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Volumn 117, Issue 21, 2011, Pages 5701-5709

Stat3 signaling in acute myeloid leukemia: Ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEUKEMIC AGENT; C 188 9; GRANULOCYTE COLONY STIMULATING FACTOR; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 79957604461     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-04-280123     Document Type: Article
Times cited : (194)

References (36)
  • 1
    • 59849101586 scopus 로고    scopus 로고
    • Function of mitochondrial Stat3 in cellular respiration
    • Wegrzyn J, Potla R, Chwae YJ, et al. Function of mitochondrial Stat3 in cellular respiration. Science. 2009;323(5915):793-797.
    • (2009) Science , vol.323 , Issue.5915 , pp. 793-797
    • Wegrzyn, J.1    Potla, R.2    Chwae, Y.J.3
  • 2
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu C-L, Meyer DJ, Campbell GS, et al. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science. 1995;269(5220):81-83.
    • (1995) Science , vol.269 , Issue.5220 , pp. 81-83
    • Yu, C.-L.1    Meyer, D.J.2    Campbell, G.S.3
  • 6
    • 0036093058 scopus 로고    scopus 로고
    • Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival
    • Benekli M, Xia Z, Donohue KA, et al. Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival. Blood. 2002;99(1):252-257.
    • (2002) Blood , vol.99 , Issue.1 , pp. 252-257
    • Benekli, M.1    Xia, Z.2    Donohue, K.A.3
  • 7
    • 0034781481 scopus 로고    scopus 로고
    • Constitutive activation of STAT transcription factors in acute myelogenous leukemia
    • DOI 10.1034/j.1600-0609.2001.00385.x
    • Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F. Constitutive activation of STAT transcription factors in acute myelogenous leukemia. Eur J Haematol. 2001;67(2):63-71. (Pubitemid 33010380)
    • (2001) European Journal of Haematology , vol.67 , Issue.2 , pp. 63-71
    • Spiekermann, K.1    Biethahn, S.2    Wilde, S.3    Hiddemann, W.4    Alves, F.5
  • 8
    • 33744500207 scopus 로고    scopus 로고
    • JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained
    • DOI 10.1038/sj.leu.2404206, PII 2404206
    • Steensma DP, McClure RF, Karp JE, et al. JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained. Leukemia. 2006;20(6):971-978. (Pubitemid 43797287)
    • (2006) Leukemia , vol.20 , Issue.6 , pp. 971-978
    • Steensma, D.P.1    McClure, R.F.2    Karp, J.E.3    Tefferi, A.4    Lasho T, L.5    Powell, H.L.6    DeWald, G.W.7    Kaufmann, S.H.8
  • 9
    • 55749116156 scopus 로고    scopus 로고
    • Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance
    • Bewry NN, Nair RR, Emmons MF, Boulware D, Pinilla-Ibarz J, Hazlehurst LA. Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance. Mol Cancer Ther. 2008;7(10):3169- 3175.
    • (2008) Mol Cancer Ther , vol.7 , Issue.10 , pp. 3169-3175
    • Bewry, N.N.1    Nair, R.R.2    Emmons, M.F.3    Boulware, D.4    Pinilla-Ibarz, J.5    Hazlehurst, L.A.6
  • 10
    • 65449117656 scopus 로고    scopus 로고
    • Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML
    • Zhou J, Bi C, Janakakumara JV, et al. Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML. Blood. 2009;113(17):4052-4062.
    • (2009) Blood , vol.113 , Issue.17 , pp. 4052-4062
    • Zhou, J.1    Bi, C.2    Janakakumara, J.V.3
  • 11
    • 62849104063 scopus 로고    scopus 로고
    • Chemical probes that competitively and selectively inhibit Stat3 activation
    • Xu X, Kasembeli M, Jiang X, Tweardy BJ, Tweardy DJ. Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS ONE. 2009;4(3):e4783.
    • (2009) PLoS ONE , vol.4 , Issue.3
    • Xu, X.1    Kasembeli, M.2    Jiang, X.3    Tweardy, B.J.4    Tweardy, D.J.5
  • 12
    • 16644362879 scopus 로고    scopus 로고
    • Increased susceptibility to liver injury after hemorrhagic shock in rats chronically fed ethanol: Role of nuclear factor-kappa B, interleukin 6, and granulocyte-colony stimulating factor
    • Ono M, Yu B, Hardison EG, Mastrangelo M-A, Tweardy DJ. Increased susceptibility to liver injury after hemorrhagic shock in rats chronically fed ethanol: role of nuclear factor-kappa B, interleukin 6, and granulocyte-colony stimulating factor. Shock. 2004;21(6):519-525.
    • (2004) Shock , vol.21 , Issue.6 , pp. 519-525
    • Ono, M.1    Yu, B.2    Hardison, E.G.3    Mastrangelo, M.-A.4    Tweardy, D.J.5
  • 13
    • 0031573141 scopus 로고    scopus 로고
    • Constitutive Activation of JAKs and STATs in BCR-Abl-Expressing Cell Lines and Peripheral Blood Cells Derived from Leukemic Patients
    • Chai SK, Nichols GL, Rothman P. Constitutive activation of JAKs and STATs in BCR-Ablexpressing cell lines and peripheral blood cells derived from leukemic patients. J Immunol. 1997;159(10):4720-4728. (Pubitemid 127471006)
    • (1997) Journal of Immunology , vol.159 , Issue.10 , pp. 4720-4728
    • Chai, S.K.1    Nichols, G.L.2    Rothman, P.3
  • 14
    • 0033178667 scopus 로고    scopus 로고
    • STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells
    • de Groot RP, Raaijmakers JAM, Lammers J-WJ, Jove R, Koenderman L. STAT5 activation by BCR-ABL contributes to transformation of K562 leukemia cells. Blood. 1999;94(3):1108-1112. (Pubitemid 29361844)
    • (1999) Blood , vol.94 , Issue.3 , pp. 1108-1112
    • De Groot, R.P.1    Raaijmakers, J.A.M.2    Lammers, J.-W.J.3    Jove, R.4    Koenderman, L.5
  • 15
    • 13544268345 scopus 로고    scopus 로고
    • Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival
    • DOI 10.1182/blood-2004-05-2006
    • Kim KT, Baird K, Ahn JY, et al. Pim-1 is upregulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival. Blood. 2005;105(4):1759-1767. (Pubitemid 40223700)
    • (2005) Blood , vol.105 , Issue.4 , pp. 1759-1767
    • Kim, K.-T.1    Baird, K.2    Ahn, J.-Y.3    Meltzer, P.4    Lilly, M.5    Levis, M.6    Small, D.7
  • 16
    • 0033451992 scopus 로고    scopus 로고
    • Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis
    • Shirogane T, Fukada T, Muller JM, Shima DT, Hibi M, Hirano T. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and anti-apoptosis. Immunity. 1999;11(6):709-719. (Pubitemid 30030710)
    • (1999) Immunity , vol.11 , Issue.6 , pp. 709-719
    • Shirogane, T.1    Fukada, T.2    Muller, J.M.M.3    Shima, D.T.4    Hibi, M.5    Hirano, T.6
  • 17
    • 76249127218 scopus 로고    scopus 로고
    • Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: Triggering the differentiation syndrome
    • Luesink M, Pennings JL, Wissink WM, et al. Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. Blood. 2009;114(27):5512-5521.
    • (2009) Blood , vol.114 , Issue.27 , pp. 5512-5521
    • Luesink, M.1    Pennings, J.L.2    Wissink, W.M.3
  • 18
    • 0034283859 scopus 로고    scopus 로고
    • Transcriptional regulation of Pim-1 by prolactin: Independence of a requirement for Jak2/Stat signaling
    • Buckley AR. Transcriptional regulation of Pim-1 by prolactin: independence of a requirement for Jak2/Stat signaling. J Neuroimmunol. 2000;109(1):40-46.
    • (2000) J Neuroimmunol , vol.109 , Issue.1 , pp. 40-46
    • Buckley, A.R.1
  • 19
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 2003;63(6):1270-1279. (Pubitemid 36348705)
    • (2003) Cancer Research , vol.63 , Issue.6 , pp. 1270-1279
    • Blaskovich, M.A.1    Sun, J.2    Cantor, A.3    Turkson, J.4    Jove, R.5    Sebti, S.M.6
  • 21
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of stat3 in macrophages and neutrophils
    • DOI 10.1016/S1074-7613(00)80005-9
    • Takeda K, Clausen BE, Kaisho T, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity. 1999;10(1):39-49. (Pubitemid 29077382)
    • (1999) Immunity , vol.10 , Issue.1 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3    Tsujimura, T.4    Terada, N.5    Forster, I.6    Akira, S.7
  • 24
    • 0034660463 scopus 로고    scopus 로고
    • Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6
    • Schuringa J-J, Wierenga ATJ, Kruijer W, Vellenga E. Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6. Blood. 2000;95(12):3765-3770. (Pubitemid 30412848)
    • (2000) Blood , vol.95 , Issue.12 , pp. 3765-3770
    • Schuringa, J.-J.1    Wierenga, A.T.J.2    Kruijer, W.3    Vellenga, E.4
  • 25
    • 3242683662 scopus 로고    scopus 로고
    • Single cell profiling of potentiated phospho-protein networks in cancer cells
    • DOI 10.1016/j.cell.2004.06.028, PII S0092867404006282
    • Irish JM, Hovland R, Krutzik PO, et al. Single cell profiling of potentiated phospho-protein networks in cancer cells. Cell. 2004;118(2):217-228. (Pubitemid 38962577)
    • (2004) Cell , vol.118 , Issue.2 , pp. 217-228
    • Irish, J.M.1    Hovland, R.2    Krutzik, P.O.3    Perez, O.D.4    Bruserud, O.5    Gjertsen, B.T.6    Nolan, G.P.7
  • 26
    • 52949129499 scopus 로고    scopus 로고
    • Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates
    • Kotecha N, Flores NJ, Irish JM, et al. Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell. 2008;14(4):335-343.
    • (2008) Cancer Cell , vol.14 , Issue.4 , pp. 335-343
    • Kotecha, N.1    Flores, N.J.2    Irish, J.M.3
  • 28
    • 27144475507 scopus 로고    scopus 로고
    • Investigation of the binding determinants of phosphopeptides targeted to the Src homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor
    • DOI 10.1021/jm050513m
    • Coleman DR, Ren Z, Mandal PK, et al. Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3: development of a high-affinity peptide inhibitor. J Med Chem. 2005;48(21):6661-6670. (Pubitemid 41504722)
    • (2005) Journal of Medicinal Chemistry , vol.48 , Issue.21 , pp. 6661-6670
    • Coleman IV, D.R.1    Ren, Z.2    Mandal, P.K.3    Cameron, A.G.4    Dyer, G.A.5    Muranjan, S.6    Campbell, M.7    Chen, X.8    McMurray, J.S.9
  • 29
    • 65249166871 scopus 로고    scopus 로고
    • Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription 3: Evaluation and molecular modeling
    • Mandal PK, Limbrick D, Coleman DR, et al. Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription 3: evaluation and molecular modeling. J Med Chem. 2009;52(8):2429-2442.
    • (2009) J Med Chem , vol.52 , Issue.8 , pp. 2429-2442
    • Mandal, P.K.1    Limbrick, D.2    Coleman, D.R.3
  • 30
    • 12344328541 scopus 로고    scopus 로고
    • Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity
    • Turkson J, Zhang S, Palmer J, et al. Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. Mol Cancer Ther. 2004;3(12):1533-1542. (Pubitemid 40136708)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.12 , pp. 1533-1542
    • Turkson, J.1    Zhang, S.2    Palmer, J.3    Kay, H.4    Stanko, J.5    Mora, L.B.6    Sebti, S.7    Yu, H.8    Jove, R.9
  • 31
    • 33750982120 scopus 로고    scopus 로고
    • Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization
    • DOI 10.1016/j.chembiol.2006.09.018, PII S1074552106003784
    • Schust J, Sperl B, Hollis A, Mayer TU, Berg T. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol. 2006;13(11):1235- 1242. (Pubitemid 44750735)
    • (2006) Chemistry and Biology , vol.13 , Issue.11 , pp. 1235-1242
    • Schust, J.1    Sperl, B.2    Hollis, A.3    Mayer, T.U.4    Berg, T.5
  • 32
  • 34
    • 58149267888 scopus 로고    scopus 로고
    • LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
    • Fuh B, Sobo M, Cen L, et al. LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model. Br J Cancer. 2009;100(1):106-112.
    • (2009) Br J Cancer , vol.100 , Issue.1 , pp. 106-112
    • Fuh, B.1    Sobo, M.2    Cen, L.3
  • 35
    • 73949111590 scopus 로고    scopus 로고
    • Anovel small-molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells
    • Lin L, Hutzen B, Li PK, et al.Anovel small-molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. Neoplasia. 2010;12(1):39-50.
    • (2010) Neoplasia , vol.12 , Issue.1 , pp. 39-50
    • Lin, L.1    Hutzen, B.2    Li, P.K.3
  • 36
    • 77954107667 scopus 로고    scopus 로고
    • Effects of STAT3 silencing on fate of chronic myelogenous leukemia K562 cells
    • Ma LD, Zhou M, Wen SH, et al. Effects of STAT3 silencing on fate of chronic myelogenous leukemia K562 cells. Leuk Lymphoma. 2010;51(7):1326-1336.
    • (2010) Leuk Lymphoma , vol.51 , Issue.7 , pp. 1326-1336
    • Ma, L.D.1    Zhou, M.2    Wen, S.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.