The Hedgehog signalling pathway as a therapeutic target in early breast cancer development

Expert Opinion on Therapeutic Targets

Volumn 13, Issue 9, 2009, Pages 1095-1103

  O'Toole, Sandra A ^a,b,c,d   Swarbrick, Alexander ^a,c   Sutherland, Robert L ^a,c  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Breast cancer; Developmental pathways; Early breast cancer; Hedgehog signalling

Indexed keywords

CYCLOPAMINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR ALPHA; JERVINE; PHYSALIN B; PHYSALIN F; PROTEIN PATCHED 1; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 3; SONIC HEDGEHOG PROTEIN; TAMOXIFEN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; ZERUMBONE;

BREAST CANCER; BREAST CARCINOGENESIS; CANCER INHIBITION; CANCER RESISTANCE; DRUG TARGETING; EARLY CANCER; HUMAN; NONHUMAN; PARACRINE SIGNALING; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CLINICAL TRIALS AS TOPIC; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, NEOPLASM; FEMALE; HEDGEHOG PROTEINS; HUMANS; SIGNAL TRANSDUCTION;

EID: 68549087254     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728220903130612     Document Type: Review

References (62)

1. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;365(9472):1687-1717
2. Smith I, Procter M, Gelber RD, et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 2007;369(9555):29-36 (Pubitemid 46039831)
3. Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353(16):1659-1672 (Pubitemid 41464705)
4. Zardawi SJ, O'Toole SA, Sutherland RL, Musgrove EA. Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer. Histol Histopathol 2009;24(3):385-398
5. Liu S, Dontu G, Wicha MS. Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res 2005;7(3):86-95 (Pubitemid 40704127)
6. Liu S, Dontu G, Mantle ID, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006;66(12):6063-6071
7. Hatsell S, Frost AR. Hedgehog signaling in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia 2007;12(2-3):163-173 (Pubitemid 47215434)
8. Clement V, Sanchez P, de Tribolet N, et al. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 2007;17(2):165-172 (Pubitemid 46107823)
9. Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004;432(7015):324-331 (Pubitemid 39551660)
10. Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003;425(6960):851-856
11. Karhadkar SS, Bova GS, Abdallah N, et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004;431(7009):707-712 (Pubitemid 39382619)
12. Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003;425(6960):846-851 (Pubitemid 37351469)
13. Berman DM, Karhadkar SS, Hallahan AR, et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002;297(5586):1559-1561
14. Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea - a paradigm shift. Cancer Res 2006;66(4):1883-1890 (Pubitemid 43294892)
15. Nusslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980;287(5785):795-801 (Pubitemid 11214475)
16. McMahon AP, Ingham PW, Tabin CJ. Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 2003;53:1-114 (Pubitemid 137639458)
17. Cohen MM Jr. The hedgehog signaling network. Am J Med Genet A 2003;123A(1):5-28
18. Machold R, Hayashi S, Rutlin M, et al. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 2003;39(6):937-950 (Pubitemid 37130210)
19. van den Brink GR, Bleuming SA, Hardwick JC, et al. Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet 2004;36(3):277-282
20. Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev 2008;22(18):2454-2472
21. Dillon R, Gadgil C, Othmer HG. Short- and long-range effects of Sonic hedgehog in limb development. Proc Natl Acad Sci USA 2003;100(18):10152-10157 (Pubitemid 37071848)
22. Gallet A, Ruel L, Staccini-Lavenant L, Therond PP. Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia. Development 2006;133(3):407-18
23. Goetz JA, Suber LM, Zeng X, Robbins DJ. Sonic Hedgehog as a mediator of long-range signaling. Bioessays 2002;24(2):157-165 (Pubitemid 34179294)
24. Lewis PM, Dunn MP, McMahon JA, et al. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 2001;105(5):599-612
25. Li Y, Zhang H, Litingtung Y, Chiang C. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc Natl Acad Sci USA 2006;103(17):6548-6553
26. Zeng X, Goetz JA, Suber LM, et al. A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature 2001;411(6838):716-720 (Pubitemid 32531680)
27. Kawakami T, Kawcak T, Li YJ, et al. Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development 2002;129(24):5753-5765 (Pubitemid 36054618)
28. Riobo NA, Manning DR. Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem J 2007;403(3):369-379 (Pubitemid 46706966)
29. Wang Y, Zhou Z, Walsh CT, McMahon AP. Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci USA 2009;106(8):2623-2628
30. Huangfu D, Liu A, Rakeman AS, et al. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 2003;426(6962):83-87 (Pubitemid 37432545)
31. Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001;15(23):3059-3087 (Pubitemid 33115673)
32. Duman-Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 2002;417(6886):299-304 (Pubitemid 34534713)
33. Ingram WJ, Wicking CA, Grimmond SM, et al. Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells. Oncogene 2002;21(53):8196-8205
34. Garber K. Hedgehog drugs begin to show results. J Natl Cancer Inst 2008;100(10):692-697
35. Cooper MK, Porter JA, Young KE, Beachy PA. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 1998;280(5369):1603-1607
36. Keeler RF, Binns W. Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology 1968;1(1):5-10
37. Chen JK, Taipale J, Young KE, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci USA 2002;99(22):14071-14076 (Pubitemid 35257626)
38. Mahindroo N, Punchihewa C, Fujii N. Hedgehog-Gli signaling pathway inhibitors as anticancer agents. J Med Chem 2009;52(13):3829-3845
39. Ericson J, Morton S, Kawakami A, et al. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 1996;87(4):661-673 (Pubitemid 26386940)
40. Unden AB, Stahle-Backdahl M, Holmberg E, et al. Fine mapping of the locus for nevoid basal cell carcinoma syndrome on chromosome 9q. Acta Derm Venereol 1997;77(1):4-9 (Pubitemid 27067278)
41. Unden AB, Zaphiropoulos PG, Bruce K, et al. Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma. Cancer Res 1997;57(12):2336-2340 (Pubitemid 27255884)
42. Xie J, Murone M, Luoh SM, et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998;391(6662):90-92 (Pubitemid 28079221)
43. Watkins DN, Berman DM, Burkholder SG, et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003;422(6929):313-317
44. Watkins DN, Berman DM, Baylin SB. Hedgehog signaling: progenitor phenotype in small-cell lung cancer. Cell Cycle 2003;2(3):196-198
45. Shaw A, Bushman W. Hedgehog signaling in the prostate. J Urol 2007;177(3):832-838
46. Yauch RL, Gould SE, Scales SJ, et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008;455(7211):406-410
47. Daniel VC, Marchionni L, Hierman JS, et al. A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro. Cancer Res 2009;69(8):3364-3373
48. De Witt Hamer PC, Van Tilborg AA, Eijk PP, et al. The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids. Oncogene 2008;27(14):2091-2096
49. Ruiz i Altaba A. Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets? Cancer Cell 2008;14(4):281-283
50. Kasper M, Jaks V, Fiaschi M, Toftgard R. Hedgehog signalling in breast cancer. Carcinogenesis 2009;30(6):903-911
51. Lewis MT, Ross S, Strickland P, et al. Defects in mouse mammary gland development cuased by conditional haploinsufficiency of Patched-1. Development 1999;126:5181-5193 (Pubitemid 30000430)
52. Moraes RC, Zhang X, Harrington N, et al. Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia. Development 2007;134(6):1231-1242 (Pubitemid 46630090)
53. Lewis MT, Ross S, Strickland PA, et al. The Gli2 transcription factor is required for normal mouse mammary gland development. Dev Biol 2001;238(1):133-144 (Pubitemid 32939291)
54. O'Toole S, Swarbrick A, Millar E, et al. Aberrant hedgehog signaling is an early event in breast cancer development. Cancer Res 2009;69:70s
55. Wicking C, Evans T, Henk B, et al. No evidence for the H133Y mutation in Sonic Hedgehog in a collection of common tumour types. Oncogene 1998;16(8):1091-1093 (Pubitemid 28107947)
56. Vorechovsky I, Benediktsson KP, Toftgard R. The patched/hedgehog/ smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations. Eur J Cancer 1999;35(5):711-713
57. Kubo M, Nakamura M, Tasaki A, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 2004;64(17):6071-6074 (Pubitemid 39129406)
58. Sinha S, Singh RK, Alam N, et al. Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma. Mol Cancer 2008;7:84. Published online 6 November 2008, doi:10.1186/1476-4598-7-84
59. Nessling M, Richter K, Schwaenen C, et al. Candidate genes in breast cancer revealed by microarray-based comparative genomic hybridization of archived tissue. Cancer Res 2005;65(2):439-447
60. Wolf I, Bose S, Desmond JC, et al. Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer. Breast Cancer Res Treat 2007;105(2):139-155 (Pubitemid 47366878)
61. Zhang X, Harrington N, Moraes RC, et al. Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo). Breast Cancer Res Treat 2009;115(3):505-521
62. Zhao J, Chen G, Cao D, et al. Expression of Gli1 correlates with the transition of breast cancer cells to estrogen-independent growth. Breast Cancer Res Treat 2009;115:505-521