Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten

Cancer Research

Volumn 70, Issue 6, 2010, Pages 2558-2567

  Barbieri, Isaia ^a   Pensa, Sara ^a   Pannellini, Tania ^b   Quaglino, Elena ^a   Maritano, Diego ^a,e   Demaria, Marco ^a   Voster, Alessandra ^a,f   Turkson, James ^d   Cavallo, Federica ^a   Watson, Christine J ^c   Provero, Paolo ^a   Piero, Musiani ^b   Poli, Valeria ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF CENTRAL FLORIDA   (United States)

^e S CROCE E CARLE HOSPITAL   (Italy)

^f RBM SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COOH TERMINAL TENSIN LIKE PROTEIN; RNA; STAT3 PROTEIN; TENSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST METASTASIS; BREAST TUMOR; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA EXTRACTION; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL NUCLEUS; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; PHOSPHORYLATION; RECEPTOR, ERBB-2; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 77950211267     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2840     Document Type: Article

References (42)

1. Fernandes A, Hamburger AW, Gerwin BI. ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells. Int J Cancer 1999;83:564-570
2. Turkson J, Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 2000;19:6613-6626
3. Kortylewski M, Jove R, Yu H. Targeting STAT3 affects melanoma on multiple fronts. Cancer Metastasis Rev 2005;24:315-327
4. Al Zaid Siddiquee K, Turkson J. STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res 2008;18: 254-267
5. Pensa S, Regis G, Boselli D, Novelli F, Poli V. STAT1 and STAT3 in tumorigenesis: two sides of the same coin? In: Stephanou A, editor. JAK-STAT Pathway in Disease. Austin: Landes Bioscience; 2009, p. 100-121
6. Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007;7:41-51.
7. Bromberg J, Wang TC. Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell 2009;15:79-80.
8. Bromberg JF, Wrzeszczynska MH, Devgan G, et al. Stat3 as an oncogene. Cell 1999;98:295-303.
9. Dechow TN, Pedranzini L, Leitch A, et al. Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc Natl Acad Sci U S A 2004;101: 10602-10607
10. Azare J, Leslie K, Al-Ahmadie H, et al. Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin β6. Mol Cell Biol 2007;27:4444-4453
11. Chan KS, Sano S, Kataoka K, et al. Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis. Oncogene 2008;27:1087-1094
12. Li Y, Du H, Qin Y, Roberts J, Cummings OW, Yan C. Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung. Cancer Res 2007;67:8494-8503
13. Diaz N, Minton S, Cox C, et al. Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res 2006; 12:20-28
14. Gritsko T, Williams A, Turkson J, et al. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res 2006;12: 11-19
15. Leslie K, Lang C, Devgan G, et al. Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res 2006;66:2544-2552
16. Berclaz G, Altermatt HJ, Rohrbach V, Siragusa A, Dreher E, Smith PD. EGFR dependent expression of STAT3 (but not STAT1) in breast cancer. Int J Oncol 2001;19:1155-1160
17. Lo HW, Hsu SC, Xia W, et al. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res 2007;67:9066-9076
18. Menard S, Balsari A, Tagliabue E, et al. Biology, prognosis and response to therapy of breast carcinomas according to HER2 score. Ann Oncol 2008;19:1706-1712
19. Muller WJ, Sinn E, Pattengale PK, Wallace R, Leder P. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 1988;54:105-115
20. Marcotte R, Muller WJ. Signal transduction in transgenic mouse models of human breast cancer-implications for human breast cancer. J Mammary Gland Biol Neoplasia 2008;13:323-335
21. Barbieri I, Quaglino E, Maritano D, et al. Stat3 is required for anchorage-independent growth and metastasis but not for mammary tumor development downstream of the ErbB-2 oncogene. Mol Carcinog 2010;49:114-120
22. Ranger JJ, Levy DE, Shahalizadeh S, Hallett M, Muller WJ. Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression. Cancer Res 2009;69:6823-6830
23. Nanni P, Pupa SM, Nicoletti G, et al. p185(neu) protein is required for tumor and anchorage-independent growth, not for cell proliferation of transgenic mammary carcinoma. Int J Cancer 2000;87: 186-194
24. Schiavone D, Dewilde S, Vallania F, Turkson J, Di Cunto F, Poli V. The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways. Biochem J 2009; 421:283-292
25. Maritano D, Sugrue ML, Tininini S, et al. The STAT3 isoforms α and β have unique and specific functions. Nat Immunol 2004;5:401-409
26. Siddiquee K, Zhang S, Guida WC, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A 2007; 104:7391-7396
27. Alonzi T, Maritano D, Gorgoni B, Rizzuto G, Libert C, Poli V. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation in the liver. Mol Cell Biol 2001;21: 1621-1632
28. Vallania F, Schiavone D, Dewilde S, et al. Genome-wide discovery of functional transcription factor binding sites by comparative genomics: the case of Stat3. Proc Natl Acad Sci U S A 2009; 106:5117-5122
29. Lo SH, Lo TB. Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. Cancer Res 2002;62:4217-4221
30. Di Carlo E, Diodoro MG, Boggio K, et al. Analysis of mammary carcinoma onset and progression in HER-2/neu oncogene transgenic mice reveals a lobular origin. Lab Invest 1999;79:1261-1269
31. Breitling R, Armengaud P, Amtmann A, Herzyk P. Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett 2004;573: 83-92.
32. Cheng GZ, Zhang WZ, Sun M, et al. Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function. J Biol Chem 2008;283:14665-14673
33. Katz M, Amit I, Citri A, et al. A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. Nat Cell Biol 2007;9: 961-969
34. Niessen CM. Tight junctions/adherens junctions: basic structure and function. J Investig Dermatol 2007;127:2525-2532
35. Pellegrin S, Mellor H. Actin stress fibres. J Cell Sci 2007;120:3491-3499
36. Albasri A, Seth R, Jackson D, et al. C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer. J Pathol 2009;218:57-65.
37. Liao YC, Chen NT, Shih YP, Dong Y, Lo SH. Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer through β-catenin. Cancer Res 2009;69:4563-4566
38. Sasaki H, Yukiue H, Kobayashi Y, Fukai I, Fujii Y. Cten mRNA expression is correlated with tumor progression in thymoma. Tumour Biol 2003;24:271-274
39. Sakashita K, Mimori K, Tanaka F, et al. Prognostic relevance of Tensin4 expression in human gastric cancer. Ann Surg Oncol 2008;15:2606-2613
40. Sasaki H, Moriyama S, Mizuno K, et al. Cten mRNA expression was correlated with tumor progression in lung cancers. Lung Cancer (Amsterdam, the Netherlands) 2003;40:151-155
41. Grivennikov S, Karin M. Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell 2008;13:7-9.
42. Guo W, Pylayeva Y, Pepe A, et al. β4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 2006;126:489-502.