303-309.
    • (2004) Prostate , vol.60 , Issue.4 , pp. 303-309
    • Lee, S.O.1    Lou, W.2    Qureshi, K.M.3    Mehraein-Ghomi, F.4    Trump, D.L.5    Gao, A.C.6
  • 59
    • 79953780211 scopus 로고    scopus 로고
    • Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes
    • Leibowitz MS, Andrade Filho PA, Ferrone S, Ferris RL. 2011. Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes. Cancer Immunol Immunother 60(4):525-535.
    • (2011) Cancer Immunol Immunother , vol.60 , Issue.4 , pp. 525-535
    • Leibowitz, M.S.1    Andrade Filho, P.A.2    Ferrone, S.3    Ferris, R.L.4
  • 60
    • 1442277094 scopus 로고    scopus 로고
    • Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: Effects of indole-3- carbinol (I3C) and genistein
    • Lian JP, Word B, Taylor S, Hammons GJ, Lyn-Cook BD. 2004. Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3- carbinol (I3C) and genistein. Anticancer Res 24(1):133-137.
    • (2004) Anticancer Res , vol.24 , Issue.1 , pp. 133-137
    • Lian, J.P.1    Word, B.2    Taylor, S.3    Hammons, G.J.4    Lyn-Cook, B.D.5
  • 61
    • 33750040230 scopus 로고    scopus 로고
    • Structure, function, and regulation of STAT proteins
    • Lim CP, Cao X. 2006. Structure, function, and regulation of STAT proteins. Mol Biosyst 2(11):536-550.
    • (2006) Mol Biosyst , vol.2 , Issue.11 , pp. 536-550
    • Lim, C.P.1    Cao, X.2
  • 62
    • 82655189564 scopus 로고    scopus 로고
    • STAT3 is necessary for proliferation and survival in colon cancerinitiating cells
    • Lin L, Liu A, Peng Z, Lin HJ, Li PK, Li C, Lin J. 2011. STAT3 is necessary for proliferation and survival in colon cancerinitiating cells. Cancer Res 71(23):7226-7237.
    • (2011) Cancer Res , vol.71 , Issue.23 , pp. 7226-7237
    • Lin, L.1    Liu, A.2    Peng, Z.3    Lin, H.J.4    Li, P.K.5    Li, C.6    Lin, J.7
  • 63
    • 38949131488 scopus 로고    scopus 로고
    • Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma
    • Liu YP, Tan YN, Wang ZL, Zeng L, Lu ZX, Li LL, Luo W, Tang M, Cao Y. 2008. Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. Int J Mol Med 21(2): 153-162.
    • (2008) Int J Mol Med , vol.21 , Issue.2 , pp. 153-162
    • Liu, Y.P.1    Tan, Y.N.2    Wang, Z.L.3    Zeng, L.4    Lu, Z.X.5    Li, L.L.6    Luo, W.7    Tang, M.8    Cao, Y.9
  • 65
    • 77951258125 scopus 로고    scopus 로고
    • STAT5 in B cell development and leukemia
    • Malin S, McManus S, Busslinger M. 2010. STAT5 in B cell development and leukemia. Curr Opin Immunol 22(2): 168-176.
    • (2010) Curr Opin Immunol , vol.22 , Issue.2 , pp. 168-176
    • Malin, S.1    McManus, S.2    Busslinger, M.3
  • 67
    • 84885472809 scopus 로고    scopus 로고
    • Role of STAT3 in Transformation and Drug Resistance in CML
    • Nair RR, Tolentino JH, Hazlehurst LA. 2012. Role of STAT3 in Transformation and Drug Resistance in CML. Front Oncol 2:30.
    • (2012) Front Oncol , vol.2 , pp. 30
    • Nair, R.R.1    Tolentino, J.H.2    Hazlehurst, L.A.3
  • 69
    • 40849096092 scopus 로고    scopus 로고
    • Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT)
    • Ozawa Y, Williams AH, Estes ML, Matsushita N, Boschelli F, Jove R, List AF. 2008. Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT). Leuk Res 32(6):893-903.
    • (2008) Leuk Res , vol.32 , Issue.6 , pp. 893-903
    • Ozawa, Y.1    Williams, A.H.2    Estes, M.L.3    Matsushita, N.4    Boschelli, F.5    Jove, R.6    List, A.F.7
  • 70
    • 0041806456 scopus 로고    scopus 로고
    • Analysis of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors
    • Paner GP, Silberman S, Hartman G, Micetich KC, Aranha GV, Alkan S. 2003. Analysis of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors. Anticancer Res 23(3B):2253-2260.
    • (2003) Anticancer Res , vol.23 , Issue.3 B , pp. 2253-2260
    • Paner, G.P.1    Silberman, S.2    Hartman, G.3    Micetich, K.C.4    Aranha, G.V.5    Alkan, S.6
  • 71
    • 85047691138 scopus 로고    scopus 로고
    • Stat3 is required for the development of skin cancer
    • Pedranzini L, Leitch A, Bromberg J. 2004. Stat3 is required for the development of skin cancer. J Clin Invest 114(5):619-622.
    • (2004) J Clin Invest , vol.114 , Issue.5 , pp. 619-622
    • Pedranzini, L.1    Leitch, A.2    Bromberg, J.3
  • 73
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type-I- and type-II-interferonmediated signalling
    • Platanias LC. 2005. Mechanisms of type-I- and type-II-interferonmediated signalling. Nat Rev Immunol 5(5):375-386.
    • (2005) Nat Rev Immunol , vol.5 , Issue.5 , pp. 375-386
    • Platanias, L.C.1
  • 74
    • 33847235341 scopus 로고    scopus 로고
    • Persistent activation of STAT3 by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells
    • Punjabi AS, Carroll PA, Chen L, Lagunoff M. 2007. Persistent activation of STAT3 by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells. J Virol 81(5):2449- 2458.
    • (2007) J Virol , vol.81 , Issue.5 , pp. 2449-2458
    • Punjabi, A.S.1    Carroll, P.A.2    Chen, L.3    Lagunoff, M.4
  • 77
    • 79957604461 scopus 로고    scopus 로고
    • Stat3 signaling in acute myeloid leukemia: Ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor
    • Redell MS, Ruiz MJ, Alonzo TA, Gerbing RB, Tweardy DJ. 2011. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood 117(21):5701-5709.
    • (2011) Blood , vol.117 , Issue.21 , pp. 5701-5709
    • Redell, M.S.1    Ruiz, M.J.2    Alonzo, T.A.3    Gerbing, R.B.4    Tweardy, D.J.5
  • 78
    • 33746570647 scopus 로고    scopus 로고
    • Tracking STAT nuclear traffic
    • Reich NC, Liu L. 2006. Tracking STAT nuclear traffic. Nat Rev Immunol 6(8):602-612.
    • (2006) Nat Rev Immunol , vol.6 , Issue.8 , pp. 602-612
    • Reich, N.C.1    Liu, L.2
  • 80
    • 52949111844 scopus 로고    scopus 로고
    • Inteferons pen the JAK-STAT pathway
    • Schindler C, Plumlee C. 2008. Inteferons pen the JAK-STAT pathway. Semin Cell Dev Biol 19(4):311-318.
    • (2008) Semin Cell Dev Biol , vol.19 , Issue.4 , pp. 311-318
    • Schindler, C.1    Plumlee, C.2
  • 81
    • 21344436180 scopus 로고    scopus 로고
    • Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3
    • Schlessinger K, Levy DE. 2005. Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3. Cancer Res 65(13):5828-5834.
    • (2005) Cancer Res , vol.65 , Issue.13 , pp. 5828-5834
    • Schlessinger, K.1    Levy, D.E.2
  • 82
    • 2142825067 scopus 로고    scopus 로고
    • Progressive dysregulation of transcription factors NF-kappa B and STAT1 in prostate cancer cells causes proangiogenic production of CXC chemokines
    • Shen H, Lentsch AB. 2004. Progressive dysregulation of transcription factors NF-kappa B and STAT1 in prostate cancer cells causes proangiogenic production of CXC chemokines. Am J Physiol Cell Physiol 286(4):C840-C847.
    • (2004) Am J Physiol Cell Physiol , vol.286 , Issue.4
    • Shen, H.1    Lentsch, A.B.2
  • 85
    • 79955780881 scopus 로고    scopus 로고
    • JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling
    • Song L, Rawal B, Nemeth JA, Haura EB. 2011. JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling. Mol Cancer Ther 10(3):481-494.
    • (2011) Mol Cancer Ther , vol.10 , Issue.3 , pp. 481-494
    • Song, L.1    Rawal, B.2    Nemeth, J.A.3    Haura, E.B.4
  • 86
    • 0031962552 scopus 로고    scopus 로고
    • Interferon-alpha resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression
    • Sun WH, Pabon C, Alsayed Y, Huang PP, Jandeska S, Uddin S, Platanias LC, Rosen ST. 1998. Interferon-alpha resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression. Blood 91(2):570-576.
    • (1998) Blood , vol.91 , Issue.2 , pp. 570-576
    • Sun, W.H.1    Pabon, C.2    Alsayed, Y.3    Huang, P.P.4    Jandeska, S.5    Uddin, S.6    Platanias, L.C.7    Rosen, S.T.8
  • 88
    • 20444476625 scopus 로고    scopus 로고
    • SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling
    • Tanaka T, Soriano MA, Grusby MJ. 2005. SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity 22(6):729-736.
    • (2005) Immunity , vol.22 , Issue.6 , pp. 729-736
    • Tanaka, T.1    Soriano, M.A.2    Grusby, M.J.3
  • 89
    • 84865295971 scopus 로고    scopus 로고
    • STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma
    • Tu B, Du L, Fan QM, Tang Z, Tang TT. 2012. STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. Cancer Lett 325(1): 80-88.
    • (2012) Cancer Lett , vol.325 , Issue.1 , pp. 80-88
    • Tu, B.1    Du, L.2    Fan, Q.M.3    Tang, Z.4    Tang, T.T.5
  • 90
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • Turkson J, Jove R. 2000. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 19(56):6613-6626.
    • (2000) Oncogene , vol.19 , Issue.56 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 94
    • 34548576919 scopus 로고    scopus 로고
    • Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides
    • Weerasinghe P, Garcia GE, Zhu Q, Yuan P, Feng L, Mao L, Jing N. 2007. Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides. Int J Oncol 31(1):129-136.
    • (2007) Int J Oncol , vol.31 , Issue.1 , pp. 129-136
    • Weerasinghe, P.1    Garcia, G.E.2    Zhu, Q.3    Yuan, P.4    Feng, L.5    Mao, L.6    Jing, N.7
  • 95
    • 0036793979 scopus 로고    scopus 로고
    • Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer
    • Widschwendter A, Tonko-Geymayer S, Welte T, Daxenbichler G, Marth C, Doppler W. 2002. Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer. Clin Cancer Res 8(10):3065-3074.
    • (2002) Clin Cancer Res , vol.8 , Issue.10 , pp. 3065-3074
    • Widschwendter, A.1    Tonko-Geymayer, S.2    Welte, T.3    Daxenbichler, G.4    Marth, C.5    Doppler, W.6
  • 97
    • 0347093460 scopus 로고    scopus 로고
    • Inhibitors of cytokine signal transduction
    • Wormald S, Hilton DJ. 2004. Inhibitors of cytokine signal transduction. J Biol Chem 279(2):821-824.
    • (2004) J Biol Chem , vol.279 , Issue.2 , pp. 821-824
    • Wormald, S.1    Hilton, D.J.2
  • 100
    • 0035866398 scopus 로고    scopus 로고
    • A novel serine-dependent proteolytic activity is responsible for truncated signal transducer and activator of transcription proteins in acute myeloid leukemia blasts
    • Xia Z, Salzler RR, Kunz DP, Baer MR, Kazim L, Baumann H, Wetzler M. 2001b. A novel serine-dependent proteolytic activity is responsible for truncated signal transducer and activator of transcription proteins in acute myeloid leukemia blasts. Cancer Res 61(4):1747-1753.
    • (2001) Cancer Res , vol.61 , Issue.4 , pp. 1747-1753
    • Xia, Z.1    Salzler, R.R.2    Kunz, D.P.3    Baer, M.R.4    Kazim, L.5    Baumann, H.6    Wetzler, M.7
  • 102
    • 84863115473 scopus 로고    scopus 로고
    • Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition
    • Xiong H, Hong J, Du W, Lin YW, Ren LL, Wang YC, Su WY, Wang JL, Cui Y, Wang ZH, Fang JY. 2012. Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition. J Biol Chem 287(8):5819-5832.
    • (2012) J Biol Chem , vol.287 , Issue.8 , pp. 5819-5832
    • Xiong, H.1    Hong, J.2    Du, W.3    Lin, Y.W.4    Ren, L.L.5    Wang, Y.C.6    Su, W.Y.7    Wang, J.L.8    Cui, Y.9    Zh, W.10    Fang, J.Y.11
  • 103
    • 69249203685 scopus 로고    scopus 로고
    • Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells
    • Xu G, Zhang C, Zhang J. 2009. Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells. Mol Med Report 2(5):819-824.
    • (2009) Mol Med Report , vol.2 , Issue.5 , pp. 819-824
    • Xu, G.1    Zhang, C.2    Zhang, J.3
  • 106
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
    • Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR. 2007. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev 21(11):1396-1408.
    • (2007) Genes Dev , vol.21 , Issue.11 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 107
    • 41849116690 scopus 로고    scopus 로고
    • Roles of unphosphorylated STATs in signaling
    • Yang J, Stark GR. 2008. Roles of unphosphorylated STATs in signaling. Cell Res 18(4):443-451.
    • (2008) Cell Res , vol.18 , Issue.4 , pp. 443-451
    • Yang, J.1    Stark, G.R.2
  • 109
    • 0036717295 scopus 로고    scopus 로고
    • Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation
    • Yoshida T, Hanada T, Tokuhisa T, Kosai K, Sata M, Kohara M, Yoshimura A. 2002. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med 196(5):641-653.
    • (2002) J Exp Med , vol.196 , Issue.5 , pp. 641-653
    • Yoshida, T.1    Hanada, T.2    Tokuhisa, T.3    Kosai, K.4    Sata, M.5    Kohara, M.6    Yoshimura, A.7
  • 110
    • 0032980574 scopus 로고    scopus 로고
    • Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway
    • You M, Yu DH, Feng GS. 1999. Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Mol Cell Biol 19(3):2416-2424.
    • (1999) Mol Cell Biol , vol.19 , Issue.3 , pp. 2416-2424
    • You, M.1    Yu, D.H.2    Feng, G.S.3
  • 111
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. 2009. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9(11):798-809.
    • (2009) Nat Rev Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 115
    • 77649178678 scopus 로고    scopus 로고
    • A novel small-molecule disrupts Stat3 SH2 domainphosphotyrosine interactions and Stat3-dependent tumor processes
    • Zhang X, Yue P, Fletcher S, Zhao W, Gunning PT, Turkson J. 2010. A novel small-molecule disrupts Stat3 SH2 domainphosphotyrosine interactions and Stat3-dependent tumor processes. Biochem Pharmacol 79(10):1398-1409.
    • (2010) Biochem Pharmacol , vol.79 , Issue.10 , pp. 1398-1409
    • Zhang, X.1    Yue, P.2    Fletcher, S.3    Zhao, W.4    Gunning, P.T.5    Turkson, J.6
  • 117
    • 0034936819 scopus 로고    scopus 로고
    • Interferon alpha induction of Stat1 and Stat2 and their prognostic significance in carcinoid tumors
    • Zhou Y, Wang S, Gobl A, Oberg K. 2001. Interferon alpha induction of Stat1 and Stat2 and their prognostic significance in carcinoid tumors. Oncology 60(4):330-338.
    • (2001) Oncology , vol.60 , Issue.4 , pp. 330-338
    • Zhou, Y.1    Wang, S.2    Gobl, A.3    Oberg, K.4
  • 118
    • 84860260532 scopus 로고    scopus 로고
    • Inhibition of STAT1 sensitizes renal cell carcinoma cells to radiotherapy and chemotherapy
    • Zhu H, Wang Z, Xu Q, Zhang Y, Zhai Y, Bai J, Liu M, Hui Z, Xu N. 2012. Inhibition of STAT1 sensitizes renal cell carcinoma cells to radiotherapy and chemotherapy. Cancer Biol Ther 13(6):401-407.
    • (2012) Cancer Biol Ther , vol.13 , Issue.6 , pp. 401-407
    • Zhu, H.1    Wang, Z.2    Xu, Q.3    Zhang, Y.4    Zhai, Y.5    Bai, J.6    Liu, M.7    Hui, Z.8    Xu, N.9
  • 119
    • 84866381896 scopus 로고    scopus 로고
    • Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistance
    • Zimmerman MA, Rahman NT, Yang D, Lahat G, Lazar AJ, Pollock RE, Lev D, Liu K. 2012. Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistance. Cancer Res 72(18):4724-4732.
    • (2012) Cancer Res , vol.72 , Issue.18 , pp. 4724-4732
    • Zimmerman, M.A.1    Rahman, N.T.2    Yang, D.3    Lahat, G.4    Lazar, A.J.5    Pollock, R.E.6    Lev, D.7    Liu, K.8


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