Inhibition of STAT1 sensitizes renal cell carcinoma cells to radiotherapy and chemotherapy

Cancer Biology and Therapy

Volumn 13, Issue 6, 2012, Pages 401-407

  Zhu, Hongxia ^a   Wang, Zaozao ^a   Xu, Qing ^a   Zhang, Ye ^b   Zhai, Yirui ^b   Bai, JinFeng ^a   Liu, Mei ^a   Hui, Zhouguang ^b   Xu, Ningzhi ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b CANCER HOSPITAL   (China)

Author keywords

Cell cycle; Chemoresistance; DNA damage; Radioresistance; Renal cell carcinoma; Signal transducer and activator of transcription 1

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PACLITAXEL; PROTEIN P21; RETINOBLASTOMA PROTEIN; STAT1 PROTEIN;

ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RESISTANCE; CARCINOMA CELL; CELL CYCLE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; DNA DAMAGE; DNA REPLICATION; GENE SILENCING; KIDNEY CARCINOMA; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 84860260532     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.19291     Document Type: Article

References (31)

1. Darnell JE Jr. STATs and gene regulation. Science 1997; 277:1630-5; PMID:9287210; http://dx.doi. org/10.1126/science.277.5332.1630.
2. Levy DE, Darnell JE Jr. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 2002; 3:651-62; PMID:12209125; http://dx.doi. org/10.1038/nrm909.
3. Brierley MM, Fish EN. Stats: multifaceted regulators of transcription. J Interferon Cytokine Res 2005; 25:733-44; PMID:16375601; http://dx.doi.org/10. 1089/jir.2005.25.733.
4. Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996; 84:431-42; PMID:8608597; http://dx.doi. org/10.1016/S0092-8674(00)81288-X.
5. Kim HS, Lee MS. STAT1 as a key modulator of cell death. Cell Signal 2007; 19:454-65; PMID:17085014; http://dx.doi.org/10.1016/j.cellsig.2006.09.003.
6. Ramana CV, Grammatikakis N, Chernov M, Nguyen H, Goh KC, Williams BR, et al. Regulation of c-myc expression by IFNgamma through Stat1-dependent and -independent pathways. EMBO J 2000; 19:263-72; PMID:10637230; http://dx.doi.org/10.1093/emboj/19.2.263.
7. Chin YE, Kitagawa M, Su WC, You ZH, Iwamoto Y, Fu XY. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science 1996; 272:719-22; PMID:8614832; http://dx.doi.org/10.1126/ science.272.5262.719.
8. Adámková L, Soucková K, Kovarík J. Transcription protein STAT1: biology and relation to cancer. Folia Biol (Praha) 2007; 53:1-6; PMID:17328836.
9. Thomas M, Finnegan CE, Rogers KM, Purcell JW, Trimble A, Johnston PG, et al. STAT1: a modulator of chemotherapy-induced apoptosis. Cancer Res 2004; 64:8357-64; PMID:15548705; http://dx.doi. org/10.1158/0008-5472.CAN-04-1864.
10. Hudelist G, Czerwenka K, Singer C, Pischinger K, Kubista E, Manavi M. cDNA array analysis of cytobrush-collected normal and malignant cervical epithelial cells: a feasibility study. Cancer Genet Cytogenet 2005; 158:35-42; PMID:15771902; http://dx.doi. org/10.1016/j.cancergencyto.2004.08.007.
11. Rajkumar T, Sabitha K, Vijayalakshmi N, Shirley S, Bose MV, Gopal G, et al. Identification and validation of genes involved in cervical tumourigenesis. BMC Cancer 2011; 11:80; PMID:21338529; http://dx.doi. org/10.1186/1471-2407-11- 80.
12. Gütgemann A, Golob M, Müller S, Buettner R, Bosserhoff AK. Isolation of invasion-associated cDNAs in melanoma. Arch Dermatol Res 2001; 293:283-90; PMID:11480587; http://dx.doi.org/10.1007/s004030100232.
13. Hui Z, Tretiakova M, Zhang Z, Li Y, Wang X, Zhu JX, et al. Radiosensitization by inhibiting STAT1 in renal cell carcinoma. Int J Radiat Oncol Biol Phys 2009; 73:288-95; PMID:19100922; http://dx.doi. org/10.1016/j.ijrobp.2008.08.043.
14. Rickardson L, Fryknäs M, Dhar S, Lövborg H, Gullbo J, Rydåker M, et al. Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles. Br J Cancer 2005; 93:483-92; PMID:16012520; http://dx.doi. org/10.1038/sj.bjc.6602699.
15. Roberts D, Schick J, Conway S, Biade S, Laub PB, Stevenson JP, et al. Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells. Br J Cancer 2005; 92:1149-58; PMID:15726096; http://dx.doi.org/10.1038/sj.bjc.6602447.
16. Khodarev NN, Beckett M, Labay E, Darga T, Roizman B, Weichselbaum RR. STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. Proc Natl Acad Sci USA 2004; 101:1714-9; PMID:14755057; http://dx.doi.org/10.1073/pnas.0308102100.
17. Stronach EA, Alfraidi AM, Rama NR, Datler C, Studd JB, Agarwal R, et al. HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer. Cancer Res 2011; 71:4412-22; PMID:21571862; http://dx.doi.org/10.1158/0008- 5472.CAN-10-4111.
18. Yagoda A, Abi-Rached B, Petrylak D. Chemotherapy for advanced renal-cell carcinoma: 1983-1993. Semin Oncol 1995; 22:42-60; PMID:7855619.
19. Ather MH, Masood N, Siddiqui T. Current management of advanced and metastatic renal cell carcinoma. Urol J 2010; 7:1-9; PMID:20209445.
20. Maity A, McKenna WG, Muschel RJ. The molecular basis for cell cycle delays following ionizing radiation: a review. Radiother Oncol 1994; 31:1-13; PMID:8041894; http://dx.doi.org/10.1016/0167-8140(94)90408-1.
21. Khodarev NN, Minn AJ, Efimova EV, Darga TE, Labay E, Beckett M, et al. Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells. Cancer Res 2007; 67:9214-20; PMID:17909027; http://dx.doi. org/10.1158/0008-5472.CAN-07-1019.
22. Pitroda SP, Wakim BT, Sood RF, Beveridge MG, Beckett MA, MacDermed DM, et al. STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect. BMC Med 2009; 7:68; PMID:19891767; http://dx.doi. org/10.1186/1741-7015-7-68.
23. Nakayama KI, Nakayama K. Ubiquitin ligases: cell cycle control and cancer. Nat Rev Cancer 2006; 6:369-81; PMID:16633365; http://dx.doi.org/10.1038/ nrc1881.
24. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. GADD45 regulates G2/M arrest, DNA repair and cell death in keratinocytes following ultraviolet exposure. J Invest Dermatol 2002; 119:22-6; PMID:12164919; http://dx.doi.org/10. 1046/j.1523-747.2002.01781.x.
25. Chan TA, Hwang PM, Hermeking H, Kinzler KW, Vogelstein B. Cooperative effects of genes controlling the G(2)/M checkpoint. Genes Dev 2000; 14:1584-8; PMID:10887152.
26. Townsend PA, Cragg MS, Davidson SM, McCormick J, Barry S, Lawrence KM, et al. STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. J Cell Sci 2005; 118:1629-39; PMID:15784679; http://dx.doi.org/10.1242/ jcs.01728.
27. Durbin JE, Hackenmiller R, Simon MC, Levy DE. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996; 84:443-50; PMID:8608598; http://dx.doi. org/10.1016/S0092-8674(00)81289-1.
28. Stein B, Brady H, Yang MX, Young DB, Barbosa MS. Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. J Biol Chem 1996; 271:11427-33; PMID:8626699; http://dx.doi.org/10.1074/jbc.271.19.11427.
29. McMullen ME, Bryant PW, Glembotski CC, Vincent PA, Pumiglia KM. Activation of p38 has opposing effects on the proliferation and migration of endothelial cells. J Biol Chem 2005; 280:20995-1003; PMID:15790570; http://dx.doi.org/10.1074/jbc. M407060200.
30. Phong MS, Van Horn RD, Li S, Tucker-Kellogg G, Surana U, Ye XS. p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cells. Mol Cell Biol 2010; 30:3816-26; PMID:20516219; http://dx.doi.org/10.1128/ MCB.00949-09.
31. Wang S, Raven JF, Koromilas AE. STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells. Mol Cancer Res 2010; 8:798-805; PMID:20407011; http://dx.doi. org/10.1158/1541-7786.MCR-10-0027.