-
1
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham P.W., McMahon A.P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15:2001;3059-3087.
-
(2001)
Genes Dev.
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
2
-
-
0036471671
-
Sonic hedgehog in the nervous system: Functions, modifications and mechanisms
-
Ho K.S., Scott M.P. Sonic hedgehog in the nervous system: functions, modifications and mechanisms. Curr. Opin. Neurobiol. 12:2002;57-63.
-
(2002)
Curr. Opin. Neurobiol.
, vol.12
, pp. 57-63
-
-
Ho, K.S.1
Scott, M.P.2
-
3
-
-
0036778132
-
Hedgehog signal transduction: Recent findings
-
Nybakken K., Perrimon N. Hedgehog signal transduction: recent findings. Curr. Opin. Genet. Dev. 12:2002;503-511.
-
(2002)
Curr. Opin. Genet. Dev.
, vol.12
, pp. 503-511
-
-
Nybakken, K.1
Perrimon, N.2
-
4
-
-
0029775625
-
Defective forebrain development in mice lacking gp330/megalin
-
Willnow T.E., et al. Defective forebrain development in mice lacking gp330/megalin. Proc. Natl. Acad. Sci. U. S. A. 93:1996;8460-8464.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 8460-8464
-
-
Willnow, T.E.1
-
5
-
-
0037067722
-
Megalin functions as an endocytic sonic hedgehog receptor
-
McCarthy R.A., et al. Megalin functions as an endocytic sonic hedgehog receptor. J. Biol. Chem. 277:2002;25660-25667.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25660-25667
-
-
McCarthy, R.A.1
-
6
-
-
0037144506
-
Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1
-
Mao J., et al. Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J. Biol. Chem. 277:2002;35156-35161.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35156-35161
-
-
Mao, J.1
-
7
-
-
0033230757
-
Ci: A complex transducer of the hedgehog signal
-
Aza-Blanc P., Kornberg T.B. Ci: a complex transducer of the hedgehog signal. Trends Genet. 15:1999;458-462.
-
(1999)
Trends Genet.
, vol.15
, pp. 458-462
-
-
Aza-Blanc, P.1
Kornberg, T.B.2
-
8
-
-
0033203419
-
The works of GLI and the power of hedgehog
-
Ruiz i Altaba A. The works of GLI and the power of hedgehog. Nat. Cell Biol. 1:1999;E147-E148.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 147-E148
-
-
Ruiz i Altaba, A.1
-
9
-
-
0036363951
-
Hedgehog-Gli signalling and the growth of the brain
-
Ruiz i Altaba A., et al. Hedgehog-Gli signalling and the growth of the brain. Nat. Rev. Neurosci. 3:2002;24-33.
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 24-33
-
-
Ruiz i Altaba, A.1
-
10
-
-
0034303585
-
Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
-
Jessell T.M. Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat. Rev. Genet. 1:2000;20-29.
-
(2000)
Nat. Rev. Genet.
, vol.1
, pp. 20-29
-
-
Jessell, T.M.1
-
11
-
-
0036559186
-
Gli and hedgehog in cancer: Tumours, embryos and stem cells
-
Ruiz i Altaba A., et al. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat. Rev. Cancer. 2:2002;361-372.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 361-372
-
-
Ruiz i Altaba, A.1
-
12
-
-
0034920373
-
Comparative biological responses to human Sonic, Indian, and Desert hedgehog
-
Pathi S., et al. Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Mech. Dev. 106:2001;107-117.
-
(2001)
Mech. Dev.
, vol.106
, pp. 107-117
-
-
Pathi, S.1
-
13
-
-
0030793114
-
Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult In vitro
-
Miao N., et al. Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult In vitro. J. Neurosci. 17:1997;5891-5899.
-
(1997)
J. Neurosci.
, vol.17
, pp. 5891-5899
-
-
Miao, N.1
-
14
-
-
0032850564
-
Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system
-
Traiffort E., et al. Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system. Eur. J. Neurosci. 11:1999;3199-3214.
-
(1999)
Eur. J. Neurosci.
, vol.11
, pp. 3199-3214
-
-
Traiffort, E.1
-
15
-
-
0035691884
-
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
-
Dahmane N., et al. The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development. 128:2001;5201-5212.
-
(2001)
Development
, vol.128
, pp. 5201-5212
-
-
Dahmane, N.1
-
16
-
-
0034907949
-
Sonic hedgehog regulates gastric gland morphogenesis in man and mouse
-
van den Brink G.R., et al. Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology. 121:2001;317-328.
-
(2001)
Gastroenterology
, vol.121
, pp. 317-328
-
-
Van den Brink, G.R.1
-
17
-
-
0032486433
-
Teratogen-mediated inhibition of target tissue response to Shh signaling
-
Cooper M.K., et al. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science. 280:1998;1603-1607.
-
(1998)
Science
, vol.280
, pp. 1603-1607
-
-
Cooper, M.K.1
-
18
-
-
0031723219
-
The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
-
Incardona J.P., et al. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development. 125:1998;3553-3562.
-
(1998)
Development
, vol.125
, pp. 3553-3562
-
-
Incardona, J.P.1
-
19
-
-
0034789139
-
Midline and laterality defects: Left and right meet in the middle
-
Roessler E., Muenke M. Midline and laterality defects: left and right meet in the middle. BioEssays. 23:2001;888-900.
-
(2001)
BioEssays
, vol.23
, pp. 888-900
-
-
Roessler, E.1
Muenke, M.2
-
20
-
-
0034107360
-
Genetics of ventral forebrain development and holoprosencephaly
-
Muenke M., Beachy P.A. Genetics of ventral forebrain development and holoprosencephaly. Curr. Opin. Genet. Dev. 10:2000;262-269.
-
(2000)
Curr. Opin. Genet. Dev.
, vol.10
, pp. 262-269
-
-
Muenke, M.1
Beachy, P.A.2
-
21
-
-
0036221373
-
Extreme variability of expression of a Sonic Hedgehog mutation: Attention difficulties and holoprosencephaly
-
Heussler H.S., et al. Extreme variability of expression of a Sonic Hedgehog mutation: attention difficulties and holoprosencephaly. Arch. Dis. Child. 86:2002;293-296.
-
(2002)
Arch. Dis. Child.
, vol.86
, pp. 293-296
-
-
Heussler, H.S.1
-
22
-
-
0030955557
-
Basal cell carcinomas in mice overexpressing sonic hedgehog
-
Oro A.E., et al. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science. 276:1997;817-821.
-
(1997)
Science
, vol.276
, pp. 817-821
-
-
Oro, A.E.1
-
23
-
-
0037200078
-
Medulloblastoma growth inhibition by Hedgehog pathway blockade
-
Berman D.M., et al. Medulloblastoma growth inhibition by Hedgehog pathway blockade. Science. 297:2002;1559-1561.
-
(2002)
Science
, vol.297
, pp. 1559-1561
-
-
Berman, D.M.1
-
24
-
-
0033679003
-
The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly
-
Incardona J.P., Roelink H. The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly. Cell. Mol. Life Sci. 57:2000;1709-1719.
-
(2000)
Cell. Mol. Life Sci.
, vol.57
, pp. 1709-1719
-
-
Incardona, J.P.1
Roelink, H.2
-
25
-
-
0032474837
-
Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
-
Bellaiche Y., et al. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature. 394:1998;85-88.
-
(1998)
Nature
, vol.394
, pp. 85-88
-
-
Bellaiche, Y.1
-
26
-
-
0032500662
-
The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate
-
Lind T., et al. The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate. J. Biol. Chem. 273:1998;26265-26268.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26265-26268
-
-
Lind, T.1
-
27
-
-
0032718876
-
A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses
-
Simmons A.D., et al. A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses. Hum. Mol. Genet. 8:1999;2155-2164.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 2155-2164
-
-
Simmons, A.D.1
-
28
-
-
0035902140
-
The Hedgehog and Wnt signalling pathways in cancer
-
Taipale J., Beachy P.A. The Hedgehog and Wnt signalling pathways in cancer. Nature. 411:2001;349-354.
-
(2001)
Nature
, vol.411
, pp. 349-354
-
-
Taipale, J.1
Beachy, P.A.2
-
29
-
-
0032409157
-
Hedgehog and Patched in neural development and disease
-
Goodrich L.V., Scott M.P. Hedgehog and Patched in neural development and disease. Neuron. 21:1998;1243-1257.
-
(1998)
Neuron
, vol.21
, pp. 1243-1257
-
-
Goodrich, L.V.1
Scott, M.P.2
-
30
-
-
0035863498
-
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
-
Wetmore C., et al. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res. 61:2001;513-516.
-
(2001)
Cancer Res.
, vol.61
, pp. 513-516
-
-
Wetmore, C.1
-
31
-
-
0032694528
-
Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
-
Aszterbaum M., et al. Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat. Med. 5:1999;1285-1291.
-
(1999)
Nat. Med.
, vol.5
, pp. 1285-1291
-
-
Aszterbaum, M.1
-
32
-
-
0036556309
-
Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly
-
Ming J.E., et al. Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly. Hum. Genet. 110:2002;297-301.
-
(2002)
Hum. Genet.
, vol.110
, pp. 297-301
-
-
Ming, J.E.1
-
33
-
-
0035849901
-
Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
-
Eggenschwiler J.T., et al. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature. 412:2001;194-198.
-
(2001)
Nature
, vol.412
, pp. 194-198
-
-
Eggenschwiler, J.T.1
-
34
-
-
0035850269
-
Developmental biology. Vesicles and the spinal cord
-
Jeong J., McMahon A.P. Developmental biology. Vesicles and the spinal cord. Nature. 412:2001;136-137.
-
(2001)
Nature
, vol.412
, pp. 136-137
-
-
Jeong, J.1
McMahon, A.P.2
-
35
-
-
0033491071
-
Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli
-
Stone A., et al. Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J. Cell Sci. 112:1999;4437-4448.
-
(1999)
J. Cell Sci.
, vol.112
, pp. 4437-4448
-
-
Stone, A.1
-
36
-
-
0036648241
-
Mutations in SUFU predispose to medulloblastoma
-
Taylor M.D., et al. Mutations in SUFU predispose to medulloblastoma. Nat. Genet. 31:2002;306-310.
-
(2002)
Nat. Genet.
, vol.31
, pp. 306-310
-
-
Taylor, M.D.1
-
37
-
-
0033808256
-
Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
-
Litingtung Y., Chiang C. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat. Neurosci. 3:2000;979-985.
-
(2000)
Nat. Neurosci.
, vol.3
, pp. 979-985
-
-
Litingtung, Y.1
Chiang, C.2
-
38
-
-
0036644995
-
GLI3 is not mutated commonly in sporadic medulloblastomas
-
Erez A., et al. GLI3 is not mutated commonly in sporadic medulloblastomas. Cancer. 95:2002;28-31.
-
(2002)
Cancer
, vol.95
, pp. 28-31
-
-
Erez, A.1
-
39
-
-
0030844141
-
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
-
Dahmane N., et al. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature. 389:1997;876-881.
-
(1997)
Nature
, vol.389
, pp. 876-881
-
-
Dahmane, N.1
-
40
-
-
0034724219
-
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
-
Nilsson M., et al. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc. Natl. Acad. Sci. U. S. A. 97:2000;3438-3443.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 3438-3443
-
-
Nilsson, M.1
-
41
-
-
0034091805
-
Basal cell carcinomas in mice overexpressing Gli2 in skin
-
Grachtchouk M., et al. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat. Genet. 24:2000;216-217.
-
(2000)
Nat. Genet.
, vol.24
, pp. 216-217
-
-
Grachtchouk, M.1
-
42
-
-
0034055649
-
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
-
Park H.L., et al. Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development. 127:2000;1593-1605.
-
(2000)
Development
, vol.127
, pp. 1593-1605
-
-
Park, H.L.1
-
43
-
-
0031020221
-
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development
-
Mo R., et al. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development. 124:1997;113-123.
-
(1997)
Development
, vol.124
, pp. 113-123
-
-
Mo, R.1
-
44
-
-
0031694448
-
Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired
-
Brown S.A., et al. Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired. Nat. Genet. 20:1998;180-183.
-
(1998)
Nat. Genet.
, vol.20
, pp. 180-183
-
-
Brown, S.A.1
-
45
-
-
0036139973
-
Zic2 controls cerebellar development in cooperation with Zic1
-
Aruga J., et al. Zic2 controls cerebellar development in cooperation with Zic1. J. Neurosci. 22:2002;218-225.
-
(2002)
J. Neurosci.
, vol.22
, pp. 218-225
-
-
Aruga, J.1
-
46
-
-
0032507944
-
Gli/Zic factors pattern the neural plate by defining domains of cell differentiation
-
Brewster R., et al. Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. Nature. 393:1998;579-583.
-
(1998)
Nature
, vol.393
, pp. 579-583
-
-
Brewster, R.1
-
47
-
-
0035831529
-
Physical and functional interactions between Zic and Gli proteins
-
Koyabu Y., et al. Physical and functional interactions between Zic and Gli proteins. J. Biol. Chem. 276:2001;6889-6892.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 6889-6892
-
-
Koyabu, Y.1
-
48
-
-
0035141226
-
Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway
-
Kim P.C., et al. Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway. J. Pediatr. Surg. 36:2001;381-384.
-
(2001)
J. Pediatr. Surg.
, vol.36
, pp. 381-384
-
-
Kim, P.C.1
-
49
-
-
18344379127
-
Introduction of wild-type patched gene suppresses the oncogenic potential of human squamous cell carcinoma cell lines including A431
-
Koike C., et al. Introduction of wild-type patched gene suppresses the oncogenic potential of human squamous cell carcinoma cell lines including A431. Oncogene. 21:2002;2670-2678.
-
(2002)
Oncogene
, vol.21
, pp. 2670-2678
-
-
Koike, C.1
-
50
-
-
0032741860
-
Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog
-
Sato N., et al. Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog. J. Clin. Invest. 104:1999;855-864.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 855-864
-
-
Sato, N.1
-
51
-
-
0035915476
-
Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia
-
Sato N., et al. Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia. J. Natl. Cancer Inst. 93:2001;1858-1864.
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 1858-1864
-
-
Sato, N.1
-
52
-
-
0036144970
-
Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease
-
Tsuboi K., Shults C.W. Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease. Exp. Neurol. 173:2002;95-104.
-
(2002)
Exp. Neurol.
, vol.173
, pp. 95-104
-
-
Tsuboi, K.1
Shults, C.W.2
-
53
-
-
0036167305
-
Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model
-
Pepinsky R.B., et al. Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model. J. Pharm. Sci. 91:2002;371-387.
-
(2002)
J. Pharm. Sci.
, vol.91
, pp. 371-387
-
-
Pepinsky, R.B.1
-
54
-
-
0036677570
-
Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure
-
Ahlgren S.C., et al. Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure. Proc. Natl. Acad. Sci. U. S. A. 99:2002;10476-10481.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 10476-10481
-
-
Ahlgren, S.C.1
-
55
-
-
0034738979
-
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
-
Taipale J., et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature. 406:2000;1005-1009.
-
(2000)
Nature
, vol.406
, pp. 1005-1009
-
-
Taipale, J.1
|