메뉴 건너뛰기




Volumn 15, Issue 2, 2013, Pages

The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ARCYRIAFLAVIN C; ARSENIC TRIOXIDE; BMS 833923; CD24 ANTIGEN; CYCLOPAMINE; CYTOKERATIN 6; FAS ANTIGEN; FAS LIGAND; GANT 58; GANT 61; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ITRACONAZOLE; LEQ 506; OSTEOPONTIN; PF 0444913; PHYSALIN F; PROTEIN PATCHED 1; ROBOTNIKININ; SARIDEGIB; SONIC HEDGEHOG PROTEIN; SONIDEGIB; TAK 441; TAMOXIFEN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; TRASTUZUMAB; UNCLASSIFIED DRUG; VISMODEGIB; ZERUMBONE;

EID: 84875805562     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3401     Document Type: Review
Times cited : (98)

References (102)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • 10.1002/ijc.25516, 21351269
    • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010, 127:2893-2917. 10.1002/ijc.25516, 21351269.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3    Forman, D.4    Mathers, C.5    Parkin, D.M.6
  • 2
    • 79953759268 scopus 로고    scopus 로고
    • The Global Economic Cost of Cancer
    • American Cancer Society
    • American Cancer Society The Global Economic Cost of Cancer. American Cancer Society., http://www.cancer.org/acs/groups/content/@internationalaffairs/documents/document/acspc-026203.pdf
  • 3
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: functions and mechanisms
    • 10.1101/gad.1693608, 18794343
    • Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev 2008, 22:2454-2472. 10.1101/gad.1693608, 18794343.
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 4
    • 0036899614 scopus 로고    scopus 로고
    • Pathways and consequences: Hedgehog signaling in human disease
    • 10.1016/S0962-8924(02)02405-4, 12495844
    • Mullor JL, Sanchez P, Ruiz i Altaba A. Pathways and consequences: Hedgehog signaling in human disease. Trends Cell Biol 2002, 12:562-569. 10.1016/S0962-8924(02)02405-4, 12495844.
    • (2002) Trends Cell Biol , vol.12 , pp. 562-569
    • Mullor, J.L.1    Sanchez, P.2    Ruiz i Altaba, A.3
  • 5
    • 80955181031 scopus 로고    scopus 로고
    • The Hedgehog's tale: developing strategies for targeting cancer
    • 10.1038/nrc3079, 3576812, 21614026
    • Ng JM, Curran T. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer 2011, 11:493-501. 10.1038/nrc3079, 3576812, 21614026.
    • (2011) Nat Rev Cancer , vol.11 , pp. 493-501
    • Ng, J.M.1    Curran, T.2
  • 6
    • 17144431776 scopus 로고    scopus 로고
    • Communicating with Hedgehogs
    • 10.1038/nrm1622, 15803137
    • Hooper JE, Scott MP. Communicating with Hedgehogs. Nat Rev Mol Cell Biol 2005, 6:306-317. 10.1038/nrm1622, 15803137.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 306-317
    • Hooper, J.E.1    Scott, M.P.2
  • 7
    • 0028948811 scopus 로고
    • The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
    • 10.1038/374363a0, 7885476
    • Porter JA, von Kessler DP, Ekker SC, Young KE, Lee JJ, Moses K, Beachy PA. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 1995, 374:363-366. 10.1038/374363a0, 7885476.
    • (1995) Nature , vol.374 , pp. 363-366
    • Porter, J.A.1    von Kessler, D.P.2    Ekker, S.C.3    Young, K.E.4    Lee, J.J.5    Moses, K.6    Beachy, P.A.7
  • 8
    • 0033598964 scopus 로고    scopus 로고
    • Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
    • 10.1016/S0092-8674(00)81677-3, 10619433
    • Burke R, Nellen D, Bellotto M, Hafen E, Senti KA, Dickson BJ, Basler K. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell 1999, 99:803-815. 10.1016/S0092-8674(00)81677-3, 10619433.
    • (1999) Cell , vol.99 , pp. 803-815
    • Burke, R.1    Nellen, D.2    Bellotto, M.3    Hafen, E.4    Senti, K.A.5    Dickson, B.J.6    Basler, K.7
  • 10
    • 77956814604 scopus 로고    scopus 로고
    • Interactions between Hedgehog proteins and their binding partners come into view
    • 10.1101/gad.1951710, 2939362, 20844013
    • Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C. Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev 2010, 24:2001-2012. 10.1101/gad.1951710, 2939362, 20844013.
    • (2010) Genes Dev , vol.24 , pp. 2001-2012
    • Beachy, P.A.1    Hymowitz, S.G.2    Lazarus, R.A.3    Leahy, D.J.4    Siebold, C.5
  • 11
    • 54049122121 scopus 로고    scopus 로고
    • The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
    • 10.1038/nature07358, 2679680, 18794898
    • McLellan JS, Zheng X, Hauk G, Ghirlando R, Beachy PA, Leahy DJ. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature 2008, 455:979-983. 10.1038/nature07358, 2679680, 18794898.
    • (2008) Nature , vol.455 , pp. 979-983
    • McLellan, J.S.1    Zheng, X.2    Hauk, G.3    Ghirlando, R.4    Beachy, P.A.5    Leahy, D.J.6
  • 12
    • 43049097898 scopus 로고    scopus 로고
    • Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding
    • 10.1016/j.devcel.2008.03.006, 18477453
    • Capurro MI, Xu P, Shi W, Li F, Jia A, Filmus J. Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev Cell 2008, 14:700-711. 10.1016/j.devcel.2008.03.006, 18477453.
    • (2008) Dev Cell , vol.14 , pp. 700-711
    • Capurro, M.I.1    Xu, P.2    Shi, W.3    Li, F.4    Jia, A.5    Filmus, J.6
  • 13
    • 0030602796 scopus 로고    scopus 로고
    • The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
    • 10.1016/S0092-8674(00)80094-X, 8706127
    • Alcedo J, Ayzenzon M, Von Ohlen T, Noll M, Hooper JE. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 1996, 86:221-232. 10.1016/S0092-8674(00)80094-X, 8706127.
    • (1996) Cell , vol.86 , pp. 221-232
    • Alcedo, J.1    Ayzenzon, M.2    Von Ohlen, T.3    Noll, M.4    Hooper, J.E.5
  • 14
    • 77952898697 scopus 로고    scopus 로고
    • Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
    • 10.1093/jmcb/mjp052, 2905064, 20083481
    • Stecca B, Ruiz IAA. Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. J Mol Cell Biol 2010, 2:84-95. 10.1093/jmcb/mjp052, 2905064, 20083481.
    • (2010) J Mol Cell Biol , vol.2 , pp. 84-95
    • Stecca, B.1    Ruiz, I.A.A.2
  • 15
    • 80052869447 scopus 로고    scopus 로고
    • Hedgehog signaling: networking to nurture a promalignant tumor microenvironment
    • 10.1158/1541-7786.MCR-11-0175, 3175256, 21775419
    • Harris LG, Samant RS, Shevde LA. Hedgehog signaling: networking to nurture a promalignant tumor microenvironment. Mol Cancer Res 2011, 9:1165-1174. 10.1158/1541-7786.MCR-11-0175, 3175256, 21775419.
    • (2011) Mol Cancer Res , vol.9 , pp. 1165-1174
    • Harris, L.G.1    Samant, R.S.2    Shevde, L.A.3
  • 16
    • 0242581681 scopus 로고    scopus 로고
    • Hedgehog signalling in the mouse requires intraflagellar transport proteins
    • 10.1038/nature02061, 14603322
    • Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 2003, 426:83-87. 10.1038/nature02061, 14603322.
    • (2003) Nature , vol.426 , pp. 83-87
    • Huangfu, D.1    Liu, A.2    Rakeman, A.S.3    Murcia, N.S.4    Niswander, L.5    Anderson, K.V.6
  • 17
    • 84867898455 scopus 로고    scopus 로고
    • Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland
    • 10.1016/j.ydbio.2012.09.005, 23000969
    • Garcia-Zaragoza E, Perez-Tavarez R, Ballester A, Lafarga V, Jimenez-Reinoso A, Ramirez A, Murillas R, Gallego MI. Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland. Dev Biol 2012, 372:28-44. 10.1016/j.ydbio.2012.09.005, 23000969.
    • (2012) Dev Biol , vol.372 , pp. 28-44
    • Garcia-Zaragoza, E.1    Perez-Tavarez, R.2    Ballester, A.3    Lafarga, V.4    Jimenez-Reinoso, A.5    Ramirez, A.6    Murillas, R.7    Gallego, M.I.8
  • 18
    • 69949136621 scopus 로고    scopus 로고
    • Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis
    • 10.1038/nm.2011, 2895420, 19701205
    • Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, Epstein EH, Dlugosz AA, Reiter JF. Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med 2009, 15:1055-1061. 10.1038/nm.2011, 2895420, 19701205.
    • (2009) Nat Med , vol.15 , pp. 1055-1061
    • Wong, S.Y.1    Seol, A.D.2    So, P.L.3    Ermilov, A.N.4    Bichakjian, C.K.5    Epstein, E.H.6    Dlugosz, A.A.7    Reiter, J.F.8
  • 19
    • 69949166247 scopus 로고    scopus 로고
    • Dual and opposing roles of primary cilia in medulloblastoma development
    • 10.1038/nm.2020, 2771737, 19701203
    • Han YG, Kim HJ, Dlugosz AA, Ellison DW, Gilbertson RJ, Alvarez-Buylla A. Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med 2009, 15:1062-1065. 10.1038/nm.2020, 2771737, 19701203.
    • (2009) Nat Med , vol.15 , pp. 1062-1065
    • Han, Y.G.1    Kim, H.J.2    Dlugosz, A.A.3    Ellison, D.W.4    Gilbertson, R.J.5    Alvarez-Buylla, A.6
  • 20
    • 64849094028 scopus 로고    scopus 로고
    • Hedgehog signalling: emerging evidence for non-canonical pathways
    • 10.1016/j.cellsig.2009.01.033, 19399989
    • Jenkins D. Hedgehog signalling: emerging evidence for non-canonical pathways. Cell Signal 2009, 21:1023-1034. 10.1016/j.cellsig.2009.01.033, 19399989.
    • (2009) Cell Signal , vol.21 , pp. 1023-1034
    • Jenkins, D.1
  • 21
    • 67349287806 scopus 로고    scopus 로고
    • The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex
    • 10.1038/ncb1880, 2844407, 19465923
    • Mille F, Thibert C, Fombonne J, Rama N, Guix C, Hayashi H, Corset V, Reed JC, Mehlen P. The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. Nat Cell Biol 2009, 11:739-746. 10.1038/ncb1880, 2844407, 19465923.
    • (2009) Nat Cell Biol , vol.11 , pp. 739-746
    • Mille, F.1    Thibert, C.2    Fombonne, J.3    Rama, N.4    Guix, C.5    Hayashi, H.6    Corset, V.7    Reed, J.C.8    Mehlen, P.9
  • 22
    • 79551514021 scopus 로고    scopus 로고
    • TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling
    • 10.1158/0008-5472.CAN-10-2993, 3077118, 21189326
    • Johnson RW, Nguyen MP, Padalecki SS, Grubbs BG, Merkel AR, Oyajobi BO, Matrisian LM, Mundy GR, Sterling JA. TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling. Cancer Res 2011, 71:822-831. 10.1158/0008-5472.CAN-10-2993, 3077118, 21189326.
    • (2011) Cancer Res , vol.71 , pp. 822-831
    • Johnson, R.W.1    Nguyen, M.P.2    Padalecki, S.S.3    Grubbs, B.G.4    Merkel, A.R.5    Oyajobi, B.O.6    Matrisian, L.M.7    Mundy, G.R.8    Sterling, J.A.9
  • 23
    • 42549142931 scopus 로고    scopus 로고
    • Mammary development in the embryo and adult: a journey of morphogenesis and commitment
    • 10.1242/dev.005439, 18296651
    • Watson CJ, Khaled WT. Mammary development in the embryo and adult: a journey of morphogenesis and commitment. Development 2008, 135:995-1003. 10.1242/dev.005439, 18296651.
    • (2008) Development , vol.135 , pp. 995-1003
    • Watson, C.J.1    Khaled, W.T.2
  • 24
    • 0242539939 scopus 로고    scopus 로고
    • Shh expression is required for embryonic hair follicle but not mammary gland development
    • 10.1016/S0012-1606(03)00401-9, 14623238
    • Michno K, Boras-Granic K, Mill P, Hui CC, Hamel PA. Shh expression is required for embryonic hair follicle but not mammary gland development. Dev Biol 2003, 264:153-165. 10.1016/S0012-1606(03)00401-9, 14623238.
    • (2003) Dev Biol , vol.264 , pp. 153-165
    • Michno, K.1    Boras-Granic, K.2    Mill, P.3    Hui, C.C.4    Hamel, P.A.5
  • 25
    • 33751235462 scopus 로고    scopus 로고
    • Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis
    • 10.1002/dvdy.20978, 2730892, 17039550
    • Kouros-Mehr H, Werb Z. Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn. 2006, 235:3404-3412. 10.1002/dvdy.20978, 2730892, 17039550.
    • (2006) Dev Dyn. , vol.235 , pp. 3404-3412
    • Kouros-Mehr, H.1    Werb, Z.2
  • 26
    • 33750372746 scopus 로고    scopus 로고
    • Gli3-mediated repression of Hedgehog targets is required for normal mammary development
    • 10.1242/dev.02542, 16914490
    • Hatsell SJ, Cowin P. Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development 2006, 133:3661-3670. 10.1242/dev.02542, 16914490.
    • (2006) Development , vol.133 , pp. 3661-3670
    • Hatsell, S.J.1    Cowin, P.2
  • 27
    • 0035477629 scopus 로고    scopus 로고
    • The Gli2 transcription factor is required for normal mouse mammary gland development
    • 10.1006/dbio.2001.0410, 11783999
    • Lewis MT, Ross S, Strickland PA, Sugnet CW, Jimenez E, Hui C, Daniel CW. The Gli2 transcription factor is required for normal mouse mammary gland development. Dev Biol 2001, 238:133-144. 10.1006/dbio.2001.0410, 11783999.
    • (2001) Dev Biol , vol.238 , pp. 133-144
    • Lewis, M.T.1    Ross, S.2    Strickland, P.A.3    Sugnet, C.W.4    Jimenez, E.5    Hui, C.6    Daniel, C.W.7
  • 28
  • 29
    • 34247398806 scopus 로고    scopus 로고
    • Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia
    • 10.1242/dev.02797, 17287253
    • Moraes RC, Zhang X, Harrington N, Fung JY, Wu MF, Hilsenbeck SG, Allred DC, Lewis MT. Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia. Development 2007, 134:1231-1242. 10.1242/dev.02797, 17287253.
    • (2007) Development , vol.134 , pp. 1231-1242
    • Moraes, R.C.1    Zhang, X.2    Harrington, N.3    Fung, J.Y.4    Wu, M.F.5    Hilsenbeck, S.G.6    Allred, D.C.7    Lewis, M.T.8
  • 32
    • 37249034086 scopus 로고    scopus 로고
    • Targeted expression of GLI1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure
    • 10.1074/jbc.M704280200, 17928300
    • Fiaschi M, Rozell B, Bergstrom A, Toftgard R, Kleman MI. Targeted expression of GLI1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure. J Biol Chem 2007, 282:36090-36101. 10.1074/jbc.M704280200, 17928300.
    • (2007) J Biol Chem , vol.282 , pp. 36090-36101
    • Fiaschi, M.1    Rozell, B.2    Bergstrom, A.3    Toftgard, R.4    Kleman, M.I.5
  • 33
    • 77951204905 scopus 로고    scopus 로고
    • Primary cilia regulate branching morphogenesis during mammary gland development
    • 10.1016/j.cub.2010.02.048, 2916967, 20381354
    • McDermott KM, Liu BY, Tlsty TD, Pazour GJ. Primary cilia regulate branching morphogenesis during mammary gland development. Curr Biol 2010, 20:731-737. 10.1016/j.cub.2010.02.048, 2916967, 20381354.
    • (2010) Curr Biol , vol.20 , pp. 731-737
    • McDermott, K.M.1    Liu, B.Y.2    Tlsty, T.D.3    Pazour, G.J.4
  • 36
    • 84873406827 scopus 로고    scopus 로고
    • Tracing the cellular origin of cancer
    • Blanpain C. Tracing the cellular origin of cancer. Nat Cell Biol 2012, 15:126-134.
    • (2012) Nat Cell Biol , vol.15 , pp. 126-134
    • Blanpain, C.1
  • 40
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • 10.1158/0008-5472.CAN-06-0054, 16778178
    • Liu S, Dontu G, Mantle ID, Patel S, Ahn NS, Jackson KW, Suri P, Wicha MS. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006, 66:6063-6071. 10.1158/0008-5472.CAN-06-0054, 16778178.
    • (2006) Cancer Res , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3    Patel, S.4    Ahn, N.S.5    Jackson, K.W.6    Suri, P.7    Wicha, M.S.8
  • 41
    • 66349097441 scopus 로고    scopus 로고
    • Development of mammary tumors by conditional expression of GLI1
    • 10.1158/0008-5472.CAN-08-3938, 2689922, 19458072
    • Fiaschi M, Rozell B, Bergstrom A, Toftgard R. Development of mammary tumors by conditional expression of GLI1. Cancer Res 2009, 69:4810-4817. 10.1158/0008-5472.CAN-08-3938, 2689922, 19458072.
    • (2009) Cancer Res , vol.69 , pp. 4810-4817
    • Fiaschi, M.1    Rozell, B.2    Bergstrom, A.3    Toftgard, R.4
  • 42
    • 47949105620 scopus 로고    scopus 로고
    • Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells
    • 10.1634/stemcells.2007-0691, 18292212
    • Li N, Singh S, Cherukuri P, Li H, Yuan Z, Ellisen LW, Wang B, Robbins D, DiRenzo J. Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells. Stem Cells 2008, 26:1253-1264. 10.1634/stemcells.2007-0691, 18292212.
    • (2008) Stem Cells , vol.26 , pp. 1253-1264
    • Li, N.1    Singh, S.2    Cherukuri, P.3    Li, H.4    Yuan, Z.5    Ellisen, L.W.6    Wang, B.7    Robbins, D.8    DiRenzo, J.9
  • 46
    • 73649145223 scopus 로고    scopus 로고
    • Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
    • 10.1002/emmm.200900039, 3378144, 20049737
    • Varnat F, Duquet A, Malerba M, Zbinden M, Mas C, Gervaz P, Ruiz i Altaba A. Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Mol Med 2009, 1:338-351. 10.1002/emmm.200900039, 3378144, 20049737.
    • (2009) EMBO Mol Med , vol.1 , pp. 338-351
    • Varnat, F.1    Duquet, A.2    Malerba, M.3    Zbinden, M.4    Mas, C.5    Gervaz, P.6    Ruiz i Altaba, A.7
  • 49
    • 68549087254 scopus 로고    scopus 로고
    • The Hedgehog signalling pathway as a therapeutic target in early breast cancer development
    • 10.1517/14728220903130612, 19659449
    • O'Toole SA, Swarbrick A, Sutherland RL. The Hedgehog signalling pathway as a therapeutic target in early breast cancer development. Expert Opin Ther Targets 2009, 13:1095-1103. 10.1517/14728220903130612, 19659449.
    • (2009) Expert Opin Ther Targets , vol.13 , pp. 1095-1103
    • O'Toole, S.A.1    Swarbrick, A.2    Sutherland, R.L.3
  • 50
    • 0030955557 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice overexpressing sonic hedgehog
    • 10.1126/science.276.5313.817, 9115210
    • Oro AE, Higgins KM, Hu Z, Bonifas JM, Epstein EH, Scott MP. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 1997, 276:817-821. 10.1126/science.276.5313.817, 9115210.
    • (1997) Science , vol.276 , pp. 817-821
    • Oro, A.E.1    Higgins, K.M.2    Hu, Z.3    Bonifas, J.M.4    Epstein, E.H.5    Scott, M.P.6
  • 52
    • 0345517109 scopus 로고    scopus 로고
    • The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations
    • 10.1016/S0959-8049(99)00017-9, 10505029
    • Vorechovsky I, Benediktsson KP, Toftgard R. The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations. Eur J Cancer 1999, 35:711-713. 10.1016/S0959-8049(99)00017-9, 10505029.
    • (1999) Eur J Cancer , vol.35 , pp. 711-713
    • Vorechovsky, I.1    Benediktsson, K.P.2    Toftgard, R.3
  • 53
    • 34447650761 scopus 로고    scopus 로고
    • High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization
    • 10.1186/bcr1356, 1410746, 16457699
    • Naylor TL, Greshock J, Wang Y, Colligon T, Yu QC, Clemmer V, Zaks TZ, Weber BL. High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Breast Cancer Res 2005, 7:R1186-1198. 10.1186/bcr1356, 1410746, 16457699.
    • (2005) Breast Cancer Res , vol.7
    • Naylor, T.L.1    Greshock, J.2    Wang, Y.3    Colligon, T.4    Yu, Q.C.5    Clemmer, V.6    Zaks, T.Z.7    Weber, B.L.8
  • 56
    • 4344586961 scopus 로고    scopus 로고
    • Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer
    • 10.1158/0008-5472.CAN-04-0416, 15342389
    • Kubo M, Nakamura M, Tasaki A, Yamanaka N, Nakashima H, Nomura M, Kuroki S, Katano M. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 2004, 64:6071-6074. 10.1158/0008-5472.CAN-04-0416, 15342389.
    • (2004) Cancer Res , vol.64 , pp. 6071-6074
    • Kubo, M.1    Nakamura, M.2    Tasaki, A.3    Yamanaka, N.4    Nakashima, H.5    Nomura, M.6    Kuroki, S.7    Katano, M.8
  • 60
    • 79954508252 scopus 로고    scopus 로고
    • Paradox of sonic hedgehog (SHH) transcriptional regulation: Alternative transcription initiation overrides the effect of downstream promoter DNA methylation
    • 10.4161/epi.6.4.14952, 21372638
    • ten Haaf A, Franken L, Heymann C, von Serenyi S, Cornelissen C, de Hoon JP, Veeck J, Luscher B, Knuchel R, Dahl E. Paradox of sonic hedgehog (SHH) transcriptional regulation: Alternative transcription initiation overrides the effect of downstream promoter DNA methylation. Epigenetics 2011, 6:465-477. 10.4161/epi.6.4.14952, 21372638.
    • (2011) Epigenetics , vol.6 , pp. 465-477
    • ten Haaf, A.1    Franken, L.2    Heymann, C.3    von Serenyi, S.4    Cornelissen, C.5    de Hoon, J.P.6    Veeck, J.7    Luscher, B.8    Knuchel, R.9    Dahl, E.10
  • 61
    • 54249097017 scopus 로고    scopus 로고
    • Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells
    • 10.1158/0008-5472.CAN-08-1078, 2596479, 18829534
    • Pratap J, Wixted JJ, Gaur T, Zaidi SK, Dobson J, Gokul KD, Hussain S, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. Cancer Res 2008, 68:7795-7802. 10.1158/0008-5472.CAN-08-1078, 2596479, 18829534.
    • (2008) Cancer Res , vol.68 , pp. 7795-7802
    • Pratap, J.1    Wixted, J.J.2    Gaur, T.3    Zaidi, S.K.4    Dobson, J.5    Gokul, K.D.6    Hussain, S.7    van Wijnen, A.J.8    Stein, J.L.9    Stein, G.S.10    Lian, J.B.11
  • 62
    • 33750595410 scopus 로고    scopus 로고
    • P63 overexpression induces the expression of Sonic Hedgehog
    • 10.1158/1541-7786.MCR-05-0149, 17050669
    • Caserta TM, Kommagani R, Yuan Z, Robbins DJ, Mercer CA, Kadakia MP. p63 overexpression induces the expression of Sonic Hedgehog. Mol Cancer Res 2006, 4:759-768. 10.1158/1541-7786.MCR-05-0149, 17050669.
    • (2006) Mol Cancer Res , vol.4 , pp. 759-768
    • Caserta, T.M.1    Kommagani, R.2    Yuan, Z.3    Robbins, D.J.4    Mercer, C.A.5    Kadakia, M.P.6
  • 63
    • 65849506662 scopus 로고    scopus 로고
    • Expression of Indian Hedgehog signaling molecules in breast cancer
    • 10.1007/s00432-008-0451-x, 18636275
    • Xuan Y, Lin Z. Expression of Indian Hedgehog signaling molecules in breast cancer. J Cancer Res Clin Oncol 2009, 135:235-240. 10.1007/s00432-008-0451-x, 18636275.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 235-240
    • Xuan, Y.1    Lin, Z.2
  • 64
    • 79952088432 scopus 로고    scopus 로고
    • Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer
    • 10.1111/j.1349-7006.2010.01779.x, 21091847
    • Souzaki M, Kubo M, Kai M, Kameda C, Tanaka H, Taguchi T, Tanaka M, Onishi H, Katano M. Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer. Cancer Sci 2011, 102:373-381. 10.1111/j.1349-7006.2010.01779.x, 21091847.
    • (2011) Cancer Sci , vol.102 , pp. 373-381
    • Souzaki, M.1    Kubo, M.2    Kai, M.3    Kameda, C.4    Tanaka, H.5    Taguchi, T.6    Tanaka, M.7    Onishi, H.8    Katano, M.9
  • 65
    • 84867116494 scopus 로고    scopus 로고
    • Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway
    • 10.1158/0008-5472.CAN-12-1248, 22875023
    • Ramaswamy B, Lu Y, Teng KY, Nuovo G, Li X, Shapiro CL, Majumder S. Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway. Cancer Res 2012, 72:5048-5059. 10.1158/0008-5472.CAN-12-1248, 22875023.
    • (2012) Cancer Res , vol.72 , pp. 5048-5059
    • Ramaswamy, B.1    Lu, Y.2    Teng, K.Y.3    Nuovo, G.4    Li, X.5    Shapiro, C.L.6    Majumder, S.7
  • 68
    • 34347226348 scopus 로고    scopus 로고
    • Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
    • 10.1073/pnas.0700776104, 1838820, 17392427
    • Stecca B, Mas C, Clement V, Zbinden M, Correa R, Piguet V, Beermann F, Ruiz IAA. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci USA 2007, 104:5895-5900. 10.1073/pnas.0700776104, 1838820, 17392427.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5895-5900
    • Stecca, B.1    Mas, C.2    Clement, V.3    Zbinden, M.4    Correa, R.5    Piguet, V.6    Beermann, F.7    Ruiz, I.A.A.8
  • 71
    • 63149124772 scopus 로고    scopus 로고
    • Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
    • 10.1073/pnas.0813203106, 2647977, 19246386
    • Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, de Sauvage FJ. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci USA 2009, 106:4254-4259. 10.1073/pnas.0813203106, 2647977, 19246386.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 4254-4259
    • Tian, H.1    Callahan, C.A.2    DuPree, K.J.3    Darbonne, W.C.4    Ahn, C.P.5    Scales, S.J.6    de Sauvage, F.J.7
  • 72
    • 79952193499 scopus 로고    scopus 로고
    • Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened
    • 10.1016/j.ydbio.2011.01.025, 3057274, 21276786
    • Visbal AP, LaMarca HL, Villanueva H, Li Y, Rosen JM, Lewis MT. Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened. Dev Biol 2011, 352:116-127. 10.1016/j.ydbio.2011.01.025, 3057274, 21276786.
    • (2011) Dev Biol , vol.352 , pp. 116-127
    • Visbal, A.P.1    LaMarca, H.L.2    Villanueva, H.3    Li, Y.4    Rosen, J.M.5    Lewis, M.T.6
  • 75
    • 84863806109 scopus 로고    scopus 로고
    • Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61
    • 10.1038/onc.2011.496, 3276742, 22056874
    • Harris LG, Pannell LK, Singh S, Samant RS, Shevde LA. Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61. Oncogene 2012, 31:3370-3380. 10.1038/onc.2011.496, 3276742, 22056874.
    • (2012) Oncogene , vol.31 , pp. 3370-3380
    • Harris, L.G.1    Pannell, L.K.2    Singh, S.3    Samant, R.S.4    Shevde, L.A.5
  • 76
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • 10.1016/j.cell.2009.11.007, 19945376
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890. 10.1016/j.cell.2009.11.007, 19945376.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 77
    • 85047698213 scopus 로고    scopus 로고
    • Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
    • 10.1038/sj.onc.1205416, 12082640
    • Blanco MJ, Moreno-Bueno G, Sarrio D, Locascio A, Cano A, Palacios J, Nieto MA. Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene 2002, 21:3241-3246. 10.1038/sj.onc.1205416, 12082640.
    • (2002) Oncogene , vol.21 , pp. 3241-3246
    • Blanco, M.J.1    Moreno-Bueno, G.2    Sarrio, D.3    Locascio, A.4    Cano, A.5    Palacios, J.6    Nieto, M.A.7
  • 78
    • 34547141894 scopus 로고    scopus 로고
    • Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    • 10.1073/pnas.0703900104, 1891217, 17537911
    • Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, Kutok JL, Hartwell K, Richardson AL, Weinberg RA. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci USA 2007, 104:10069-10074. 10.1073/pnas.0703900104, 1891217, 17537911.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10069-10074
    • Mani, S.A.1    Yang, J.2    Brooks, M.3    Schwaninger, G.4    Zhou, A.5    Miura, N.6    Kutok, J.L.7    Hartwell, K.8    Richardson, A.L.9    Weinberg, R.A.10
  • 79
    • 33747890209 scopus 로고    scopus 로고
    • The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells
    • 10.1158/0008-5472.CAN-06-0452, 16885353
    • Sterling JA, Oyajobi BO, Grubbs B, Padalecki SS, Munoz SA, Gupta A, Story B, Zhao M, Mundy GR. The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells. Cancer Res 2006, 66:7548-7553. 10.1158/0008-5472.CAN-06-0452, 16885353.
    • (2006) Cancer Res , vol.66 , pp. 7548-7553
    • Sterling, J.A.1    Oyajobi, B.O.2    Grubbs, B.3    Padalecki, S.S.4    Munoz, S.A.5    Gupta, A.6    Story, B.7    Zhao, M.8    Mundy, G.R.9
  • 80
    • 79953202493 scopus 로고    scopus 로고
    • Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysis
    • 10.1074/jbc.M110.174920, 3058990, 21169638
    • Das S, Samant RS, Shevde LA. Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysis. J Biol Chem 2011, 286:9612-9622. 10.1074/jbc.M110.174920, 3058990, 21169638.
    • (2011) J Biol Chem , vol.286 , pp. 9612-9622
    • Das, S.1    Samant, R.S.2    Shevde, L.A.3
  • 82
    • 84859074645 scopus 로고    scopus 로고
    • Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastases
    • 10.1371/journal.pone.0034374, 3315536, 22479615
    • Das S, Tucker JA, Khullar S, Samant RS, Shevde LA. Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastases. PloS One 2012, 7:e34374. 10.1371/journal.pone.0034374, 3315536, 22479615.
    • (2012) PloS One , vol.7
    • Das, S.1    Tucker, J.A.2    Khullar, S.3    Samant, R.S.4    Shevde, L.A.5
  • 83
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005, 365:1687-1717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 85
    • 0032486433 scopus 로고    scopus 로고
    • Teratogen-mediated inhibition of target tissue response to Shh signaling
    • 10.1126/science.280.5369.1603, 9616123
    • Cooper MK, Porter JA, Young KE, Beachy PA. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 1998, 280:1603-1607. 10.1126/science.280.5369.1603, 9616123.
    • (1998) Science , vol.280 , pp. 1603-1607
    • Cooper, M.K.1    Porter, J.A.2    Young, K.E.3    Beachy, P.A.4
  • 86
    • 45549094236 scopus 로고    scopus 로고
    • Dose-and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse
    • 10.1093/toxsci/kfn076, 2927868, 18411234
    • Lipinski RJ, Hutson PR, Hannam PW, Nydza RJ, Washington IM, Moore RW, Girdaukas GG, Peterson RE, Bushman W. Dose-and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse. Toxicol Sci 2008, 104:189-197. 10.1093/toxsci/kfn076, 2927868, 18411234.
    • (2008) Toxicol Sci , vol.104 , pp. 189-197
    • Lipinski, R.J.1    Hutson, P.R.2    Hannam, P.W.3    Nydza, R.J.4    Washington, I.M.5    Moore, R.W.6    Girdaukas, G.G.7    Peterson, R.E.8    Bushman, W.9
  • 87
    • 37249013214 scopus 로고    scopus 로고
    • ClinicalTrials.gov
    • ClinicalTrials.gov. , http://clinicaltrials.gov/ct2/home
  • 94
    • 34249867843 scopus 로고    scopus 로고
    • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
    • 10.1073/pnas.0609699104, 1866313, 17494766
    • Lauth M, Bergstrom A, Shimokawa T, Toftgard R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci USA 2007, 104:8455-8460. 10.1073/pnas.0609699104, 1866313, 17494766.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8455-8460
    • Lauth, M.1    Bergstrom, A.2    Shimokawa, T.3    Toftgard, R.4
  • 96
    • 77955804589 scopus 로고    scopus 로고
    • Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
    • 10.1073/pnas.1006822107, 2922148, 20624968
    • Kim J, Lee JJ, Kim J, Gardner D, Beachy PA. Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci USA 2010, 107:13432-13437. 10.1073/pnas.1006822107, 2922148, 20624968.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 13432-13437
    • Kim, J.1    Lee, J.J.2    Kim, J.3    Gardner, D.4    Beachy, P.A.5
  • 101
    • 58149506283 scopus 로고    scopus 로고
    • GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
    • 10.1101/gad.1753809, 2632164, 19136624
    • Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernandez-Zapico ME, Hanahan D. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev 2009, 23:24-36. 10.1101/gad.1753809, 2632164, 19136624.
    • (2009) Genes Dev , vol.23 , pp. 24-36
    • Nolan-Stevaux, O.1    Lau, J.2    Truitt, M.L.3    Chu, G.C.4    Hebrok, M.5    Fernandez-Zapico, M.E.6    Hanahan, D.7
  • 102
    • 79952392467 scopus 로고    scopus 로고
    • Why don't we get more cancer? A proposed role of the microenviron ment in restraining cancer progression
    • 10.1038/nm.2328, 3569482, 21383745
    • Bissell MJ, Hines WC. Why don't we get more cancer? A proposed role of the microenviron ment in restraining cancer progression. Nat Med 2011, 17:320-329. 10.1038/nm.2328, 3569482, 21383745.
    • (2011) Nat Med , vol.17 , pp. 320-329
    • Bissell, M.J.1    Hines, W.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.