Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer

Clinical Cancer Research

Volumn 8, Issue 10, 2002, Pages 3065-3074

  Widschwendter, Andreas ^a,b   Tonko Geymayer, Sibylle ^b   Welte, Thomas ^b   Daxenbichler, Günter ^a   Marth, Christian ^a   Doppler, Wolfgang ^b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

ADULT; AGED; ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RETROSPECTIVE STUDY; SIGNAL TRANSDUCTION;

ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; COHORT STUDIES; DNA, NEOPLASM; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MIDDLE AGED; MILK PROTEINS; PHOSPHORYLATION; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TYROSINE;

EID: 0036793979     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Gouilleux-Gruart, V., Debierre-Grockiego, F., Gouilleux, F., Capiod, J-C., Claisse, J-F., Delobel, J., and Prin, L. Activated Stat related transcription factors in acute leukemia. Leuk. Lymphoma, 28: 83-88, 1997.
2. Bowman, T., Garcia, R., Turkson, J., and Jove, R. STATs in oncogenesis. Oncogene, 19: 2474-2488, 2000.
3. Lin, T. S., Mahajan, S., and Frank, D. A. STAT signaling in the pathogenesis and treatment of leukemias. Oncogene, 19: 2496-2504, 2000.
4. Coffer, P. J., Koenderman, L., and de Groot, R. P. The role of STATs in myeloid differentiation and leukemia. Oncogene, 19: 2511-2522, 2000.
5. Bromberg, J. F. Activation of STAT proteins and growth control. Bioessays, 23: 161-191, 2001.
6. Shen, Y., Devgan, G., Darnell, J. E., Jr., and Bromberg, J. F. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc. Natl. Acad. Sci. USA, 98: 1543-1548, 2001.
7. Levy, D. E., and Gillialand, D. G. Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruption in mice. Oncogene, 19: 2505-2510, 2000.
8. Chin, Y. E., Kitagawa, M., Kuida, K., Flavell, R. A., and Fu, X. Y. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol. Cell. Biol., 17: 5328-5337, 1997.
9. Johnson, M. R., Valentine, C., Basilico, C., and Mansukhani, A. FGF signaling activates STAT1 and p21 and inhibits the estrogen response and proliferation of MCF-7 cells. Oncogene, 16: 2647-2656, 1998.
10. Gooch, J. L., Herrera, R. E., and Yee, D. The role of p21 in interferon γ-mediated growth inhibition of human breast cancer cells. Cell Growth Differ., 11: 335-342, 2000.
11. Lee, C-K., Smith, E., Gimeno, R., Gertner, R., and Levy, D. E. STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-γ. J. Immunol., 164: 1286-1292, 2000.
12. Chapman, R. S., Lourenco, P. C., Tonner, E., Flint, D. J., Selbert, S., Takeda, K., Akira, S., Clarke, A. R., and Watson, C. J. Supression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev., 13: 2604-2616, 1999.
13. Watson, C. J., and Miller, W. R. Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br. J. Cancer, 71: 840-844, 1995.
14. Garcia, R., Bowman, T. L., Niu, G., Yu, H., Minton, S., Muro-Cacho, C. A., Cox, C. E., Falcone, R., Faiclough, R., Parsons, S., Laudano, A., Gazit, A., Levitzki, A., Kraker, A., and Jove, R. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene, 20: 2499-2513, 2001.
15. Page, C., Huang, M., Jin, X., Cho, K., Lilja, J., Reynolds, R. K., and Lin, J. Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells. Int. J. Oncol., 17: 23-28, 2000.
16. Garimorth, K., Welte, T., and Doppler, W. Generation of carboxyterminally deleted forms of STAT5 during preparation of cell extracts. Exp. Cell Res., 246: 148-151, 1998.
17. Welte, T., Garimorth, K., Philipp, S., and Doppler, W. Prolactin-dependent activation of a tyrosine phosphorylated DNA binding factor in mouse mammary epithelial cells. Mol. Endocrinol., 8: 1091-1102, 1994.
18. Mayr, S., Welte, T., Windegger, M., Lechner, J., May, P., Heinrich, P. C., Horn, F., and Doppler, W. Selective coupling of STAT factors to the mouse prolactin receptor. Eur. J. Biochem., 258: 784-793, 1998.
19. Blankenstein, M. A., and Benraad, T. J. Multilaboratory assessment of tissue prognostic factors in breast cancer: the EORTC receptor study group experience. In: K. S. Tonkin and A. M. Smith (eds.), Breast Cancer 1992, pp. 58-64. Montreal: Rodar Publishing Inc., 1992.
20. Widschwendter, A. Analysis of prolactin receptor transcripts in human hormone dependent tissues (Thesis). Innsbruck, Austria: University of Innsbruck. 1996.
21. Schmitt-Ney, M., Doppler, W., Ball, R. K., and Groner, B. β-Casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor. Mol. Cell. Biol., 11: 3745-3755, 1991.
22. Liu, X. W., Robinson, G. W., Wagner, K. U., Garrett, L., Wynshawboris, A., and Hennighausen, L. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev., 11: 179-186, 1997.
23. Teglund, S., McKay, C., Schuetz, E., van Deursen, J. M., Stravopodis, D., Wang, D., Brown, M., Bodner, S., Grosveld, G., and Ihle, J. N. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell, 93: 841-850, 1998.
24. Liu, B., Liao, J., Rao, X., Kushner, S. A., Chung, C. D., Chang, D. D., and Shuai, K. Inhibition of Stat1-mediated gene activation by PIASI. Proc. Natl. Acad. Sci. USA, 195: 10626-10631, 1998.
25. Shang, Y., Baumrucker, C. R., and Green, M. H. The induction and activation of STAT1 by all-trans-retinoic acid are mediated by RAR β pathways in breast cancer cells. Oncogene, 18: 6725-6732, 1999.
26. Chin, Y. E., Kitagawa, M., Su, W. C. S., You, Z. H., Iwamoto, Y., and Fu, X. Y. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21(WAF1/CIP1) mediated by STAT1. Science (Wash. DC), 272: 719-722, 1996.
27. WAF1 promoter region. Cancer Res., 60: 3290-3298, 2000.
28. Ouchi, T., Lee, S. W., Ouchi, M., Aaronson, S. A., and Horvath, C. M. Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-γ target genes. Proc. Natl. Acad. Sci. USA, 97: 5208-5213, 2000.
29. Kaplan, D. H., Shankaran, V., Dighe, A. S., Stockert, E., Aguet, M., Old, L. J., and Schreiber, R. D. Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice. Proc. Natl. Acad. Sci. USA, 95: 7556-7561, 1998.
30. Ramana, C. V., Chatterjee-Kishore, M., Nguyen, H., and Stark, G. R. Complex roles of Stat1 in regulating gene expression. Oncogene, 19: 2619-2627, 2000.
31. David, M., Petricoin, E. F., Igarashi, K., Feldman, G. M., Finbloom, D. S., and Larner, A. C. Prolactin activates the interferon-regulated p91 transcription factor and the JAK 2 kinase by tyrosine phosphorylation. Proc. Natl. Acad. Sci. USA, 91: 7174-7178, 1994.
32. Watanabe, G., Kaganoi, J., Imamura, M., Shimada, Y., Itami, A., Uchida, S., Sato, F., and Kitagawa, M. Progression of esophageal carcinoma by loss of EGF-STAT1 pathway. Cancer J., 7: 132-139, 2001.
33. Alexander, W. S., Starr, R., Fenner, J. E., Scott, C. L., Handman, E., Sprigg, N. S., Corbin, J. E., Cornish, A. L., Darwiche, R., Owczarek, C. M., Kay, T. W., Nicola, N. A., Hertzog, P. J., Metcalf, D., and Hilton, D. J. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell, 98: 597-608, 1999.
34. Cataldo, L., Chen, N. Y., Yuan, Q., Li, W., Ramamoorthy, P., Wagner, T. E., Sticca, R. P., and Chen, W. Y. Inhibition of oncogene STAT3 phosphorylation by a prolactin antagonist, hPRL-G129R, in T-47D human breast cancer cells. Int. J. Oncol., 17: 1179-1185, 2000.
35. Geymayer, S., and Doppler, W. Activation of NF-κB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated β-casein gene expression. FASEB J., 14: 1159-1170, 2000.
36. Cogswell, P. C., Guttridge, D. C., Funkhouser, W. K., and Baldwin, A. S., Jr. Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and Bcl-3. Oncogene. 19: 1123-1131, 2000.