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Volumn 117, Issue 12, 2011, Pages 3409-3420

High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; BCR ABL PROTEIN; BETA INTERFERON; DASATINIB; HYDROXYUREA; IMATINIB; MESSENGER RNA; NILOTINIB; PROTEIN TYROSINE KINASE INHIBITOR; STAT5 PROTEIN;

EID: 79953113891     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-10-248211     Document Type: Article
Times cited : (163)

References (56)
  • 1
    • 0023105320 scopus 로고
    • A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia
    • DOI 10.1038/325635a0
    • Chan LC, Karhi KK, Rayter SI, et al. A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia. Nature. 1987;325(6105):635-637. (Pubitemid 17055688)
    • (1987) Nature , vol.325 , Issue.6105 , pp. 635-637
    • Chan, L.C.1    Karhi, K.K.2    Rayter, S.I.3
  • 3
    • 0023133732 scopus 로고
    • 1-positive ALL
    • Clark SS, McLaughlin J, Crist WM, Champlin R, Witte ON. Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL. Science. 1987;235(4784):85-88. (Pubitemid 17229276)
    • (1987) Science , vol.235 , Issue.4784 , pp. 85-88
    • Clark, S.S.1    McLaughlin, J.2    Crist, W.M.3
  • 4
    • 0023634256 scopus 로고
    • Chronic myelogenous leukemia in blast crisis: Analysis of 242 patients
    • Kantarjian HM, Keating MJ, Talpaz M, et al. Chronic myelogenous leukemia in blast crisis: analysis of 242 patients. Am J Med. 1987;83(3):445-454.
    • (1987) Am J Med , vol.83 , Issue.3 , pp. 445-454
    • Kantarjian, H.M.1    Keating, M.J.2    Talpaz, M.3
  • 5
    • 0030853063 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells
    • Deininger MW, Goldman JM, Lydon N, Melo JV. The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood. 1997;90(9):3691-3698. (Pubitemid 27473440)
    • (1997) Blood , vol.90 , Issue.9 , pp. 3691-3698
    • Deininger, M.W.N.1    Goldman, J.M.2    Lydon, N.3    Melo, J.V.4
  • 6
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996;2(5):561-566.
    • (1996) Nat Med , vol.2 , Issue.5 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 7
    • 34247470836 scopus 로고    scopus 로고
    • Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia
    • DOI 10.1038/nrc2126, PII NRC2126
    • Weisberg E, Manley PW, Cowan-Jacob SW, Hochhaus A, Griffin JD. Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia. Nat Rev Cancer. 2007;7(5):345-356. (Pubitemid 46652483)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.5 , pp. 345-356
    • Weisberg, E.1    Manley, P.W.2    Cowan-Jacob, S.W.3    Hochhaus, A.4    Griffin, J.D.5
  • 8
    • 0033816156 scopus 로고    scopus 로고
    • Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
    • Buchdunger E, Cioffi CL, Law N, et al. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther. 2000;295(1):139-145.
    • (2000) J Pharmacol Exp Ther , vol.295 , Issue.1 , pp. 139-145
    • Buchdunger, E.1    Cioffi, C.L.2    Law, N.3
  • 9
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
    • Buchdunger E, Zimmermann J, Mett H, et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 1996;56(1):100-104.
    • (1996) Cancer Res , vol.56 , Issue.1 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3
  • 13
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • DOI 10.1182/blood-2002-09-2896
    • Branford S, Rudzki Z, Walsh S, et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood. 2003;102(1):276-283. (Pubitemid 36759665)
    • (2003) Blood , vol.102 , Issue.1 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Parkinson, I.4    Grigg, A.5    Szer, J.6    Taylor, K.7    Herrmann, R.8    Seymour, J.F.9    Arthur, C.10    Joske, D.11    Lynch, K.12    Hughes, T.13
  • 14
    • 33947266607 scopus 로고    scopus 로고
    • Optimizing therapy of chronic myeloid leukemia
    • DOI 10.1016/j.exphem.2007.01.023, PII S0301472X07000264
    • Deininger MW. Optimizing therapy of chronic myeloid leukemia. Exp Hematol. 2007;35(4)[suppl 1]:144-154. (Pubitemid 46427992)
    • (2007) Experimental Hematology , vol.35 , Issue.4 SUPPL. , pp. 144-154
    • Deininger, M.W.N.1
  • 16
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • DOI 10.1016/S1535-6108(02)00096-X
    • Shah NP, Nicoll JM, Nagar B, et al. Multiple BCRABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2002;2(2):117-125. (Pubitemid 41039112)
    • (2002) Cancer Cell , vol.2 , Issue.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3    Gorre, M.E.4    Paquette, R.L.5    Kuriyan, J.6    Sawyers, C.L.7
  • 17
    • 47049127238 scopus 로고    scopus 로고
    • Emerging stem cell concepts for imatinib-resistant chronic myeloid leukaemia: Implications for the biology, management, and therapy of the disease
    • DOI 10.1111/j.1365-2141.2008.07197.x
    • Valent P. Emerging stem cell concepts for imatinib-resistant chronic myeloid leukaemia: implications for the biology, management, and therapy of the disease. Br J Haematol. 2008;142(3):361-378. (Pubitemid 351965483)
    • (2008) British Journal of Haematology , vol.142 , Issue.3 , pp. 361-378
    • Valent, P.1
  • 18
    • 65249185560 scopus 로고    scopus 로고
    • Mechanisms of primary and secondary resistance to imatinib in chronic myeloid leukemia
    • Quintas-Cardama A, Kantarjian HM, Cortes JE. Mechanisms of primary and secondary resistance to imatinib in chronic myeloid leukemia. Cancer Control. 2009;16(2):122-131.
    • (2009) Cancer Control , vol.16 , Issue.2 , pp. 122-131
    • Quintas-Cardama, A.1    Kantarjian, H.M.2    Cortes, J.E.3
  • 19
    • 33847407174 scopus 로고    scopus 로고
    • + progenitors via JAK-2/STAT-5 pathway activation
    • + progenitors via JAK-2/STAT-5 pathway activation. Blood. 2007;109(5):2147-2155.
    • (2007) Blood , vol.109 , Issue.5 , pp. 2147-2155
    • Wang, Y.1    Cai, D.2    Brendel, C.3
  • 20
    • 0037438640 scopus 로고    scopus 로고
    • BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
    • DOI 10.1182/blood.V101.2.690
    • Donato NJ, Wu JY, Stapley J, et al. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood. 2003;101(2):690-698. (Pubitemid 36077594)
    • (2003) Blood , vol.101 , Issue.2 , pp. 690-698
    • Donato, N.J.1    Wu, J.Y.2    Stapley, J.3    Gallick, G.4    Lin, H.5    Arlinghaus, R.6    Talpaz, M.7
  • 21
    • 43549100498 scopus 로고    scopus 로고
    • Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells
    • Wu J, Meng F, Lu H, et al. Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. Blood. 2008;111(7):3821-3829.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3821-3829
    • Wu, J.1    Meng, F.2    Lu, H.3
  • 22
    • 0000506439 scopus 로고    scopus 로고
    • P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members
    • DOI 10.1074/jbc.271.49.31704
    • Ilaria RL Jr, Van Etten RA. P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem. 1996;271(49):31704-31710. (Pubitemid 26408636)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.49 , pp. 31704-31710
    • Ilaria Jr., R.L.1    Van Etten, R.A.2
  • 24
    • 0034653929 scopus 로고    scopus 로고
    • STAT5 activation contributes to growth and viability in Bcr/Abl- Transformed cells
    • Sillaber C, Gesbert F, Frank DA, Sattler M, Griffin JD. STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells. Blood. 2000;95(6):2118-2125. (Pubitemid 30151654)
    • (2000) Blood , vol.95 , Issue.6 , pp. 2118-2125
    • Sillaber, C.1    Gesbert, F.2    Frank, D.A.3    Sattler, M.4    Griffin, J.D.5
  • 25
    • 2942648711 scopus 로고    scopus 로고
    • Signal transduction pathways in Bcr-Abl transformed cells
    • Arlinghaus R, Sun T. Signal transduction pathways in Bcr-Abl transformed cells. Cancer Treat Res. 2004;119:239-270.
    • (2004) Cancer Treat Res , vol.119 , pp. 239-270
    • Arlinghaus, R.1    Sun, T.2
  • 28
    • 33746139407 scopus 로고    scopus 로고
    • Janus kinase 2: A critical target in chronic myelogenous leukemia
    • DOI 10.1158/0008-5472.CAN-06-0025
    • Samanta AK, Lin H, Sun T, Kantarjian H, Arlinghaus RB. Janus kinase 2: a critical target in chronic myelogenous leukemia. Cancer Res. 2006;66(13):6468-6472. (Pubitemid 44085597)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6468-6472
    • Samanta, A.K.1    Lin, H.2    Sun, T.3    Kantarjian, H.4    Arlinghaus, R.B.5
  • 29
    • 77953667590 scopus 로고    scopus 로고
    • Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia
    • 2
    • Hoelbl A, Schuster C, Kovacic B, et al. Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia. EMBO Mol Med. Mar 3;2(3):98-110.
    • EMBO Mol Med. Mar , vol.3 , Issue.3 , pp. 98-110
    • Hoelbl, A.1    Schuster, C.2    Kovacic, B.3
  • 30
    • 64949147229 scopus 로고    scopus 로고
    • Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients
    • Samanta AK, Chakraborty SN, Wang Y, et al. Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients. Oncogene. 2009;28(14):1669-1681.
    • (2009) Oncogene , vol.28 , Issue.14 , pp. 1669-1681
    • Samanta, A.K.1    Chakraborty, S.N.2    Wang, Y.3
  • 31
    • 0029863169 scopus 로고    scopus 로고
    • Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl
    • DOI 10.1084/jem.183.3.811
    • Carlesso N, Frank DA, Griffin JD. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J Exp Med. 1996;183(3):811-820. (Pubitemid 26113953)
    • (1996) Journal of Experimental Medicine , vol.183 , Issue.3 , pp. 811-820
    • Carlesso, N.1    Frank, D.A.2    Griffin, J.D.3
  • 32
    • 0029810923 scopus 로고    scopus 로고
    • Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
    • Shuai K, Halpern J, ten Hoeve J, Rao X, Sawyers CL. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene. 1996;13(2):247-254.
    • (1996) Oncogene , vol.13 , Issue.2 , pp. 247-254
    • Shuai, K.1    Halpern, J.2    Ten Hoeve, J.3    Rao, X.4    Sawyers, C.L.5
  • 33
    • 4444268818 scopus 로고    scopus 로고
    • Inactivation of stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
    • DOI 10.1128/MCB.24.18.8037-8047.2004
    • Cui Y, Riedlinger G, Miyoshi K, et al. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol. 2004;24(18):8037-8047. (Pubitemid 39167454)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.18 , pp. 8037-8047
    • Cui, Y.1    Riedlinger, G.2    Miyoshi, K.3    Tang, W.4    Li, C.5    Deng, C.-X.6    Robinson, G.W.7    Hennighausen, L.8
  • 37
    • 0034142208 scopus 로고    scopus 로고
    • A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5
    • Wang D, Moriggl R, Stravopodis D, et al.Asmall amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5. EMBO J. 2000;19(3):392-399. (Pubitemid 30072609)
    • (2000) EMBO Journal , vol.19 , Issue.3 , pp. 392-399
    • Wang, D.1    Moriggl, R.2    Stravopodis, D.3    Carpino, N.4    Marine, J.-C.5    Teglund, S.6    Feng, J.7    Ihle, J.N.8
  • 39
    • 47149112573 scopus 로고    scopus 로고
    • Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2
    • Grebien F, Kerenyi MA, Kovacic B, et al. Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood. 2008;111(9):4511-4522.
    • (2008) Blood , vol.111 , Issue.9 , pp. 4511-4522
    • Grebien, F.1    Kerenyi, M.A.2    Kovacic, B.3
  • 40
    • 73549084274 scopus 로고    scopus 로고
    • Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: Subcellular distribution and role of the transforming oncoprotein KIT D816V
    • Baumgartner C, Cerny-Reiterer S, Sonneck K, et al. Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V. Am J Pathol. 2009;175(6):2416-2429.
    • (2009) Am J Pathol , vol.175 , Issue.6 , pp. 2416-2429
    • Baumgartner, C.1    Cerny-Reiterer, S.2    Sonneck, K.3
  • 42
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • DOI 10.1126/science.1062538
    • Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 2001;293(5531):876-880. (Pubitemid 32743979)
    • (2001) Science , vol.293 , Issue.5531 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Nagesh, R.P.6    Sawyers, C.L.7
  • 43
    • 68949106066 scopus 로고    scopus 로고
    • Predictors of primary imatinib resistance in chronic myelogenous leukemia are distinct from those in secondary imatinib resistance
    • Zhang WW, Cortes JE, Yao H, et al. Predictors of primary imatinib resistance in chronic myelogenous leukemia are distinct from those in secondary imatinib resistance. J Clin Oncol. 2009;27(22):3642-3649.
    • (2009) J Clin Oncol , vol.27 , Issue.22 , pp. 3642-3649
    • Zhang, W.W.1    Cortes, J.E.2    Yao, H.3
  • 47
    • 69249236962 scopus 로고    scopus 로고
    • The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia
    • Klemm L, Duy C, Iacobucci I, et al. The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell. 2009;16(3):232-245.
    • (2009) Cancer Cell , vol.16 , Issue.3 , pp. 232-245
    • Klemm, L.1    Duy, C.2    Iacobucci, I.3
  • 50
    • 0030986407 scopus 로고    scopus 로고
    • Bcl-2 and c-myc expression, cell cycle kinetics and apoptosis during the progression of chronic myelogenous leukemia from diagnosis to blastic phase
    • DOI 10.1016/S0145-2126(97)00006-4, PII S0145212697000064
    • Handa H, Hegde UP, Kotelnikov VM, et al. Bcl-2 and c-myc expression, cell cycle kinetics and apoptosis during the progression of chronic myelogenous leukemia from diagnosis to blastic phase. Leuk Res. 1997;21(6):479-489. (Pubitemid 27384902)
    • (1997) Leukemia Research , vol.21 , Issue.6 , pp. 479-489
    • Handa, H.1    Hegde, U.P.2    Kotelnikov, V.M.3    Mundle, S.D.4    Dong, L.-M.5    Burke, P.6    Rose, S.7    Gaskin, F.8    Raza, A.9    Preisler, H.D.10
  • 51
    • 33644525274 scopus 로고    scopus 로고
    • Gene expression changes associated with progression and response in chronic myeloid leukemia
    • Radich JP, Dai H, Mao M, et al. Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2006;103(8):2794-2799.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.8 , pp. 2794-2799
    • Radich, J.P.1    Dai, H.2    Mao, M.3
  • 52
    • 0036493796 scopus 로고    scopus 로고
    • Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: Possible inadequacy of a negative feedback mechanism
    • DOI 10.1182/blood.V99.5.1766
    • Schultheis B, Carapeti-Marootian M, Hochhaus A, Weisser A, Goldman JM, Melo JV. Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism. Blood. 2002;99(5):1766-1775. (Pubitemid 34533052)
    • (2002) Blood , vol.99 , Issue.5 , pp. 1766-1775
    • Schultheis, B.1    Carapeti-Marootian, M.2    Hochhaus, A.3    Weisser, A.4    Goldman, J.M.5    Melo, J.V.6
  • 53
    • 48449091213 scopus 로고    scopus 로고
    • The proto-oncogene expression varies over the course of chronic myeloid leukemia
    • Vidovic A, Jankovic G, Colovic M, et al. The proto-oncogene expression varies over the course of chronic myeloid leukemia. Hematology. 2008;13(1):34-40.
    • (2008) Hematology , vol.13 , Issue.1 , pp. 34-40
    • Vidovic, A.1    Jankovic, G.2    Colovic, M.3
  • 55
    • 0034163579 scopus 로고    scopus 로고
    • The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5
    • Lord JD, McIntosh BC, Greenberg PD, Nelson BH. The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5. J Immunol. 2000;164(5):2533-2541. (Pubitemid 30115483)
    • (2000) Journal of Immunology , vol.164 , Issue.5 , pp. 2533-2541
    • Lord, J.D.1    McIntosh, B.C.2    Greenberg, P.D.3    Nelson, B.H.4
  • 56
    • 33846030792 scopus 로고    scopus 로고
    • In vivo transcript profiling and phylogenetic analysis identifies suppressor of cytokine signaling 2 as a direct signal transducer and activator of transcription 5b target in liver
    • Vidal OM, Merino R, Rico-Bautista E, et al. In vivo transcript profiling and phylogenetic analysis identifies suppressor of cytokine signaling 2 as a direct signal transducer and activator of transcription 5b target in liver. Mol Endocrinol. 2007;21(1):293-311.
    • (2007) Mol Endocrinol , vol.21 , Issue.1 , pp. 293-311
    • Vidal, O.M.1    Merino, R.2    Rico-Bautista, E.3


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